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Q5TGY1

- TMCO4_HUMAN

UniProt

Q5TGY1 - TMCO4_HUMAN

Protein

Transmembrane and coiled-coil domain-containing protein 4

Gene

TMCO4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 4
    Gene namesi
    Name:TMCO4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:27393. TMCO4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670794.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 634634Transmembrane and coiled-coil domain-containing protein 4PRO_0000305149Add
    BLAST

    Proteomic databases

    MaxQBiQ5TGY1.
    PaxDbiQ5TGY1.
    PRIDEiQ5TGY1.

    PTM databases

    PhosphoSiteiQ5TGY1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5TGY1.
    BgeeiQ5TGY1.
    CleanExiHS_TMCO4.
    GenevestigatoriQ5TGY1.

    Organism-specific databases

    HPAiHPA014601.

    Interactioni

    Protein-protein interaction databases

    IntActiQ5TGY1. 1 interaction.
    STRINGi9606.ENSP00000294543.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TGY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili150 – 19041Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TMCO4 family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280803.
    HOGENOMiHOG000019995.
    HOVERGENiHBG096742.
    InParanoidiQ5TGY1.
    OMAiPEQSSFC.
    OrthoDBiEOG779NZJ.
    PhylomeDBiQ5TGY1.
    TreeFamiTF312951.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR007941. DUF726.
    [Graphical view]
    PANTHERiPTHR17920. PTHR17920. 1 hit.
    PfamiPF05277. DUF726. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5TGY1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMWNRPCQR LPQQPLVAEP TAEGEPHLPT GRELTEANRF AYAALCGISL    50
    SQLFPEPEHS SFCTEFMAGL VQWLELSEAV LPTMTAFASG LGGEGADVFV 100
    QILLKDPILK DDPTVITQDL LSFSLKDGHY DARARVLVCH MTSLLQVPLE 150
    ELDVLEEMFL ESLKEIKEEE SEMAEASRKK KENRRKWKRY LLIGLATVGG 200
    GTVIGVTGGL AAPLVAAGAA TIIGSAGAAA LGSAAGIAIM TSLFGAAGAG 250
    LTGYKMKKRV GAIEEFTFLP LTEGRQLHIT IAVTGWLASG KYRTFSAPWA 300
    ALAHSREQYC LAWEAKYLME LGNALETILS GLANMVAQEA LKYTVLSGIV 350
    AALTWPASLL SVANVIDNPW GVCLHRSAEV GKHLAHILLS RQQGRRPVTL 400
    IGFSLGARVI YFCLQEMAQE KDCQGIIEDV ILLGAPVEGE AKHWEPFRKV 450
    VSGRIINGYC RGDWLLSFVY RTSSVQLRVA GLQPVLLQDR RVENVDLTSV 500
    VSGHLDYAKQ MDAILKAVGI RTKPGWDEKG LLLAPGCLPS EEPRQAAAAA 550
    SSGETPHQVG QTQGPISGDT SKLAMSTDPS QAQVPVGLDQ SEGASLPAAA 600
    SPERPPICSH GMDPNPLGCP DCACKTQGPS TGLD 634
    Length:634
    Mass (Da):67,910
    Last modified:December 21, 2004 - v1
    Checksum:i9D2F5E263A9E98E3
    GO
    Isoform 2 (identifier: Q5TGY1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         254-293: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:594
    Mass (Da):63,318
    Checksum:i988DFBC5AD13E392
    GO

    Sequence cautioni

    The sequence CAB42850.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB42851.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI19015.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI20091.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti605 – 6051P → S in CAE45994. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721Q → K.
    Corresponds to variant rs10917536 [ dbSNP | Ensembl ].
    VAR_035169
    Natural varianti478 – 4781R → H.2 Publications
    Corresponds to variant rs4515815 [ dbSNP | Ensembl ].
    VAR_035170

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei254 – 29340Missing in isoform 2. 1 PublicationVSP_028242Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640987 mRNA. Translation: CAE45994.1.
    AL031727, AL031730 Genomic DNA. Translation: CAI19015.1. Sequence problems.
    AL031727, AL031730 Genomic DNA. Translation: CAI19016.1.
    AL031730, AL031727 Genomic DNA. Translation: CAI20091.1. Sequence problems.
    AL031730, AL031727 Genomic DNA. Translation: CAI20092.1.
    BC053600 mRNA. Translation: AAH53600.1.
    AL049846 mRNA. Translation: CAB42850.1. Different initiation.
    AL049847 mRNA. Translation: CAB42851.1. Different initiation.
    CCDSiCCDS198.1. [Q5TGY1-1]
    RefSeqiNP_859070.3. NM_181719.4. [Q5TGY1-1]
    XP_005245879.1. XM_005245822.2. [Q5TGY1-1]
    XP_005245880.1. XM_005245823.2. [Q5TGY1-1]
    XP_005245881.1. XM_005245824.2. [Q5TGY1-1]
    XP_005245882.1. XM_005245825.2. [Q5TGY1-1]
    XP_005245884.1. XM_005245827.2. [Q5TGY1-2]
    XP_006710613.1. XM_006710550.1. [Q5TGY1-1]
    XP_006710614.1. XM_006710551.1. [Q5TGY1-1]
    UniGeneiHs.656313.

    Genome annotation databases

    EnsembliENST00000294543; ENSP00000294543; ENSG00000162542. [Q5TGY1-1]
    GeneIDi255104.
    KEGGihsa:255104.
    UCSCiuc001bcn.3. human. [Q5TGY1-1]
    uc001bcp.1. human. [Q5TGY1-2]

    Polymorphism databases

    DMDMi74746530.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640987 mRNA. Translation: CAE45994.1 .
    AL031727 , AL031730 Genomic DNA. Translation: CAI19015.1 . Sequence problems.
    AL031727 , AL031730 Genomic DNA. Translation: CAI19016.1 .
    AL031730 , AL031727 Genomic DNA. Translation: CAI20091.1 . Sequence problems.
    AL031730 , AL031727 Genomic DNA. Translation: CAI20092.1 .
    BC053600 mRNA. Translation: AAH53600.1 .
    AL049846 mRNA. Translation: CAB42850.1 . Different initiation.
    AL049847 mRNA. Translation: CAB42851.1 . Different initiation.
    CCDSi CCDS198.1. [Q5TGY1-1 ]
    RefSeqi NP_859070.3. NM_181719.4. [Q5TGY1-1 ]
    XP_005245879.1. XM_005245822.2. [Q5TGY1-1 ]
    XP_005245880.1. XM_005245823.2. [Q5TGY1-1 ]
    XP_005245881.1. XM_005245824.2. [Q5TGY1-1 ]
    XP_005245882.1. XM_005245825.2. [Q5TGY1-1 ]
    XP_005245884.1. XM_005245827.2. [Q5TGY1-2 ]
    XP_006710613.1. XM_006710550.1. [Q5TGY1-1 ]
    XP_006710614.1. XM_006710551.1. [Q5TGY1-1 ]
    UniGenei Hs.656313.

    3D structure databases

    ProteinModelPortali Q5TGY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5TGY1. 1 interaction.
    STRINGi 9606.ENSP00000294543.

    PTM databases

    PhosphoSitei Q5TGY1.

    Polymorphism databases

    DMDMi 74746530.

    Proteomic databases

    MaxQBi Q5TGY1.
    PaxDbi Q5TGY1.
    PRIDEi Q5TGY1.

    Protocols and materials databases

    DNASUi 255104.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294543 ; ENSP00000294543 ; ENSG00000162542 . [Q5TGY1-1 ]
    GeneIDi 255104.
    KEGGi hsa:255104.
    UCSCi uc001bcn.3. human. [Q5TGY1-1 ]
    uc001bcp.1. human. [Q5TGY1-2 ]

    Organism-specific databases

    CTDi 255104.
    GeneCardsi GC01M020009.
    H-InvDB HIX0000206.
    HGNCi HGNC:27393. TMCO4.
    HPAi HPA014601.
    neXtProti NX_Q5TGY1.
    PharmGKBi PA142670794.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280803.
    HOGENOMi HOG000019995.
    HOVERGENi HBG096742.
    InParanoidi Q5TGY1.
    OMAi PEQSSFC.
    OrthoDBi EOG779NZJ.
    PhylomeDBi Q5TGY1.
    TreeFami TF312951.

    Miscellaneous databases

    GenomeRNAii 255104.
    NextBioi 92486.
    PROi Q5TGY1.

    Gene expression databases

    ArrayExpressi Q5TGY1.
    Bgeei Q5TGY1.
    CleanExi HS_TMCO4.
    Genevestigatori Q5TGY1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR007941. DUF726.
    [Graphical view ]
    PANTHERi PTHR17920. PTHR17920. 1 hit.
    Pfami PF05277. DUF726. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-478.
      Tissue: Small intestine.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-478.
      Tissue: Brain.
    4. Rhodes S.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-421 (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiTMCO4_HUMAN
    AccessioniPrimary (citable) accession number: Q5TGY1
    Secondary accession number(s): Q5TGY2
    , Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3