STPG1

Functionⁱ

May positively contribute to the induction of apoptosis triggered by O₆-methylguanine.1 Publication

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: O(6)-methylguanine-induced apoptosis 2 Short name: MAPO2 Alternative name(s): Sperm-tail PG-rich repeat-containing protein 1
Gene namesⁱ	Name:STPG1 Synonyms:C1orf201
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28070. STPG1.

HGNCⁱ

HGNC:28070. STPG1.

Subcellular locationⁱ

Cytoplasm By similarity
Nucleus By similarity

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell
nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000001460.
PharmGKBⁱ	PA143485320.

Polymorphism and mutation databases

BioMutaⁱ	STPG1.
DMDMⁱ	74746565.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305170	1 – 334	O(6)-methylguanine-induced apoptosis 2Add BLAST		334

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	72	PhosphotyrosineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q5TH74.
PeptideAtlas More...PeptideAtlasⁱ	Q5TH74.
PRIDEⁱ	Q5TH74.

PTM databases

iPTMnetⁱ	Q5TH74.
PhosphoSitePlusⁱ	Q5TH74.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000001460.
CleanExⁱ	HS_C1orf201.
ExpressionAtlasⁱ	Q5TH74. baseline and differential.
Genevisibleⁱ	Q5TH74. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024301.

HPAⁱ

HPA024301.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000337461.

STRINGⁱ

9606.ENSP00000337461.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5TH74.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	67 – 74	STPGR 1	8
Repeatⁱ	109 – 117	STPGR 2	9
Repeatⁱ	148 – 155	STPGR 3	8
Repeatⁱ	187 – 206	STPGR 4Add BLAST	20
Repeatⁱ	225 – 257	STPGR 5Add BLAST	33
Repeatⁱ	267 – 282	STPGR 6Add BLAST	16
Repeatⁱ	306 – 316	STPGR 7Add BLAST	11

Sequence similaritiesⁱ

Belongs to the STPG1 family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IK80. Eukaryota. ENOG4111MU0. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011598.
HOGENOMⁱ	HOG000007868.
HOVERGENⁱ	HBG107567.
InParanoidⁱ	Q5TH74.
OMAⁱ	GKQSFLY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ABV.
PhylomeDBⁱ	Q5TH74.
TreeFamⁱ	TF328937.

Family and domain databases

InterProⁱ	View protein in InterPro IPR010736. SHIPPO-rpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07004. SHIPPO-rpt. 4 hits.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q5TH74-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK 
        60         70         80         90        100
GFNSQAKRFP HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR 
       110        120        130        140        150
LDTIISKYPA ANAYTIPSDF ISKRDFSNSC SSMFQLPSFM KALKFETPAP 
       160        170        180        190        200
NYYNASVSCC KQRNNVCTRA GFMSKTQRGS FAFADKGPPP GHYDINESLV 
       210        220        230        240        250
KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP KKTLFPKNPI 
       260        270        280        290        300
LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA 
       310        320        330 
PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL

Length:334

Mass (Da):36,786

Last modified:December 21, 2004 - v1

Checksum:ⁱ8DA37D63A36E478E

GO

Isoform 2 (identifier: Q5TH74-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-92: Missing.

« Hide

        10         20         30         40         50
MFPSMCARLD TIISKYPAAN AYTIPSDFIS KRDFSNSCSS MFQLPSFMKA 
        60         70         80         90        100
LKFETPAPNY YNASVSCCKQ RNNVCTRAGF MSKTQRGSFA FADKGPPPGH 
       110        120        130        140        150
YDINESLVKQ SPNTLMSCFK SKTNRGLKLT STGPGPGYYN PSDCTKVPKK 
       160        170        180        190        200
TLFPKNPILN FSAQPSPLPP KPPFPGPGQY EIVDYLGPRK HFISSASFVS 
       210        220        230        240 
NTSRWTAAPP QPGLPGPATY KPELPGKQSF LYNEDKKWIP VL

Show »

Length:242

Mass (Da):26,700

Checksum:ⁱCD6E23C0C52E0F1C

GO

Isoform 3 (identifier: Q5TH74-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-47: Missing.
48-62: EKKGFNSQAKRFPHK → MNALANIPDVPVKYR

« Hide

        10         20         30         40         50
MNALANIPDV PVKYRKNDIP GPGFYNVIHQ SPVSNSVSLS KKGTCMFPSM 
        60         70         80         90        100
CARLDTIISK YPAANAYTIP SDFISKRDFS NSCSSMFQLP SFMKALKFET 
       110        120        130        140        150
PAPNYYNASV SCCKQRNNVC TRAGFMSKTQ RGSFAFADKG PPPGHYDINE 
       160        170        180        190        200
SLVKQSPNTL MSCFKSKTNR GLKLTSTGPG PGYYNPSDCT KVPKKTLFPK 
       210        220        230        240        250
NPILNFSAQP SPLPPKPPFP GPGQYEIVDY LGPRKHFISS ASFVSNTSRW 
       260        270        280 
TAAPPQPGLP GPATYKPELP GKQSFLYNED KKWIPVL

Show »

Length:287

Mass (Da):31,539

Checksum:ⁱAF90B7815DEAB5E2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	93	M → T in AAH35061 (PubMed:15489334).Curated	1
Sequence conflictⁱ	105	I → V in AAH35061 (PubMed:15489334).Curated	1
Sequence conflictⁱ	163	R → I in AAH17650 (PubMed:15489334).Curated	1
Sequence conflictⁱ	233	P → T in AAH35061 (PubMed:15489334).Curated	1
Sequence conflictⁱ	332	P → R in AAH35061 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035614	254	S → F in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_028252	1 – 92	Missing in isoform 2. 1 PublicationAdd BLAST	92
Alternative sequenceⁱVSP_028253	1 – 47	Missing in isoform 3. 1 PublicationAdd BLAST	47
Alternative sequenceⁱVSP_028254	48 – 62	EKKGF…RFPHK → MNALANIPDVPVKYR in isoform 3. 1 PublicationAdd BLAST	15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL031431 Genomic DNA. Translation: CAI21410.1. AL031431 Genomic DNA. Translation: CAI21411.1. BC017650 mRNA. Translation: AAH17650.1. BC035061 mRNA. Translation: AAH35061.1. BC047705 mRNA. Translation: AAH47705.1. BC063891 mRNA. Translation: AAH63891.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS253.1. [Q5TH74-3] CCDS55581.1. [Q5TH74-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001185941.1. NM_001199012.1. [Q5TH74-1] NP_001185942.1. NM_001199013.1. [Q5TH74-1] NP_001185943.1. NM_001199014.1. [Q5TH74-2] NP_835223.1. NM_178122.4. [Q5TH74-3] XP_006711088.1. XM_006711025.2. [Q5TH74-1] XP_011540706.1. XM_011542404.1. [Q5TH74-1] XP_016858257.1. XM_017002768.1. [Q5TH74-3] XP_016858258.1. XM_017002769.1. [Q5TH74-2] XP_016858259.1. XM_017002770.1. [Q5TH74-2]
UniGeneⁱ	Hs.403187.

Genome annotation databases

Ensemblⁱ	ENST00000003583; ENSP00000003583; ENSG00000001460. [Q5TH74-3] ENST00000337248; ENSP00000337461; ENSG00000001460. [Q5TH74-1] ENST00000374409; ENSP00000363530; ENSG00000001460. [Q5TH74-1]
GeneIDⁱ	90529.
KEGGⁱ	hsa:90529.
UCSC genome browser More...UCSCⁱ	uc001bja.4. human. [Q5TH74-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL031431 Genomic DNA. Translation: CAI21410.1. AL031431 Genomic DNA. Translation: CAI21411.1. BC017650 mRNA. Translation: AAH17650.1. BC035061 mRNA. Translation: AAH35061.1. BC047705 mRNA. Translation: AAH47705.1. BC063891 mRNA. Translation: AAH63891.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS253.1. [Q5TH74-3] CCDS55581.1. [Q5TH74-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001185941.1. NM_001199012.1. [Q5TH74-1] NP_001185942.1. NM_001199013.1. [Q5TH74-1] NP_001185943.1. NM_001199014.1. [Q5TH74-2] NP_835223.1. NM_178122.4. [Q5TH74-3] XP_006711088.1. XM_006711025.2. [Q5TH74-1] XP_011540706.1. XM_011542404.1. [Q5TH74-1] XP_016858257.1. XM_017002768.1. [Q5TH74-3] XP_016858258.1. XM_017002769.1. [Q5TH74-2] XP_016858259.1. XM_017002770.1. [Q5TH74-2]
UniGeneⁱ	Hs.403187.

3D structure databases

ProteinModelPortalⁱ	Q5TH74.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000337461.

STRINGⁱ

9606.ENSP00000337461.

PTM databases

iPTMnetⁱ	Q5TH74.
PhosphoSitePlusⁱ	Q5TH74.

Polymorphism and mutation databases

BioMutaⁱ	STPG1.
DMDMⁱ	74746565.

Proteomic databases

PaxDbⁱ	Q5TH74.
PeptideAtlas More...PeptideAtlasⁱ	Q5TH74.
PRIDEⁱ	Q5TH74.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	90529.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000003583; ENSP00000003583; ENSG00000001460. [Q5TH74-3] ENST00000337248; ENSP00000337461; ENSG00000001460. [Q5TH74-1] ENST00000374409; ENSP00000363530; ENSG00000001460. [Q5TH74-1]
GeneIDⁱ	90529.
KEGGⁱ	hsa:90529.
UCSC genome browser More...UCSCⁱ	uc001bja.4. human. [Q5TH74-1]

Organism-specific databases

CTDⁱ	90529.
GeneCardsⁱ	STPG1.
H-InvDBⁱ	HIX0000262.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28070. STPG1.
Human Protein Atlas More...HPAⁱ	HPA024301.
MIMⁱ	615826. gene.
neXtProtⁱ	NX_Q5TH74.
Open Targets More...OpenTargetsⁱ	ENSG00000001460.
PharmGKBⁱ	PA143485320.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IK80. Eukaryota. ENOG4111MU0. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011598.
HOGENOMⁱ	HOG000007868.
HOVERGENⁱ	HBG107567.
InParanoidⁱ	Q5TH74.
OMAⁱ	GKQSFLY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ABV.
PhylomeDBⁱ	Q5TH74.
TreeFamⁱ	TF328937.

Miscellaneous databases

GenomeRNAiⁱ	90529.
Protein Ontology More...PROⁱ	PR:Q5TH74.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000001460.
CleanExⁱ	HS_C1orf201.
ExpressionAtlasⁱ	Q5TH74. baseline and differential.
Genevisibleⁱ	Q5TH74. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR010736. SHIPPO-rpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07004. SHIPPO-rpt. 4 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STPG1_HUMAN
Accessionⁱ	Q5TH74Primary (citable) accession number: Q5TH74 Secondary accession number(s): Q49AP0 , Q6P3R4, Q86VU9, Q8WVQ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	December 21, 2004
	Last modified:	July 5, 2017
	This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5TH74 (STPG1_HUMAN)

Your basket is currently empty.

O(6)-methylguanine-induced apoptosis 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (3)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