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UniProtKB - Q5TEA6 (SE1L2_HUMAN)

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Protein

Protein sel-1 homolog 2

Gene

SEL1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sel-1 homolog 2
Alternative name(s):
Suppressor of lin-12-like protein 2
Short name:
Sel-1L2
Gene namesi
Name:SEL1L2
Synonyms:C20orf50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15897. SEL1L2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 662ExtracellularSequence analysisAdd BLAST639
Transmembranei663 – 683HelicalSequence analysisAdd BLAST21
Topological domaini684 – 688CytoplasmicSequence analysis5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80343.
OpenTargetsiENSG00000101251.
PharmGKBiPA162402870.

Polymorphism and mutation databases

DMDMi158706355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000030515924 – 688Protein sel-1 homolog 2Add BLAST665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5TEA6.
PeptideAtlasiQ5TEA6.
PRIDEiQ5TEA6.

PTM databases

iPTMnetiQ5TEA6.
PhosphoSitePlusiQ5TEA6.

Expressioni

Gene expression databases

BgeeiENSG00000101251.
CleanExiHS_SEL1L2.
ExpressionAtlasiQ5TEA6. baseline and differential.
GenevisibleiQ5TEA6. HS.

Organism-specific databases

HPAiHPA059121.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000284951.

Structurei

3D structure databases

ProteinModelPortaliQ5TEA6.
SMRiQ5TEA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati107 – 142Sel1-like 1Add BLAST36
Repeati143 – 178Sel1-like 2Add BLAST36
Repeati179 – 214Sel1-like 3Add BLAST36
Repeati215 – 250Sel1-like 4Add BLAST36
Repeati297 – 333Sel1-like 5Add BLAST37
Repeati334 – 370Sel1-like 6Add BLAST37
Repeati371 – 406Sel1-like 7Add BLAST36
Repeati407 – 442Sel1-like 8Add BLAST36
Repeati443 – 478Sel1-like 9Add BLAST36
Repeati551 – 586Sel1-like 10Add BLAST36
Repeati588 – 623Sel1-like 11Add BLAST36

Sequence similaritiesi

Belongs to the sel-1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00530000063170.
HOGENOMiHOG000239927.
HOVERGENiHBG057766.
InParanoidiQ5TEA6.
KOiK14026.
OMAiSMMSQMI.
OrthoDBiEOG091G0315.
PhylomeDBiQ5TEA6.
TreeFamiTF315257.

Family and domain databases

InterProiView protein in InterPro
IPR006597. Sel1-like.
PfamiView protein in Pfam
PF08238. Sel1. 11 hits.
SMARTiView protein in SMART
SM00671. SEL1. 11 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TEA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPLSLLIEI LIILGVTIKT IKAEEHNKRQ KERNVTTQVS VNEIKQYLSH 
        60         70         80         90        100
ILEQRTSSNV INKRENLLEK KKNQRKIRIK GIQNKDILKR NKNHLQKQAE 
       110        120        130        140        150
KNFTDEGDQL FKMGIKVLQQ SKSQKQKEEA YLLFAKAADM GNLKAMEKMA 
       160        170        180        190        200
DALLFGNFGV QNITAAIQLY ESLAKEGSCK AQNALGFLSS YGIGMEYDQA 
       210        220        230        240        250
KALIYYTFGS AGGNMMSQMI LGYRYLSGIN VLQNCEVALS YYKKVADYIA 
       260        270        280        290        300
DTFEKSEGVP VEKVRLTERP ENLSSNSEIL DWDIYQYYKF LAERGDVQIQ 
       310        320        330        340        350
VSLGQLHLIG RKGLDQDYYK ALHYFLKAAK AGSANAMAFI GKMYLEGNAA 
       360        370        380        390        400
VPQNNATAFK YFSMAASKGN AIGLHGLGLL YFHGKGVPLN YAEALKYFQK 
       410        420        430        440        450
AAEKGWPDAQ FQLGFMYYSG SGIWKDYKLA FKYFYLASQS GQPLAIYYLA 
       460        470        480        490        500
KMYATGTGVV RSCRTAVELY KGVCELGHWA EKFLTAYFAY KDGDIDSSLV 
       510        520        530        540        550
QYALLAEMGY EVAQSNSAFI LESKKANILE KEKMYPMALL LWNRAAIQGN 
       560        570        580        590        600
AFARVKIGDY HYYGYGTKKD YQTAATHYSI AANKYHNAQA MFNLAYMYEH 
       610        620        630        640        650
GLGITKDIHL ARRLYDMAAQ TSPDAHIPVL FAVMKLETTH LLRDILFFNF 
       660        670        680 
TTRWNWLKLD NTIGPHWDLF VIGLIVPGLI LLLRNHHG
Length:688
Mass (Da):77,964
Last modified:October 2, 2007 - v2
Checksum:iCC5ADD19835156B8
GO
Isoform 2 (identifier: Q5TEA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     469-605: LYKGVCELGH...YMYEHGLGIT → KRLTFLKKRRCIQWRFSYGIELPF

Show »
Length:575
Mass (Da):65,485
Checksum:i87552FD0B42F10CC
GO

Sequence cautioni

The sequence CAI22078 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI22983 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053964477G → S. Corresponds to variant dbSNP:rs11697581Ensembl.1
Natural variantiVAR_035172687H → Q. Corresponds to variant dbSNP:rs2073290Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046937469 – 605LYKGV…GLGIT → KRLTFLKKRRCIQWRFSYGI ELPF in isoform 2. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117333, AL109657 Genomic DNA. Translation: CAI22078.1. Sequence problems.
AL354683 Genomic DNA. No translation available.
AK302170 mRNA. Translation: BAG63537.1.
AL109657, AL117333 Genomic DNA. Translation: CAI22983.1. Sequence problems.
CCDSiCCDS59443.1. [Q5TEA6-2]
RefSeqiNP_001258468.1. NM_001271539.1. [Q5TEA6-2]
XP_006723710.1. XM_006723647.2. [Q5TEA6-1]
UniGeneiHs.590879.

Genome annotation databases

EnsembliENST00000284951; ENSP00000284951; ENSG00000101251. [Q5TEA6-1]
ENST00000378072; ENSP00000367312; ENSG00000101251. [Q5TEA6-2]
GeneIDi80343.
KEGGihsa:80343.
UCSCiuc010zrl.4. human. [Q5TEA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117333, AL109657 Genomic DNA. Translation: CAI22078.1. Sequence problems.
AL354683 Genomic DNA. No translation available.
AK302170 mRNA. Translation: BAG63537.1.
AL109657, AL117333 Genomic DNA. Translation: CAI22983.1. Sequence problems.
CCDSiCCDS59443.1. [Q5TEA6-2]
RefSeqiNP_001258468.1. NM_001271539.1. [Q5TEA6-2]
XP_006723710.1. XM_006723647.2. [Q5TEA6-1]
UniGeneiHs.590879.

3D structure databases

ProteinModelPortaliQ5TEA6.
SMRiQ5TEA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000284951.

PTM databases

iPTMnetiQ5TEA6.
PhosphoSitePlusiQ5TEA6.

Polymorphism and mutation databases

DMDMi158706355.

Proteomic databases

PaxDbiQ5TEA6.
PeptideAtlasiQ5TEA6.
PRIDEiQ5TEA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284951; ENSP00000284951; ENSG00000101251. [Q5TEA6-1]
ENST00000378072; ENSP00000367312; ENSG00000101251. [Q5TEA6-2]
GeneIDi80343.
KEGGihsa:80343.
UCSCiuc010zrl.4. human. [Q5TEA6-1]

Organism-specific databases

CTDi80343.
DisGeNETi80343.
GeneCardsiSEL1L2.
H-InvDBiHIX0015651.
HGNCiHGNC:15897. SEL1L2.
HPAiHPA059121.
MIMi614289. gene.
neXtProtiNX_Q5TEA6.
OpenTargetsiENSG00000101251.
PharmGKBiPA162402870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00530000063170.
HOGENOMiHOG000239927.
HOVERGENiHBG057766.
InParanoidiQ5TEA6.
KOiK14026.
OMAiSMMSQMI.
OrthoDBiEOG091G0315.
PhylomeDBiQ5TEA6.
TreeFamiTF315257.

Miscellaneous databases

GenomeRNAii80343.
PROiPR:Q5TEA6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101251.
CleanExiHS_SEL1L2.
ExpressionAtlasiQ5TEA6. baseline and differential.
GenevisibleiQ5TEA6. HS.

Family and domain databases

InterProiView protein in InterPro
IPR006597. Sel1-like.
PfamiView protein in Pfam
PF08238. Sel1. 11 hits.
SMARTiView protein in SMART
SM00671. SEL1. 11 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSE1L2_HUMAN
AccessioniPrimary (citable) accession number: Q5TEA6
Secondary accession number(s): B4DXX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 7, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.