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Protein

Rho GTPase-activating protein 40

Gene

ARHGAP40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 40
Alternative name(s):
Rho-type GTPase-activating protein 40
Gene namesi
Name:ARHGAP40
Synonyms:C20orf95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16226. ARHGAP40.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi187611445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Rho GTPase-activating protein 40PRO_0000331532Add
BLAST

Proteomic databases

PaxDbiQ5TG30.
PRIDEiQ5TG30.

PTM databases

PhosphoSiteiQ5TG30.

Expressioni

Gene expression databases

BgeeiQ5TG30.
CleanExiHS_C20orf95.
ExpressionAtlasiQ5TG30. baseline and differential.

Organism-specific databases

HPAiHPA042636.
HPA042840.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362442.

Structurei

3D structure databases

ProteinModelPortaliQ5TG30.
SMRiQ5TG30. Positions 266-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini270 – 469200Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG329973.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000015106.
HOVERGENiHBG072023.
InParanoidiQ5TG30.
OMAiMDGFWME.
PhylomeDBiQ5TG30.
TreeFamiTF314044.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TG30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQLPQKNLL RLHPAGSAGC STGVESSSMD GFWMEVEQIQ QRDELREEDS
60 70 80 90 100
GGNEGQLPEE GEAESQWLQD TGLSGLLGGL GLDGDHQELL STLTQTQVAA
110 120 130 140 150
VCRRLDIYAR SVRRQHKTPV RDVRDVFGVF NSGKMSSENG DSGMKGAQLS
160 170 180 190 200
SGASKFPPAA EPGGLQEQAG REEAFNMDSA YSEQAAVLLQ RSRPSRGGTS
210 220 230 240 250
AWGKCSLPKF TVPKGRLGVT RIGDLSLQDM RKVPSLALIE LTALCDILGL
260 270 280 290 300
DLKRSKAGKW KAAETRLFGV PLDSLLEADH KVLPSTQVPL VLQALLSCLE
310 320 330 340 350
KRGLDMEGIL RVPGSQARVK GLEQKLERDF YAGLFSWDEV HHNDASDLLK
360 370 380 390 400
RFIRKLPTPL LTAEYLPAFA VVPNIPNLKQ RLQVLHLLIL ILPEPNRNAL
410 420 430 440 450
KALLEFLRKV VAREQHNKMT LRNVSTVMAP NLFLHQGRPP KLPKGKEKQL
460 470 480 490 500
AEGAAEVVQI MVHYQDLLWT VASFLVAQVR KLNDSSSRRP QLCDAGLKTW
510 520 530 540 550
LRRMHADRDK AGDGLEATPK VAKIQVVWPI KDPLKVPLTP STKVAHVLRQ
560 570 580 590 600
FTEHLSPGSK GQEDSEDMDS LLLHHRSMES ANILLYEVGG NINEHRLDPD
610 620
AYLLDLYRAN PHGEWVLKQN PT
Length:622
Mass (Da):68,908
Last modified:April 29, 2008 - v3
Checksum:i4F2E42DDF1A64267
GO

Sequence cautioni

The sequence CAI19168.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331G → R.
Corresponds to variant rs6100455 [ dbSNP | Ensembl ].
VAR_042892
Natural varianti413 – 4131R → L.
Corresponds to variant rs6070872 [ dbSNP | Ensembl ].
VAR_042893
Natural varianti463 – 4631H → N.
Corresponds to variant rs16987460 [ dbSNP | Ensembl ].
VAR_042894

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035419 Genomic DNA. Translation: CAI19168.2. Sequence problems.
UniGeneiHs.451997.

Genome annotation databases

EnsembliENST00000373345; ENSP00000362442; ENSG00000124143.
UCSCiuc021wdn.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035419 Genomic DNA. Translation: CAI19168.2. Sequence problems.
UniGeneiHs.451997.

3D structure databases

ProteinModelPortaliQ5TG30.
SMRiQ5TG30. Positions 266-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362442.

PTM databases

PhosphoSiteiQ5TG30.

Polymorphism and mutation databases

DMDMi187611445.

Proteomic databases

PaxDbiQ5TG30.
PRIDEiQ5TG30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373345; ENSP00000362442; ENSG00000124143.
UCSCiuc021wdn.1. human.

Organism-specific databases

GeneCardsiGC20P037252.
HGNCiHGNC:16226. ARHGAP40.
HPAiHPA042636.
HPA042840.
neXtProtiNX_Q5TG30.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG329973.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000015106.
HOVERGENiHBG072023.
InParanoidiQ5TG30.
OMAiMDGFWME.
PhylomeDBiQ5TG30.
TreeFamiTF314044.

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Miscellaneous databases

PROiQ5TG30.

Gene expression databases

BgeeiQ5TG30.
CleanExiHS_C20orf95.
ExpressionAtlasiQ5TG30. baseline and differential.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRHG40_HUMAN
AccessioniPrimary (citable) accession number: Q5TG30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 24, 2015
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.