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Q5TGY1

- TMCO4_HUMAN

UniProt

Q5TGY1 - TMCO4_HUMAN

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Protein

Transmembrane and coiled-coil domain-containing protein 4

Gene
TMCO4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 4
Gene namesi
Name:TMCO4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:27393. TMCO4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei203 – 22321Helical; Reviewed predictionAdd
BLAST
Transmembranei231 – 25121Helical; Reviewed predictionAdd
BLAST
Transmembranei346 – 36621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Transmembrane and coiled-coil domain-containing protein 4PRO_0000305149Add
BLAST

Proteomic databases

MaxQBiQ5TGY1.
PaxDbiQ5TGY1.
PRIDEiQ5TGY1.

PTM databases

PhosphoSiteiQ5TGY1.

Expressioni

Gene expression databases

ArrayExpressiQ5TGY1.
BgeeiQ5TGY1.
CleanExiHS_TMCO4.
GenevestigatoriQ5TGY1.

Organism-specific databases

HPAiHPA014601.

Interactioni

Protein-protein interaction databases

IntActiQ5TGY1. 1 interaction.
STRINGi9606.ENSP00000294543.

Structurei

3D structure databases

ProteinModelPortaliQ5TGY1.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili150 – 19041 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the TMCO4 family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280803.
HOGENOMiHOG000019995.
HOVERGENiHBG096742.
InParanoidiQ5TGY1.
OMAiPEQSSFC.
OrthoDBiEOG779NZJ.
PhylomeDBiQ5TGY1.
TreeFamiTF312951.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR007941. DUF726.
[Graphical view]
PANTHERiPTHR17920. PTHR17920. 1 hit.
PfamiPF05277. DUF726. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5TGY1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAMWNRPCQR LPQQPLVAEP TAEGEPHLPT GRELTEANRF AYAALCGISL    50
SQLFPEPEHS SFCTEFMAGL VQWLELSEAV LPTMTAFASG LGGEGADVFV 100
QILLKDPILK DDPTVITQDL LSFSLKDGHY DARARVLVCH MTSLLQVPLE 150
ELDVLEEMFL ESLKEIKEEE SEMAEASRKK KENRRKWKRY LLIGLATVGG 200
GTVIGVTGGL AAPLVAAGAA TIIGSAGAAA LGSAAGIAIM TSLFGAAGAG 250
LTGYKMKKRV GAIEEFTFLP LTEGRQLHIT IAVTGWLASG KYRTFSAPWA 300
ALAHSREQYC LAWEAKYLME LGNALETILS GLANMVAQEA LKYTVLSGIV 350
AALTWPASLL SVANVIDNPW GVCLHRSAEV GKHLAHILLS RQQGRRPVTL 400
IGFSLGARVI YFCLQEMAQE KDCQGIIEDV ILLGAPVEGE AKHWEPFRKV 450
VSGRIINGYC RGDWLLSFVY RTSSVQLRVA GLQPVLLQDR RVENVDLTSV 500
VSGHLDYAKQ MDAILKAVGI RTKPGWDEKG LLLAPGCLPS EEPRQAAAAA 550
SSGETPHQVG QTQGPISGDT SKLAMSTDPS QAQVPVGLDQ SEGASLPAAA 600
SPERPPICSH GMDPNPLGCP DCACKTQGPS TGLD 634
Length:634
Mass (Da):67,910
Last modified:December 21, 2004 - v1
Checksum:i9D2F5E263A9E98E3
GO
Isoform 2 (identifier: Q5TGY1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-293: Missing.

Note: No experimental confirmation available.

Show »
Length:594
Mass (Da):63,318
Checksum:i988DFBC5AD13E392
GO

Sequence cautioni

The sequence CAB42850.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAB42851.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI19015.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI20091.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721Q → K.
Corresponds to variant rs10917536 [ dbSNP | Ensembl ].
VAR_035169
Natural varianti478 – 4781R → H.2 Publications
Corresponds to variant rs4515815 [ dbSNP | Ensembl ].
VAR_035170

