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Q5TG30 (RHG40_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho GTPase-activating protein 40
Alternative name(s):
Rho-type GTPase-activating protein 40
Gene names
Name:ARHGAP40
Synonyms:C20orf95
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state By similarity.

Sequence similarities

Contains 1 Rho-GAP domain.

Sequence caution

The sequence CAI19168.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionGTPase activation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

   Molecular_functionGTPase activator activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 622622Rho GTPase-activating protein 40
PRO_0000331532

Regions

Domain270 – 469200Rho-GAP

Natural variations

Natural variant1331G → R.
Corresponds to variant rs6100455 [ dbSNP | Ensembl ].
VAR_042892
Natural variant4131R → L.
Corresponds to variant rs6070872 [ dbSNP | Ensembl ].
VAR_042893
Natural variant4631H → N.
Corresponds to variant rs16987460 [ dbSNP | Ensembl ].
VAR_042894

Sequences

Sequence LengthMass (Da)Tools
Q5TG30 [UniParc].

Last modified April 29, 2008. Version 3.
Checksum: 4F2E42DDF1A64267

FASTA62268,908
        10         20         30         40         50         60 
MDQLPQKNLL RLHPAGSAGC STGVESSSMD GFWMEVEQIQ QRDELREEDS GGNEGQLPEE 

        70         80         90        100        110        120 
GEAESQWLQD TGLSGLLGGL GLDGDHQELL STLTQTQVAA VCRRLDIYAR SVRRQHKTPV 

       130        140        150        160        170        180 
RDVRDVFGVF NSGKMSSENG DSGMKGAQLS SGASKFPPAA EPGGLQEQAG REEAFNMDSA 

       190        200        210        220        230        240 
YSEQAAVLLQ RSRPSRGGTS AWGKCSLPKF TVPKGRLGVT RIGDLSLQDM RKVPSLALIE 

       250        260        270        280        290        300 
LTALCDILGL DLKRSKAGKW KAAETRLFGV PLDSLLEADH KVLPSTQVPL VLQALLSCLE 

       310        320        330        340        350        360 
KRGLDMEGIL RVPGSQARVK GLEQKLERDF YAGLFSWDEV HHNDASDLLK RFIRKLPTPL 

       370        380        390        400        410        420 
LTAEYLPAFA VVPNIPNLKQ RLQVLHLLIL ILPEPNRNAL KALLEFLRKV VAREQHNKMT 

       430        440        450        460        470        480 
LRNVSTVMAP NLFLHQGRPP KLPKGKEKQL AEGAAEVVQI MVHYQDLLWT VASFLVAQVR 

       490        500        510        520        530        540 
KLNDSSSRRP QLCDAGLKTW LRRMHADRDK AGDGLEATPK VAKIQVVWPI KDPLKVPLTP 

       550        560        570        580        590        600 
STKVAHVLRQ FTEHLSPGSK GQEDSEDMDS LLLHHRSMES ANILLYEVGG NINEHRLDPD 

       610        620 
AYLLDLYRAN PHGEWVLKQN PT 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL035419 Genomic DNA. Translation: CAI19168.2. Sequence problems.
UniGeneHs.451997.

3D structure databases

ProteinModelPortalQ5TG30.
SMRQ5TG30. Positions 229-480.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5TG30.

Polymorphism databases

DMDM187611445.

Proteomic databases

PaxDbQ5TG30.
PRIDEQ5TG30.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373345; ENSP00000362442; ENSG00000124143.
UCSCuc021wdn.1. human.

Organism-specific databases

GeneCardsGC20P037252.
HGNCHGNC:16226. ARHGAP40.
HPAHPA042636.
HPA042840.
neXtProtNX_Q5TG30.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG329973.
HOGENOMHOG000015106.
HOVERGENHBG072023.
InParanoidQ5TG30.
OMAENGDSGM.
PhylomeDBQ5TG30.
TreeFamTF314044.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ5TG30.
CleanExHS_C20orf95.
GenevestigatorQ5TG30.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
InterProIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
PROSITEPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ5TG30.

Entry information

Entry nameRHG40_HUMAN
AccessionPrimary (citable) accession number: Q5TG30
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM