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Protein

O(6)-methylguanine-induced apoptosis 2

Gene

STPG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
O(6)-methylguanine-induced apoptosis 2
Short name:
MAPO2
Alternative name(s):
Sperm-tail PG-rich repeat-containing protein 1
Gene namesi
Name:STPG1
Synonyms:C1orf201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28070. STPG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000001460.
PharmGKBiPA143485320.

Polymorphism and mutation databases

BioMutaiSTPG1.
DMDMi74746565.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051701 – 334O(6)-methylguanine-induced apoptosis 2Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5TH74.
PRIDEiQ5TH74.

PTM databases

iPTMnetiQ5TH74.
PhosphoSitePlusiQ5TH74.

Expressioni

Gene expression databases

BgeeiENSG00000001460.
CleanExiHS_C1orf201.
ExpressionAtlasiQ5TH74. baseline and differential.
GenevisibleiQ5TH74. HS.

Organism-specific databases

HPAiHPA024301.
HPA050593.

Structurei

3D structure databases

ProteinModelPortaliQ5TH74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati67 – 74STPGR 18
Repeati109 – 117STPGR 29
Repeati148 – 155STPGR 38
Repeati187 – 206STPGR 4Add BLAST20
Repeati225 – 257STPGR 5Add BLAST33
Repeati267 – 282STPGR 6Add BLAST16
Repeati306 – 316STPGR 7Add BLAST11

Sequence similaritiesi

Belongs to the STPG1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IK80. Eukaryota.
ENOG4111MU0. LUCA.
GeneTreeiENSGT00390000011598.
HOGENOMiHOG000007868.
HOVERGENiHBG107567.
InParanoidiQ5TH74.
OMAiRWTAAPP.
OrthoDBiEOG091G0ABV.
PhylomeDBiQ5TH74.
TreeFamiTF328937.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TH74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK
60 70 80 90 100
GFNSQAKRFP HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR
110 120 130 140 150
LDTIISKYPA ANAYTIPSDF ISKRDFSNSC SSMFQLPSFM KALKFETPAP
160 170 180 190 200
NYYNASVSCC KQRNNVCTRA GFMSKTQRGS FAFADKGPPP GHYDINESLV
210 220 230 240 250
KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP KKTLFPKNPI
260 270 280 290 300
LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA
310 320 330
PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL
Length:334
Mass (Da):36,786
Last modified:December 21, 2004 - v1
Checksum:i8DA37D63A36E478E
GO
Isoform 2 (identifier: Q5TH74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:242
Mass (Da):26,700
Checksum:iCD6E23C0C52E0F1C
GO
Isoform 3 (identifier: Q5TH74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     48-62: EKKGFNSQAKRFPHK → MNALANIPDVPVKYR

Show »
Length:287
Mass (Da):31,539
Checksum:iAF90B7815DEAB5E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93M → T in AAH35061 (PubMed:15489334).Curated1
Sequence conflicti105I → V in AAH35061 (PubMed:15489334).Curated1
Sequence conflicti163R → I in AAH17650 (PubMed:15489334).Curated1
Sequence conflicti233P → T in AAH35061 (PubMed:15489334).Curated1
Sequence conflicti332P → R in AAH35061 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035614254S → F in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0282521 – 92Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0282531 – 47Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_02825448 – 62EKKGF…RFPHK → MNALANIPDVPVKYR in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031431 Genomic DNA. Translation: CAI21410.1.
AL031431 Genomic DNA. Translation: CAI21411.1.
BC017650 mRNA. Translation: AAH17650.1.
BC035061 mRNA. Translation: AAH35061.1.
BC047705 mRNA. Translation: AAH47705.1.
BC063891 mRNA. Translation: AAH63891.1.
CCDSiCCDS253.1. [Q5TH74-3]
CCDS55581.1. [Q5TH74-1]
RefSeqiNP_001185941.1. NM_001199012.1. [Q5TH74-1]
NP_001185942.1. NM_001199013.1. [Q5TH74-1]
NP_001185943.1. NM_001199014.1. [Q5TH74-2]
NP_835223.1. NM_178122.4. [Q5TH74-3]
XP_006711088.1. XM_006711025.2. [Q5TH74-1]
XP_011540706.1. XM_011542404.1. [Q5TH74-1]
XP_016858257.1. XM_017002768.1. [Q5TH74-3]
XP_016858258.1. XM_017002769.1. [Q5TH74-2]
XP_016858259.1. XM_017002770.1. [Q5TH74-2]
UniGeneiHs.403187.

