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Protein

Zinc finger protein 697

Gene

ZNF697

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 211C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 697
Gene namesi
Name:ZNF697
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143067.4.
HGNCiHGNC:32034. ZNF697.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143067.
PharmGKBiPA142670495.

Polymorphism and mutation databases

BioMutaiZNF697.
DMDMi158706492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051381 – 545Zinc finger protein 697Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki2Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ5TEC3.
MaxQBiQ5TEC3.
PaxDbiQ5TEC3.
PeptideAtlasiQ5TEC3.
PRIDEiQ5TEC3.

PTM databases

iPTMnetiQ5TEC3.
PhosphoSitePlusiQ5TEC3.

Expressioni

Gene expression databases

BgeeiENSG00000143067.
CleanExiHS_ZNF697.
GenevisibleiQ5TEC3. HS.

Organism-specific databases

HPAiHPA049933.

Interactioni

Protein-protein interaction databases

BioGridi124778. 10 interactors.
IntActiQ5TEC3. 5 interactors.
STRINGi9606.ENSP00000396857.

Structurei

3D structure databases

ProteinModelPortaliQ5TEC3.
SMRiQ5TEC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 134Poly-Glu5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 211C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00820000127150.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5TEC3.
OMAiKPAHRRF.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5TEC3.
TreeFamiTF350831.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q5TEC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQEDNQGVC AHQDSEDKGM GSDFEDSEDR EGDPEEREMG SNPHDTNKRE
60 70 80 90 100
GHPEPEMGSN PQDSRHREAV PDICTEGQLS EEEGVSVRGE EDDQSGVADM
110 120 130 140 150
AMFPGLSESD SISRSLREDD DESAGENRLE EEEEQPAPPV LPWRRHLSLG
160 170 180 190 200
SRHRGDKPAH RRFHRLHHPM AVDLGELDSL VASIMDAPTI CPDCGESFSP
210 220 230 240 250
GAAFLQHQRI HRLAEAAAAA SLEPFGLAGE CDAMVGMMGV GVAGGFGAGP
260 270 280 290 300
PLARPPREKP FRCGECGKGF SRNTYLTNHL RLHTGERPNL CADCGKSFSW
310 320 330 340 350
RADLLKHRRL HTGEKPYPCP ECGEAFSLSS HLLSHRRAHA AASGAGAAAL
360 370 380 390 400
RPFACGECGK GFVRRSHLAN HQRIHTGEKP HGCGECGKRF SWRSDLVKHQ
410 420 430 440 450
RVHTGEKPYM CSECGETFSV SSHLFTHKRT HSGERPYVCR ECGKGFGRNS
460 470 480 490 500
HLVNHLRVHT GEKPFRCGQC EKRFSDFSTL TQHQRTHTGE KPYTCIECGK
510 520 530 540
SFIQSSHLIR HRRIHTGNKP HKCAGCGKGF RYKTHLAQHQ KLHLC
Length:545
Mass (Da):60,461
Last modified:October 2, 2007 - v2
Checksum:i15860E7AECBE5ACC
GO

Sequence cautioni

The sequence CAI21950 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078436158P → T1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109966 Genomic DNA. Translation: CAI21950.1. Sequence problems.
BC007260 mRNA. Translation: AAH07260.1.
CCDSiCCDS44202.1.
RefSeqiNP_001073939.1. NM_001080470.1.
XP_005271372.1. XM_005271315.3.
XP_011540718.1. XM_011542416.2.
UniGeneiHs.381105.

Genome annotation databases

EnsembliENST00000421812; ENSP00000396857; ENSG00000143067.
GeneIDi90874.
KEGGihsa:90874.
UCSCiuc001ehy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN697_HUMAN
AccessioniPrimary (citable) accession number: Q5TEC3
Secondary accession number(s): Q96IT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 27, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families