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Protein

Histone H3

Gene

HIST2H3PS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H3UniRule annotation
Gene namesi
Name:HIST2H3PS2Imported
ORF Names:RP5-998N21.6-001Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32060. HIST2H3PS2.

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

  • nucleosome Source: UniProtKB-KW
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000385479.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CO0X-ray2.25B/D2-16[»]
2V85X-ray2.00D/E2-14[»]
2VNFX-ray1.76B/D2-11[»]
4H75X-ray2.10B2-9[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 132HistoneInterPro annotationAdd BLAST132

Sequence similaritiesi

Belongs to the histone H3 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
HOVERGENiHBG001172.
OMAiMANLAHK.
OrthoDBiEOG091G0XGD.
TreeFamiTF314241.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00622. HISTONEH3.
SMARTiView protein in SMART
SM00428. H3. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00322. HISTONE_H3_1. 1 hit.
PS00959. HISTONE_H3_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TEC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR
60 70 80 90 100
EIRRYQKSTE LLIRKLPFQR LVREIAQEFK TDLRFQSSAV MALQEAREAY
110 120 130
LVGLFEDTNL CAIHAKRVTI MPKDIQLVSR IRGERA
Length:136
Mass (Da):15,430
Last modified:December 21, 2004 - v1
Checksum:i6916448FA50B0FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC239798 Genomic DNA. No translation available.
AL109948 Genomic DNA. Translation: CAI23568.1.

Genome annotation databases

EnsembliENST00000392948; ENSP00000476960; ENSG00000203818.
UCSCiuc057jyp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC239798 Genomic DNA. No translation available.
AL109948 Genomic DNA. Translation: CAI23568.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CO0X-ray2.25B/D2-16[»]
2V85X-ray2.00D/E2-14[»]
2VNFX-ray1.76B/D2-11[»]
4H75X-ray2.10B2-9[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000385479.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392948; ENSP00000476960; ENSG00000203818.
UCSCiuc057jyp.1. human.

Organism-specific databases

HGNCiHGNC:32060. HIST2H3PS2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
HOGENOMiHOG000155290.
HOVERGENiHBG001172.
OMAiMANLAHK.
OrthoDBiEOG091G0XGD.
TreeFamiTF314241.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00622. HISTONEH3.
SMARTiView protein in SMART
SM00428. H3. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00322. HISTONE_H3_1. 1 hit.
PS00959. HISTONE_H3_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TEC6_HUMAN
AccessioniPrimary (citable) accession number: Q5TEC6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 15, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.