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Protein

O(6)-methylguanine-induced apoptosis 2

Gene

STPG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
O(6)-methylguanine-induced apoptosis 2
Short name:
MAPO2
Alternative name(s):
Sperm-tail PG-rich repeat-containing protein 1
Gene namesi
Name:STPG1
Synonyms:C1orf201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28070. STPG1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485320.

Polymorphism and mutation databases

BioMutaiSTPG1.
DMDMi74746565.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334O(6)-methylguanine-induced apoptosis 2PRO_0000305170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei72 – 721Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5TH74.
PRIDEiQ5TH74.

PTM databases

PhosphoSiteiQ5TH74.

Expressioni

Gene expression databases

BgeeiQ5TH74.
CleanExiHS_C1orf201.
ExpressionAtlasiQ5TH74. baseline and differential.
GenevestigatoriQ5TH74.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000003583.

Structurei

3D structure databases

ProteinModelPortaliQ5TH74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati67 – 748STPGR 1
Repeati109 – 1179STPGR 2
Repeati148 – 1558STPGR 3
Repeati187 – 20620STPGR 4Add
BLAST
Repeati225 – 25733STPGR 5Add
BLAST
Repeati267 – 28216STPGR 6Add
BLAST
Repeati306 – 31611STPGR 7Add
BLAST

Sequence similaritiesi

Belongs to the STPG1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG44145.
GeneTreeiENSGT00390000011598.
HOGENOMiHOG000007868.
HOVERGENiHBG107567.
InParanoidiQ5TH74.
OMAiSNTGRWT.
OrthoDBiEOG7DFXDM.
PhylomeDBiQ5TH74.
TreeFamiTF328937.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TH74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK
60 70 80 90 100
GFNSQAKRFP HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR
110 120 130 140 150
LDTIISKYPA ANAYTIPSDF ISKRDFSNSC SSMFQLPSFM KALKFETPAP
160 170 180 190 200
NYYNASVSCC KQRNNVCTRA GFMSKTQRGS FAFADKGPPP GHYDINESLV
210 220 230 240 250
KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP KKTLFPKNPI
260 270 280 290 300
LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA
310 320 330
PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL
Length:334
Mass (Da):36,786
Last modified:December 21, 2004 - v1
Checksum:i8DA37D63A36E478E
GO
Isoform 2 (identifier: Q5TH74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:242
Mass (Da):26,700
Checksum:iCD6E23C0C52E0F1C
GO
Isoform 3 (identifier: Q5TH74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     48-62: EKKGFNSQAKRFPHK → MNALANIPDVPVKYR

Show »
Length:287
Mass (Da):31,539
Checksum:iAF90B7815DEAB5E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931M → T in AAH35061 (PubMed:15489334).Curated
Sequence conflicti105 – 1051I → V in AAH35061 (PubMed:15489334).Curated
Sequence conflicti163 – 1631R → I in AAH17650 (PubMed:15489334).Curated
Sequence conflicti233 – 2331P → T in AAH35061 (PubMed:15489334).Curated
Sequence conflicti332 – 3321P → R in AAH35061 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti254 – 2541S → F in a breast cancer sample; somatic mutation. 1 Publication
VAR_035614

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 2. 1 PublicationVSP_028252Add
BLAST
Alternative sequencei1 – 4747Missing in isoform 3. 1 PublicationVSP_028253Add
BLAST
Alternative sequencei48 – 6215EKKGF…RFPHK → MNALANIPDVPVKYR in isoform 3. 1 PublicationVSP_028254Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031431 Genomic DNA. Translation: CAI21410.1.
AL031431 Genomic DNA. Translation: CAI21411.1.
BC017650 mRNA. Translation: AAH17650.1.
BC035061 mRNA. Translation: AAH35061.1.
BC047705 mRNA. Translation: AAH47705.1.
BC063891 mRNA. Translation: AAH63891.1.
CCDSiCCDS253.1. [Q5TH74-3]
CCDS55581.1. [Q5TH74-1]
RefSeqiNP_001185941.1. NM_001199012.1. [Q5TH74-1]
NP_001185942.1. NM_001199013.1. [Q5TH74-1]
NP_001185943.1. NM_001199014.1. [Q5TH74-2]
NP_835223.1. NM_178122.4. [Q5TH74-3]
XP_005246085.1. XM_005246028.2. [Q5TH74-2]
XP_006711088.1. XM_006711025.2. [Q5TH74-1]
UniGeneiHs.403187.

Genome annotation databases

EnsembliENST00000003583; ENSP00000003583; ENSG00000001460. [Q5TH74-3]
ENST00000337248; ENSP00000337461; ENSG00000001460. [Q5TH74-1]
ENST00000374409; ENSP00000363530; ENSG00000001460. [Q5TH74-1]
GeneIDi90529.
KEGGihsa:90529.
UCSCiuc001bja.3. human. [Q5TH74-3]
uc001bjb.3. human. [Q5TH74-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031431 Genomic DNA. Translation: CAI21410.1.
AL031431 Genomic DNA. Translation: CAI21411.1.
BC017650 mRNA. Translation: AAH17650.1.
BC035061 mRNA. Translation: AAH35061.1.
BC047705 mRNA. Translation: AAH47705.1.
BC063891 mRNA. Translation: AAH63891.1.
CCDSiCCDS253.1. [Q5TH74-3]
CCDS55581.1. [Q5TH74-1]
RefSeqiNP_001185941.1. NM_001199012.1. [Q5TH74-1]
NP_001185942.1. NM_001199013.1. [Q5TH74-1]
NP_001185943.1. NM_001199014.1. [Q5TH74-2]
NP_835223.1. NM_178122.4. [Q5TH74-3]
XP_005246085.1. XM_005246028.2. [Q5TH74-2]
XP_006711088.1. XM_006711025.2. [Q5TH74-1]
UniGeneiHs.403187.

3D structure databases

ProteinModelPortaliQ5TH74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000003583.

PTM databases

PhosphoSiteiQ5TH74.

Polymorphism and mutation databases

BioMutaiSTPG1.
DMDMi74746565.

Proteomic databases

PaxDbiQ5TH74.
PRIDEiQ5TH74.

Protocols and materials databases

DNASUi90529.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000003583; ENSP00000003583; ENSG00000001460. [Q5TH74-3]
ENST00000337248; ENSP00000337461; ENSG00000001460. [Q5TH74-1]
ENST00000374409; ENSP00000363530; ENSG00000001460. [Q5TH74-1]
GeneIDi90529.
KEGGihsa:90529.
UCSCiuc001bja.3. human. [Q5TH74-3]
uc001bjb.3. human. [Q5TH74-1]

Organism-specific databases

CTDi90529.
GeneCardsiGC01M024685.
H-InvDBHIX0000262.
HGNCiHGNC:28070. STPG1.
MIMi615826. gene.
neXtProtiNX_Q5TH74.
PharmGKBiPA143485320.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44145.
GeneTreeiENSGT00390000011598.
HOGENOMiHOG000007868.
HOVERGENiHBG107567.
InParanoidiQ5TH74.
OMAiSNTGRWT.
OrthoDBiEOG7DFXDM.
PhylomeDBiQ5TH74.
TreeFamiTF328937.

Miscellaneous databases

GenomeRNAii90529.
NextBioi76825.
PROiQ5TH74.
SOURCEiSearch...

Gene expression databases

BgeeiQ5TH74.
CleanExiHS_C1orf201.
ExpressionAtlasiQ5TH74. baseline and differential.
GenevestigatoriQ5TH74.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain, Lung and Testis.
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. "The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O(6)-methylguanine."
    Fujikane R., Sanada M., Sekiguchi M., Hidaka M.
    PLoS ONE 7:E44817-E44817(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-254.

Entry informationi

Entry nameiSTPG1_HUMAN
AccessioniPrimary (citable) accession number: Q5TH74
Secondary accession number(s): Q49AP0
, Q6P3R4, Q86VU9, Q8WVQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: April 29, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.