Reviewed, UniProtKB/Swiss-Prot Q5THK1 (CV030_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C22orf30

Gene names

Name:

C22orf30

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2151 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.5 Ref.6
Sequence caution	The sequence BAB15536.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB15536.1 differs from that shown. Reason: Frameshift at position 1174. The sequence CAI22445.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5THK1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5THK1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2001-2151: AEPEKRPKKV...EEEQEQSSGC → VKEEGV

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5THK1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1234-1239: SLKSIE → SPCLTT
     1240-2151: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q5THK1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2061-2151: CLETIFEEPK...EEEQEQSSGC → DLDSSCPSTD...TWAGRGDSSL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2151	2151	Uncharacterized protein C22orf30		PRO_0000295739
Amino acid modifications
	Modified residue	157	1	Phosphoserine Ref.5
	Modified residue	1029	1	Phosphoserine Ref.6
	Modified residue	1994	1	Phosphoserine
Natural variations
	Alternative sequence	1234 – 1239	6	SLKSIE → SPCLTT in isoform 3.		VSP_027046
	Alternative sequence	1240 – 2151	912	Missing in isoform 3.		VSP_027047
	Alternative sequence	2001 – 2151	151	AEPEK…QSSGC → VKEEGV in isoform 2.		VSP_027048
	Alternative sequence	2061 – 2151	91	CLETI…QSSGC → DLDSSCPSTDSETGHFLVFG YAQRQAQPHPLLASRRLIGC SSPEGRGHPRSYPYWRRLLV LCWYLPGWRAGRVTWLRLAT WAGRGDSSL in isoform 4.		VSP_027049
	Natural variant	455	1	N → S: dbSNP rs140081.		VAR_059641
	Natural variant	740	1	L → P: dbSNP rs140080.		VAR_059642
	Natural variant	876	1	M → I: dbSNP rs17821493.		VAR_059643
	Natural variant	961	1	T → I: dbSNP rs140079.		VAR_059644
	Natural variant	963	1	D → N: dbSNP rs9619227.		VAR_059645
	Natural variant	1151	1	S → P: dbSNP rs12159328.		VAR_059646
	Natural variant	1221	1	S → L: dbSNP rs140078.		VAR_059647
	Natural variant	1395	1	L → F: dbSNP rs3804090.		VAR_059648
	Natural variant	1784	1	V → I: dbSNP rs16989427.		VAR_059649
Experimental info
	Sequence conflict	885	1	I → N in BAB15536. Ref.3
