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Q5TG30

- RHG40_HUMAN

UniProt

Q5TG30 - RHG40_HUMAN

Protein

Rho GTPase-activating protein 40

Gene

ARHGAP40

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 3 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: Reactome
    2. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho GTPase-activating protein 40
    Alternative name(s):
    Rho-type GTPase-activating protein 40
    Gene namesi
    Name:ARHGAP40
    Synonyms:C20orf95
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16226. ARHGAP40.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 622622Rho GTPase-activating protein 40PRO_0000331532Add
    BLAST

    Proteomic databases

    PaxDbiQ5TG30.
    PRIDEiQ5TG30.

    PTM databases

    PhosphoSiteiQ5TG30.

    Expressioni

    Gene expression databases

    BgeeiQ5TG30.
    CleanExiHS_C20orf95.
    GenevestigatoriQ5TG30.

    Organism-specific databases

    HPAiHPA042636.
    HPA042840.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TG30.
    SMRiQ5TG30. Positions 266-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini270 – 469200Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG329973.
    HOGENOMiHOG000015106.
    HOVERGENiHBG072023.
    InParanoidiQ5TG30.
    OMAiENGDSGM.
    PhylomeDBiQ5TG30.
    TreeFamiTF314044.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    InterProiIPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view]
    PfamiPF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00324. RhoGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    PROSITEiPS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5TG30-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQLPQKNLL RLHPAGSAGC STGVESSSMD GFWMEVEQIQ QRDELREEDS    50
    GGNEGQLPEE GEAESQWLQD TGLSGLLGGL GLDGDHQELL STLTQTQVAA 100
    VCRRLDIYAR SVRRQHKTPV RDVRDVFGVF NSGKMSSENG DSGMKGAQLS 150
    SGASKFPPAA EPGGLQEQAG REEAFNMDSA YSEQAAVLLQ RSRPSRGGTS 200
    AWGKCSLPKF TVPKGRLGVT RIGDLSLQDM RKVPSLALIE LTALCDILGL 250
    DLKRSKAGKW KAAETRLFGV PLDSLLEADH KVLPSTQVPL VLQALLSCLE 300
    KRGLDMEGIL RVPGSQARVK GLEQKLERDF YAGLFSWDEV HHNDASDLLK 350
    RFIRKLPTPL LTAEYLPAFA VVPNIPNLKQ RLQVLHLLIL ILPEPNRNAL 400
    KALLEFLRKV VAREQHNKMT LRNVSTVMAP NLFLHQGRPP KLPKGKEKQL 450
    AEGAAEVVQI MVHYQDLLWT VASFLVAQVR KLNDSSSRRP QLCDAGLKTW 500
    LRRMHADRDK AGDGLEATPK VAKIQVVWPI KDPLKVPLTP STKVAHVLRQ 550
    FTEHLSPGSK GQEDSEDMDS LLLHHRSMES ANILLYEVGG NINEHRLDPD 600
    AYLLDLYRAN PHGEWVLKQN PT 622
    Length:622
    Mass (Da):68,908
    Last modified:April 29, 2008 - v3
    Checksum:i4F2E42DDF1A64267
    GO

    Sequence cautioni

    The sequence CAI19168.2 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331G → R.
    Corresponds to variant rs6100455 [ dbSNP | Ensembl ].
    VAR_042892
    Natural varianti413 – 4131R → L.
    Corresponds to variant rs6070872 [ dbSNP | Ensembl ].
    VAR_042893
    Natural varianti463 – 4631H → N.
    Corresponds to variant rs16987460 [ dbSNP | Ensembl ].
    VAR_042894

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035419 Genomic DNA. Translation: CAI19168.2. Sequence problems.
    UniGeneiHs.451997.

    Genome annotation databases

    EnsembliENST00000373345; ENSP00000362442; ENSG00000124143.
    UCSCiuc021wdn.1. human.

    Polymorphism databases

    DMDMi187611445.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035419 Genomic DNA. Translation: CAI19168.2 . Sequence problems.
    UniGenei Hs.451997.

    3D structure databases

    ProteinModelPortali Q5TG30.
    SMRi Q5TG30. Positions 266-479.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5TG30.

    Polymorphism databases

    DMDMi 187611445.

    Proteomic databases

    PaxDbi Q5TG30.
    PRIDEi Q5TG30.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373345 ; ENSP00000362442 ; ENSG00000124143 .
    UCSCi uc021wdn.1. human.

    Organism-specific databases

    GeneCardsi GC20P037252.
    HGNCi HGNC:16226. ARHGAP40.
    HPAi HPA042636.
    HPA042840.
    neXtProti NX_Q5TG30.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329973.
    HOGENOMi HOG000015106.
    HOVERGENi HBG072023.
    InParanoidi Q5TG30.
    OMAi ENGDSGM.
    PhylomeDBi Q5TG30.
    TreeFami TF314044.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    PROi Q5TG30.

    Gene expression databases

    Bgeei Q5TG30.
    CleanExi HS_C20orf95.
    Genevestigatori Q5TG30.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    InterProi IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view ]
    Pfami PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00324. RhoGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    PROSITEi PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRHG40_HUMAN
    AccessioniPrimary (citable) accession number: Q5TG30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 77 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3