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Q5TH74 (STPG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
O(6)-methylguanine-induced apoptosis 2

Short name=MAPO2
Alternative name(s):
Sperm-tail PG-rich repeat-containing protein 1
Gene names
Name:STPG1
Synonyms:C1orf201
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. Ref.4

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the STPG1 family.

Contains 7 STPGR (Sperm-tail PG-rich) repeats.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5TH74-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5TH74-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
Isoform 3 (identifier: Q5TH74-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     48-62: EKKGFNSQAKRFPHK → MNALANIPDVPVKYR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334O(6)-methylguanine-induced apoptosis 2
PRO_0000305170

Regions

Repeat67 – 748STPGR 1
Repeat109 – 1179STPGR 2
Repeat148 – 1558STPGR 3
Repeat187 – 20620STPGR 4
Repeat225 – 25733STPGR 5
Repeat267 – 28216STPGR 6
Repeat306 – 31611STPGR 7

Amino acid modifications

Modified residue721Phosphotyrosine Ref.3

Natural variations

Alternative sequence1 – 9292Missing in isoform 2.
VSP_028252
Alternative sequence1 – 4747Missing in isoform 3.
VSP_028253
Alternative sequence48 – 6215EKKGF…RFPHK → MNALANIPDVPVKYR in isoform 3.
VSP_028254
Natural variant2541S → F in a breast cancer sample; somatic mutation. Ref.5
VAR_035614

Experimental info

Sequence conflict931M → T in AAH35061. Ref.2
Sequence conflict1051I → V in AAH35061. Ref.2
Sequence conflict1631R → I in AAH17650. Ref.2
Sequence conflict2331P → T in AAH35061. Ref.2
Sequence conflict3321P → R in AAH35061. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 8DA37D63A36E478E

FASTA33436,786
        10         20         30         40         50         60 
MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK GFNSQAKRFP 

        70         80         90        100        110        120 
HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR LDTIISKYPA ANAYTIPSDF 

       130        140        150        160        170        180 
ISKRDFSNSC SSMFQLPSFM KALKFETPAP NYYNASVSCC KQRNNVCTRA GFMSKTQRGS 

       190        200        210        220        230        240 
FAFADKGPPP GHYDINESLV KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP 

       250        260        270        280        290        300 
KKTLFPKNPI LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA 

       310        320        330 
PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL 

« Hide

Isoform 2 [UniParc].

Checksum: CD6E23C0C52E0F1C
Show »

FASTA24226,700
Isoform 3 [UniParc].

Checksum: AF90B7815DEAB5E2
Show »

FASTA28731,539

References

« Hide 'large scale' references
[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Brain, Lung and Testis.
[3]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[4]"The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O(6)-methylguanine."
Fujikane R., Sanada M., Sekiguchi M., Hidaka M.
PLoS ONE 7:E44817-E44817(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-254.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL031431 Genomic DNA. Translation: CAI21410.1.
AL031431 Genomic DNA. Translation: CAI21411.1.
BC017650 mRNA. Translation: AAH17650.1.
BC035061 mRNA. Translation: AAH35061.1.
BC047705 mRNA. Translation: AAH47705.1.
BC063891 mRNA. Translation: AAH63891.1.
CCDSCCDS253.1. [Q5TH74-3]
CCDS55581.1. [Q5TH74-1]
RefSeqNP_001185941.1. NM_001199012.1. [Q5TH74-1]
NP_001185942.1. NM_001199013.1. [Q5TH74-1]
NP_001185943.1. NM_001199014.1. [Q5TH74-2]
NP_835223.1. NM_178122.4. [Q5TH74-3]
XP_005246084.1. XM_005246027.2. [Q5TH74-3]
XP_005246085.1. XM_005246028.1. [Q5TH74-2]
XP_006711088.1. XM_006711025.1. [Q5TH74-1]
UniGeneHs.403187.

3D structure databases

ProteinModelPortalQ5TH74.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000003583.

PTM databases

PhosphoSiteQ5TH74.

Polymorphism databases

DMDM74746565.

Proteomic databases

PaxDbQ5TH74.
PRIDEQ5TH74.

Protocols and materials databases

DNASU90529.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000003583; ENSP00000003583; ENSG00000001460. [Q5TH74-3]
ENST00000337248; ENSP00000337461; ENSG00000001460. [Q5TH74-1]
ENST00000374409; ENSP00000363530; ENSG00000001460. [Q5TH74-1]
ENST00000440416; ENSP00000408712; ENSG00000001460. [Q5TH74-3]
GeneID90529.
KEGGhsa:90529.
UCSCuc001bja.3. human. [Q5TH74-3]
uc001bjb.3. human. [Q5TH74-1]

Organism-specific databases

CTD90529.
GeneCardsGC01M024684.
H-InvDBHIX0000262.
HGNCHGNC:28070. STPG1.
HPAHPA024301.
HPA050593.
neXtProtNX_Q5TH74.
PharmGKBPA143485320.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44145.
HOGENOMHOG000007868.
HOVERGENHBG107567.
InParanoidQ5TH74.
OMARWTAAPP.
OrthoDBEOG7DFXDM.
PhylomeDBQ5TH74.
TreeFamTF328937.

Gene expression databases

ArrayExpressQ5TH74.
BgeeQ5TH74.
CleanExHS_C1orf201.
GenevestigatorQ5TH74.

Family and domain databases

InterProIPR010736. SHIPPO-rpt.
[Graphical view]
PfamPF07004. SHIPPO-rpt. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi90529.
NextBio76825.
PROQ5TH74.

Entry information

Entry nameSTPG1_HUMAN
AccessionPrimary (citable) accession number: Q5TH74
Secondary accession number(s): Q49AP0 expand/collapse secondary AC list , Q6P3R4, Q86VU9, Q8WVQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM