Q5TGZ0 (MOS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial inner membrane organizing system protein 1

Gene names

Name:	MINOS1
Synonyms:	C1orf151

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in mitochondrial architecture By similarity.
Subunit structure	Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Ref.4
Subcellular location	Mitochondrion inner membrane; Single-pass membrane protein. Note: The C-terminus is located in the intermembrane space By similarity, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (Ref.4). Ref.4
Sequence similarities	Belongs to the mitochondrial organizing structure protein type 1 family.
Sequence caution	The sequence AAH09927.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5TGZ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5TGZ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     22-24: GTG → ESW
     25-78: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 78	78	Mitochondrial inner membrane organizing system protein 1		PRO_0000249459
Regions
	Transmembrane	17 – 36	20	Helical; Potential
	Topological domain	37 – 78	42	Mitochondrial intermembrane Potential
Natural variations
	Alternative sequence	22 – 24	3	GTG → ESW in isoform 2.		VSP_042062
	Alternative sequence	25 – 78	54	Missing in isoform 2.		VSP_042063

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 6E4F618F07E969BE	FASTA	78	8,808
	10 20 30 40 50 60 MSESELGRKW DRCLADAVVK IGTGFGLGIV FSLTFFKRRM WPLAFGSGMG LGMAYSNCQH 70 DFQAPYLLHG KYVKEQEQ
	Isoform 2 [UniParc]. Checksum: 6742A374D82A5696	FASTA	24	2,809
	10 20 MSESELGRKW DRCLADAVVK IESW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Uterus.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]	"MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization." Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M. Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, TOPOLOGY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL031727 Genomic DNA. Translation: CAI19017.1. BC009927 mRNA. Translation: AAH09927.1. Different initiation. BC070388 mRNA. Translation: AAH70388.1.
IPI	IPI00062298.
RefSeq	NP_001027535.1. NM_001032363.3.
UniGene	Hs.466662.
3D structure databases
ProteinModelPortal	Q5TGZ0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000325562.
Polymorphism databases
DMDM	74746535.
Proteomic databases
PaxDb	Q5TGZ0.
PeptideAtlas	Q5TGZ0.
PRIDE	Q5TGZ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322753; ENSP00000325562; ENSG00000173436.
GeneID	440574.
KEGG	hsa:440574.
UCSC	uc001bci.2. human.
Organism-specific databases
CTD	440574.
GeneCards	GC01P019924.
HGNC	HGNC:32068. MINOS1.
neXtProt	NX_Q5TGZ0.
PharmGKB	PA142672468.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149266.
HOGENOM	HOG000205880.
HOVERGEN	HBG080363.
OMA	MSDSELG.
OrthoDB	EOG4WDDDF.
Gene expression databases
Bgee	Q5TGZ0.
CleanEx	HS_C1orf151.
Genevestigator	Q5TGZ0.
GermOnline	ENSG00000173436. Homo sapiens.
Family and domain databases
InterPro	IPR007512. DUF543. [Graphical view]
PANTHER	PTHR21304. PTHR21304. 1 hit.
Pfam	PF04418. DUF543. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MINOS1. human.
NextBio	109375.

Entry information

Entry name

MOS1_HUMAN

Accession

Primary (citable) accession number: Q5TGZ0
Secondary accession number(s): Q96G68

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.