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Q5TH74

- STPG1_HUMAN

UniProt

Q5TH74 - STPG1_HUMAN

Protein

O(6)-methylguanine-induced apoptosis 2

Gene

STPG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.1 Publication

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    O(6)-methylguanine-induced apoptosis 2
    Short name:
    MAPO2
    Alternative name(s):
    Sperm-tail PG-rich repeat-containing protein 1
    Gene namesi
    Name:STPG1
    Synonyms:C1orf201
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28070. STPG1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485320.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334O(6)-methylguanine-induced apoptosis 2PRO_0000305170Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei72 – 721Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5TH74.
    PRIDEiQ5TH74.

    PTM databases

    PhosphoSiteiQ5TH74.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5TH74.
    BgeeiQ5TH74.
    CleanExiHS_C1orf201.
    GenevestigatoriQ5TH74.

    Organism-specific databases

    HPAiHPA024301.
    HPA050593.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000003583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TH74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati67 – 748STPGR 1
    Repeati109 – 1179STPGR 2
    Repeati148 – 1558STPGR 3
    Repeati187 – 20620STPGR 4Add
    BLAST
    Repeati225 – 25733STPGR 5Add
    BLAST
    Repeati267 – 28216STPGR 6Add
    BLAST
    Repeati306 – 31611STPGR 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the STPG1 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG44145.
    HOGENOMiHOG000007868.
    HOVERGENiHBG107567.
    InParanoidiQ5TH74.
    OMAiRWTAAPP.
    OrthoDBiEOG7DFXDM.
    PhylomeDBiQ5TH74.
    TreeFamiTF328937.

    Family and domain databases

    InterProiIPR010736. SHIPPO-rpt.
    [Graphical view]
    PfamiPF07004. SHIPPO-rpt. 5 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5TH74-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK    50
    GFNSQAKRFP HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR 100
    LDTIISKYPA ANAYTIPSDF ISKRDFSNSC SSMFQLPSFM KALKFETPAP 150
    NYYNASVSCC KQRNNVCTRA GFMSKTQRGS FAFADKGPPP GHYDINESLV 200
    KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP KKTLFPKNPI 250
    LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA 300
    PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL 334
    Length:334
    Mass (Da):36,786
    Last modified:December 21, 2004 - v1
    Checksum:i8DA37D63A36E478E
    GO
    Isoform 2 (identifier: Q5TH74-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-92: Missing.

    Show »
    Length:242
    Mass (Da):26,700
    Checksum:iCD6E23C0C52E0F1C
    GO
    Isoform 3 (identifier: Q5TH74-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-47: Missing.
         48-62: EKKGFNSQAKRFPHK → MNALANIPDVPVKYR

    Show »
    Length:287
    Mass (Da):31,539
    Checksum:iAF90B7815DEAB5E2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931M → T in AAH35061. (PubMed:15489334)Curated
    Sequence conflicti105 – 1051I → V in AAH35061. (PubMed:15489334)Curated
    Sequence conflicti163 – 1631R → I in AAH17650. (PubMed:15489334)Curated
    Sequence conflicti233 – 2331P → T in AAH35061. (PubMed:15489334)Curated
    Sequence conflicti332 – 3321P → R in AAH35061. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti254 – 2541S → F in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035614

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9292Missing in isoform 2. 1 PublicationVSP_028252Add
    BLAST
    Alternative sequencei1 – 4747Missing in isoform 3. 1 PublicationVSP_028253Add
    BLAST
    Alternative sequencei48 – 6215EKKGF…RFPHK → MNALANIPDVPVKYR in isoform 3. 1 PublicationVSP_028254Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL031431 Genomic DNA. Translation: CAI21410.1.
    AL031431 Genomic DNA. Translation: CAI21411.1.
    BC017650 mRNA. Translation: AAH17650.1.
    BC035061 mRNA. Translation: AAH35061.1.
    BC047705 mRNA. Translation: AAH47705.1.
    BC063891 mRNA. Translation: AAH63891.1.
    CCDSiCCDS253.1. [Q5TH74-3]
    CCDS55581.1. [Q5TH74-1]
    RefSeqiNP_001185941.1. NM_001199012.1. [Q5TH74-1]
    NP_001185942.1. NM_001199013.1. [Q5TH74-1]
    NP_001185943.1. NM_001199014.1. [Q5TH74-2]
    NP_835223.1. NM_178122.4. [Q5TH74-3]
    XP_005246084.1. XM_005246027.2. [Q5TH74-3]
    XP_005246085.1. XM_005246028.1. [Q5TH74-2]
    XP_006711088.1. XM_006711025.1. [Q5TH74-1]
    UniGeneiHs.403187.

    Genome annotation databases

    EnsembliENST00000003583; ENSP00000003583; ENSG00000001460. [Q5TH74-3]
    ENST00000337248; ENSP00000337461; ENSG00000001460. [Q5TH74-1]
    ENST00000374409; ENSP00000363530; ENSG00000001460. [Q5TH74-1]
    GeneIDi90529.
    KEGGihsa:90529.
    UCSCiuc001bja.3. human. [Q5TH74-3]
    uc001bjb.3. human. [Q5TH74-1]

    Polymorphism databases

    DMDMi74746565.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL031431 Genomic DNA. Translation: CAI21410.1 .
    AL031431 Genomic DNA. Translation: CAI21411.1 .
    BC017650 mRNA. Translation: AAH17650.1 .
    BC035061 mRNA. Translation: AAH35061.1 .
    BC047705 mRNA. Translation: AAH47705.1 .
    BC063891 mRNA. Translation: AAH63891.1 .
    CCDSi CCDS253.1. [Q5TH74-3 ]
    CCDS55581.1. [Q5TH74-1 ]
    RefSeqi NP_001185941.1. NM_001199012.1. [Q5TH74-1 ]
    NP_001185942.1. NM_001199013.1. [Q5TH74-1 ]
    NP_001185943.1. NM_001199014.1. [Q5TH74-2 ]
    NP_835223.1. NM_178122.4. [Q5TH74-3 ]
    XP_005246084.1. XM_005246027.2. [Q5TH74-3 ]
    XP_005246085.1. XM_005246028.1. [Q5TH74-2 ]
    XP_006711088.1. XM_006711025.1. [Q5TH74-1 ]
    UniGenei Hs.403187.

    3D structure databases

    ProteinModelPortali Q5TH74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000003583.

    PTM databases

    PhosphoSitei Q5TH74.

    Polymorphism databases

    DMDMi 74746565.

    Proteomic databases

    PaxDbi Q5TH74.
    PRIDEi Q5TH74.

    Protocols and materials databases

    DNASUi 90529.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000003583 ; ENSP00000003583 ; ENSG00000001460 . [Q5TH74-3 ]
    ENST00000337248 ; ENSP00000337461 ; ENSG00000001460 . [Q5TH74-1 ]
    ENST00000374409 ; ENSP00000363530 ; ENSG00000001460 . [Q5TH74-1 ]
    GeneIDi 90529.
    KEGGi hsa:90529.
    UCSCi uc001bja.3. human. [Q5TH74-3 ]
    uc001bjb.3. human. [Q5TH74-1 ]

    Organism-specific databases

    CTDi 90529.
    GeneCardsi GC01M024684.
    H-InvDB HIX0000262.
    HGNCi HGNC:28070. STPG1.
    HPAi HPA024301.
    HPA050593.
    MIMi 615826. gene.
    neXtProti NX_Q5TH74.
    PharmGKBi PA143485320.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44145.
    HOGENOMi HOG000007868.
    HOVERGENi HBG107567.
    InParanoidi Q5TH74.
    OMAi RWTAAPP.
    OrthoDBi EOG7DFXDM.
    PhylomeDBi Q5TH74.
    TreeFami TF328937.

    Miscellaneous databases

    GenomeRNAii 90529.
    NextBioi 76825.
    PROi Q5TH74.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5TH74.
    Bgeei Q5TH74.
    CleanExi HS_C1orf201.
    Genevestigatori Q5TH74.

    Family and domain databases

    InterProi IPR010736. SHIPPO-rpt.
    [Graphical view ]
    Pfami PF07004. SHIPPO-rpt. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain, Lung and Testis.
    3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    4. "The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O(6)-methylguanine."
      Fujikane R., Sanada M., Sekiguchi M., Hidaka M.
      PLoS ONE 7:E44817-E44817(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-254.

    Entry informationi

    Entry nameiSTPG1_HUMAN
    AccessioniPrimary (citable) accession number: Q5TH74
    Secondary accession number(s): Q49AP0
    , Q6P3R4, Q86VU9, Q8WVQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families
    6. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3