	Sequence conflict	1223	1	S → F in BAB15536. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: A1E0277094885E1F	FASTA	2,151	237,300
	10 20 30 40 50 60 MLSSGVETQP VPLDSSMSAV VQELYSELPV SVSRELHADP EPSVIPDVKP GASSSLLSQN 70 80 90 100 110 120 RALPLELQRT HVESCCEETY ETLDHGSEPG RCGLVDSTAG GSVASGILDR AKRSESMEPK 130 140 150 160 170 180 VFRDPGGQAG IIREPSEGAK EDPHQHSTAA EEKTSPSQED LLMQSSKELS HVDLPEDFLR 190 200 210 220 230 240 SKEGNVQITA ETLLKSAEVQ GMKVNGTKTD NNEGHKNGNV SKDLSAGCGE FQEVDKIMTS 250 260 270 280 290 300 DEVSETSTLV TPEPLTFVDP VLTEATPKEK ECEELKSCPW LSLPGNSAIS NVDNGKEELC 310 320 330 340 350 360 KPNLVCEADD NHQQLHGHHN EQPSSTHDSP TATSPLKENS EVSCFTSDLS GPESRTISLE 370 380 390 400 410 420 NCGFEGGGLL KRSAEKTDSS YFYRGDDQGK NLASREENEE RLLIPRSERG GPFLFNAREP 430 440 450 460 470 480 EKEISGRCSG EKEPVVSPKE NIHNNCIQDS LHTGNSSSLM PNSFTEATEV MLNKNDLKIT 490 500 510 520 530 540 VHVQGNLTNP EDHKETFTNM SHPGGHSEES SFSSLMQIEE AGQTTPVEPN ILSKSFYTKD 550 560 570 580 590 600 CNSLVSIQRN LEGNTQLNEA SCNDFLFERK SIVSLMPEDQ ISPVSEVLKP KQGTALLLPS 610 620 630 640 650 660 PEFDYRPESE KVIQTSHDDI PLLDEQSIAC EMNELSCTNE LVVNKVESEC VLNQQVSLNS 670 680 690 700 710 720 QEHANLPTDS LLHLNKEMPL ATGRDAHQSH HPPLEGRADV IADIQTIPIQ TKIKDISPPG 730 740 750 760 770 780 NQTCGASSNC PTLNIKPVSL ERKKEMADSG TKALHSRLRS NKREAAGFPQ VVSVIECHSV 790 800 810 820 830 840 QSQDISSCHR VRKNVSQENM CSASAAFKSS KISLQVDNSL ITKYENAFQH RDHCCQGTGH 850 860 870 880 890 900 SVEKSSCKVS YTSQERELDG KETNGSLPGD KIRNKMVAGL LNSGISNKTI HTSSSIKLSE 910 920 930 940 950 960 EGLEGKEQDV SKETVFCKYN ISDHAIQELN QTVNIPGPEK VLDQSPTVMF SSFKNVKSVE 970 980 990 1000 1010 1020 TLDQKADEVL DCQSNQNRPD ECKSEGQSAK EMLSSDQRET VTEPHGEVNH NQKDLLVSSG 1030 1040 1050 1060 1070 1080 SNNSLPCGSP KKCNLKGAFV KMSGCDESTE GMVDIVYTDC SNKLAEGVLD VKASNLLDCG 1090 1100 1110 1120 1130 1140 ARQEKLAFQE DSRSTLSRRE LDAAHTGTTG QDSDFPVTAA STVDFLKIKK SCEENVCRSL 1150 1160 1170 1180 1190 1200 KDCEMEKCPD SCAHEMESVA DHEPNKRILG RVNLSLNDSH YGQQDKGTSL RETQEMTEGS 1210 1220 1230 1240 1250 1260 RLEPNSEFGK ESTFGISSKE SMSCHDESSV SLRSLKSIEI MPSQENSETN VNSEETDLKN 1270 1280 1290 1300 1310 1320 LCKPKDGEML CENVKDCTVL PEMKEIVSRD WSNSSDRDSV CTCVEKNACK ACHPHENSSD 1330 1340 1350 1360 1370 1380 RHLPLTVKTD IKVKGEETEE HQRGRLGYLT VGEQSEELVT RETGDGDPVS NISQTHFKCR 1390 1400 1410 1420 1430 1440 GILNHAEKQQ SPEVLDYMLQ KEEKYIRQQK AHTISQQCIS SSLLLDDAQN QNQPKADKDE 1450 1460 1470 1480 1490 1500 STMINEITLA KLAKDSIVAQ TQKLEDQKEE RLHHPLRKDT ESCTSPCLLG APRKAQDPSS 1510 1520 1530 1540 1550 1560 AGCDQIHGAF AKKGVLPLKK QPHRTCKKVS YQEQIIVGRK IGKIRSSAFL KSSSNPIPTK 1570 1580 1590 1600 1610 1620 AHRLLSLCTL SAPTRLEPET APTKSLVSHI PKQMSTPCHP LRSLNFRKTT KESALLNKLS 1630 1640 1650 1660 1670 1680 ILASKLAPAM KTQKLRYRRC SSELLPMAKS YKRLRYKRLL DGFSSSTEQL NPYLAASGWD 1690 1700 1710 1720 1730 1740 KRPNSKPMAL YSLESIKMTF IDLSNKMPSL LFGSEIFPVS FHVKSSSSDC TTESSRTFPE 1750 1760 1770 1780 1790 1800 HCAPARLALG EALQCPSQPP KWTFSFFLSH GCPGMATFRE DTGVHSQTHT QAPPQPPAPL 1810 1820 1830 1840 1850 1860 QDYGGTAIVQ TRADCSVLGL HTLLALCSPG CYRIWTKKRS FSSHMPTMQR LFMTQFTQGL 1870 1880 1890 1900 1910 1920 KGLRSPASIA DKVFCSLPYS VGRVLSIWSQ HGPSVCSFEI SSLHSPHCKR QPSLGTTSSH 1930 1940 1950 1960 1970 1980 TMLPYVPLPG MEATYNTSGS QTRLEPPFPA LVPKSCLVAE SAVSKLLLSA SEFQVRGLDE 1990 2000 2010 2020 2030 2040 LDGVKAACPC PQSSPPEQKE AEPEKRPKKV SQIRIRKTIP RPDPNLTPMG LPRPKRLKKK 2050 2060 2070 2080 2090 2100 EFSLEEIYTN KNYKSPPANR CLETIFEEPK ERNGTLISIS QQKRKRVLEF QDFTVPRKRR 2110 2120 2130 2140 2150 ARGKVKVAGS FTRAQKAAVQ SRELDALLIQ KLMELETFFA KEEEQEQSSG C
	Isoform 2. Checksum: BE3CD185A946DA43	FASTA	2,006	220,377
	10 20 30 40 50 60 MLSSGVETQP VPLDSSMSAV VQELYSELPV SVSRELHADP EPSVIPDVKP GASSSLLSQN 70 80 90 100 110 120 RALPLELQRT HVESCCEETY ETLDHGSEPG RCGLVDSTAG GSVASGILDR AKRSESMEPK 130 140 150 160 170 180 VFRDPGGQAG IIREPSEGAK EDPHQHSTAA EEKTSPSQED LLMQSSKELS HVDLPEDFLR 190 200 210 220 230 240 SKEGNVQITA ETLLKSAEVQ GMKVNGTKTD NNEGHKNGNV SKDLSAGCGE FQEVDKIMTS 250 260 270 280 290 300 DEVSETSTLV TPEPLTFVDP VLTEATPKEK ECEELKSCPW LSLPGNSAIS NVDNGKEELC 310 320 330 340 350 360 KPNLVCEADD NHQQLHGHHN EQPSSTHDSP TATSPLKENS EVSCFTSDLS GPESRTISLE 370 380 390 400 410 420 NCGFEGGGLL KRSAEKTDSS YFYRGDDQGK NLASREENEE RLLIPRSERG GPFLFNAREP 430 440 450 460 470 480 EKEISGRCSG EKEPVVSPKE NIHNNCIQDS LHTGNSSSLM PNSFTEATEV MLNKNDLKIT 490 500 510 520 530 540 VHVQGNLTNP EDHKETFTNM SHPGGHSEES SFSSLMQIEE AGQTTPVEPN ILSKSFYTKD 550 560 570 580 590 600 CNSLVSIQRN LEGNTQLNEA SCNDFLFERK SIVSLMPEDQ ISPVSEVLKP KQGTALLLPS 610 620 630 640 650 660 PEFDYRPESE KVIQTSHDDI PLLDEQSIAC EMNELSCTNE LVVNKVESEC VLNQQVSLNS 670 680 690 700 710 720 QEHANLPTDS LLHLNKEMPL ATGRDAHQSH HPPLEGRADV IADIQTIPIQ TKIKDISPPG 730 740 750 760 770 780 NQTCGASSNC PTLNIKPVSL ERKKEMADSG TKALHSRLRS NKREAAGFPQ VVSVIECHSV 790 800 810 820 830 840 