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Q5TH74

- STPG1_HUMAN

UniProt

Q5TH74 - STPG1_HUMAN

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Protein

O(6)-methylguanine-induced apoptosis 2

Gene

STPG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.1 Publication

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
O(6)-methylguanine-induced apoptosis 2
Short name:
MAPO2
Alternative name(s):
Sperm-tail PG-rich repeat-containing protein 1
Gene namesi
Name:STPG1
Synonyms:C1orf201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28070. STPG1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485320.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334O(6)-methylguanine-induced apoptosis 2PRO_0000305170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5TH74.
PRIDEiQ5TH74.

PTM databases

PhosphoSiteiQ5TH74.

Expressioni

Gene expression databases

BgeeiQ5TH74.
CleanExiHS_C1orf201.
ExpressionAtlasiQ5TH74. baseline and differential.
GenevestigatoriQ5TH74.

Organism-specific databases

HPAiHPA024301.
HPA050593.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000003583.

Structurei

3D structure databases

ProteinModelPortaliQ5TH74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati67 – 748STPGR 1
Repeati109 – 1179STPGR 2
Repeati148 – 1558STPGR 3
Repeati187 – 20620STPGR 4Add
BLAST
Repeati225 – 25733STPGR 5Add
BLAST
Repeati267 – 28216STPGR 6Add
BLAST
Repeati306 – 31611STPGR 7Add
BLAST

Sequence similaritiesi

Belongs to the STPG1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG44145.
GeneTreeiENSGT00390000011598.
HOGENOMiHOG000007868.
HOVERGENiHBG107567.
InParanoidiQ5TH74.
OMAiRWTAAPP.
OrthoDBiEOG7DFXDM.
PhylomeDBiQ5TH74.
TreeFamiTF328937.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5TH74-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK
60 70 80 90 100
GFNSQAKRFP HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR
110 120 130 140 150
LDTIISKYPA ANAYTIPSDF ISKRDFSNSC SSMFQLPSFM KALKFETPAP
160 170 180 190 200
NYYNASVSCC KQRNNVCTRA GFMSKTQRGS FAFADKGPPP GHYDINESLV
210 220 230 240 250
KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP KKTLFPKNPI
260 270 280 290 300
LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA
310 320 330
PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL
Length:334
Mass (Da):36,786
Last modified:December 21, 2004 - v1
Checksum:i8DA37D63A36E478E
GO
Isoform 2 (identifier: Q5TH74-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:242
Mass (Da):26,700
Checksum:iCD6E23C0C52E0F1C
GO
Isoform 3 (identifier: Q5TH74-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     48-62: EKKGFNSQAKRFPHK → MNALANIPDVPVKYR

Show »
Length:287
Mass (Da):31,539
Checksum:iAF90B7815DEAB5E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931M → T in AAH35061. (PubMed:15489334)Curated
Sequence conflicti105 – 1051I → V in AAH35061. (PubMed:15489334)Curated
Sequence conflicti163 – 1631R → I in AAH17650. (PubMed:15489334)Curated
Sequence conflicti233 – 2331P → T in AAH35061. (PubMed:15489334)Curated
Sequence conflicti332 – 3321P → R in AAH35061. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti254 – 2541S → F in a breast cancer sample; somatic mutation. 1 Publication
VAR_035614

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 2. 1 PublicationVSP_028252Add
BLAST
Alternative sequencei1 – 4747Missing in isoform 3. 1 PublicationVSP_028253Add
BLAST
Alternative sequencei48 – 6215EKKGF…RFPHK → MNALANIPDVPVKYR in isoform 3. 1 PublicationVSP_028254Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031431 Genomic DNA. Translation: CAI21410.1.
AL031431 Genomic DNA. Translation: CAI21411.1.
BC017650 mRNA. Translation: AAH17650.1.
BC035061 mRNA. Translation: AAH35061.1.
BC047705 mRNA. Translation: AAH47705.1.
BC063891 mRNA. Translation: AAH63891.1.
CCDSiCCDS253.1. [Q5TH74-3]
CCDS55581.1. [Q5TH74-1]
RefSeqiNP_001185941.1. NM_001199012.1. [Q5TH74-1]
NP_001185942.1. NM_001199013.1. [Q5TH74-1]
NP_001185943.1. NM_001199014.1. [Q5TH74-2]
NP_835223.1. NM_178122.4. [Q5TH74-3]
XP_005246084.1. XM_005246027.2. [Q5TH74-3]
XP_005246085.1. XM_005246028.1. [Q5TH74-2]
XP_006711088.1. XM_006711025.1. [Q5TH74-1]
UniGeneiHs.403187.

