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Protein

Transmembrane and coiled-coil domain-containing protein 4

Gene

TMCO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 4
Gene namesi
Name:TMCO4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27393. TMCO4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Transmembrane and coiled-coil domain-containing protein 4PRO_0000305149Add
BLAST

Proteomic databases

MaxQBiQ5TGY1.
PaxDbiQ5TGY1.
PRIDEiQ5TGY1.

PTM databases

PhosphoSiteiQ5TGY1.

Expressioni

Gene expression databases

BgeeiQ5TGY1.
CleanExiHS_TMCO4.
ExpressionAtlasiQ5TGY1. baseline and differential.
GenevestigatoriQ5TGY1.

Organism-specific databases

HPAiHPA014601.

Interactioni

Protein-protein interaction databases

BioGridi129076. 1 interaction.
IntActiQ5TGY1. 1 interaction.
STRINGi9606.ENSP00000294543.

Structurei

3D structure databases

ProteinModelPortaliQ5TGY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili150 – 19041Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TMCO4 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280803.
GeneTreeiENSGT00390000001400.
HOGENOMiHOG000019995.
HOVERGENiHBG096742.
InParanoidiQ5TGY1.
OMAiSFCTEFM.
OrthoDBiEOG779NZJ.
PhylomeDBiQ5TGY1.
TreeFamiTF312951.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR007941. DUF726.
[Graphical view]
PANTHERiPTHR17920. PTHR17920. 1 hit.
PfamiPF05277. DUF726. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TGY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMWNRPCQR LPQQPLVAEP TAEGEPHLPT GRELTEANRF AYAALCGISL
60 70 80 90 100
SQLFPEPEHS SFCTEFMAGL VQWLELSEAV LPTMTAFASG LGGEGADVFV
110 120 130 140 150
QILLKDPILK DDPTVITQDL LSFSLKDGHY DARARVLVCH MTSLLQVPLE
160 170 180 190 200
ELDVLEEMFL ESLKEIKEEE SEMAEASRKK KENRRKWKRY LLIGLATVGG
210 220 230 240 250
GTVIGVTGGL AAPLVAAGAA TIIGSAGAAA LGSAAGIAIM TSLFGAAGAG
260 270 280 290 300
LTGYKMKKRV GAIEEFTFLP LTEGRQLHIT IAVTGWLASG KYRTFSAPWA
310 320 330 340 350
ALAHSREQYC LAWEAKYLME LGNALETILS GLANMVAQEA LKYTVLSGIV
360 370 380 390 400
AALTWPASLL SVANVIDNPW GVCLHRSAEV GKHLAHILLS RQQGRRPVTL
410 420 430 440 450
IGFSLGARVI YFCLQEMAQE KDCQGIIEDV ILLGAPVEGE AKHWEPFRKV
460 470 480 490 500
VSGRIINGYC RGDWLLSFVY RTSSVQLRVA GLQPVLLQDR RVENVDLTSV
510 520 530 540 550
VSGHLDYAKQ MDAILKAVGI RTKPGWDEKG LLLAPGCLPS EEPRQAAAAA
560 570 580 590 600
SSGETPHQVG QTQGPISGDT SKLAMSTDPS QAQVPVGLDQ SEGASLPAAA
610 620 630
SPERPPICSH GMDPNPLGCP DCACKTQGPS TGLD
Length:634
Mass (Da):67,910
Last modified:December 21, 2004 - v1
Checksum:i9D2F5E263A9E98E3
GO
Isoform 2 (identifier: Q5TGY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-293: Missing.

Note: No experimental confirmation available.

Show »
Length:594
Mass (Da):63,318
Checksum:i988DFBC5AD13E392
GO

Sequence cautioni

The sequence CAB42850.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB42851.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI19015.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI20091.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti605 – 6051P → S in CAE45994 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721Q → K.
Corresponds to variant rs10917536 [ dbSNP | Ensembl ].
VAR_035169
Natural varianti478 – 4781R → H.2 Publications
Corresponds to variant rs4515815 [ dbSNP | Ensembl ].
VAR_035170

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei254 – 29340Missing in isoform 2. 1 PublicationVSP_028242Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640987 mRNA. Translation: CAE45994.1.
AL031727, AL031730 Genomic DNA. Translation: CAI19015.1. Sequence problems.
AL031727, AL031730 Genomic DNA. Translation: CAI19016.1.
AL031730, AL031727 Genomic DNA. Translation: CAI20091.1. Sequence problems.
AL031730, AL031727 Genomic DNA. Translation: CAI20092.1.
BC053600 mRNA. Translation: AAH53600.1.
AL049846 mRNA. Translation: CAB42850.1. Different initiation.
AL049847 mRNA. Translation: CAB42851.1. Different initiation.
CCDSiCCDS198.1. [Q5TGY1-1]
RefSeqiNP_859070.3. NM_181719.4. [Q5TGY1-1]
XP_005245879.1. XM_005245822.2. [Q5TGY1-1]
XP_005245880.1. XM_005245823.2. [Q5TGY1-1]
XP_005245881.1. XM_005245824.2. [Q5TGY1-1]
XP_005245882.1. XM_005245825.2. [Q5TGY1-1]
XP_005245884.1. XM_005245827.2. [Q5TGY1-2]
XP_006710613.1. XM_006710550.1. [Q5TGY1-1]
XP_006710614.1. XM_006710551.1. [Q5TGY1-1]
UniGeneiHs.656313.

Genome annotation databases

EnsembliENST00000294543; ENSP00000294543; ENSG00000162542. [Q5TGY1-1]
GeneIDi255104.
KEGGihsa:255104.
UCSCiuc001bcn.3. human. [Q5TGY1-1]
uc001bcp.1. human. [Q5TGY1-2]

Polymorphism databases

DMDMi74746530.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640987 mRNA. Translation: CAE45994.1.
AL031727, AL031730 Genomic DNA. Translation: CAI19015.1. Sequence problems.
AL031727, AL031730 Genomic DNA. Translation: CAI19016.1.
AL031730, AL031727 Genomic DNA. Translation: CAI20091.1. Sequence problems.
AL031730, AL031727 Genomic DNA. Translation: CAI20092.1.
BC053600 mRNA. Translation: AAH53600.1.
AL049846 mRNA. Translation: CAB42850.1. Different initiation.
AL049847 mRNA. Translation: CAB42851.1. Different initiation.
CCDSiCCDS198.1. [Q5TGY1-1]
RefSeqiNP_859070.3. NM_181719.4. [Q5TGY1-1]
XP_005245879.1. XM_005245822.2. [Q5TGY1-1]
XP_005245880.1. XM_005245823.2. [Q5TGY1-1]
XP_005245881.1. XM_005245824.2. [Q5TGY1-1]
XP_005245882.1. XM_005245825.2. [Q5TGY1-1]
XP_005245884.1. XM_005245827.2. [Q5TGY1-2]
XP_006710613.1. XM_006710550.1. [Q5TGY1-1]
XP_006710614.1. XM_006710551.1. [Q5TGY1-1]
UniGeneiHs.656313.

3D structure databases

ProteinModelPortaliQ5TGY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129076. 1 interaction.
IntActiQ5TGY1. 1 interaction.
STRINGi9606.ENSP00000294543.

PTM databases

PhosphoSiteiQ5TGY1.

Polymorphism databases

DMDMi74746530.

Proteomic databases

MaxQBiQ5TGY1.
PaxDbiQ5TGY1.
PRIDEiQ5TGY1.

Protocols and materials databases

DNASUi255104.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294543; ENSP00000294543; ENSG00000162542. [Q5TGY1-1]
GeneIDi255104.
KEGGihsa:255104.
UCSCiuc001bcn.3. human. [Q5TGY1-1]
uc001bcp.1. human. [Q5TGY1-2]

Organism-specific databases

CTDi255104.
GeneCardsiGC01M020009.
H-InvDBHIX0000206.
HGNCiHGNC:27393. TMCO4.
HPAiHPA014601.
neXtProtiNX_Q5TGY1.
PharmGKBiPA142670794.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG280803.
GeneTreeiENSGT00390000001400.
HOGENOMiHOG000019995.
HOVERGENiHBG096742.
InParanoidiQ5TGY1.
OMAiSFCTEFM.
OrthoDBiEOG779NZJ.
PhylomeDBiQ5TGY1.
TreeFamiTF312951.

Miscellaneous databases

GenomeRNAii255104.
NextBioi92486.
PROiQ5TGY1.

Gene expression databases

BgeeiQ5TGY1.
CleanExiHS_TMCO4.
ExpressionAtlasiQ5TGY1. baseline and differential.
GenevestigatoriQ5TGY1.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR007941. DUF726.
[Graphical view]
PANTHERiPTHR17920. PTHR17920. 1 hit.
PfamiPF05277. DUF726. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-478.
    Tissue: Small intestine.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-478.
    Tissue: Brain.
  4. Rhodes S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-421 (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiTMCO4_HUMAN
AccessioniPrimary (citable) accession number: Q5TGY1
Secondary accession number(s): Q5TGY2
, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: January 7, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.