ID   STPG1_HUMAN             Reviewed;         334 AA.
AC   Q5TH74; Q49AP0; Q6P3R4; Q86VU9; Q8WVQ3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 119.
DE   RecName: Full=O(6)-methylguanine-induced apoptosis 2;
DE            Short=MAPO2;
DE   AltName: Full=Sperm-tail PG-rich repeat-containing protein 1;
GN   Name=STPG1; Synonyms=C1orf201;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC   TISSUE=Brain, Lung, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-72, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [4]
RP   FUNCTION.
RX   PubMed=23028632; DOI=10.1371/journal.pone.0044817;
RA   Fujikane R., Sanada M., Sekiguchi M., Hidaka M.;
RT   "The identification of a novel gene, MAPO2, that is involved in the
RT   induction of apoptosis triggered by O(6)-methylguanine.";
RL   PLoS ONE 7:E44817-E44817(2012).
RN   [5]
RP   VARIANT [LARGE SCALE ANALYSIS] PHE-254.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May positively contribute to the induction of apoptosis
CC       triggered by O(6)-methylguanine. {ECO:0000269|PubMed:23028632}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q5TH74-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5TH74-2; Sequence=VSP_028252;
CC       Name=3;
CC         IsoId=Q5TH74-3; Sequence=VSP_028253, VSP_028254;
CC   -!- SIMILARITY: Belongs to the STPG1 family. {ECO:0000305}.
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DR   EMBL; AL031431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC017650; AAH17650.1; -; mRNA.
DR   EMBL; BC035061; AAH35061.1; -; mRNA.
DR   EMBL; BC047705; AAH47705.1; -; mRNA.
DR   EMBL; BC063891; AAH63891.1; -; mRNA.
DR   CCDS; CCDS253.1; -. [Q5TH74-3]
DR   CCDS; CCDS55581.1; -. [Q5TH74-1]
DR   RefSeq; NP_001185941.1; NM_001199012.1. [Q5TH74-1]
DR   RefSeq; NP_001185942.1; NM_001199013.1. [Q5TH74-1]
DR   RefSeq; NP_001185943.1; NM_001199014.1. [Q5TH74-2]
DR   RefSeq; NP_835223.1; NM_178122.4. [Q5TH74-3]
DR   RefSeq; XP_006711088.1; XM_006711025.2.
DR   RefSeq; XP_011540705.1; XM_011542403.2. [Q5TH74-3]
DR   RefSeq; XP_011540706.1; XM_011542404.1.
DR   RefSeq; XP_016858257.1; XM_017002768.1.
DR   RefSeq; XP_016858258.1; XM_017002769.1.
DR   RefSeq; XP_016858259.1; XM_017002770.1.
DR   AlphaFoldDB; Q5TH74; -.
DR   BioGRID; 124732; 2.
DR   STRING; 9606.ENSP00000363530; -.
DR   iPTMnet; Q5TH74; -.
DR   PhosphoSitePlus; Q5TH74; -.
DR   BioMuta; STPG1; -.
DR   DMDM; 74746565; -.
DR   MassIVE; Q5TH74; -.
DR   PaxDb; 9606-ENSP00000363530; -.
DR   PeptideAtlas; Q5TH74; -.
DR   ProteomicsDB; 65145; -. [Q5TH74-1]
DR   ProteomicsDB; 65146; -. [Q5TH74-2]
DR   ProteomicsDB; 65147; -. [Q5TH74-3]
DR   Antibodypedia; 15730; 35 antibodies from 11 providers.
DR   DNASU; 90529; -.
DR   Ensembl; ENST00000003583.12; ENSP00000003583.8; ENSG00000001460.18. [Q5TH74-3]
DR   Ensembl; ENST00000337248.9; ENSP00000337461.4; ENSG00000001460.18. [Q5TH74-1]
DR   Ensembl; ENST00000374409.5; ENSP00000363530.1; ENSG00000001460.18. [Q5TH74-1]
DR   GeneID; 90529; -.
DR   KEGG; hsa:90529; -.