QSQDISSCHR VRKNVSQENM CSASAAFKSS KISLQVDNSL ITKYENAFQH RDHCCQGTGH 850 860 870 880 890 900 SVEKSSCKVS YTSQERELDG KETNGSLPGD KIRNKMVAGL LNSGISNKTI HTSSSIKLSE 910 920 930 940 950 960 EGLEGKEQDV SKETVFCKYN ISDHAIQELN QTVNIPGPEK VLDQSPTVMF SSFKNVKSVE 970 980 990 1000 1010 1020 TLDQKADEVL DCQSNQNRPD ECKSEGQSAK EMLSSDQRET VTEPHGEVNH NQKDLLVSSG 1030 1040 1050 1060 1070 1080 SNNSLPCGSP KKCNLKGAFV KMSGCDESTE GMVDIVYTDC SNKLAEGVLD VKASNLLDCG 1090 1100 1110 1120 1130 1140 ARQEKLAFQE DSRSTLSRRE LDAAHTGTTG QDSDFPVTAA STVDFLKIKK SCEENVCRSL 1150 1160 1170 1180 1190 1200 KDCEMEKCPD SCAHEMESVA DHEPNKRILG RVNLSLNDSH YGQQDKGTSL RETQEMTEGS 1210 1220 1230 1240 1250 1260 RLEPNSEFGK ESTFGISSKE SMSCHDESSV SLRSLKSIEI MPSQENSETN VNSEETDLKN 1270 1280 1290 1300 1310 1320 LCKPKDGEML CENVKDCTVL PEMKEIVSRD WSNSSDRDSV CTCVEKNACK ACHPHENSSD 1330 1340 1350 1360 1370 1380 RHLPLTVKTD IKVKGEETEE HQRGRLGYLT VGEQSEELVT RETGDGDPVS NISQTHFKCR 1390 1400 1410 1420 1430 1440 GILNHAEKQQ SPEVLDYMLQ KEEKYIRQQK AHTISQQCIS SSLLLDDAQN QNQPKADKDE 1450 1460 1470 1480 1490 1500 STMINEITLA KLAKDSIVAQ TQKLEDQKEE RLHHPLRKDT ESCTSPCLLG APRKAQDPSS 1510 1520 1530 1540 1550 1560 AGCDQIHGAF AKKGVLPLKK QPHRTCKKVS YQEQIIVGRK IGKIRSSAFL KSSSNPIPTK 1570 1580 1590 1600 1610 1620 AHRLLSLCTL SAPTRLEPET APTKSLVSHI PKQMSTPCHP LRSLNFRKTT KESALLNKLS 1630 1640 1650 1660 1670 1680 ILASKLAPAM KTQKLRYRRC SSELLPMAKS YKRLRYKRLL DGFSSSTEQL NPYLAASGWD 1690 1700 1710 1720 1730 1740 KRPNSKPMAL YSLESIKMTF IDLSNKMPSL LFGSEIFPVS FHVKSSSSDC TTESSRTFPE 1750 1760 1770 1780 1790 1800 HCAPARLALG EALQCPSQPP KWTFSFFLSH GCPGMATFRE DTGVHSQTHT QAPPQPPAPL 1810 1820 1830 1840 1850 1860 QDYGGTAIVQ TRADCSVLGL HTLLALCSPG CYRIWTKKRS FSSHMPTMQR LFMTQFTQGL 1870 1880 1890 1900 1910 1920 KGLRSPASIA DKVFCSLPYS VGRVLSIWSQ HGPSVCSFEI SSLHSPHCKR QPSLGTTSSH 1930 1940 1950 1960 1970 1980 TMLPYVPLPG MEATYNTSGS QTRLEPPFPA LVPKSCLVAE SAVSKLLLSA SEFQVRGLDE 1990 2000 LDGVKAACPC PQSSPPEQKE VKEEGV
	Isoform 3. Checksum: A755F4609C90D017	FASTA	1,239	135,393
	10 20 30 40 50 60 MLSSGVETQP VPLDSSMSAV VQELYSELPV SVSRELHADP EPSVIPDVKP GASSSLLSQN 70 80 90 100 110 120 RALPLELQRT HVESCCEETY ETLDHGSEPG RCGLVDSTAG GSVASGILDR AKRSESMEPK 130 140 150 160 170 180 VFRDPGGQAG IIREPSEGAK EDPHQHSTAA EEKTSPSQED LLMQSSKELS HVDLPEDFLR 190 200 210 220 230 240 SKEGNVQITA ETLLKSAEVQ GMKVNGTKTD NNEGHKNGNV SKDLSAGCGE FQEVDKIMTS 250 260 270 280 290 300 DEVSETSTLV TPEPLTFVDP VLTEATPKEK ECEELKSCPW LSLPGNSAIS NVDNGKEELC 310 320 330 340 350 360 KPNLVCEADD NHQQLHGHHN EQPSSTHDSP TATSPLKENS EVSCFTSDLS GPESRTISLE 370 380 390 400 410 420 NCGFEGGGLL KRSAEKTDSS YFYRGDDQGK NLASREENEE RLLIPRSERG GPFLFNAREP 430 440 450 460 470 480 EKEISGRCSG EKEPVVSPKE NIHNNCIQDS LHTGNSSSLM PNSFTEATEV MLNKNDLKIT 490 500 510 520 530 540 VHVQGNLTNP EDHKETFTNM SHPGGHSEES SFSSLMQIEE AGQTTPVEPN ILSKSFYTKD 550 560 570 580 590 600 CNSLVSIQRN LEGNTQLNEA SCNDFLFERK SIVSLMPEDQ ISPVSEVLKP KQGTALLLPS 610 620 630 640 650 660 PEFDYRPESE KVIQTSHDDI PLLDEQSIAC EMNELSCTNE LVVNKVESEC VLNQQVSLNS 670 680 690 700 710 720 QEHANLPTDS LLHLNKEMPL ATGRDAHQSH HPPLEGRADV IADIQTIPIQ TKIKDISPPG 730 740 750 760 770 780 NQTCGASSNC PTLNIKPVSL ERKKEMADSG TKALHSRLRS NKREAAGFPQ VVSVIECHSV 790 800 810 820 830 840 QSQDISSCHR VRKNVSQENM CSASAAFKSS KISLQVDNSL ITKYENAFQH RDHCCQGTGH 850 860 870 880 890 900 SVEKSSCKVS YTSQERELDG KETNGSLPGD KIRNKMVAGL LNSGISNKTI HTSSSIKLSE 910 920 930 940 950 960 EGLEGKEQDV SKETVFCKYN ISDHAIQELN QTVNIPGPEK VLDQSPTVMF SSFKNVKSVE 970 980 990 1000 1010 1020 TLDQKADEVL DCQSNQNRPD ECKSEGQSAK EMLSSDQRET VTEPHGEVNH NQKDLLVSSG 1030 1040 1050 1060 1070 1080 SNNSLPCGSP KKCNLKGAFV KMSGCDESTE GMVDIVYTDC SNKLAEGVLD VKASNLLDCG 1090 1100 1110 1120 1130 1140 ARQEKLAFQE DSRSTLSRRE LDAAHTGTTG QDSDFPVTAA STVDFLKIKK SCEENVCRSL 1150 1160 1170 1180 1190 1200 KDCEMEKCPD SCAHEMESVA DHEPNKRILG RVNLSLNDSH YGQQDKGTSL RETQEMTEGS 1210 1220 1230 RLEPNSEFGK ESTFGISSKE SMSCHDESSV SLRSPCLTT
	Isoform 4. Checksum: 1936AAA31D63A913	FASTA	2,149	236,883
	10 20 30 40 50 60 MLSSGVETQP VPLDSSMSAV VQELYSELPV SVSRELHADP EPSVIPDVKP GASSSLLSQN 70 80 90 100 110 120 RALPLELQRT HVESCCEETY ETLDHGSEPG RCGLVDSTAG GSVASGILDR AKRSESMEPK 130 140 150 160 170 180 VFRDPGGQAG IIREPSEGAK EDPHQHSTAA EEKTSPSQED LLMQSSKELS HVDLPEDFLR 190 200 210 220 230 240 SKEGNVQITA ETLLKSAEVQ GMKVNGTKTD NNEGHKNGNV SKDLSAGCGE FQEVDKIMTS 250 260 270 280 290 300 DEVSETSTLV TPEPLTFVDP VLTEATPKEK ECEELKSCPW LSLPGNSAIS NVDNGKEELC 310 320 330 340 350 360 KPNLVCEADD NHQQLHGHHN EQPSSTHDSP TATSPLKENS EVSCFTSDLS GPESRTISLE 370 380 390 400 410 420 NCGFEGGGLL KRSAEKTDSS YFYRGDDQGK NLASREENEE RLLIPRSERG GPFLFNAREP 430 440 450 460 470 480 EKEISGRCSG EKEPVVSPKE NIHNNCIQDS LHTGNSSSLM PNSFTEATEV MLNKNDLKIT 490 500 510 520 530 540 VHVQGNLTNP EDHKETFTNM