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Protein

Intermediate filament family orphan 2

Gene

IFFO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate filament family orphan 2
Gene namesi
Name:IFFO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169991.10.
HGNCiHGNC:27006. IFFO2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169991.

Polymorphism and mutation databases

BioMutaiIFFO2.
DMDMi327478574.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261851 – 517Intermediate filament family orphan 2Add BLAST517

Proteomic databases

EPDiQ5TF58.
MaxQBiQ5TF58.
PaxDbiQ5TF58.
PeptideAtlasiQ5TF58.
PRIDEiQ5TF58.

PTM databases

iPTMnetiQ5TF58.
PhosphoSitePlusiQ5TF58.

Expressioni

Gene expression databases

BgeeiENSG00000169991.
CleanExiHS_IFFO2.
ExpressionAtlasiQ5TF58. baseline and differential.
GenevisibleiQ5TF58. HS.

Organism-specific databases

HPAiHPA015987.
HPA064603.

Interactioni

Protein-protein interaction databases

BioGridi126024. 4 interactors.
IntActiQ5TF58. 1 interactor.
STRINGi9606.ENSP00000387941.

Structurei

3D structure databases

ProteinModelPortaliQ5TF58.
SMRiQ5TF58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2455. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00510000046803.
HOGENOMiHOG000049269.
HOVERGENiHBG107991.
InParanoidiQ5TF58.
OMAiIQDEISD.
OrthoDBiEOG091G048Y.
PhylomeDBiQ5TF58.
TreeFamiTF331217.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TF58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSLLFGEM ALAFGCPPGG GGGGCPGGGG GGGGAGPGPS PVTAALRDDL
60 70 80 90 100
GSNIHLLKGL NVRFRCFLAK VHELERRNRL LEKQLEQQQS ERERRLRYKT
110 120 130 140 150
FSREQAVQTG PELLRPPAPG GGHGLSSGAA AGANANAVAL GGLPPGGGSH
160 170 180 190 200
PQHYGRLPGT IWSYTQVRRT GGGGVETVQG PGVSWVHPDG VGVQIDTITP
210 220 230 240 250
EIRALYNVLA KVKRERDEYK RRWEEELAKR MNLQTMVDTL QEAAQEADAI
260 270 280 290 300
QEEMNEKIER LKAELVVFKG LMSDPMTDLD TKIQEKAMKV DMDICRRIDI
310 320 330 340 350
TAKLCDVAQQ RNSEDVSKIF QVVPKKKERK VASDDDISEQ DGEVNRFSDD
360 370 380 390 400
EVGSMNITDE MKRMFNQLRE TFDFDDDCDS LTWEENEDTL LLWEDFTNCN
410 420 430 440 450
PTIDLQGEQE ENLGNLIHET ESFFKTRDKE YQETIGQIEL ELATAKSDMN
460 470 480 490 500
RHLHEYMEMC SMKRGLDVQM ETCRRLIKGS ADRNSPSPSS VASSDSGSTD
510
EIQDEFEREA DVEPMVS
Length:517
Mass (Da):57,328
Last modified:April 5, 2011 - v3
Checksum:iF5A9FCEA675DF445
GO

Sequence cautioni

The sequence CAI23419 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080251 Genomic DNA. Translation: CAI23419.1. Sequence problems.
AK024480 mRNA. Translation: BAB15770.1.
CCDSiCCDS44076.1.
RefSeqiNP_001129737.1. NM_001136265.1.
UniGeneiHs.466625.

Genome annotation databases

EnsembliENST00000455833; ENSP00000387941; ENSG00000169991.
GeneIDi126917.
KEGGihsa:126917.
UCSCiuc001bbd.3. human.

Similar proteinsi

Entry informationi

Entry nameiIFFO2_HUMAN
AccessioniPrimary (citable) accession number: Q5TF58
Secondary accession number(s): Q9H7K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 5, 2011
Last modified: September 27, 2017
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM