Q5TF39 (NAGT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium-dependent glucose transporter 1

Gene names

Name:	NAGLT1
Synonyms:	KIAA1919
ORF Names:	HSPC100

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as a sodium-dependent glucose transporter By similarity.
Subcellular location	Apical cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the major facilitator superfamily.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Sugar transport Symport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Sodium-dependent glucose transporter 1		PRO_0000294510
Regions
	Topological domain	1	1	Cytoplasmic Potential
	Transmembrane	2 – 24	23	Helical; Potential
	Topological domain	25 – 35	11	Extracellular Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Topological domain	57 – 61	5	Cytoplasmic Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Topological domain	83 – 93	11	Extracellular Potential
	Transmembrane	94 – 114	21	Helical; Potential
	Topological domain	115 – 123	9	Cytoplasmic Potential
	Transmembrane	124 – 144	21	Helical; Potential
	Topological domain	145 – 184	40	Extracellular Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Topological domain	206 – 228	23	Cytoplasmic Potential
	Transmembrane	229 – 249	21	Helical; Potential
	Topological domain	250 – 271	22	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Potential
	Topological domain	293 – 294	2	Cytoplasmic Potential
	Transmembrane	295 – 315	21	Helical; Potential
	Topological domain	316 – 319	4	Extracellular Potential
	Transmembrane	320 – 340	21	Helical; Potential
	Topological domain	341 – 355	15	Cytoplasmic Potential
	Transmembrane	356 – 376	21	Helical; Potential
	Topological domain	377 – 384	8	Extracellular Potential
	Transmembrane	385 – 405	21	Helical; Potential
	Topological domain	406 – 518	113	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	30	1	N-linked (GlcNAc...) Potential
	Glycosylation	152	1	N-linked (GlcNAc...) Potential
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	93	1	S → P. Ref.4 Corresponds to variant rs17853558 [ dbSNP | Ensembl ].		VAR_033192

Sequences

	Sequence		Length	Mass (Da)
	Q5TF39 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: FCB02A5E428BD0F5	FASTA	518	56,218
	10 20 30 40 50 60 MLCASFLGLG LSVAIVGPTF QDLATNVNRN ISSLSFIFVG RALGYLSGSV IGGFLVDVMN 70 80 90 100 110 120 YFLLLGISMS ATTVGLYLVP FCKTAILLTV MMSIFGVSIG ILDTGGNVLI LAIWGDKGAP 130 140 150 160 170 180 HMQALHFSFA LGAFLAPLLA KLALGPTASA ENHTESDFHP ALNQSSDADS EALFGVPNDK 190 200 210 220 230 240 NLLWAYAVIG TYMFLVSVIF FCLFLKNSSK QEKARASAET FRRAKYHNAL LCLLFLFFFF 250 260 270 280 290 300 YVGAEVTYGS YVFSFATTHA GMKESEAAGL NSIFWGTFAA CRGLAIFFAT CLQPGTMIVL 310 320 330 340 350 360 SNIGSLTSSL FLVLFDKNPI CLWIATSVYG ASMATTFPSG VSWIEQYTTI HGKSAAFFVI 370 380 390 400 410 420 GASLGEMAIP AVIGILQGKY PDLPVVLYTS LGASIATGIL FPVLYKLATS PLDRQRKEDR 430 440 450 460 470 480 KSEDQKALLS SSGLNEYEEE NEEEDAEKWN EMDFEMIETN DTMRHSIIET SRSSLTEPTA 490 500 510 EVYNQYPSNA LVFESSPFNT GSAHVKHLPE TRTKGTNV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-93. Tissue: Testis.
[5]	"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:179-187(2001) [PubMed: 11572484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-518. Tissue: Brain.
[6]	"Human partial CDS cloned from CD34+ stem cells." Zhang Q.-H., Ye M., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 423-518. Tissue: Umbilical cord blood.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK292735 mRNA. Translation: BAF85424.1. AL080317 Genomic DNA. Translation: CAI19190.1. CH471051 Genomic DNA. Translation: EAW48296.1. BC036115 mRNA. Translation: AAH36115.1. AB067506 mRNA. Translation: BAB67812.1. AF161363 mRNA. Translation: AAF28923.1.
IPI	IPI00217751.
RefSeq	NP_699200.2. NM_153369.2.
UniGene	Hs.400572.
3D structure databases
ProteinModelPortal	Q5TF39.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5TF39.
Polymorphism databases
DMDM	74746358.
Proteomic databases
PRIDE	Q5TF39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368847; ENSP00000357840; ENSG00000173214.
GeneID	91749.
KEGG	hsa:91749.
UCSC	uc003puv.2. human.
Organism-specific databases
CTD	91749.
GeneCards	GC06P111581.
H-InvDB	HIX0200831.
HGNC	HGNC:21053. KIAA1919.
HPA	HPA031784.
neXtProt	NX_Q5TF39.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG10653.
GeneTree	ENSGT00530000063320.
HOGENOM	HBG445191.
HOVERGEN	HBG108171.
InParanoid	Q5TF39.
OMA	WAYAVIG.
OrthoDB	EOG4R23TQ.
PhylomeDB	Q5TF39.
Gene expression databases
ArrayExpress	Q5TF39.
Bgee	Q5TF39.
CleanEx	HS_KIAA1919.
Genevestigator	Q5TF39.
Family and domain databases
InterPro	IPR011701. MFS. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
KO	K08175.
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
ProtoNet	Search...
Other
NextBio	77431.

Entry information

Entry name

NAGT1_HUMAN

Accession

Primary (citable) accession number: Q5TF39
Secondary accession number(s): A8K9M0 , Q8IYB6, Q96PW9, Q9P0D6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.