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Q5TGY1 (TMCO4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane and coiled-coil domain-containing protein 4
Gene names
Name:TMCO4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length634 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMCO4 family.

Sequence caution

The sequence CAB42850.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAB42851.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI19015.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI20091.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5TGY1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5TGY1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     254-293: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 634634Transmembrane and coiled-coil domain-containing protein 4
PRO_0000305149

Regions

Transmembrane203 – 22321Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane346 – 36621Helical; Potential
Coiled coil150 – 19041 Potential

Natural variations

Alternative sequence254 – 29340Missing in isoform 2.
VSP_028242
Natural variant721Q → K.
Corresponds to variant rs10917536 [ dbSNP | Ensembl ].
VAR_035169
Natural variant4781R → H. Ref.1 Ref.3
Corresponds to variant rs4515815 [ dbSNP | Ensembl ].
VAR_035170

Experimental info

Sequence conflict6051P → S in CAE45994. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 9D2F5E263A9E98E3

FASTA63467,910
        10         20         30         40         50         60 
MAMWNRPCQR LPQQPLVAEP TAEGEPHLPT GRELTEANRF AYAALCGISL SQLFPEPEHS 

        70         80         90        100        110        120 
SFCTEFMAGL VQWLELSEAV LPTMTAFASG LGGEGADVFV QILLKDPILK DDPTVITQDL 

       130        140        150        160        170        180 
LSFSLKDGHY DARARVLVCH MTSLLQVPLE ELDVLEEMFL ESLKEIKEEE SEMAEASRKK 

       190        200        210        220        230        240 
KENRRKWKRY LLIGLATVGG GTVIGVTGGL AAPLVAAGAA TIIGSAGAAA LGSAAGIAIM 

       250        260        270        280        290        300 
TSLFGAAGAG LTGYKMKKRV GAIEEFTFLP LTEGRQLHIT IAVTGWLASG KYRTFSAPWA 

       310        320        330        340        350        360 
ALAHSREQYC LAWEAKYLME LGNALETILS GLANMVAQEA LKYTVLSGIV AALTWPASLL 

       370        380        390        400        410        420 
SVANVIDNPW GVCLHRSAEV GKHLAHILLS RQQGRRPVTL IGFSLGARVI YFCLQEMAQE 

       430        440        450        460        470        480 
KDCQGIIEDV ILLGAPVEGE AKHWEPFRKV VSGRIINGYC RGDWLLSFVY RTSSVQLRVA 

       490        500        510        520        530        540 
GLQPVLLQDR RVENVDLTSV VSGHLDYAKQ MDAILKAVGI RTKPGWDEKG LLLAPGCLPS 

       550        560        570        580        590        600 
EEPRQAAAAA SSGETPHQVG QTQGPISGDT SKLAMSTDPS QAQVPVGLDQ SEGASLPAAA 

       610        620        630 
SPERPPICSH GMDPNPLGCP DCACKTQGPS TGLD 

« Hide

Isoform 2 [UniParc].

Checksum: 988DFBC5AD13E392
Show »

FASTA59463,318

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-478.
Tissue: Small intestine.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-478.
Tissue: Brain.
[4]Rhodes S.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-421 (ISOFORMS 1 AND 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640987 mRNA. Translation: CAE45994.1.
AL031727, AL031730 Genomic DNA. Translation: CAI19015.1. Sequence problems.
AL031727, AL031730 Genomic DNA. Translation: CAI19016.1.
AL031730, AL031727 Genomic DNA. Translation: CAI20091.1. Sequence problems.
AL031730, AL031727 Genomic DNA. Translation: CAI20092.1.
BC053600 mRNA. Translation: AAH53600.1.
AL049846 mRNA. Translation: CAB42850.1. Different initiation.
AL049847 mRNA. Translation: CAB42851.1. Different initiation.
CCDSCCDS198.1. [Q5TGY1-1]
RefSeqNP_859070.3. NM_181719.4. [Q5TGY1-1]
XP_005245879.1. XM_005245822.2. [Q5TGY1-1]
XP_005245880.1. XM_005245823.2. [Q5TGY1-1]
XP_005245881.1. XM_005245824.2. [Q5TGY1-1]
XP_005245882.1. XM_005245825.2. [Q5TGY1-1]
XP_005245884.1. XM_005245827.2. [Q5TGY1-2]
XP_006710613.1. XM_006710550.1. [Q5TGY1-1]
XP_006710614.1. XM_006710551.1. [Q5TGY1-1]
UniGeneHs.656313.

3D structure databases

ProteinModelPortalQ5TGY1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ5TGY1. 1 interaction.
STRING9606.ENSP00000294543.

PTM databases

PhosphoSiteQ5TGY1.

Polymorphism databases

DMDM74746530.

Proteomic databases

MaxQBQ5TGY1.
PaxDbQ5TGY1.
PRIDEQ5TGY1.

Protocols and materials databases

DNASU255104.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294543; ENSP00000294543; ENSG00000162542. [Q5TGY1-1]
ENST00000375122; ENSP00000364264; ENSG00000162542. [Q5TGY1-2]
GeneID255104.
KEGGhsa:255104.
UCSCuc001bcn.3. human. [Q5TGY1-1]
uc001bcp.1. human. [Q5TGY1-2]

Organism-specific databases

CTD255104.
GeneCardsGC01M020009.
H-InvDBHIX0000206.
HGNCHGNC:27393. TMCO4.
HPAHPA014601.
neXtProtNX_Q5TGY1.
PharmGKBPA142670794.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG280803.
HOGENOMHOG000019995.
HOVERGENHBG096742.
InParanoidQ5TGY1.
OMAPEQSSFC.
OrthoDBEOG779NZJ.
PhylomeDBQ5TGY1.
TreeFamTF312951.

Gene expression databases

ArrayExpressQ5TGY1.
BgeeQ5TGY1.
CleanExHS_TMCO4.
GenevestigatorQ5TGY1.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR007941. DUF726.
[Graphical view]
PANTHERPTHR17920. PTHR17920. 1 hit.
PfamPF05277. DUF726. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi255104.
NextBio92486.
PROQ5TGY1.

Entry information

Entry nameTMCO4_HUMAN
AccessionPrimary (citable) accession number: Q5TGY1
Secondary accession number(s): Q5TGY2 expand/collapse secondary AC list , Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM