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Protein
Submitted name:

Complement factor H

Gene

CFH

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Complement factor HImported
Gene namesi
Name:CFHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000000971.15
HGNCiHGNC:4883 CFH

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000000971

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500426229919 – 385Sequence analysisAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi114 ↔ 141PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiQ5TFM2
PeptideAtlasiQ5TFM2
PRIDEiQ5TFM2

Expressioni

Gene expression databases

BgeeiENSG00000000971
ExpressionAtlasiQ5TFM2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5TFM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 82SushiInterPro annotationAdd BLAST64
Domaini83 – 143SushiInterPro annotationAdd BLAST61
Domaini144 – 200SushiInterPro annotationAdd BLAST57
Domaini201 – 258SushiInterPro annotationAdd BLAST58
Domaini323 – 380SushiInterPro annotationAdd BLAST58

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00910000143999
HOGENOMiHOG000049040
HOVERGENiHBG005665

Family and domain databases

CDDicd00033 CCP, 5 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 6 hits
SMARTiView protein in SMART
SM00032 CCP, 6 hits
SUPFAMiSSF57535 SSF57535, 6 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 5 hits

Sequencei

Sequence statusi: Complete.

Q5TFM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLAKIICL MLWAICVAED CNELPPRRNT EILTGSWSDQ TYPEGTQAIY
60 70 80 90 100
KCRPGYRSLG NVIMVCRKGE WVALNPLRKC QKRPCGHPGD TPFGTFTLTG
110 120 130 140 150
GNVFEYGVKA VYTCNEGYQL LGEINYRECD TDGWTNDIPI CEEISCKSPD
160 170 180 190 200
VINGSPISQK IIYKENERFQ YKCNMGYEYS ERGDAVCTES GWRPLPSCEE
210 220 230 240 250
KSCDNPYIPN GDYSPLRIKH RTGDEITYQC RNGFYPATRG NTAKCTSTGW
260 270 280 290 300
IPAPRCTLKP CDYPDIKHGG LYHENMRRPY FPVAVGKYYS YYCDEHFETP
310 320 330 340 350
SGSYWDHIHC TQDGWSPAVP CLRKCYFPYL ENGYNQNHGR KFVQGKSIDV
360 370 380
ACHPGYALPK AQTTVTCMEN GWSPTPRCIR VSFTL
Length:385
Mass (Da):43,846
Last modified:December 21, 2004 - v1
Checksum:iBB07DCEF072E97E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049744 Genomic DNA No translation available.
KF455126 Genomic DNA No translation available.
KF455128 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000359637; ENSP00000352658; ENSG00000000971
UCSCiuc009wyx.4 human

Similar proteinsi

Entry informationi

Entry nameiQ5TFM2_HUMAN
AccessioniPrimary (citable) accession number: Q5TFM2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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