SHPGGHSEES SFSSLMQIEE AGQTTPVEPN ILSKSFYTKD 550 560 570 580 590 600 CNSLVSIQRN LEGNTQLNEA SCNDFLFERK SIVSLMPEDQ ISPVSEVLKP KQGTALLLPS 610 620 630 640 650 660 PEFDYRPESE KVIQTSHDDI PLLDEQSIAC EMNELSCTNE LVVNKVESEC VLNQQVSLNS 670 680 690 700 710 720 QEHANLPTDS LLHLNKEMPL ATGRDAHQSH HPPLEGRADV IADIQTIPIQ TKIKDISPPG 730 740 750 760 770 780 NQTCGASSNC PTLNIKPVSL ERKKEMADSG TKALHSRLRS NKREAAGFPQ VVSVIECHSV 790 800 810 820 830 840 QSQDISSCHR VRKNVSQENM CSASAAFKSS KISLQVDNSL ITKYENAFQH RDHCCQGTGH 850 860 870 880 890 900 SVEKSSCKVS YTSQERELDG KETNGSLPGD KIRNKMVAGL LNSGISNKTI HTSSSIKLSE 910 920 930 940 950 960 EGLEGKEQDV SKETVFCKYN ISDHAIQELN QTVNIPGPEK VLDQSPTVMF SSFKNVKSVE 970 980 990 1000 1010 1020 TLDQKADEVL DCQSNQNRPD ECKSEGQSAK EMLSSDQRET VTEPHGEVNH NQKDLLVSSG 1030 1040 1050 1060 1070 1080 SNNSLPCGSP KKCNLKGAFV KMSGCDESTE GMVDIVYTDC SNKLAEGVLD VKASNLLDCG 1090 1100 1110 1120 1130 1140 ARQEKLAFQE DSRSTLSRRE LDAAHTGTTG QDSDFPVTAA STVDFLKIKK SCEENVCRSL 1150 1160 1170 1180 1190 1200 KDCEMEKCPD SCAHEMESVA DHEPNKRILG RVNLSLNDSH YGQQDKGTSL RETQEMTEGS 1210 1220 1230 1240 1250 1260 RLEPNSEFGK ESTFGISSKE SMSCHDESSV SLRSLKSIEI MPSQENSETN VNSEETDLKN 1270 1280 1290 1300 1310 1320 LCKPKDGEML CENVKDCTVL PEMKEIVSRD WSNSSDRDSV CTCVEKNACK ACHPHENSSD 1330 1340 1350 1360 1370 1380 RHLPLTVKTD IKVKGEETEE HQRGRLGYLT VGEQSEELVT RETGDGDPVS NISQTHFKCR 1390 1400 1410 1420 1430 1440 GILNHAEKQQ SPEVLDYMLQ KEEKYIRQQK AHTISQQCIS SSLLLDDAQN QNQPKADKDE 1450 1460 1470 1480 1490 1500 STMINEITLA KLAKDSIVAQ TQKLEDQKEE RLHHPLRKDT ESCTSPCLLG APRKAQDPSS 1510 1520 1530 1540 1550 1560 AGCDQIHGAF AKKGVLPLKK QPHRTCKKVS YQEQIIVGRK IGKIRSSAFL KSSSNPIPTK 1570 1580 1590 1600 1610 1620 AHRLLSLCTL SAPTRLEPET APTKSLVSHI PKQMSTPCHP LRSLNFRKTT KESALLNKLS 1630 1640 1650 1660 1670 1680 ILASKLAPAM KTQKLRYRRC SSELLPMAKS YKRLRYKRLL DGFSSSTEQL NPYLAASGWD 1690 1700 1710 1720 1730 1740 KRPNSKPMAL YSLESIKMTF IDLSNKMPSL LFGSEIFPVS FHVKSSSSDC TTESSRTFPE 1750 1760 1770 1780 1790 1800 HCAPARLALG EALQCPSQPP KWTFSFFLSH GCPGMATFRE DTGVHSQTHT QAPPQPPAPL 1810 1820 1830 1840 1850 1860 QDYGGTAIVQ TRADCSVLGL HTLLALCSPG CYRIWTKKRS FSSHMPTMQR LFMTQFTQGL 1870 1880 1890 1900 1910 1920 KGLRSPASIA DKVFCSLPYS VGRVLSIWSQ HGPSVCSFEI SSLHSPHCKR QPSLGTTSSH 1930 1940 1950 1960 1970 1980 TMLPYVPLPG MEATYNTSGS QTRLEPPFPA LVPKSCLVAE SAVSKLLLSA SEFQVRGLDE 1990 2000 2010 2020 2030 2040 LDGVKAACPC PQSSPPEQKE AEPEKRPKKV SQIRIRKTIP RPDPNLTPMG LPRPKRLKKK 2050 2060 2070 2080 2090 2100 EFSLEEIYTN KNYKSPPANR DLDSSCPSTD SETGHFLVFG YAQRQAQPHP LLASRRLIGC 2110 2120 2130 2140 SSPEGRGHPR SYPYWRRLLV LCWYLPGWRA GRVTWLRLAT WAGRGDSSL

