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Protein
Submitted name:

Complement factor H

Gene

CFH

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Complement factor HImported
Gene namesi
Name:CFHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4883. CFH.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000000971.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500426229919 – 385Sequence analysisAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi114 ↔ 141PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiQ5TFM2.
PeptideAtlasiQ5TFM2.
PRIDEiQ5TFM2.

Expressioni

Gene expression databases

BgeeiENSG00000000971.
ExpressionAtlasiQ5TFM2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5TFM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 82Sushi (CCP/SCR)InterPro annotationAdd BLAST64
Domaini83 – 143Sushi (CCP/SCR)InterPro annotationAdd BLAST61
Domaini144 – 200Sushi (CCP/SCR)InterPro annotationAdd BLAST57
Domaini201 – 258Sushi (CCP/SCR)InterPro annotationAdd BLAST58
Domaini323 – 380Sushi (CCP/SCR)InterPro annotationAdd BLAST58

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00870000136398.
HOGENOMiHOG000049040.
HOVERGENiHBG005665.

Family and domain databases

CDDicd00033. CCP. 5 hits.
InterProiView protein in InterPro
IPR000436. Sushi_SCR_CCP_dom.
PfamiView protein in Pfam
PF00084. Sushi. 6 hits.
SMARTiView protein in SMART
SM00032. CCP. 6 hits.
SUPFAMiSSF57535. SSF57535. 6 hits.
PROSITEiView protein in PROSITE
PS50923. SUSHI. 5 hits.

Sequencei

Sequence statusi: Complete.

Q5TFM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLAKIICL MLWAICVAED CNELPPRRNT EILTGSWSDQ TYPEGTQAIY
60 70 80 90 100
KCRPGYRSLG NVIMVCRKGE WVALNPLRKC QKRPCGHPGD TPFGTFTLTG
110 120 130 140 150
GNVFEYGVKA VYTCNEGYQL LGEINYRECD TDGWTNDIPI CEEISCKSPD
160 170 180 190 200
VINGSPISQK IIYKENERFQ YKCNMGYEYS ERGDAVCTES GWRPLPSCEE
210 220 230 240 250
KSCDNPYIPN GDYSPLRIKH RTGDEITYQC RNGFYPATRG NTAKCTSTGW
260 270 280 290 300
IPAPRCTLKP CDYPDIKHGG LYHENMRRPY FPVAVGKYYS YYCDEHFETP
310 320 330 340 350
SGSYWDHIHC TQDGWSPAVP CLRKCYFPYL ENGYNQNHGR KFVQGKSIDV
360 370 380
ACHPGYALPK AQTTVTCMEN GWSPTPRCIR VSFTL
Length:385
Mass (Da):43,846
Last modified:December 21, 2004 - v1
Checksum:iBB07DCEF072E97E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049744 Genomic DNA. No translation available.
KF455126 Genomic DNA. No translation available.
KF455128 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000359637; ENSP00000352658; ENSG00000000971.
UCSCiuc009wyx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049744 Genomic DNA. No translation available.
KF455126 Genomic DNA. No translation available.
KF455128 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5TFM2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ5TFM2.
PeptideAtlasiQ5TFM2.
PRIDEiQ5TFM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359637; ENSP00000352658; ENSG00000000971.
UCSCiuc009wyx.4. human.

Organism-specific databases

HGNCiHGNC:4883. CFH.
OpenTargetsiENSG00000000971.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00870000136398.
HOGENOMiHOG000049040.
HOVERGENiHBG005665.

Miscellaneous databases

ChiTaRSiCFH. human.

Gene expression databases

BgeeiENSG00000000971.
ExpressionAtlasiQ5TFM2. baseline and differential.

Family and domain databases

CDDicd00033. CCP. 5 hits.
InterProiView protein in InterPro
IPR000436. Sushi_SCR_CCP_dom.
PfamiView protein in Pfam
PF00084. Sushi. 6 hits.
SMARTiView protein in SMART
SM00032. CCP. 6 hits.
SUPFAMiSSF57535. SSF57535. 6 hits.
PROSITEiView protein in PROSITE
PS50923. SUSHI. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TFM2_HUMAN
AccessioniPrimary (citable) accession number: Q5TFM2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: February 15, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.