DR   MANE-Select; ENST00000337248.9; ENSP00000337461.4; NM_001199013.2; NP_001185942.1.
DR   UCSC; uc001bja.4; human. [Q5TH74-1]
DR   AGR; HGNC:28070; -.
DR   CTD; 90529; -.
DR   DisGeNET; 90529; -.
DR   GeneCards; STPG1; -.
DR   HGNC; HGNC:28070; STPG1.
DR   HPA; ENSG00000001460; Tissue enhanced (testis).
DR   MIM; 615826; gene.
DR   neXtProt; NX_Q5TH74; -.
DR   OpenTargets; ENSG00000001460; -.
DR   PharmGKB; PA143485320; -.
DR   VEuPathDB; HostDB:ENSG00000001460; -.
DR   eggNOG; ENOG502R2KG; Eukaryota.
DR   GeneTree; ENSGT00390000011598; -.
DR   HOGENOM; CLU_071847_0_0_1; -.
DR   InParanoid; Q5TH74; -.
DR   OMA; GQYENPI; -.
DR   OrthoDB; 2906240at2759; -.
DR   PhylomeDB; Q5TH74; -.
DR   TreeFam; TF328937; -.
DR   PathwayCommons; Q5TH74; -.
DR   BioGRID-ORCS; 90529; 11 hits in 1161 CRISPR screens.
DR   GenomeRNAi; 90529; -.
DR   Pharos; Q5TH74; Tbio.
DR   PRO; PR:Q5TH74; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5TH74; Protein.
DR   Bgee; ENSG00000001460; Expressed in right testis and 124 other cell types or tissues.
DR   ExpressionAtlas; Q5TH74; baseline and differential.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
DR   GO; GO:1902110; P:positive regulation of mitochondrial membrane permeability involved in apoptotic process; IMP:UniProtKB.
DR   InterPro; IPR010736; SHIPPO-rpt.
DR   PANTHER; PTHR35678; PROTEIN STPG4; 1.
DR   PANTHER; PTHR35678:SF1; PROTEIN STPG4; 1.
DR   Pfam; PF07004; SHIPPO-rpt; 4.
DR   Genevisible; Q5TH74; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Apoptosis; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..334
FT                   /note="O(6)-methylguanine-induced apoptosis 2"
FT                   /id="PRO_0000305170"
FT   REPEAT          67..74
FT                   /note="STPGR 1"
FT   REPEAT          109..117
FT                   /note="STPGR 2"
FT   REPEAT          148..155
FT                   /note="STPGR 3"
FT   REPEAT          187..206
FT                   /note="STPGR 4"
FT   REPEAT          225..257
FT                   /note="STPGR 5"
FT   REPEAT          267..282
FT                   /note="STPGR 6"
FT   REPEAT          306..316
FT                   /note="STPGR 7"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         72
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0007744|PubMed:19690332"
FT   VAR_SEQ         1..92
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_028252"
FT   VAR_SEQ         1..47
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_028253"
FT   VAR_SEQ         48..62
FT                   /note="EKKGFNSQAKRFPHK -> MNALANIPDVPVKYR (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_028254"
FT   VARIANT         254
FT                   /note="S -> F (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035614"
FT   CONFLICT        93
FT                   /note="M -> T (in Ref. 2; AAH35061)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        105
FT                   /note="I -> V (in Ref. 2; AAH35061)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        163
FT                   /note="R -> I (in Ref. 2; AAH17650)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        233
FT                   /note="P -> T (in Ref. 2; AAH35061)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        332
FT                   /note="P -> R (in Ref. 2; AAH35061)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   334 AA;  36786 MW;  8DA37D63A36E478E CRC64;
     MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK GFNSQAKRFP
     HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR LDTIISKYPA ANAYTIPSDF
     ISKRDFSNSC SSMFQLPSFM KALKFETPAP NYYNASVSCC KQRNNVCTRA GFMSKTQRGS
     FAFADKGPPP GHYDINESLV KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP
     KKTLFPKNPI LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA
     PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL
//