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Protein

Sterile alpha motif domain-containing protein 5

Gene

SAMD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Sterile alpha motif domain-containing protein 5
Short name:
SAM domain-containing protein 5
Gene namesi
Name:SAMD5
Synonyms:SAMDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21180. SAMD5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134888862.

Polymorphism and mutation databases

BioMutaiSAMD5.
DMDMi74746493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Sterile alpha motif domain-containing protein 5PRO_0000311361Add
BLAST

Proteomic databases

PaxDbiQ5TGI4.
PRIDEiQ5TGI4.

PTM databases

iPTMnetiQ5TGI4.
PhosphoSiteiQ5TGI4.

Expressioni

Gene expression databases

BgeeiQ5TGI4.
CleanExiHS_SAMD5.
ExpressionAtlasiQ5TGI4. baseline and differential.
GenevisibleiQ5TGI4. HS.

Organism-specific databases

HPAiHPA067811.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356444.

Structurei

3D structure databases

ProteinModelPortaliQ5TGI4.
SMRiQ5TGI4. Positions 9-60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6565SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410INAV. Eukaryota.
ENOG4111JDA. LUCA.
GeneTreeiENSGT00510000048701.
HOGENOMiHOG000048262.
HOVERGENiHBG096715.
InParanoidiQ5TGI4.
OMAiFTLEPQQ.
OrthoDBiEOG7CRTS3.
PhylomeDBiQ5TGI4.
TreeFamiTF339222.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TGI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTNIVYEWL KALQLPQYAE SFVDNGYDDL EVCKQIGDPD LDAIGVLAPA
60 70 80 90 100
HRRRILEAVR RLREQDANAA GLYFTLEPQP APPGPPADAV PTGRRGEPCG
110 120 130 140 150
GPAQGTRGDS RGHTTAPRSR ELVSYPKLKL KIMIRDKLVR DGIHLSKPPY
160 170
SRKVPMAGIL EYLMNWPKSS QSR
Length:173
Mass (Da):19,231
Last modified:December 21, 2004 - v1
Checksum:i6869A7A22FD73745
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354880, AL034350 Genomic DNA. Translation: CAI18904.1.
AL034350, AL354880 Genomic DNA. Translation: CAI23090.1.
CCDSiCCDS34548.1.
RefSeqiNP_001025231.1. NM_001030060.2.
UniGeneiHs.567973.

Genome annotation databases

EnsembliENST00000367474; ENSP00000356444; ENSG00000203727.
GeneIDi389432.
KEGGihsa:389432.
UCSCiuc003qmc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354880, AL034350 Genomic DNA. Translation: CAI18904.1.
AL034350, AL354880 Genomic DNA. Translation: CAI23090.1.
CCDSiCCDS34548.1.
RefSeqiNP_001025231.1. NM_001030060.2.
UniGeneiHs.567973.

3D structure databases

ProteinModelPortaliQ5TGI4.
SMRiQ5TGI4. Positions 9-60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356444.

PTM databases

iPTMnetiQ5TGI4.
PhosphoSiteiQ5TGI4.

Polymorphism and mutation databases

BioMutaiSAMD5.
DMDMi74746493.

Proteomic databases

PaxDbiQ5TGI4.
PRIDEiQ5TGI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367474; ENSP00000356444; ENSG00000203727.
GeneIDi389432.
KEGGihsa:389432.
UCSCiuc003qmc.3. human.

Organism-specific databases

CTDi389432.
GeneCardsiSAMD5.
HGNCiHGNC:21180. SAMD5.
HPAiHPA067811.
neXtProtiNX_Q5TGI4.
PharmGKBiPA134888862.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INAV. Eukaryota.
ENOG4111JDA. LUCA.
GeneTreeiENSGT00510000048701.
HOGENOMiHOG000048262.
HOVERGENiHBG096715.
InParanoidiQ5TGI4.
OMAiFTLEPQQ.
OrthoDBiEOG7CRTS3.
PhylomeDBiQ5TGI4.
TreeFamiTF339222.

Miscellaneous databases

GenomeRNAii389432.
PROiQ5TGI4.

Gene expression databases

BgeeiQ5TGI4.
CleanExiHS_SAMD5.
ExpressionAtlasiQ5TGI4. baseline and differential.
GenevisibleiQ5TGI4. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSAMD5_HUMAN
AccessioniPrimary (citable) accession number: Q5TGI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.