PXDC1

Functionⁱ

GO - Molecular functionⁱ

phosphatidylinositol binding Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PX domain-containing protein 1
Gene namesⁱ	Name:PXDC1 Synonyms:C6orf145
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168994.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21361 PXDC1
neXtProtⁱ	NX_Q5TGL8

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000168994
PharmGKBⁱ	PA134944183

Polymorphism and mutation databases

BioMutaⁱ	PXDC1
DMDMⁱ	215274177

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000297573	1 – 231	PX domain-containing protein 1Add BLAST		231

Proteomic databases

EPDⁱ	Q5TGL8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5TGL8
PaxDbⁱ	Q5TGL8
PeptideAtlas More...PeptideAtlasⁱ	Q5TGL8
PRIDEⁱ	Q5TGL8
TopDownProteomicsⁱ	Q5TGL8

PTM databases

iPTMnetⁱ	Q5TGL8
PhosphoSitePlusⁱ	Q5TGL8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168994
CleanExⁱ	HS_C6orf145
ExpressionAtlasⁱ	Q5TGL8 baseline and differential
Genevisibleⁱ	Q5TGL8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019246

HPAⁱ

HPA019246

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	1287515 interactors.
IntActⁱ	Q5TGL8 2 interactors.
STRINGⁱ	9606.ENSP00000369636

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5TGL8
SMRⁱ	Q5TGL8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 134	PXAdd BLAST		134

Phylogenomic databases

eggNOGⁱ	ENOG410IEEQ Eukaryota ENOG411016X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009209
HOGENOMⁱ	HOG000063722
HOVERGENⁱ	HBG096286
InParanoidⁱ	Q5TGL8
OMAⁱ	IQPCFQS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P94
PhylomeDBⁱ	Q5TGL8
TreeFamⁱ	TF331154

Family and domain databases

Gene3Dⁱ	3.30.1520.101 hit
InterProⁱ	View protein in InterPro IPR001683 Phox IPR036871 PX_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00787 PX, 1 hit
SUPFAMⁱ	SSF64268 SSF64268, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5TGL8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASAVFEGTS LVNMFVRGCW VNGIRRLIVS RRGDEEEFFE IRTEWSDRSV 
        60         70         80         90        100
LYLHRSLADL GRLWQRLRDA FPEDRSELAQ GPLRQGLVAI KEAHDIETRL 
       110        120        130        140        150
NEVEKLLKTI ISMPCKYSRS EVVLTFFERS PLDQVLKNDN VHKIQPSFQS 
       160        170        180        190        200
PVKISEIMRS NGFCLANTET IVIDHSIPNG RDQQLGVDPT EHLFENGSEF 
       210        220        230 
PSELEDGDDP AAYVTNLSYY HLVPFETDIW D

Length:231

Mass (Da):26,560

Last modified:November 25, 2008 - v3

Checksum:ⁱ22FD56F8F1562CFE

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_034643	184	Q → H2 PublicationsCorresponds to variant dbSNP:rs226959Ensembl.	1
Natural variantⁱVAR_034644	189	P → Q1 PublicationCorresponds to variant dbSNP:rs17855666Ensembl.	1
Natural variantⁱVAR_035619	203	E → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs368727869Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK289598 mRNA Translation: BAF82287.1 AL832792 mRNA Translation: CAI46167.1 AL391422 Genomic DNA No translation available. AL033523 Genomic DNA No translation available. BC045715 mRNA Translation: AAH45715.3 BC056908 mRNA Translation: AAH56908.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4486.1
NCBI Reference Sequences More...RefSeqⁱ	NP_899229.2, NM_183373.3
UniGeneⁱ	Hs.484500

Genome annotation databases

Ensemblⁱ	ENST00000380283; ENSP00000369636; ENSG00000168994
GeneIDⁱ	221749
KEGGⁱ	hsa:221749
UCSC genome browser More...UCSCⁱ	uc003mvt.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q5TGL8	F1RWZ1 F7E000 A0A2K6FKJ0 H9FRA5 G7P4C2 UPI000B7B44F3 F7GLN0 H9Z6D3 A0A2K5M9I4 A0A0D9R4J4 +43	Sus scrofa (Pig) Callithrix jacchus (White-tufted-ear marmoset) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Papio anubis (Olive baboon) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca nemestrina (Pig-tailed macaque) Cebus capucinus imitator And more	231	UniRef90_Q5TGL8	Cluster: PX domain-containing protein 1	54

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q5TGL8	F1RWZ1 UPI000944E980 UPI0007044838 A0A1S2ZNU3 UPI000CEAC811 A0A2K6FKJ0 UPI000787926C A0A061IAC9 A0A2K5R444 UPI0003336C56 +57	Sus scrofa (Pig) Rhinolophus sinicus (Chinese rufous horseshoe bat) Tupaia chinensis (Chinese tree shrew) Erinaceus europaeus (Western European hedgehog) Physeter catodon (Sperm whale) (Physeter macrocephalus) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Cebus capucinus imitator Octodon degus (Degu) (Sciurus degus) And more	231	UniRef50_Q5TGL8	Cluster: PX domain-containing protein 1	68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK289598 mRNA Translation: BAF82287.1 AL832792 mRNA Translation: CAI46167.1 AL391422 Genomic DNA No translation available. AL033523 Genomic DNA No translation available. BC045715 mRNA Translation: AAH45715.3 BC056908 mRNA Translation: AAH56908.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4486.1
NCBI Reference Sequences More...RefSeqⁱ	NP_899229.2, NM_183373.3
UniGeneⁱ	Hs.484500

3D structure databases

ProteinModelPortalⁱ	Q5TGL8
SMRⁱ	Q5TGL8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	1287515 interactors.
IntActⁱ	Q5TGL8 2 interactors.
STRINGⁱ	9606.ENSP00000369636

PTM databases

iPTMnetⁱ	Q5TGL8
PhosphoSitePlusⁱ	Q5TGL8

Polymorphism and mutation databases

BioMutaⁱ	PXDC1
DMDMⁱ	215274177

Proteomic databases

EPDⁱ	Q5TGL8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5TGL8
PaxDbⁱ	Q5TGL8
PeptideAtlas More...PeptideAtlasⁱ	Q5TGL8
PRIDEⁱ	Q5TGL8
TopDownProteomicsⁱ	Q5TGL8

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	221749
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000380283; ENSP00000369636; ENSG00000168994
GeneIDⁱ	221749
KEGGⁱ	hsa:221749
UCSC genome browser More...UCSCⁱ	uc003mvt.3 human

Organism-specific databases

CTDⁱ	221749
EuPathDBⁱ	HostDB:ENSG00000168994.13
GeneCardsⁱ	PXDC1
H-InvDBⁱ	HIX0005545 HIX0122211
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21361 PXDC1
Human Protein Atlas More...HPAⁱ	HPA019246
neXtProtⁱ	NX_Q5TGL8
Open Targets More...OpenTargetsⁱ	ENSG00000168994
PharmGKBⁱ	PA134944183
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEEQ Eukaryota ENOG411016X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009209
HOGENOMⁱ	HOG000063722
HOVERGENⁱ	HBG096286
InParanoidⁱ	Q5TGL8
OMAⁱ	IQPCFQS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P94
PhylomeDBⁱ	Q5TGL8
TreeFamⁱ	TF331154

Miscellaneous databases

GenomeRNAiⁱ	221749
Protein Ontology More...PROⁱ	PR:Q5TGL8

Gene expression databases

Bgeeⁱ	ENSG00000168994
CleanExⁱ	HS_C6orf145
ExpressionAtlasⁱ	Q5TGL8 baseline and differential
Genevisibleⁱ	Q5TGL8 HS

Family and domain databases

Gene3Dⁱ	3.30.1520.101 hit
InterProⁱ	View protein in InterPro IPR001683 Phox IPR036871 PX_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00787 PX, 1 hit
SUPFAMⁱ	SSF64268 SSF64268, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PXDC1_HUMAN
Accessionⁱ	Q5TGL8Primary (citable) accession number: Q5TGL8 Secondary accession number(s): A8K0N3, Q6PGP0, Q86XB7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
	Last sequence update:	November 25, 2008
	Last modified:	March 28, 2018
	This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5TGL8 (PXDC1_HUMAN)

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PX domain-containing protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