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Protein

MICOS complex subunit MIC10

Gene

MINOS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC10
Alternative name(s):
Mitochondrial inner membrane organizing system protein 1
Gene namesi
Name:MINOS1
Synonyms:C1orf151, MIC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32068. MINOS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3620HelicalSequence AnalysisAdd
BLAST
Topological domaini37 – 7842Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672468.

Polymorphism and mutation databases

BioMutaiMINOS1.
DMDMi74746535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 7877MICOS complex subunit MIC10PRO_0000249459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ5TGZ0.
PaxDbiQ5TGZ0.
PeptideAtlasiQ5TGZ0.
PRIDEiQ5TGZ0.

Expressioni

Gene expression databases

BgeeiQ5TGZ0.
CleanExiHS_C1orf151.
ExpressionAtlasiQ5TGZ0. baseline and differential.
GenevisibleiQ5TGZ0. HS.

Organism-specific databases

HPAiHPA059930.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60 and QIL1/MIC13. Interacts with APOO/MIC23/MIC26 and APOOL/MIC27.3 Publications

Protein-protein interaction databases

BioGridi136699. 25 interactions.
STRINGi9606.ENSP00000325562.

Structurei

3D structure databases

ProteinModelPortaliQ5TGZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic10 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149266.
GeneTreeiENSGT00390000005732.
HOGENOMiHOG000205880.
HOVERGENiHBG080363.
InParanoidiQ5TGZ0.
KOiK17784.
OMAiKKWDRCL.
OrthoDBiEOG793B9Z.
PhylomeDBiQ5TGZ0.
TreeFamiTF300259.

Family and domain databases

InterProiIPR007512. DUF543.
[Graphical view]
PANTHERiPTHR21304. PTHR21304. 1 hit.
PfamiPF04418. DUF543. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TGZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSESELGRKW DRCLADAVVK IGTGFGLGIV FSLTFFKRRM WPLAFGSGMG
60 70
LGMAYSNCQH DFQAPYLLHG KYVKEQEQ
Length:78
Mass (Da):8,808
Last modified:December 21, 2004 - v1
Checksum:i6E4F618F07E969BE
GO
Isoform 2 (identifier: Q5TGZ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-24: GTG → ESW
     25-78: Missing.

Note: No experimental confirmation available.
Show »
Length:24
Mass (Da):2,809
Checksum:i6742A374D82A5696
GO

Sequence cautioni

The sequence AAH09927.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 243GTG → ESW in isoform 2. 1 PublicationVSP_042062
Alternative sequencei25 – 7854Missing in isoform 2. 1 PublicationVSP_042063Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031727 Genomic DNA. Translation: CAI19017.1.
BC009927 mRNA. Translation: AAH09927.1. Different initiation.
BC070388 mRNA. Translation: AAH70388.1.
CCDSiCCDS30620.1. [Q5TGZ0-1]
RefSeqiNP_001027535.1. NM_001032363.3. [Q5TGZ0-1]
UniGeneiHs.466662.

Genome annotation databases

EnsembliENST00000322753; ENSP00000325562; ENSG00000173436.
GeneIDi440574.
KEGGihsa:440574.
UCSCiuc001bci.2. human. [Q5TGZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031727 Genomic DNA. Translation: CAI19017.1.
BC009927 mRNA. Translation: AAH09927.1. Different initiation.
BC070388 mRNA. Translation: AAH70388.1.
CCDSiCCDS30620.1. [Q5TGZ0-1]
RefSeqiNP_001027535.1. NM_001032363.3. [Q5TGZ0-1]
UniGeneiHs.466662.

3D structure databases

ProteinModelPortaliQ5TGZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136699. 25 interactions.
STRINGi9606.ENSP00000325562.

Polymorphism and mutation databases

BioMutaiMINOS1.
DMDMi74746535.

Proteomic databases

MaxQBiQ5TGZ0.
PaxDbiQ5TGZ0.
PeptideAtlasiQ5TGZ0.
PRIDEiQ5TGZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322753; ENSP00000325562; ENSG00000173436.
GeneIDi440574.
KEGGihsa:440574.
UCSCiuc001bci.2. human. [Q5TGZ0-1]

Organism-specific databases

CTDi440574.
GeneCardsiGC01P019924.
HGNCiHGNC:32068. MINOS1.
HPAiHPA059930.
neXtProtiNX_Q5TGZ0.
PharmGKBiPA142672468.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149266.
GeneTreeiENSGT00390000005732.
HOGENOMiHOG000205880.
HOVERGENiHBG080363.
InParanoidiQ5TGZ0.
KOiK17784.
OMAiKKWDRCL.
OrthoDBiEOG793B9Z.
PhylomeDBiQ5TGZ0.
TreeFamiTF300259.

Miscellaneous databases

ChiTaRSiMINOS1. human.
GenomeRNAii440574.
NextBioi109375.
PROiQ5TGZ0.

Gene expression databases

BgeeiQ5TGZ0.
CleanExiHS_C1orf151.
ExpressionAtlasiQ5TGZ0. baseline and differential.
GenevisibleiQ5TGZ0. HS.

Family and domain databases

InterProiIPR007512. DUF543.
[Graphical view]
PANTHERiPTHR21304. PTHR21304. 1 hit.
PfamiPF04418. DUF543. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Uterus.
  3. "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."
    Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.
    Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MICOS COMPLEX, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  5. Cited for: NOMENCLATURE.
  6. "The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions."
    Koob S., Barrera M., Anand R., Reichert A.S.
    Biochim. Biophys. Acta 1853:1551-1563(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH APOO; APOOL AND IMMT.
  7. "QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology."
    Guarani V., McNeill E.M., Paulo J.A., Huttlin E.L., Froehlich F., Gygi S.P., Van Vactor D., Harper J.W.
    Elife 4:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH QIL1 AND IMMT.

Entry informationi

Entry nameiMIC10_HUMAN
AccessioniPrimary (citable) accession number: Q5TGZ0
Secondary accession number(s): Q96G68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: July 22, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.