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Protein

Sodium-dependent glucose transporter 1

Gene

MFSD4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-HSA-428808. Na+-dependent glucose transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent glucose transporter 1By similarity
Alternative name(s):
Major facilitator superfamily domain-containing protein 4BImported
Gene namesi
Name:MFSD4BImported
Synonyms:KIAA1919, NAGLT1
ORF Names:HSPC100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21053. MFSD4B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi91749.
OpenTargetsiENSG00000173214.
PharmGKBiPA128394744.

Polymorphism and mutation databases

BioMutaiNAGLT1.
DMDMi74746358.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002945101 – 518Sodium-dependent glucose transporter 1Add BLAST518

Proteomic databases

EPDiQ5TF39.
MaxQBiQ5TF39.
PaxDbiQ5TF39.
PeptideAtlasiQ5TF39.
PRIDEiQ5TF39.

PTM databases

iPTMnetiQ5TF39.
PhosphoSitePlusiQ5TF39.

Expressioni

Gene expression databases

BgeeiENSG00000173214.
CleanExiHS_KIAA1919.
GenevisibleiQ5TF39. HS.

Organism-specific databases

HPAiHPA031784.

Interactioni

Protein-protein interaction databases

BioGridi124873. 7 interactors.
STRINGi9606.ENSP00000357840.

Structurei

3D structure databases

ProteinModelPortaliQ5TF39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG4W. Eukaryota.
ENOG410Y4JH. LUCA.
GeneTreeiENSGT00530000063320.
HOGENOMiHOG000013196.
HOVERGENiHBG108171.
InParanoidiQ5TF39.
KOiK08175.
OMAiTTHAGMK.
OrthoDBiEOG091G0536.
PhylomeDBiQ5TF39.
TreeFamiTF314613.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5TF39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCASFLGLG LSVAIVGPTF QDLATNVNRN ISSLSFIFVG RALGYLSGSV
60 70 80 90 100
IGGFLVDVMN YFLLLGISMS ATTVGLYLVP FCKTAILLTV MMSIFGVSIG
110 120 130 140 150
ILDTGGNVLI LAIWGDKGAP HMQALHFSFA LGAFLAPLLA KLALGPTASA
160 170 180 190 200
ENHTESDFHP ALNQSSDADS EALFGVPNDK NLLWAYAVIG TYMFLVSVIF
210 220 230 240 250
FCLFLKNSSK QEKARASAET FRRAKYHNAL LCLLFLFFFF YVGAEVTYGS
260 270 280 290 300
YVFSFATTHA GMKESEAAGL NSIFWGTFAA CRGLAIFFAT CLQPGTMIVL
310 320 330 340 350
SNIGSLTSSL FLVLFDKNPI CLWIATSVYG ASMATTFPSG VSWIEQYTTI
360 370 380 390 400
HGKSAAFFVI GASLGEMAIP AVIGILQGKY PDLPVVLYTS LGASIATGIL
410 420 430 440 450
FPVLYKLATS PLDRQRKEDR KSEDQKALLS SSGLNEYEEE NEEEDAEKWN
460 470 480 490 500
EMDFEMIETN DTMRHSIIET SRSSLTEPTA EVYNQYPSNA LVFESSPFNT
510
GSAHVKHLPE TRTKGTNV
Length:518
Mass (Da):56,218
Last modified:December 21, 2004 - v1
Checksum:iFCB02A5E428BD0F5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03319293S → P.1 PublicationCorresponds to variant rs17853558dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292735 mRNA. Translation: BAF85424.1.
AL080317 Genomic DNA. Translation: CAI19190.1.
CH471051 Genomic DNA. Translation: EAW48296.1.
BC036115 mRNA. Translation: AAH36115.1.
AB067506 mRNA. Translation: BAB67812.1.
AF161363 mRNA. Translation: AAF28923.1.
CCDSiCCDS5090.1.
RefSeqiNP_699200.2. NM_153369.2.
UniGeneiHs.400572.

Genome annotation databases

EnsembliENST00000368847; ENSP00000357840; ENSG00000173214.
GeneIDi91749.
KEGGihsa:91749.
UCSCiuc003puv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292735 mRNA. Translation: BAF85424.1.
AL080317 Genomic DNA. Translation: CAI19190.1.
CH471051 Genomic DNA. Translation: EAW48296.1.
BC036115 mRNA. Translation: AAH36115.1.
AB067506 mRNA. Translation: BAB67812.1.
AF161363 mRNA. Translation: AAF28923.1.
CCDSiCCDS5090.1.
RefSeqiNP_699200.2. NM_153369.2.
UniGeneiHs.400572.

3D structure databases

ProteinModelPortaliQ5TF39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124873. 7 interactors.
STRINGi9606.ENSP00000357840.

PTM databases

iPTMnetiQ5TF39.
PhosphoSitePlusiQ5TF39.

Polymorphism and mutation databases

BioMutaiNAGLT1.
DMDMi74746358.

Proteomic databases

EPDiQ5TF39.
MaxQBiQ5TF39.
PaxDbiQ5TF39.
PeptideAtlasiQ5TF39.
PRIDEiQ5TF39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368847; ENSP00000357840; ENSG00000173214.
GeneIDi91749.
KEGGihsa:91749.
UCSCiuc003puv.5. human.

Organism-specific databases

CTDi91749.
DisGeNETi91749.
GeneCardsiKIAA1919.
HGNCiHGNC:21053. MFSD4B.
HPAiHPA031784.
neXtProtiNX_Q5TF39.
OpenTargetsiENSG00000173214.
PharmGKBiPA128394744.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4W. Eukaryota.
ENOG410Y4JH. LUCA.
GeneTreeiENSGT00530000063320.
HOGENOMiHOG000013196.
HOVERGENiHBG108171.
InParanoidiQ5TF39.
KOiK08175.
OMAiTTHAGMK.
OrthoDBiEOG091G0536.
PhylomeDBiQ5TF39.
TreeFamiTF314613.

Enzyme and pathway databases

ReactomeiR-HSA-428808. Na+-dependent glucose transporters.

Miscellaneous databases

ChiTaRSiKIAA1919. human.
GenomeRNAii91749.
PROiQ5TF39.

Gene expression databases

BgeeiENSG00000173214.
CleanExiHS_KIAA1919.
GenevisibleiQ5TF39. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMFS4B_HUMAN
AccessioniPrimary (citable) accession number: Q5TF39
Secondary accession number(s): A8K9M0
, Q8IYB6, Q96PW9, Q9P0D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.