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Protein

Transcription factor HES-3

Gene

HES3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-3
Alternative name(s):
Class B basic helix-loop-helix protein 43
Short name:
bHLHb43
Hairy and enhancer of split 3
Gene namesi
Name:HES3
Synonyms:BHLHB43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26226. HES3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671692.

Polymorphism and mutation databases

BioMutaiHES3.
DMDMi74746514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Transcription factor HES-3PRO_0000269174Add
BLAST

Proteomic databases

PaxDbiQ5TGS1.
PRIDEiQ5TGS1.

Expressioni

Gene expression databases

CleanExiHS_HES3.

Organism-specific databases

HPAiHPA047927.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliQ5TGS1.
SMRiQ5TGS1. Positions 1-52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4949bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini65 – 9935OrangeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi175 – 1784WRPW motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi111 – 17060Pro-richAdd
BLAST

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 Orange domain.Curated

Phylogenomic databases

eggNOGiENOG410INMI. Eukaryota.
ENOG4112CPE. LUCA.
GeneTreeiENSGT00730000111482.
HOGENOMiHOG000236346.
HOVERGENiHBG005959.
InParanoidiQ5TGS1.
KOiK09088.
OMAiCTPAVWA.
OrthoDBiEOG091G0D3I.
PhylomeDBiQ5TGS1.
TreeFamiTF351373.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TGS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKRRARIN VSLEQLKSLL EKHYSHQIRK RKLEKADILE LSVKYMRSLQ
60 70 80 90 100
NSLQGLWPVP RGAEQPSGFR SCLPGVSQLL RRGDEVGSGL RCPLVPESAA
110 120 130 140 150
GSTMDSAGLG QEAPALFRPC TPAVWAPAPA AGGPRSPPPL LLLPESLPGS
160 170 180
SASVPPPQPA SSRCAESPGL GLRVWRPWGS PGDDLN
Length:186
Mass (Da):19,968
Last modified:December 21, 2004 - v1
Checksum:iF64A0949CBB0654D
GO

Sequence cautioni

The sequence CAI19439 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031847 Genomic DNA. Translation: CAI19439.1. Sequence problems.
CCDSiCCDS41238.1.
RefSeqiNP_001019769.1. NM_001024598.3.
UniGeneiHs.532677.

Genome annotation databases

EnsembliENST00000377898; ENSP00000367130; ENSG00000173673.
GeneIDi390992.
KEGGihsa:390992.
UCSCiuc009vly.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031847 Genomic DNA. Translation: CAI19439.1. Sequence problems.
CCDSiCCDS41238.1.
RefSeqiNP_001019769.1. NM_001024598.3.
UniGeneiHs.532677.

3D structure databases

ProteinModelPortaliQ5TGS1.
SMRiQ5TGS1. Positions 1-52.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiHES3.
DMDMi74746514.

Proteomic databases

PaxDbiQ5TGS1.
PRIDEiQ5TGS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377898; ENSP00000367130; ENSG00000173673.
GeneIDi390992.
KEGGihsa:390992.
UCSCiuc009vly.2. human.

Organism-specific databases

CTDi390992.
GeneCardsiHES3.
HGNCiHGNC:26226. HES3.
HPAiHPA047927.
MIMi609971. gene.
neXtProtiNX_Q5TGS1.
PharmGKBiPA142671692.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INMI. Eukaryota.
ENOG4112CPE. LUCA.
GeneTreeiENSGT00730000111482.
HOGENOMiHOG000236346.
HOVERGENiHBG005959.
InParanoidiQ5TGS1.
KOiK09088.
OMAiCTPAVWA.
OrthoDBiEOG091G0D3I.
PhylomeDBiQ5TGS1.
TreeFamiTF351373.

Miscellaneous databases

GenomeRNAii390992.
PROiQ5TGS1.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HES3.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHES3_HUMAN
AccessioniPrimary (citable) accession number: Q5TGS1
Secondary accession number(s): Q5TGS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.