Q5TH74 (STPG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
O(6)-methylguanine-induced apoptosis 2
Short name=MAPO2

Alternative name(s):
Sperm-tail PG-rich repeat-containing protein 1

Gene names

Name:	STPG1
Synonyms:	C1orf201

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine. Ref.4
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the STPG1 family. Contains 7 STPGR (Sperm-tail PG-rich) repeats.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5TH74-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5TH74-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Isoform 3 (identifier: Q5TH74-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     48-62: EKKGFNSQAKRFPHK → MNALANIPDVPVKYR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	O(6)-methylguanine-induced apoptosis 2		PRO_0000305170
Regions
	Repeat	67 – 74	8	STPGR 1
	Repeat	109 – 117	9	STPGR 2
	Repeat	148 – 155	8	STPGR 3
	Repeat	187 – 206	20	STPGR 4
	Repeat	225 – 257	33	STPGR 5
	Repeat	267 – 282	16	STPGR 6
	Repeat	306 – 316	11	STPGR 7
Amino acid modifications
	Modified residue	72	1	Phosphotyrosine Ref.3
Natural variations
	Alternative sequence	1 – 92	92	Missing in isoform 2.		VSP_028252
	Alternative sequence	1 – 47	47	Missing in isoform 3.		VSP_028253
	Alternative sequence	48 – 62	15	EKKGF…RFPHK → MNALANIPDVPVKYR in isoform 3.		VSP_028254
	Natural variant	254	1	S → F in a breast cancer sample; somatic mutation. Ref.5		VAR_035614
Experimental info
	Sequence conflict	93	1	M → T in AAH35061. Ref.2
	Sequence conflict	105	1	I → V in AAH35061. Ref.2
	Sequence conflict	163	1	R → I in AAH17650. Ref.2
	Sequence conflict	233	1	P → T in AAH35061. Ref.2
	Sequence conflict	332	1	P → R in AAH35061. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 8DA37D63A36E478E	FASTA	334	36,786
	10 20 30 40 50 60 MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK GFNSQAKRFP 70 80 90 100 110 120 HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR LDTIISKYPA ANAYTIPSDF 130 140 150 160 170 180 ISKRDFSNSC SSMFQLPSFM KALKFETPAP NYYNASVSCC KQRNNVCTRA GFMSKTQRGS 190 200 210 220 230 240 FAFADKGPPP GHYDINESLV KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP 250 260 270 280 290 300 KKTLFPKNPI LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA 310 320 330 PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL
	Isoform 2 [UniParc]. Checksum: CD6E23C0C52E0F1C	FASTA	242	26,700
	10 20 30 40 50 60 MFPSMCARLD TIISKYPAAN AYTIPSDFIS KRDFSNSCSS MFQLPSFMKA LKFETPAPNY 70 80 90 100 110 120 YNASVSCCKQ RNNVCTRAGF MSKTQRGSFA FADKGPPPGH YDINESLVKQ SPNTLMSCFK 130 140 150 160 170 180 SKTNRGLKLT STGPGPGYYN PSDCTKVPKK TLFPKNPILN FSAQPSPLPP KPPFPGPGQY 190 200 210 220 230 240 EIVDYLGPRK HFISSASFVS NTSRWTAAPP QPGLPGPATY KPELPGKQSF LYNEDKKWIP VL
	Isoform 3 [UniParc]. Checksum: AF90B7815DEAB5E2	FASTA	287	31,539
	10 20 30 40 50 60 MNALANIPDV PVKYRKNDIP GPGFYNVIHQ SPVSNSVSLS KKGTCMFPSM CARLDTIISK 70 80 90 100 110 120 YPAANAYTIP SDFISKRDFS NSCSSMFQLP SFMKALKFET PAPNYYNASV SCCKQRNNVC 130 140 150 160 170 180 TRAGFMSKTQ RGSFAFADKG PPPGHYDINE SLVKQSPNTL MSCFKSKTNR GLKLTSTGPG 190 200 210 220 230 240 PGYYNPSDCT KVPKKTLFPK NPILNFSAQP SPLPPKPPFP GPGQYEIVDY LGPRKHFISS 250 260 270 280 ASFVSNTSRW TAAPPQPGLP GPATYKPELP GKQSFLYNED KKWIPVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain, Lung and Testis.
[3]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-72, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[4]	"The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O(6)-methylguanine." Fujikane R., Sanada M., Sekiguchi M., Hidaka M. PLoS ONE 7:E44817-E44817(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-254.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL031431 Genomic DNA. Translation: CAI21410.1. AL031431 Genomic DNA. Translation: CAI21411.1. BC017650 mRNA. Translation: AAH17650.1. BC035061 mRNA. Translation: AAH35061.1. BC047705 mRNA. Translation: AAH47705.1. BC063891 mRNA. Translation: AAH63891.1.
IPI	IPI00642810. IPI00647342. IPI00867604.
RefSeq	NP_001185941.1. NM_001199012.1. NP_001185942.1. NM_001199013.1. NP_001185943.1. NM_001199014.1. NP_835223.1. NM_178122.4.
UniGene	Hs.403187.
3D structure databases
ProteinModelPortal	Q5TH74.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000003583.
PTM databases
PhosphoSite	Q5TH74.
Polymorphism databases
DMDM	74746565.
Proteomic databases
PaxDb	Q5TH74.
PRIDE	Q5TH74.
Protocols and materials databases
DNASU	90529.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000003583; ENSP00000003583; ENSG00000001460. ENST00000337248; ENSP00000337461; ENSG00000001460. ENST00000374409; ENSP00000363530; ENSG00000001460. ENST00000440416; ENSP00000408712; ENSG00000001460.
GeneID	90529.
KEGG	hsa:90529.
UCSC	uc001bja.3. human. uc001bjb.3. human.
Organism-specific databases
CTD	90529.
GeneCards	GC01M024684.
H-InvDB	HIX0000262.
HGNC	HGNC:28070. STPG1.
HPA	HPA024301.
neXtProt	NX_Q5TH74.
PharmGKB	PA143485320.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG44145.
HOGENOM	HOG000007868.
HOVERGEN	HBG107567.
InParanoid	Q5TH74.
OMA	GKQSFLY.
OrthoDB	EOG434W6J.
Gene expression databases
ArrayExpress	Q5TH74.
Bgee	Q5TH74.
CleanEx	HS_C1orf201.
Genevestigator	Q5TH74.
Family and domain databases
InterPro	IPR010736. SHIPPO-rpt. [Graphical view]
Pfam	PF07004. SHIPPO-rpt. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	90529.
NextBio	76825.

Entry information

Entry name

STPG1_HUMAN

Accession

Primary (citable) accession number: Q5TH74
Secondary accession number(s): Q49AP0 , Q6P3R4, Q86VU9, Q8WVQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.