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Protein

O(6)-methylguanine-induced apoptosis 2

Gene

STPG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May positively contribute to the induction of apoptosis triggered by O6-methylguanine.1 Publication

GO - Biological processi

  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of mitochondrial membrane permeability involved in apoptotic process Source: UniProtKB
  • positive regulation of protein homodimerization activity Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
O(6)-methylguanine-induced apoptosis 2
Short name:
MAPO2
Alternative name(s):
Sperm-tail PG-rich repeat-containing protein 1
Gene namesi
Name:STPG1
Synonyms:C1orf201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000001460.17
HGNCiHGNC:28070 STPG1
MIMi615826 gene
neXtProtiNX_Q5TH74

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000001460
PharmGKBiPA143485320

Polymorphism and mutation databases

BioMutaiSTPG1
DMDMi74746565

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051701 – 334O(6)-methylguanine-induced apoptosis 2Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5TH74
PeptideAtlasiQ5TH74
PRIDEiQ5TH74

PTM databases

iPTMnetiQ5TH74
PhosphoSitePlusiQ5TH74

Expressioni

Gene expression databases

BgeeiENSG00000001460
CleanExiHS_C1orf201
ExpressionAtlasiQ5TH74 baseline and differential
GenevisibleiQ5TH74 HS

Organism-specific databases

HPAiHPA024301

Interactioni

Protein-protein interaction databases

BioGridi1247323 interactors.
STRINGi9606.ENSP00000337461

Structurei

3D structure databases

ProteinModelPortaliQ5TH74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati67 – 74STPGR 18
Repeati109 – 117STPGR 29
Repeati148 – 155STPGR 38
Repeati187 – 206STPGR 4Add BLAST20
Repeati225 – 257STPGR 5Add BLAST33
Repeati267 – 282STPGR 6Add BLAST16
Repeati306 – 316STPGR 7Add BLAST11

Sequence similaritiesi

Belongs to the STPG1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IK80 Eukaryota
ENOG4111MU0 LUCA
GeneTreeiENSGT00390000011598
HOGENOMiHOG000007868
HOVERGENiHBG107567
InParanoidiQ5TH74
OMAiGKQSFLY
OrthoDBiEOG091G0ABV
PhylomeDBiQ5TH74
TreeFamiTF328937

Family and domain databases

InterProiView protein in InterPro
IPR010736 SHIPPO-rpt
PfamiView protein in Pfam
PF07004 SHIPPO-rpt, 4 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TH74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK
60 70 80 90 100
GFNSQAKRFP HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR
110 120 130 140 150
LDTIISKYPA ANAYTIPSDF ISKRDFSNSC SSMFQLPSFM KALKFETPAP
160 170 180 190 200
NYYNASVSCC KQRNNVCTRA GFMSKTQRGS FAFADKGPPP GHYDINESLV
210 220 230 240 250
KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP KKTLFPKNPI
260 270 280 290 300
LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA
310 320 330
PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL
Length:334
Mass (Da):36,786
Last modified:December 21, 2004 - v1
Checksum:i8DA37D63A36E478E
GO
Isoform 2 (identifier: Q5TH74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:242
Mass (Da):26,700
Checksum:iCD6E23C0C52E0F1C
GO
Isoform 3 (identifier: Q5TH74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     48-62: EKKGFNSQAKRFPHK → MNALANIPDVPVKYR

Show »
Length:287
Mass (Da):31,539
Checksum:iAF90B7815DEAB5E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93M → T in AAH35061 (PubMed:15489334).Curated1
Sequence conflicti105I → V in AAH35061 (PubMed:15489334).Curated1
Sequence conflicti163R → I in AAH17650 (PubMed:15489334).Curated1
Sequence conflicti233P → T in AAH35061 (PubMed:15489334).Curated1
Sequence conflicti332P → R in AAH35061 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035614254S → F in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0282521 – 92Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0282531 – 47Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_02825448 – 62EKKGF…RFPHK → MNALANIPDVPVKYR in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031431 Genomic DNA No translation available.
BC017650 mRNA Translation: AAH17650.1
BC035061 mRNA Translation: AAH35061.1
BC047705 mRNA Translation: AAH47705.1
BC063891 mRNA Translation: AAH63891.1
CCDSiCCDS253.1 [Q5TH74-3]
CCDS55581.1 [Q5TH74-1]
RefSeqiNP_001185941.1, NM_001199012.1 [Q5TH74-1]
NP_001185942.1, NM_001199013.1 [Q5TH74-1]
NP_001185943.1, NM_001199014.1 [Q5TH74-2]
NP_835223.1, NM_178122.4 [Q5TH74-3]
XP_006711088.1, XM_006711025.2 [Q5TH74-1]
XP_011540706.1, XM_011542404.1 [Q5TH74-1]
XP_016858257.1, XM_017002768.1 [Q5TH74-3]
XP_016858258.1, XM_017002769.1 [Q5TH74-2]
XP_016858259.1, XM_017002770.1 [Q5TH74-2]
UniGeneiHs.403187

Genome annotation databases

EnsembliENST00000003583; ENSP00000003583; ENSG00000001460 [Q5TH74-3]
ENST00000337248; ENSP00000337461; ENSG00000001460 [Q5TH74-1]
ENST00000374409; ENSP00000363530; ENSG00000001460 [Q5TH74-1]
GeneIDi90529
KEGGihsa:90529
UCSCiuc001bja.4 human [Q5TH74-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTPG1_HUMAN
AccessioniPrimary (citable) accession number: Q5TH74
Secondary accession number(s): Q49AP0
, Q6P3R4, Q86VU9, Q8WVQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: January 31, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome