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Protein

Signal-regulatory protein beta-1 isoform 3

Gene

SIRPB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.By similarity

Enzyme and pathway databases

BioCyciZFISH:G66-32938-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein beta-1 isoform 3
Short name:
SIRP-beta-1 isoform 3
Gene namesi
Name:SIRPB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15928. SIRPB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 371ExtracellularSequence analysisAdd BLAST342
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 398CytoplasmicSequence analysis6

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10326.
OpenTargetsiENSG00000101307.
PharmGKBiPA38051.

Polymorphism and mutation databases

BioMutaiZNF786.
DMDMi205829937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000034910830 – 398Signal-regulatory protein beta-1 isoform 3Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 120PROSITE-ProRule annotation1 Publication
Disulfide bondi169 ↔ 227PROSITE-ProRule annotation
Glycosylationi244N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi272 ↔ 330PROSITE-ProRule annotation
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ5TFQ8.
PaxDbiQ5TFQ8.
PeptideAtlasiQ5TFQ8.
PRIDEiQ5TFQ8.

Expressioni

Gene expression databases

BgeeiENSG00000101307.
CleanExiHS_SIRPB1.
ExpressionAtlasiQ5TFQ8. baseline and differential.
GenevisibleiQ5TFQ8. HS.

Interactioni

Protein-protein interaction databases

BioGridi115609. 5 interactors.
STRINGi9606.ENSP00000279477.

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 45Combined sources6
Beta strandi50 – 52Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi65 – 69Combined sources5
Beta strandi76 – 80Combined sources5
Beta strandi89 – 93Combined sources5
Beta strandi95 – 97Combined sources3
Beta strandi105 – 107Combined sources3
Helixi112 – 114Combined sources3
Beta strandi116 – 124Combined sources9
Beta strandi127 – 129Combined sources3
Beta strandi131 – 135Combined sources5
Beta strandi139 – 144Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJVX-ray1.80A/B30-148[»]
ProteinModelPortaliQ5TFQ8.
SMRiQ5TFQ8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5TFQ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 136Ig-like V-typeAdd BLAST106
Domaini147 – 246Ig-like C1-type 1Add BLAST100
Domaini253 – 347Ig-like C1-type 2Add BLAST95

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKYM. Eukaryota.
ENOG410YKK2. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000230874.
HOVERGENiHBG056632.
KOiK06551.
OMAiLSETIRX.
OrthoDBiEOG091G05RP.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q5TFQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVPASWPHL PSPFLLMTLL LGRLTGVAGE EELQVIQPDK SISVAAGESA
60 70 80 90 100
TLHCTVTSLI PVGPIQWFRG AGPGRELIYN QKEGHFPRVT TVSDLTKRNN
110 120 130 140 150
MDFSIRISNI TPADAGTYYC VKFRKGSPDH VEFKSGAGTE LSVRAKPSAP
160 170 180 190 200
VVSGPAARAT PQHTVSFTCE SHGFSPRDIT LKWFKNGNEL SDFQTNVDPA
210 220 230 240 250
GDSVSYSIHS TAKVVLTRED VHSQVICEVA HVTLQGDPLR GTANLSETIR
260 270 280 290 300
VPPTLEVTQQ PVRAENQVNV TCQVRKFYPQ RLQLTWLENG NVSRTETAST
310 320 330 340 350
LTENKDGTYN WMSWLLVNVS AHRDDVKLTC QVEHDGQPAV SKSHDLKVSA
360 370 380 390
HPKEQGSNTA PGPALASAAP LLIAFLLGPK VLLVVGVSVI YVYWKQKA
Length:398
Mass (Da):43,359
Last modified:February 5, 2008 - v1
Checksum:i7F3B930235BD556C
GO
Isoform 1 (identifier: O00241-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry O00241.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:398
Mass (Da):43,211
GO
Isoform 2 (identifier: O00241-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry O00241.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:181
Mass (Da):19,394
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05607723R → G.2 PublicationsCorresponds to variant rs1535882dbSNPEnsembl.1
Natural variantiVAR_05941151T → I.Corresponds to variant rs1135196dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289866 mRNA. Translation: BAF82555.1.
BX537992 mRNA. Translation: CAD97951.1.
AL049634, AL138804, AL592544 Genomic DNA. Translation: CAI21866.1.
AL592544, AL049634, AL138804 Genomic DNA. Translation: CAI21700.1.
CCDSiCCDS46571.1. [Q5TFQ8-1]
RefSeqiNP_001129316.1. NM_001135844.3. [Q5TFQ8-1]
NP_001316086.1. NM_001329157.1. [Q5TFQ8-1]
UniGeneiHs.664861.

Genome annotation databases

EnsembliENST00000279477; ENSP00000279477; ENSG00000101307. [Q5TFQ8-1]
ENST00000568365; ENSP00000456826; ENSG00000101307. [Q5TFQ8-1]
GeneIDi10326.
KEGGihsa:10326.
UCSCiuc002wfl.5. human. [Q5TFQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289866 mRNA. Translation: BAF82555.1.
BX537992 mRNA. Translation: CAD97951.1.
AL049634, AL138804, AL592544 Genomic DNA. Translation: CAI21866.1.
AL592544, AL049634, AL138804 Genomic DNA. Translation: CAI21700.1.
CCDSiCCDS46571.1. [Q5TFQ8-1]
RefSeqiNP_001129316.1. NM_001135844.3. [Q5TFQ8-1]
NP_001316086.1. NM_001329157.1. [Q5TFQ8-1]
UniGeneiHs.664861.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJVX-ray1.80A/B30-148[»]
ProteinModelPortaliQ5TFQ8.
SMRiQ5TFQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115609. 5 interactors.
STRINGi9606.ENSP00000279477.

Polymorphism and mutation databases

BioMutaiZNF786.
DMDMi205829937.

Proteomic databases

MaxQBiQ5TFQ8.
PaxDbiQ5TFQ8.
PeptideAtlasiQ5TFQ8.
PRIDEiQ5TFQ8.

Protocols and materials databases

DNASUi10326.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279477; ENSP00000279477; ENSG00000101307. [Q5TFQ8-1]
ENST00000568365; ENSP00000456826; ENSG00000101307. [Q5TFQ8-1]
GeneIDi10326.
KEGGihsa:10326.
UCSCiuc002wfl.5. human. [Q5TFQ8-1]

Organism-specific databases

CTDi10326.
DisGeNETi10326.
GeneCardsiSIRPB1.
HGNCiHGNC:15928. SIRPB1.
neXtProtiNX_Q5TFQ8.
OpenTargetsiENSG00000101307.
PharmGKBiPA38051.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKYM. Eukaryota.
ENOG410YKK2. LUCA.
GeneTreeiENSGT00440000033339.
HOGENOMiHOG000230874.
HOVERGENiHBG056632.
KOiK06551.
OMAiLSETIRX.
OrthoDBiEOG091G05RP.

Enzyme and pathway databases

BioCyciZFISH:G66-32938-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5TFQ8.
GenomeRNAii10326.

Gene expression databases

BgeeiENSG00000101307.
CleanExiHS_SIRPB1.
ExpressionAtlasiQ5TFQ8. baseline and differential.
GenevisibleiQ5TFQ8. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIRBL_HUMAN
AccessioniPrimary (citable) accession number: Q5TFQ8
Secondary accession number(s): Q7Z3B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.