UniProtKB - Q5TH74 (STPG1_HUMAN)
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Protein
O(6)-methylguanine-induced apoptosis 2
Gene
STPG1
Organism
Homo sapiens (Human)
Status
Functioni
May positively contribute to the induction of apoptosis triggered by O6-methylguanine.1 Publication
GO - Biological processi
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of mitochondrial membrane permeability involved in apoptotic process Source: UniProtKB
- positive regulation of protein homodimerization activity Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: O(6)-methylguanine-induced apoptosis 2Short name: MAPO2 Alternative name(s): Sperm-tail PG-rich repeat-containing protein 1 |
Gene namesi | Name:STPG1 Synonyms:C1orf201 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000001460.17 |
HGNCi | HGNC:28070 STPG1 |
MIMi | 615826 gene |
neXtProti | NX_Q5TH74 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000001460 |
PharmGKBi | PA143485320 |
Polymorphism and mutation databases
BioMutai | STPG1 |
DMDMi | 74746565 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305170 | 1 – 334 | O(6)-methylguanine-induced apoptosis 2Add BLAST | 334 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 72 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q5TH74 |
PeptideAtlasi | Q5TH74 |
PRIDEi | Q5TH74 |
PTM databases
iPTMneti | Q5TH74 |
PhosphoSitePlusi | Q5TH74 |
Expressioni
Gene expression databases
Bgeei | ENSG00000001460 |
CleanExi | HS_C1orf201 |
ExpressionAtlasi | Q5TH74 baseline and differential |
Genevisiblei | Q5TH74 HS |
Organism-specific databases
HPAi | HPA024301 |
Interactioni
Protein-protein interaction databases
BioGridi | 1247323 interactors. |
STRINGi | 9606.ENSP00000337461 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 67 – 74 | STPGR 1 | 8 | |
Repeati | 109 – 117 | STPGR 2 | 9 | |
Repeati | 148 – 155 | STPGR 3 | 8 | |
Repeati | 187 – 206 | STPGR 4Add BLAST | 20 | |
Repeati | 225 – 257 | STPGR 5Add BLAST | 33 | |
Repeati | 267 – 282 | STPGR 6Add BLAST | 16 | |
Repeati | 306 – 316 | STPGR 7Add BLAST | 11 |
Sequence similaritiesi
Belongs to the STPG1 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG410IK80 Eukaryota ENOG4111MU0 LUCA |
GeneTreei | ENSGT00390000011598 |
HOGENOMi | HOG000007868 |
HOVERGENi | HBG107567 |
InParanoidi | Q5TH74 |
OMAi | GKQSFLY |
OrthoDBi | EOG091G0ABV |
PhylomeDBi | Q5TH74 |
TreeFami | TF328937 |
Family and domain databases
InterProi | View protein in InterPro IPR010736 SHIPPO-rpt |
Pfami | View protein in Pfam PF07004 SHIPPO-rpt, 4 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5TH74-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK
60 70 80 90 100
GFNSQAKRFP HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR
110 120 130 140 150
LDTIISKYPA ANAYTIPSDF ISKRDFSNSC SSMFQLPSFM KALKFETPAP
160 170 180 190 200
NYYNASVSCC KQRNNVCTRA GFMSKTQRGS FAFADKGPPP GHYDINESLV
210 220 230 240 250
KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP KKTLFPKNPI
260 270 280 290 300
LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA
310 320 330
PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 | M → T in AAH35061 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 105 | I → V in AAH35061 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 163 | R → I in AAH17650 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 233 | P → T in AAH35061 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 332 | P → R in AAH35061 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035614 | 254 | S → F in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028252 | 1 – 92 | Missing in isoform 2. 1 PublicationAdd BLAST | 92 | |
Alternative sequenceiVSP_028253 | 1 – 47 | Missing in isoform 3. 1 PublicationAdd BLAST | 47 | |
Alternative sequenceiVSP_028254 | 48 – 62 | EKKGF…RFPHK → MNALANIPDVPVKYR in isoform 3. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031431 Genomic DNA No translation available. BC017650 mRNA Translation: AAH17650.1 BC035061 mRNA Translation: AAH35061.1 BC047705 mRNA Translation: AAH47705.1 BC063891 mRNA Translation: AAH63891.1 |
CCDSi | CCDS253.1 [Q5TH74-3] CCDS55581.1 [Q5TH74-1] |
RefSeqi | NP_001185941.1, NM_001199012.1 [Q5TH74-1] NP_001185942.1, NM_001199013.1 [Q5TH74-1] NP_001185943.1, NM_001199014.1 [Q5TH74-2] NP_835223.1, NM_178122.4 [Q5TH74-3] XP_006711088.1, XM_006711025.2 [Q5TH74-1] XP_011540706.1, XM_011542404.1 [Q5TH74-1] XP_016858257.1, XM_017002768.1 [Q5TH74-3] XP_016858258.1, XM_017002769.1 [Q5TH74-2] XP_016858259.1, XM_017002770.1 [Q5TH74-2] |
UniGenei | Hs.403187 |
Genome annotation databases
Ensembli | ENST00000003583; ENSP00000003583; ENSG00000001460 [Q5TH74-3] ENST00000337248; ENSP00000337461; ENSG00000001460 [Q5TH74-1] ENST00000374409; ENSP00000363530; ENSG00000001460 [Q5TH74-1] |
GeneIDi | 90529 |
KEGGi | hsa:90529 |
UCSCi | uc001bja.4 human [Q5TH74-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | STPG1_HUMAN | |
Accessioni | Q5TH74Primary (citable) accession number: Q5TH74 Secondary accession number(s): Q49AP0 Q8WVQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | January 31, 2018 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |