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Protein

Transcription factor HES-3

Gene

HES3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-3
Alternative name(s):
Class B basic helix-loop-helix protein 43
Short name:
bHLHb43
Hairy and enhancer of split 3
Gene namesi
Name:HES3
Synonyms:BHLHB43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000173673.7.
HGNCiHGNC:26226. HES3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi390992.
OpenTargetsiENSG00000173673.
PharmGKBiPA142671692.

Polymorphism and mutation databases

BioMutaiHES3.
DMDMi74746514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002691741 – 186Transcription factor HES-3Add BLAST186

Proteomic databases

PaxDbiQ5TGS1.
PRIDEiQ5TGS1.

Expressioni

Gene expression databases

BgeeiENSG00000173673.
CleanExiHS_HES3.

Organism-specific databases

HPAiHPA047927.
HPA072697.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

  • protein dimerization activity Source: InterPro
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi9606.ENSP00000367130.

Structurei

3D structure databases

ProteinModelPortaliQ5TGS1.
SMRiQ5TGS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 49bHLHPROSITE-ProRule annotationAdd BLAST49
Domaini65 – 99OrangeAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi175 – 178WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 170Pro-richAdd BLAST60

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiENOG410INMI. Eukaryota.
ENOG4112CPE. LUCA.
GeneTreeiENSGT00730000111482.
HOGENOMiHOG000236346.
HOVERGENiHBG005959.
InParanoidiQ5TGS1.
KOiK09088.
OMAiCTPAVWA.
OrthoDBiEOG091G0D3I.
PhylomeDBiQ5TGS1.
TreeFamiTF351373.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TGS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKRRARIN VSLEQLKSLL EKHYSHQIRK RKLEKADILE LSVKYMRSLQ
60 70 80 90 100
NSLQGLWPVP RGAEQPSGFR SCLPGVSQLL RRGDEVGSGL RCPLVPESAA
110 120 130 140 150
GSTMDSAGLG QEAPALFRPC TPAVWAPAPA AGGPRSPPPL LLLPESLPGS
160 170 180
SASVPPPQPA SSRCAESPGL GLRVWRPWGS PGDDLN
Length:186
Mass (Da):19,968
Last modified:December 21, 2004 - v1
Checksum:iF64A0949CBB0654D
GO

Sequence cautioni

The sequence CAI19439 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031847 Genomic DNA. Translation: CAI19439.1. Sequence problems.
CCDSiCCDS41238.1.
RefSeqiNP_001019769.1. NM_001024598.3.
UniGeneiHs.532677.

Genome annotation databases

EnsembliENST00000377898; ENSP00000367130; ENSG00000173673.
GeneIDi390992.
KEGGihsa:390992.
UCSCiuc009vly.2. human.

Similar proteinsi

Entry informationi

Entry nameiHES3_HUMAN
AccessioniPrimary (citable) accession number: Q5TGS1
Secondary accession number(s): Q5TGS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot