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Protein

PX domain-containing protein 1

Gene

PXDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
PX domain-containing protein 1
Gene namesi
Name:PXDC1
Synonyms:C6orf145
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000168994.13
HGNCiHGNC:21361 PXDC1
neXtProtiNX_Q5TGL8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168994
PharmGKBiPA134944183

Polymorphism and mutation databases

BioMutaiPXDC1
DMDMi215274177

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002975731 – 231PX domain-containing protein 1Add BLAST231

Proteomic databases

EPDiQ5TGL8
MaxQBiQ5TGL8
PaxDbiQ5TGL8
PeptideAtlasiQ5TGL8
PRIDEiQ5TGL8
TopDownProteomicsiQ5TGL8

PTM databases

iPTMnetiQ5TGL8
PhosphoSitePlusiQ5TGL8

Expressioni

Gene expression databases

BgeeiENSG00000168994
CleanExiHS_C6orf145
ExpressionAtlasiQ5TGL8 baseline and differential
GenevisibleiQ5TGL8 HS

Organism-specific databases

HPAiHPA019246

Interactioni

Protein-protein interaction databases

BioGridi1287515 interactors.
IntActiQ5TGL8 2 interactors.
STRINGi9606.ENSP00000369636

Structurei

3D structure databases

ProteinModelPortaliQ5TGL8
SMRiQ5TGL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 134PXAdd BLAST134

Phylogenomic databases

eggNOGiENOG410IEEQ Eukaryota
ENOG411016X LUCA
GeneTreeiENSGT00390000009209
HOGENOMiHOG000063722
HOVERGENiHBG096286
InParanoidiQ5TGL8
OMAiIQPCFQS
OrthoDBiEOG091G0P94
PhylomeDBiQ5TGL8
TreeFamiTF331154

Family and domain databases

Gene3Di3.30.1520.101 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TGL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAVFEGTS LVNMFVRGCW VNGIRRLIVS RRGDEEEFFE IRTEWSDRSV
60 70 80 90 100
LYLHRSLADL GRLWQRLRDA FPEDRSELAQ GPLRQGLVAI KEAHDIETRL
110 120 130 140 150
NEVEKLLKTI ISMPCKYSRS EVVLTFFERS PLDQVLKNDN VHKIQPSFQS
160 170 180 190 200
PVKISEIMRS NGFCLANTET IVIDHSIPNG RDQQLGVDPT EHLFENGSEF
210 220 230
PSELEDGDDP AAYVTNLSYY HLVPFETDIW D
Length:231
Mass (Da):26,560
Last modified:November 25, 2008 - v3
Checksum:i22FD56F8F1562CFE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034643184Q → H2 PublicationsCorresponds to variant dbSNP:rs226959Ensembl.1
Natural variantiVAR_034644189P → Q1 PublicationCorresponds to variant dbSNP:rs17855666Ensembl.1
Natural variantiVAR_035619203E → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs368727869Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289598 mRNA Translation: BAF82287.1
AL832792 mRNA Translation: CAI46167.1
AL391422 Genomic DNA No translation available.
AL033523 Genomic DNA No translation available.
BC045715 mRNA Translation: AAH45715.3
BC056908 mRNA Translation: AAH56908.1
CCDSiCCDS4486.1
RefSeqiNP_899229.2, NM_183373.3
UniGeneiHs.484500

Genome annotation databases

EnsembliENST00000380283; ENSP00000369636; ENSG00000168994
GeneIDi221749
KEGGihsa:221749
UCSCiuc003mvt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPXDC1_HUMAN
AccessioniPrimary (citable) accession number: Q5TGL8
Secondary accession number(s): A8K0N3, Q6PGP0, Q86XB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome