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Q5TGZ0

- MIC10_HUMAN

UniProt

Q5TGZ0 - MIC10_HUMAN

Protein

MICOS complex subunit MIC10

Gene

MINOS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MICOS complex subunit MIC10
    Alternative name(s):
    Mitochondrial inner membrane organizing system protein 1
    Gene namesi
    Name:MINOS1
    Synonyms:C1orf151, MIC10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:32068. MINOS1.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Single-pass membrane protein 1 Publication
    Note: The C-terminus is located in the intermembrane space By similarity, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354).1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672468.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 7877MICOS complex subunit MIC10PRO_0000249459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ5TGZ0.
    PaxDbiQ5TGZ0.
    PeptideAtlasiQ5TGZ0.
    PRIDEiQ5TGZ0.

    Expressioni

    Gene expression databases

    BgeeiQ5TGZ0.
    CleanExiHS_C1orf151.
    GenevestigatoriQ5TGZ0.

    Organism-specific databases

    HPAiHPA059930.

    Interactioni

    Subunit structurei

    Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9.1 Publication

    Protein-protein interaction databases

    BioGridi136699. 22 interactions.
    STRINGi9606.ENSP00000325562.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TGZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini37 – 7842Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3620HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MICOS complex subunit Mic10 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149266.
    HOGENOMiHOG000205880.
    HOVERGENiHBG080363.
    KOiK17784.
    OMAiAYEECNF.
    OrthoDBiEOG793B9Z.
    PhylomeDBiQ5TGZ0.
    TreeFamiTF300259.

    Family and domain databases

    InterProiIPR007512. DUF543.
    [Graphical view]
    PANTHERiPTHR21304. PTHR21304. 1 hit.
    PfamiPF04418. DUF543. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5TGZ0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSESELGRKW DRCLADAVVK IGTGFGLGIV FSLTFFKRRM WPLAFGSGMG   50
    LGMAYSNCQH DFQAPYLLHG KYVKEQEQ 78
    Length:78
    Mass (Da):8,808
    Last modified:December 21, 2004 - v1
    Checksum:i6E4F618F07E969BE
    GO
    Isoform 2 (identifier: Q5TGZ0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         22-24: GTG → ESW
         25-78: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:24
    Mass (Da):2,809
    Checksum:i6742A374D82A5696
    GO

    Sequence cautioni

    The sequence AAH09927.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei22 – 243GTG → ESW in isoform 2. 1 PublicationVSP_042062
    Alternative sequencei25 – 7854Missing in isoform 2. 1 PublicationVSP_042063Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL031727 Genomic DNA. Translation: CAI19017.1.
    BC009927 mRNA. Translation: AAH09927.1. Different initiation.
    BC070388 mRNA. Translation: AAH70388.1.
    CCDSiCCDS30620.1. [Q5TGZ0-1]
    RefSeqiNP_001027535.1. NM_001032363.3. [Q5TGZ0-1]
    UniGeneiHs.466662.

    Genome annotation databases

    EnsembliENST00000322753; ENSP00000325562; ENSG00000173436. [Q5TGZ0-1]
    GeneIDi440574.
    KEGGihsa:440574.
    UCSCiuc001bci.2. human. [Q5TGZ0-1]

    Polymorphism databases

    DMDMi74746535.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL031727 Genomic DNA. Translation: CAI19017.1 .
    BC009927 mRNA. Translation: AAH09927.1 . Different initiation.
    BC070388 mRNA. Translation: AAH70388.1 .
    CCDSi CCDS30620.1. [Q5TGZ0-1 ]
    RefSeqi NP_001027535.1. NM_001032363.3. [Q5TGZ0-1 ]
    UniGenei Hs.466662.

    3D structure databases

    ProteinModelPortali Q5TGZ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 136699. 22 interactions.
    STRINGi 9606.ENSP00000325562.

    Polymorphism databases

    DMDMi 74746535.

    Proteomic databases

    MaxQBi Q5TGZ0.
    PaxDbi Q5TGZ0.
    PeptideAtlasi Q5TGZ0.
    PRIDEi Q5TGZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322753 ; ENSP00000325562 ; ENSG00000173436 . [Q5TGZ0-1 ]
    GeneIDi 440574.
    KEGGi hsa:440574.
    UCSCi uc001bci.2. human. [Q5TGZ0-1 ]

    Organism-specific databases

    CTDi 440574.
    GeneCardsi GC01P019924.
    HGNCi HGNC:32068. MINOS1.
    HPAi HPA059930.
    neXtProti NX_Q5TGZ0.
    PharmGKBi PA142672468.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149266.
    HOGENOMi HOG000205880.
    HOVERGENi HBG080363.
    KOi K17784.
    OMAi AYEECNF.
    OrthoDBi EOG793B9Z.
    PhylomeDBi Q5TGZ0.
    TreeFami TF300259.

    Miscellaneous databases

    ChiTaRSi MINOS1. human.
    NextBioi 109375.
    PROi Q5TGZ0.

    Gene expression databases

    Bgeei Q5TGZ0.
    CleanExi HS_C1orf151.
    Genevestigatori Q5TGZ0.

    Family and domain databases

    InterProi IPR007512. DUF543.
    [Graphical view ]
    PANTHERi PTHR21304. PTHR21304. 1 hit.
    Pfami PF04418. DUF543. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Uterus.
    3. "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."
      Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.
      Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MICOS COMPLEX, FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
    4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    5. Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMIC10_HUMAN
    AccessioniPrimary (citable) accession number: Q5TGZ0
    Secondary accession number(s): Q96G68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3