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Protein

Zinc finger protein 697

Gene

ZNF697

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 697
Gene namesi
Name:ZNF697
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32034. ZNF697.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670495.

Polymorphism and mutation databases

BioMutaiZNF697.
DMDMi158706492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Zinc finger protein 697PRO_0000305138Add
BLAST

Proteomic databases

MaxQBiQ5TEC3.
PaxDbiQ5TEC3.
PeptideAtlasiQ5TEC3.
PRIDEiQ5TEC3.

PTM databases

iPTMnetiQ5TEC3.
PhosphoSiteiQ5TEC3.

Expressioni

Gene expression databases

BgeeiQ5TEC3.
CleanExiHS_ZNF697.
GenevisibleiQ5TEC3. HS.

Organism-specific databases

HPAiHPA049933.

Interactioni

Protein-protein interaction databases

BioGridi124778. 10 interactions.
STRINGi9606.ENSP00000396857.

Structurei

3D structure databases

ProteinModelPortaliQ5TEC3.
SMRiQ5TEC3. Positions 188-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi130 – 1345Poly-Glu

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri189 – 21123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00820000127150.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5TEC3.
OMAiKPAHRRF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5TEC3.
TreeFamiTF350831.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TEC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQEDNQGVC AHQDSEDKGM GSDFEDSEDR EGDPEEREMG SNPHDTNKRE
60 70 80 90 100
GHPEPEMGSN PQDSRHREAV PDICTEGQLS EEEGVSVRGE EDDQSGVADM
110 120 130 140 150
AMFPGLSESD SISRSLREDD DESAGENRLE EEEEQPAPPV LPWRRHLSLG
160 170 180 190 200
SRHRGDKPAH RRFHRLHHPM AVDLGELDSL VASIMDAPTI CPDCGESFSP
210 220 230 240 250
GAAFLQHQRI HRLAEAAAAA SLEPFGLAGE CDAMVGMMGV GVAGGFGAGP
260 270 280 290 300
PLARPPREKP FRCGECGKGF SRNTYLTNHL RLHTGERPNL CADCGKSFSW
310 320 330 340 350
RADLLKHRRL HTGEKPYPCP ECGEAFSLSS HLLSHRRAHA AASGAGAAAL
360 370 380 390 400
RPFACGECGK GFVRRSHLAN HQRIHTGEKP HGCGECGKRF SWRSDLVKHQ
410 420 430 440 450
RVHTGEKPYM CSECGETFSV SSHLFTHKRT HSGERPYVCR ECGKGFGRNS
460 470 480 490 500
HLVNHLRVHT GEKPFRCGQC EKRFSDFSTL TQHQRTHTGE KPYTCIECGK
510 520 530 540
SFIQSSHLIR HRRIHTGNKP HKCAGCGKGF RYKTHLAQHQ KLHLC
Length:545
Mass (Da):60,461
Last modified:October 2, 2007 - v2
Checksum:i15860E7AECBE5ACC
GO

Sequence cautioni

The sequence CAI21950.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109966 Genomic DNA. Translation: CAI21950.1. Sequence problems.
BC007260 mRNA. Translation: AAH07260.1.
CCDSiCCDS44202.1.
RefSeqiNP_001073939.1. NM_001080470.1.
XP_005271372.1. XM_005271315.2.
XP_011540718.1. XM_011542416.1.
UniGeneiHs.381105.

Genome annotation databases

EnsembliENST00000421812; ENSP00000396857; ENSG00000143067.
GeneIDi90874.
KEGGihsa:90874.
UCSCiuc001ehy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109966 Genomic DNA. Translation: CAI21950.1. Sequence problems.
BC007260 mRNA. Translation: AAH07260.1.
CCDSiCCDS44202.1.
RefSeqiNP_001073939.1. NM_001080470.1.
XP_005271372.1. XM_005271315.2.
XP_011540718.1. XM_011542416.1.
UniGeneiHs.381105.

3D structure databases

ProteinModelPortaliQ5TEC3.
SMRiQ5TEC3. Positions 188-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124778. 10 interactions.
STRINGi9606.ENSP00000396857.

PTM databases

iPTMnetiQ5TEC3.
PhosphoSiteiQ5TEC3.

Polymorphism and mutation databases

BioMutaiZNF697.
DMDMi158706492.

Proteomic databases

MaxQBiQ5TEC3.
PaxDbiQ5TEC3.
PeptideAtlasiQ5TEC3.
PRIDEiQ5TEC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421812; ENSP00000396857; ENSG00000143067.
GeneIDi90874.
KEGGihsa:90874.
UCSCiuc001ehy.2. human.

Organism-specific databases

CTDi90874.
GeneCardsiZNF697.
HGNCiHGNC:32034. ZNF697.
HPAiHPA049933.
neXtProtiNX_Q5TEC3.
PharmGKBiPA142670495.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00820000127150.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5TEC3.
OMAiKPAHRRF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5TEC3.
TreeFamiTF350831.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF697. human.
GenomeRNAii90874.
PROiQ5TEC3.

Gene expression databases

BgeeiQ5TEC3.
CleanExiHS_ZNF697.
GenevisibleiQ5TEC3. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 316-545.
    Tissue: Skin.

Entry informationi

Entry nameiZN697_HUMAN
AccessioniPrimary (citable) accession number: Q5TEC3
Secondary accession number(s): Q96IT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 6, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.