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Q5TGZ0 (MOS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial inner membrane organizing system protein 1
Gene names
Name:MINOS1
Synonyms:C1orf151
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length78 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in mitochondrial architecture By similarity.

Subunit structure

Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Ref.3

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein. Note: The C-terminus is located in the intermembrane space By similarity, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (Ref.3). Ref.3

Sequence similarities

Belongs to the mitochondrial organizing structure protein type 1 family.

Sequence caution

The sequence AAH09927.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5TGZ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5TGZ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     22-24: GTG → ESW
     25-78: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 7877Mitochondrial inner membrane organizing system protein 1
PRO_0000249459

Regions

Transmembrane17 – 3620Helical; Potential
Topological domain37 – 7842Mitochondrial intermembrane Potential

Amino acid modifications

Modified residue21N-acetylserine Ref.4

Natural variations

Alternative sequence22 – 243GTG → ESW in isoform 2.
VSP_042062
Alternative sequence25 – 7854Missing in isoform 2.
VSP_042063

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 6E4F618F07E969BE

FASTA788,808
        10         20         30         40         50         60 
MSESELGRKW DRCLADAVVK IGTGFGLGIV FSLTFFKRRM WPLAFGSGMG LGMAYSNCQH 

        70 
DFQAPYLLHG KYVKEQEQ 

« Hide

Isoform 2 [UniParc].

Checksum: 6742A374D82A5696
Show »

FASTA242,809

References

« Hide 'large scale' references
[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Uterus.
[3]"MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."
Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.
Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, TOPOLOGY.
[4]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL031727 Genomic DNA. Translation: CAI19017.1.
BC009927 mRNA. Translation: AAH09927.1. Different initiation.
BC070388 mRNA. Translation: AAH70388.1.
CCDSCCDS30620.1. [Q5TGZ0-1]
RefSeqNP_001027535.1. NM_001032363.3. [Q5TGZ0-1]
UniGeneHs.466662.

3D structure databases

ProteinModelPortalQ5TGZ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid136699. 22 interactions.
STRING9606.ENSP00000325562.

Polymorphism databases

DMDM74746535.

Proteomic databases

MaxQBQ5TGZ0.
PaxDbQ5TGZ0.
PeptideAtlasQ5TGZ0.
PRIDEQ5TGZ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322753; ENSP00000325562; ENSG00000173436. [Q5TGZ0-1]
GeneID440574.
KEGGhsa:440574.
UCSCuc001bci.2. human. [Q5TGZ0-1]

Organism-specific databases

CTD440574.
GeneCardsGC01P019924.
HGNCHGNC:32068. MINOS1.
HPAHPA059930.
neXtProtNX_Q5TGZ0.
PharmGKBPA142672468.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149266.
HOGENOMHOG000205880.
HOVERGENHBG080363.
KOK17784.
OMAAYEECNF.
OrthoDBEOG793B9Z.
PhylomeDBQ5TGZ0.
TreeFamTF300259.

Gene expression databases

BgeeQ5TGZ0.
CleanExHS_C1orf151.
GenevestigatorQ5TGZ0.

Family and domain databases

InterProIPR007512. DUF543.
[Graphical view]
PANTHERPTHR21304. PTHR21304. 1 hit.
PfamPF04418. DUF543. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMINOS1. human.
NextBio109375.
PROQ5TGZ0.

Entry information

Entry nameMOS1_HUMAN
AccessionPrimary (citable) accession number: Q5TGZ0
Secondary accession number(s): Q96G68
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM