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Q5TG30

- RHG40_HUMAN

UniProt

Q5TG30 - RHG40_HUMAN

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Protein
Rho GTPase-activating protein 40
Gene
ARHGAP40, C20orf95
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: Reactome
  2. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 40
Alternative name(s):
Rho-type GTPase-activating protein 40
Gene namesi
Synonyms:C20orf95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16226. ARHGAP40.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Rho GTPase-activating protein 40
PRO_0000331532Add
BLAST

Proteomic databases

PaxDbiQ5TG30.
PRIDEiQ5TG30.

PTM databases

PhosphoSiteiQ5TG30.

Expressioni

Gene expression databases

BgeeiQ5TG30.
CleanExiHS_C20orf95.
GenevestigatoriQ5TG30.

Organism-specific databases

HPAiHPA042636.
HPA042840.

Structurei

3D structure databases

ProteinModelPortaliQ5TG30.
SMRiQ5TG30. Positions 266-479.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini270 – 469200Rho-GAP
Add
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.

Phylogenomic databases

eggNOGiNOG329973.
HOGENOMiHOG000015106.
HOVERGENiHBG072023.
InParanoidiQ5TG30.
OMAiENGDSGM.
PhylomeDBiQ5TG30.
TreeFamiTF314044.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TG30-1 [UniParc]FASTAAdd to Basket

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MDQLPQKNLL RLHPAGSAGC STGVESSSMD GFWMEVEQIQ QRDELREEDS    50
GGNEGQLPEE GEAESQWLQD TGLSGLLGGL GLDGDHQELL STLTQTQVAA 100
VCRRLDIYAR SVRRQHKTPV RDVRDVFGVF NSGKMSSENG DSGMKGAQLS 150
SGASKFPPAA EPGGLQEQAG REEAFNMDSA YSEQAAVLLQ RSRPSRGGTS 200
AWGKCSLPKF TVPKGRLGVT RIGDLSLQDM RKVPSLALIE LTALCDILGL 250
DLKRSKAGKW KAAETRLFGV PLDSLLEADH KVLPSTQVPL VLQALLSCLE 300
KRGLDMEGIL RVPGSQARVK GLEQKLERDF YAGLFSWDEV HHNDASDLLK 350
RFIRKLPTPL LTAEYLPAFA VVPNIPNLKQ RLQVLHLLIL ILPEPNRNAL 400
KALLEFLRKV VAREQHNKMT LRNVSTVMAP NLFLHQGRPP KLPKGKEKQL 450
AEGAAEVVQI MVHYQDLLWT VASFLVAQVR KLNDSSSRRP QLCDAGLKTW 500
LRRMHADRDK AGDGLEATPK VAKIQVVWPI KDPLKVPLTP STKVAHVLRQ 550
FTEHLSPGSK GQEDSEDMDS LLLHHRSMES ANILLYEVGG NINEHRLDPD 600
AYLLDLYRAN PHGEWVLKQN PT 622
Length:622
Mass (Da):68,908
Last modified:April 29, 2008 - v3
Checksum:i4F2E42DDF1A64267
GO

Sequence cautioni

The sequence CAI19168.2 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331G → R.
Corresponds to variant rs6100455 [ dbSNP | Ensembl ].
VAR_042892
Natural varianti413 – 4131R → L.
Corresponds to variant rs6070872 [ dbSNP | Ensembl ].
VAR_042893
Natural varianti463 – 4631H → N.
Corresponds to variant rs16987460 [ dbSNP | Ensembl ].
VAR_042894

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035419 Genomic DNA. Translation: CAI19168.2. Sequence problems.
UniGeneiHs.451997.

Genome annotation databases

EnsembliENST00000373345; ENSP00000362442; ENSG00000124143.
UCSCiuc021wdn.1. human.

Polymorphism databases

DMDMi187611445.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035419 Genomic DNA. Translation: CAI19168.2 . Sequence problems.
UniGenei Hs.451997.

3D structure databases

ProteinModelPortali Q5TG30.
SMRi Q5TG30. Positions 266-479.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5TG30.

Polymorphism databases

DMDMi 187611445.

Proteomic databases

PaxDbi Q5TG30.
PRIDEi Q5TG30.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373345 ; ENSP00000362442 ; ENSG00000124143 .
UCSCi uc021wdn.1. human.

Organism-specific databases

GeneCardsi GC20P037252.
HGNCi HGNC:16226. ARHGAP40.
HPAi HPA042636.
HPA042840.
neXtProti NX_Q5TG30.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG329973.
HOGENOMi HOG000015106.
HOVERGENi HBG072023.
InParanoidi Q5TG30.
OMAi ENGDSGM.
PhylomeDBi Q5TG30.
TreeFami TF314044.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

PROi Q5TG30.

Gene expression databases

Bgeei Q5TG30.
CleanExi HS_C20orf95.
Genevestigatori Q5TG30.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view ]
Pfami PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
PROSITEi PS50238. RHOGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRHG40_HUMAN
AccessioniPrimary (citable) accession number: Q5TG30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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