Genome annotation databases

EnsembliENST00000003583; ENSP00000003583; ENSG00000001460. [Q5TH74-3]
ENST00000337248; ENSP00000337461; ENSG00000001460. [Q5TH74-1]
ENST00000374409; ENSP00000363530; ENSG00000001460. [Q5TH74-1]
GeneIDi90529.
KEGGihsa:90529.
UCSCiuc001bja.3. human. [Q5TH74-3]
uc001bjb.3. human. [Q5TH74-1]

Polymorphism databases

DMDMi74746565.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031431 Genomic DNA. Translation: CAI21410.1 .
AL031431 Genomic DNA. Translation: CAI21411.1 .
BC017650 mRNA. Translation: AAH17650.1 .
BC035061 mRNA. Translation: AAH35061.1 .
BC047705 mRNA. Translation: AAH47705.1 .
BC063891 mRNA. Translation: AAH63891.1 .
CCDSi CCDS253.1. [Q5TH74-3 ]
CCDS55581.1. [Q5TH74-1 ]
RefSeqi NP_001185941.1. NM_001199012.1. [Q5TH74-1 ]
NP_001185942.1. NM_001199013.1. [Q5TH74-1 ]
NP_001185943.1. NM_001199014.1. [Q5TH74-2 ]
NP_835223.1. NM_178122.4. [Q5TH74-3 ]
XP_005246084.1. XM_005246027.2. [Q5TH74-3 ]
XP_005246085.1. XM_005246028.1. [Q5TH74-2 ]
XP_006711088.1. XM_006711025.1. [Q5TH74-1 ]
UniGenei Hs.403187.

3D structure databases

ProteinModelPortali Q5TH74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000003583.

PTM databases

PhosphoSitei Q5TH74.

Polymorphism databases

DMDMi 74746565.

Proteomic databases

PaxDbi Q5TH74.
PRIDEi Q5TH74.

Protocols and materials databases

DNASUi 90529.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000003583 ; ENSP00000003583 ; ENSG00000001460 . [Q5TH74-3 ]
ENST00000337248 ; ENSP00000337461 ; ENSG00000001460 . [Q5TH74-1 ]
ENST00000374409 ; ENSP00000363530 ; ENSG00000001460 . [Q5TH74-1 ]
GeneIDi 90529.
KEGGi hsa:90529.
UCSCi uc001bja.3. human. [Q5TH74-3 ]
uc001bjb.3. human. [Q5TH74-1 ]

Organism-specific databases

CTDi 90529.
GeneCardsi GC01M024685.
H-InvDB HIX0000262.
HGNCi HGNC:28070. STPG1.
HPAi HPA024301.
HPA050593.
MIMi 615826. gene.
neXtProti NX_Q5TH74.
PharmGKBi PA143485320.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44145.
GeneTreei ENSGT00390000011598.
HOGENOMi HOG000007868.
HOVERGENi HBG107567.
InParanoidi Q5TH74.
OMAi RWTAAPP.
OrthoDBi EOG7DFXDM.
PhylomeDBi Q5TH74.
TreeFami TF328937.

Miscellaneous databases

GenomeRNAii 90529.
NextBioi 76825.
PROi Q5TH74.
SOURCEi Search...

Gene expression databases

Bgeei Q5TH74.
CleanExi HS_C1orf201.
ExpressionAtlasi Q5TH74. baseline and differential.
Genevestigatori Q5TH74.

Family and domain databases

InterProi IPR010736. SHIPPO-rpt.
[Graphical view ]
Pfami PF07004. SHIPPO-rpt. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain, Lung and Testis.
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. "The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O(6)-methylguanine."
    Fujikane R., Sanada M., Sekiguchi M., Hidaka M.
    PLoS ONE 7:E44817-E44817(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-254.

Entry informationi

Entry nameiSTPG1_HUMAN
AccessioniPrimary (citable) accession number: Q5TH74
Secondary accession number(s): Q49AP0
, Q6P3R4, Q86VU9, Q8WVQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3