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Protein

Failed axon connections homolog

Gene

FAXC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in axonal development.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Failed axon connections homolog
Gene namesi
Name:FAXC
Synonyms:C6orf168
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20742. FAXC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918761.

Polymorphism and mutation databases

BioMutaiFAXC.
DMDMi73917723.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Failed axon connections homologPRO_0000089556Add
BLAST

Proteomic databases

PaxDbiQ5TGI0.
PeptideAtlasiQ5TGI0.
PRIDEiQ5TGI0.

PTM databases

iPTMnetiQ5TGI0.
PhosphoSiteiQ5TGI0.

Expressioni

Gene expression databases

BgeeiQ5TGI0.
CleanExiHS_C6orf168.
GenevisibleiQ5TGI0. HS.

Organism-specific databases

HPAiHPA039106.

Interactioni

Protein-protein interaction databases

BioGridi124136. 6 interactions.
STRINGi9606.ENSP00000374328.

Structurei

3D structure databases

ProteinModelPortaliQ5TGI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4244. Eukaryota.
ENOG4111HSJ. LUCA.
GeneTreeiENSGT00390000000753.
HOGENOMiHOG000065732.
HOVERGENiHBG074915.
InParanoidiQ5TGI0.
OMAiYTGHSLF.
OrthoDBiEOG793B7J.
PhylomeDBiQ5TGI0.
TreeFamiTF314915.

Family and domain databases

InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR033468. Metaxin_GST.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF17171. GST_C_6. 1 hit.
PF17172. GST_N_4. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TGI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHWGVGFASS RPCVVDLSWN QSISFFGWWA GSEEPFSFYG DIIAFPLQDY
60 70 80 90 100
GGIMAGLGSD PWWKKTLYLT GGALLAAAAY LLHELLVIRK QQEIDSKDAI
110 120 130 140 150
ILHQFARPNN GVPSLSPFCL KMETYLRMAD LPYQNYFGGK LSAQGKMPWI
160 170 180 190 200
EYNHEKVSGT EFIIDFLEEK LGVNLNKNLG PHERAISRAV TKMVEEHFYW
210 220 230 240 250
TLAYCQWVDN LNETRKMLSL SGGGPFSNLL RWVVCHITKG IVKREMHGHG
260 270 280 290 300
IGRFSEEEIY MLMEKDMRSL AGLLGDKKYI MGPKLSTLDA TVFGHLAQAM
310 320 330 340 350
WTLPGTRPER LIKGELINLA MYCERIRRKF WPEWHHDDDN TIYESEESSE
360 370 380 390 400
GSKTHTPLLD FSFYSRTETF EDEGAENSFS RTPDTDFTGH SLFDSDVDMD

DYTDHEQCK
Length:409
Mass (Da):46,843
Last modified:August 30, 2005 - v2
Checksum:iBD2E4ED4FFB14F31
GO
Isoform 2 (identifier: Q5TGI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-280: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,975
Checksum:i12DE6FED0DC83FDE
GO

Sequence cautioni

The sequence BAB71576.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 280280Missing in isoform 2. 1 PublicationVSP_056994Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057793 mRNA. Translation: BAB71576.1. Different initiation.
AK096480 mRNA. Translation: BAG53301.1.
AL034371 Genomic DNA. Translation: CAI19992.2.
CH471051 Genomic DNA. Translation: EAW48484.1.
BC004869 mRNA. Translation: AAH04869.2.
BC006515 mRNA. Translation: AAH06515.1.
BC011583 mRNA. Translation: AAH11583.1.
CCDSiCCDS34500.1. [Q5TGI0-1]
RefSeqiNP_115900.1. NM_032511.2. [Q5TGI0-1]
XP_011534490.1. XM_011536188.1.
UniGeneiHs.573245.

Genome annotation databases

EnsembliENST00000389677; ENSP00000374328; ENSG00000146267. [Q5TGI0-1]
ENST00000538471; ENSP00000445267; ENSG00000146267. [Q5TGI0-2]
GeneIDi84553.
KEGGihsa:84553.
UCSCiuc003ppi.5. human. [Q5TGI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057793 mRNA. Translation: BAB71576.1. Different initiation.
AK096480 mRNA. Translation: BAG53301.1.
AL034371 Genomic DNA. Translation: CAI19992.2.
CH471051 Genomic DNA. Translation: EAW48484.1.
BC004869 mRNA. Translation: AAH04869.2.
BC006515 mRNA. Translation: AAH06515.1.
BC011583 mRNA. Translation: AAH11583.1.
CCDSiCCDS34500.1. [Q5TGI0-1]
RefSeqiNP_115900.1. NM_032511.2. [Q5TGI0-1]
XP_011534490.1. XM_011536188.1.
UniGeneiHs.573245.

3D structure databases

ProteinModelPortaliQ5TGI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124136. 6 interactions.
STRINGi9606.ENSP00000374328.

PTM databases

iPTMnetiQ5TGI0.
PhosphoSiteiQ5TGI0.

Polymorphism and mutation databases

BioMutaiFAXC.
DMDMi73917723.

Proteomic databases

PaxDbiQ5TGI0.
PeptideAtlasiQ5TGI0.
PRIDEiQ5TGI0.

Protocols and materials databases

DNASUi84553.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389677; ENSP00000374328; ENSG00000146267. [Q5TGI0-1]
ENST00000538471; ENSP00000445267; ENSG00000146267. [Q5TGI0-2]
GeneIDi84553.
KEGGihsa:84553.
UCSCiuc003ppi.5. human. [Q5TGI0-1]

Organism-specific databases

CTDi84553.
GeneCardsiFAXC.
HGNCiHGNC:20742. FAXC.
HPAiHPA039106.
neXtProtiNX_Q5TGI0.
PharmGKBiPA134918761.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4244. Eukaryota.
ENOG4111HSJ. LUCA.
GeneTreeiENSGT00390000000753.
HOGENOMiHOG000065732.
HOVERGENiHBG074915.
InParanoidiQ5TGI0.
OMAiYTGHSLF.
OrthoDBiEOG793B7J.
PhylomeDBiQ5TGI0.
TreeFamiTF314915.

Miscellaneous databases

GenomeRNAii84553.
PROiQ5TGI0.

Gene expression databases

BgeeiQ5TGI0.
CleanExiHS_C6orf168.
GenevisibleiQ5TGI0. HS.

Family and domain databases

InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR033468. Metaxin_GST.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF17171. GST_C_6. 1 hit.
PF17172. GST_N_4. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney, Ovary and Skin.

Entry informationi

Entry nameiFAXC_HUMAN
AccessioniPrimary (citable) accession number: Q5TGI0
Secondary accession number(s): B3KU39
, Q96F61, Q96LU3, Q9BR58, Q9BSS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.