References

[1]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-2151 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1332-2151 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1945-2151 (ISOFORM 1). Tissue: Adrenal gland, Lung and Uterus.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1699-2151 (ISOFORM 4). Tissue: Uterus.
[5]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, MASS SPECTROMETRY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1029, MASS SPECTROMETRY.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1029 AND SER-1994, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CT841517 mRNA. Translation: CAJ86447.1. AL031255, AC005004 Genomic DNA. Translation: CAI22445.1. Sequence problems. AL031255, AC005004 Genomic DNA. Translation: CAI22448.1. AK026712 mRNA. Translation: BAB15536.1. Sequence problems. AK123082 mRNA. Translation: BAC85533.1. Different initiation. AK130944 mRNA. Translation: BAC85470.1. Different initiation. BC040859 mRNA. Translation: AAH40859.1. Different initiation.
IPI	IPI00217178. IPI00643747. IPI00852797. IPI00854670.
RefSeq	NP_775837.2.
UniGene	Hs.438906
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5THK1.
Proteomic databases
PRIDE	Q5THK1.
Genome annotation databases
Ensembl	ENST00000327423; ENSP00000331845; ENSG00000183530; Homo sapiens. [Genome view]
GeneID	253143.
KEGG	hsa:253143.
UCSC	uc003alo.1. human. uc003alp.2. human. uc010gwj.1. human.
Organism-specific databases
CTD	253143.
GeneCards	GC22M030402.
HGNC	HGNC:28738. C22orf30.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q5THK1.
HOVERGEN	Q5THK1.
Gene expression databases
ArrayExpress	Q5THK1.
Bgee	Q5THK1.
CleanEx	HS_C22orf30.
Genevestigator	Q5THK1.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	92063.

Entry information

Entry name

CV030_HUMAN

Accession

Primary (citable) accession number: Q5THK1
Secondary accession number(s): Q5THK4 , Q6ZNN1, Q6ZWH0, Q8IW74, Q9H5T4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	December 21, 2004
Last modified:	November 24, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.