Genome annotation databases

EnsembliENST00000003583; ENSP00000003583; ENSG00000001460. [Q5TH74-3]
ENST00000337248; ENSP00000337461; ENSG00000001460. [Q5TH74-1]
ENST00000374409; ENSP00000363530; ENSG00000001460. [Q5TH74-1]
GeneIDi90529.
KEGGihsa:90529.
UCSCiuc001bja.4. human. [Q5TH74-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031431 Genomic DNA. Translation: CAI21410.1.
AL031431 Genomic DNA. Translation: CAI21411.1.
BC017650 mRNA. Translation: AAH17650.1.
BC035061 mRNA. Translation: AAH35061.1.
BC047705 mRNA. Translation: AAH47705.1.
BC063891 mRNA. Translation: AAH63891.1.
CCDSiCCDS253.1. [Q5TH74-3]
CCDS55581.1. [Q5TH74-1]
RefSeqiNP_001185941.1. NM_001199012.1. [Q5TH74-1]
NP_001185942.1. NM_001199013.1. [Q5TH74-1]
NP_001185943.1. NM_001199014.1. [Q5TH74-2]
NP_835223.1. NM_178122.4. [Q5TH74-3]
XP_006711088.1. XM_006711025.2. [Q5TH74-1]
XP_011540706.1. XM_011542404.1. [Q5TH74-1]
XP_016858257.1. XM_017002768.1. [Q5TH74-3]
XP_016858258.1. XM_017002769.1. [Q5TH74-2]
XP_016858259.1. XM_017002770.1. [Q5TH74-2]
UniGeneiHs.403187.

3D structure databases

ProteinModelPortaliQ5TH74.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5TH74.
PhosphoSitePlusiQ5TH74.

Polymorphism and mutation databases

BioMutaiSTPG1.
DMDMi74746565.

Proteomic databases

PaxDbiQ5TH74.
PRIDEiQ5TH74.

Protocols and materials databases

DNASUi90529.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000003583; ENSP00000003583; ENSG00000001460. [Q5TH74-3]
ENST00000337248; ENSP00000337461; ENSG00000001460. [Q5TH74-1]
ENST00000374409; ENSP00000363530; ENSG00000001460. [Q5TH74-1]
GeneIDi90529.
KEGGihsa:90529.
UCSCiuc001bja.4. human. [Q5TH74-1]

Organism-specific databases

CTDi90529.
GeneCardsiSTPG1.
H-InvDBHIX0000262.
HGNCiHGNC:28070. STPG1.
HPAiHPA024301.
HPA050593.
MIMi615826. gene.
neXtProtiNX_Q5TH74.
OpenTargetsiENSG00000001460.
PharmGKBiPA143485320.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK80. Eukaryota.
ENOG4111MU0. LUCA.
GeneTreeiENSGT00390000011598.
HOGENOMiHOG000007868.
HOVERGENiHBG107567.
InParanoidiQ5TH74.
OMAiRWTAAPP.
OrthoDBiEOG091G0ABV.
PhylomeDBiQ5TH74.
TreeFamiTF328937.

Miscellaneous databases

GenomeRNAii90529.
PROiQ5TH74.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000001460.
CleanExiHS_C1orf201.
ExpressionAtlasiQ5TH74. baseline and differential.
GenevisibleiQ5TH74. HS.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTPG1_HUMAN
AccessioniPrimary (citable) accession number: Q5TH74
Secondary accession number(s): Q49AP0
, Q6P3R4, Q86VU9, Q8WVQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.