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei254 – 29340Missing in isoform 2. VSP_028242Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti605 – 6051P → S in CAE45994. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640987 mRNA. Translation: CAE45994.1.
AL031727, AL031730 Genomic DNA. Translation: CAI19015.1. Sequence problems.
AL031727, AL031730 Genomic DNA. Translation: CAI19016.1.
AL031730, AL031727 Genomic DNA. Translation: CAI20091.1. Sequence problems.
AL031730, AL031727 Genomic DNA. Translation: CAI20092.1.
BC053600 mRNA. Translation: AAH53600.1.
AL049846 mRNA. Translation: CAB42850.1. Different initiation.
AL049847 mRNA. Translation: CAB42851.1. Different initiation.
CCDSiCCDS198.1. [Q5TGY1-1]
RefSeqiNP_859070.3. NM_181719.4. [Q5TGY1-1]
XP_005245879.1. XM_005245822.2. [Q5TGY1-1]
XP_005245880.1. XM_005245823.2. [Q5TGY1-1]
XP_005245881.1. XM_005245824.2. [Q5TGY1-1]
XP_005245882.1. XM_005245825.2. [Q5TGY1-1]
XP_005245884.1. XM_005245827.2. [Q5TGY1-2]
XP_006710613.1. XM_006710550.1. [Q5TGY1-1]
XP_006710614.1. XM_006710551.1. [Q5TGY1-1]
UniGeneiHs.656313.

Genome annotation databases

EnsembliENST00000294543; ENSP00000294543; ENSG00000162542. [Q5TGY1-1]
ENST00000375122; ENSP00000364264; ENSG00000162542. [Q5TGY1-2]
GeneIDi255104.
KEGGihsa:255104.
UCSCiuc001bcn.3. human. [Q5TGY1-1]
uc001bcp.1. human. [Q5TGY1-2]

Polymorphism databases

DMDMi74746530.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640987 mRNA. Translation: CAE45994.1 .
AL031727 , AL031730 Genomic DNA. Translation: CAI19015.1 . Sequence problems.
AL031727 , AL031730 Genomic DNA. Translation: CAI19016.1 .
AL031730 , AL031727 Genomic DNA. Translation: CAI20091.1 . Sequence problems.
AL031730 , AL031727 Genomic DNA. Translation: CAI20092.1 .
BC053600 mRNA. Translation: AAH53600.1 .
AL049846 mRNA. Translation: CAB42850.1 . Different initiation.
AL049847 mRNA. Translation: CAB42851.1 . Different initiation.
CCDSi CCDS198.1. [Q5TGY1-1 ]
RefSeqi NP_859070.3. NM_181719.4. [Q5TGY1-1 ]
XP_005245879.1. XM_005245822.2. [Q5TGY1-1 ]
XP_005245880.1. XM_005245823.2. [Q5TGY1-1 ]
XP_005245881.1. XM_005245824.2. [Q5TGY1-1 ]
XP_005245882.1. XM_005245825.2. [Q5TGY1-1 ]
XP_005245884.1. XM_005245827.2. [Q5TGY1-2 ]
XP_006710613.1. XM_006710550.1. [Q5TGY1-1 ]
XP_006710614.1. XM_006710551.1. [Q5TGY1-1 ]
UniGenei Hs.656313.

3D structure databases

ProteinModelPortali Q5TGY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5TGY1. 1 interaction.
STRINGi 9606.ENSP00000294543.

PTM databases

PhosphoSitei Q5TGY1.

Polymorphism databases

DMDMi 74746530.

Proteomic databases

MaxQBi Q5TGY1.
PaxDbi Q5TGY1.
PRIDEi Q5TGY1.

Protocols and materials databases

DNASUi 255104.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294543 ; ENSP00000294543 ; ENSG00000162542 . [Q5TGY1-1 ]
ENST00000375122 ; ENSP00000364264 ; ENSG00000162542 . [Q5TGY1-2 ]
GeneIDi 255104.
KEGGi hsa:255104.
UCSCi uc001bcn.3. human. [Q5TGY1-1 ]
uc001bcp.1. human. [Q5TGY1-2 ]

Organism-specific databases

CTDi 255104.
GeneCardsi GC01M020009.
H-InvDB HIX0000206.
HGNCi HGNC:27393. TMCO4.
HPAi HPA014601.
neXtProti NX_Q5TGY1.
PharmGKBi PA142670794.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG280803.
HOGENOMi HOG000019995.
HOVERGENi HBG096742.
InParanoidi Q5TGY1.
OMAi PEQSSFC.
OrthoDBi EOG779NZJ.
PhylomeDBi Q5TGY1.
TreeFami TF312951.

Miscellaneous databases

GenomeRNAii 255104.
NextBioi 92486.
PROi Q5TGY1.

Gene expression databases

ArrayExpressi Q5TGY1.
Bgeei Q5TGY1.
CleanExi HS_TMCO4.
Genevestigatori Q5TGY1.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR007941. DUF726.
[Graphical view ]
PANTHERi PTHR17920. PTHR17920. 1 hit.
Pfami PF05277. DUF726. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-478.
    Tissue: Small intestine.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-478.
    Tissue: Brain.
  4. Rhodes S.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-421 (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiTMCO4_HUMAN
AccessioniPrimary (citable) accession number: Q5TGY1
Secondary accession number(s): Q5TGY2
, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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