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Protein

Sodium-dependent glucose transporter 1

Gene

MFSD4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Sugar transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent glucose transporter 1By similarity
Alternative name(s):
Major facilitator superfamily domain-containing protein 4BImported
Gene namesi
Name:MFSD4BImported
Synonyms:KIAA1919, NAGLT1
ORF Names:HSPC100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000173214.5
HGNCiHGNC:21053 MFSD4B
MIMi617331 gene
neXtProtiNX_Q5TF39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi91749
OpenTargetsiENSG00000173214
PharmGKBiPA128394744

Polymorphism and mutation databases

BioMutaiNAGLT1
DMDMi74746358

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002945101 – 518Sodium-dependent glucose transporter 1Add BLAST518

Proteomic databases

EPDiQ5TF39
MaxQBiQ5TF39
PaxDbiQ5TF39
PeptideAtlasiQ5TF39
PRIDEiQ5TF39

PTM databases

iPTMnetiQ5TF39
PhosphoSitePlusiQ5TF39

Expressioni

Gene expression databases

BgeeiENSG00000173214
CleanExiHS_KIAA1919
GenevisibleiQ5TF39 HS

Organism-specific databases

HPAiHPA031784

Interactioni

Protein-protein interaction databases

BioGridi124873, 11 interactors
IntActiQ5TF39, 1 interactor
STRINGi9606.ENSP00000357840

Structurei

3D structure databases

ProteinModelPortaliQ5TF39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG4W Eukaryota
ENOG410Y4JH LUCA
GeneTreeiENSGT00530000063320
HOGENOMiHOG000013196
HOVERGENiHBG108171
InParanoidiQ5TF39
KOiK08175
OMAiWNEMDFE
OrthoDBiEOG091G0536
PhylomeDBiQ5TF39
TreeFamiTF314613

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits

Sequencei

Sequence statusi: Complete.

Q5TF39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCASFLGLG LSVAIVGPTF QDLATNVNRN ISSLSFIFVG RALGYLSGSV
60 70 80 90 100
IGGFLVDVMN YFLLLGISMS ATTVGLYLVP FCKTAILLTV MMSIFGVSIG
110 120 130 140 150
ILDTGGNVLI LAIWGDKGAP HMQALHFSFA LGAFLAPLLA KLALGPTASA
160 170 180 190 200
ENHTESDFHP ALNQSSDADS EALFGVPNDK NLLWAYAVIG TYMFLVSVIF
210 220 230 240 250
FCLFLKNSSK QEKARASAET FRRAKYHNAL LCLLFLFFFF YVGAEVTYGS
260 270 280 290 300
YVFSFATTHA GMKESEAAGL NSIFWGTFAA CRGLAIFFAT CLQPGTMIVL
310 320 330 340 350
SNIGSLTSSL FLVLFDKNPI CLWIATSVYG ASMATTFPSG VSWIEQYTTI
360 370 380 390 400
HGKSAAFFVI GASLGEMAIP AVIGILQGKY PDLPVVLYTS LGASIATGIL
410 420 430 440 450
FPVLYKLATS PLDRQRKEDR KSEDQKALLS SSGLNEYEEE NEEEDAEKWN
460 470 480 490 500
EMDFEMIETN DTMRHSIIET SRSSLTEPTA EVYNQYPSNA LVFESSPFNT
510
GSAHVKHLPE TRTKGTNV
Length:518
Mass (Da):56,218
Last modified:December 21, 2004 - v1
Checksum:iFCB02A5E428BD0F5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03319293S → P1 PublicationCorresponds to variant dbSNP:rs17853558Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292735 mRNA Translation: BAF85424.1
AL080317 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48296.1
BC036115 mRNA Translation: AAH36115.1
AB067506 mRNA Translation: BAB67812.1
AF161363 mRNA Translation: AAF28923.1
CCDSiCCDS5090.1
RefSeqiNP_699200.2, NM_153369.2
UniGeneiHs.400572

Genome annotation databases

EnsembliENST00000368847; ENSP00000357840; ENSG00000173214
GeneIDi91749
KEGGihsa:91749
UCSCiuc003puv.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMFS4B_HUMAN
AccessioniPrimary (citable) accession number: Q5TF39
Secondary accession number(s): A8K9M0
, Q8IYB6, Q96PW9, Q9P0D6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health