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Protein

Hepatoma-derived growth factor-like protein 1

Gene

HDGFL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-like protein 1
Alternative name(s):
PWWP domain-containing protein 1
Gene namesi
Name:HDGFL1
Synonyms:PWWP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21095. HDGFL1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi154150.
OpenTargetsiENSG00000112273.
PharmGKBiPA134981303.

Polymorphism and mutation databases

BioMutaiHDGFL1.
DMDMi74746497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003346521 – 251Hepatoma-derived growth factor-like protein 1Add BLAST251

Proteomic databases

PaxDbiQ5TGJ6.
PeptideAtlasiQ5TGJ6.
PRIDEiQ5TGJ6.

PTM databases

PhosphoSitePlusiQ5TGJ6.

Expressioni

Gene expression databases

BgeeiENSG00000112273.
CleanExiHS_HDGFL1.
ExpressionAtlasiQ5TGJ6. baseline and differential.
GenevisibleiQ5TGJ6. HS.

Organism-specific databases

HPAiHPA045679.
HPA063707.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000230012.

Structurei

3D structure databases

ProteinModelPortaliQ5TGJ6.
SMRiQ5TGJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 62PWWPPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 241Glu-richAdd BLAST103
Compositional biasi163 – 190Ala-richAdd BLAST28

Sequence similaritiesi

Belongs to the HDGF family.Curated

Phylogenomic databases

eggNOGiKOG1904. Eukaryota.
ENOG410Y5WD. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiQ5TGJ6.
KOiK16641.
OMAiKRLFPYK.
OrthoDBiEOG091G045X.
PhylomeDBiQ5TGJ6.
TreeFamiTF105385.

Family and domain databases

InterProiView protein in InterPro
IPR000313. PWWP_dom.
PfamiView protein in Pfam
PF00855. PWWP. 1 hit.
SMARTiView protein in SMART
SM00293. PWWP. 1 hit.
PROSITEiView protein in PROSITE
PS50812. PWWP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TGJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAYGMPMYK SGDLVFAKLK GYAHWPARIE HMTQPNRYQV FFFGTHETAF
60 70 80 90 100
LSPKRLFPYK ECKEKFGKPN KRRGFSAGLW EIENNPTVQA SDCPLASEKG
110 120 130 140 150
SGDGPWPEPE AAEGDEDKPT HAGGGGDELG KPDDDKPTEE EKGPLKRSAG
160 170 180 190 200
DPPEDAPKRP KEAAPDQEEE AEAERAAEAE RAAAAAAATA VDEESPFLVA
210 220 230 240 250
VENGSAPSEP GLVCEPPQPE EEELREEEVA DEEASQEWHA EAPGGGDRDS

L
Length:251
Mass (Da):27,234
Last modified:December 21, 2004 - v1
Checksum:iB97777F3DAD16A77
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28R → G in BAB71292 (PubMed:14702039).Curated1
Sequence conflicti31H → R in BAB71292 (PubMed:14702039).Curated1
Sequence conflicti92D → Y in BAB71292 (PubMed:14702039).Curated1
Sequence conflicti198L → P in BAB71292 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04344787T → M. Corresponds to variant dbSNP:rs2076506Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056824 mRNA. Translation: BAB71292.1.
AL033539 Genomic DNA. No translation available.
CH471087 Genomic DNA. Translation: EAW55436.1.
CCDSiCCDS34347.1.
RefSeqiNP_612641.2. NM_138574.3.
UniGeneiHs.629246.

Genome annotation databases

EnsembliENST00000510882; ENSP00000442129; ENSG00000112273.
GeneIDi154150.
KEGGihsa:154150.
UCSCiuc003nds.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHDGL1_HUMAN
AccessioniPrimary (citable) accession number: Q5TGJ6
Secondary accession number(s): Q96MJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 21, 2004
Last modified: June 7, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families