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Protein

Protein sel-1 homolog 2

Gene

SEL1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sel-1 homolog 2
Alternative name(s):
Suppressor of lin-12-like protein 2
Short name:
Sel-1L2
Gene namesi
Name:SEL1L2
Synonyms:C20orf50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15897. SEL1L2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 662639ExtracellularSequence analysisAdd
BLAST
Transmembranei663 – 68321HelicalSequence analysisAdd
BLAST
Topological domaini684 – 6885CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402870.

Polymorphism and mutation databases

DMDMi158706355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 688665Protein sel-1 homolog 2PRO_0000305159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Cross-linki101 – 101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5TEA6.
PRIDEiQ5TEA6.

PTM databases

iPTMnetiQ5TEA6.
PhosphoSiteiQ5TEA6.

Expressioni

Gene expression databases

BgeeiQ5TEA6.
CleanExiHS_SEL1L2.
ExpressionAtlasiQ5TEA6. baseline and differential.
GenevisibleiQ5TEA6. HS.

Organism-specific databases

HPAiHPA059121.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000284951.

Structurei

3D structure databases

ProteinModelPortaliQ5TEA6.
SMRiQ5TEA6. Positions 113-620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati107 – 14236Sel1-like 1Add
BLAST
Repeati143 – 17836Sel1-like 2Add
BLAST
Repeati179 – 21436Sel1-like 3Add
BLAST
Repeati215 – 25036Sel1-like 4Add
BLAST
Repeati297 – 33337Sel1-like 5Add
BLAST
Repeati334 – 37037Sel1-like 6Add
BLAST
Repeati371 – 40636Sel1-like 7Add
BLAST
Repeati407 – 44236Sel1-like 8Add
BLAST
Repeati443 – 47836Sel1-like 9Add
BLAST
Repeati551 – 58636Sel1-like 10Add
BLAST
Repeati588 – 62336Sel1-like 11Add
BLAST

Sequence similaritiesi

Belongs to the sel-1 family.Curated
Contains 11 Sel1-like repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00530000063170.
HOGENOMiHOG000239927.
HOVERGENiHBG057766.
InParanoidiQ5TEA6.
KOiK14026.
OMAiNCEVALS.
OrthoDBiEOG7DRJ2J.
PhylomeDBiQ5TEA6.
TreeFamiTF315257.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 11 hits.
[Graphical view]
SMARTiSM00671. SEL1. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TEA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPLSLLIEI LIILGVTIKT IKAEEHNKRQ KERNVTTQVS VNEIKQYLSH
60 70 80 90 100
ILEQRTSSNV INKRENLLEK KKNQRKIRIK GIQNKDILKR NKNHLQKQAE
110 120 130 140 150
KNFTDEGDQL FKMGIKVLQQ SKSQKQKEEA YLLFAKAADM GNLKAMEKMA
160 170 180 190 200
DALLFGNFGV QNITAAIQLY ESLAKEGSCK AQNALGFLSS YGIGMEYDQA
210 220 230 240 250
KALIYYTFGS AGGNMMSQMI LGYRYLSGIN VLQNCEVALS YYKKVADYIA
260 270 280 290 300
DTFEKSEGVP VEKVRLTERP ENLSSNSEIL DWDIYQYYKF LAERGDVQIQ
310 320 330 340 350
VSLGQLHLIG RKGLDQDYYK ALHYFLKAAK AGSANAMAFI GKMYLEGNAA
360 370 380 390 400
VPQNNATAFK YFSMAASKGN AIGLHGLGLL YFHGKGVPLN YAEALKYFQK
410 420 430 440 450
AAEKGWPDAQ FQLGFMYYSG SGIWKDYKLA FKYFYLASQS GQPLAIYYLA
460 470 480 490 500
KMYATGTGVV RSCRTAVELY KGVCELGHWA EKFLTAYFAY KDGDIDSSLV
510 520 530 540 550
QYALLAEMGY EVAQSNSAFI LESKKANILE KEKMYPMALL LWNRAAIQGN
560 570 580 590 600
AFARVKIGDY HYYGYGTKKD YQTAATHYSI AANKYHNAQA MFNLAYMYEH
610 620 630 640 650
GLGITKDIHL ARRLYDMAAQ TSPDAHIPVL FAVMKLETTH LLRDILFFNF
660 670 680
TTRWNWLKLD NTIGPHWDLF VIGLIVPGLI LLLRNHHG
Length:688
Mass (Da):77,964
Last modified:October 2, 2007 - v2
Checksum:iCC5ADD19835156B8
GO
Isoform 2 (identifier: Q5TEA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     469-605: LYKGVCELGH...YMYEHGLGIT → KRLTFLKKRRCIQWRFSYGIELPF

Show »
Length:575
Mass (Da):65,485
Checksum:i87552FD0B42F10CC
GO

Sequence cautioni

The sequence CAI22078.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI22983.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti477 – 4771G → S.
Corresponds to variant rs11697581 [ dbSNP | Ensembl ].
VAR_053964
Natural varianti687 – 6871H → Q.
Corresponds to variant rs2073290 [ dbSNP | Ensembl ].
VAR_035172

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei469 – 605137LYKGV…GLGIT → KRLTFLKKRRCIQWRFSYGI ELPF in isoform 2. 1 PublicationVSP_046937Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117333, AL109657 Genomic DNA. Translation: CAI22078.1. Sequence problems.
AL354683 Genomic DNA. No translation available.
AK302170 mRNA. Translation: BAG63537.1.
AL109657, AL117333 Genomic DNA. Translation: CAI22983.1. Sequence problems.
CCDSiCCDS59443.1. [Q5TEA6-2]
RefSeqiNP_001258468.1. NM_001271539.1. [Q5TEA6-2]
XP_006723710.1. XM_006723647.2. [Q5TEA6-1]
UniGeneiHs.590879.

Genome annotation databases

EnsembliENST00000284951; ENSP00000284951; ENSG00000101251. [Q5TEA6-1]
ENST00000378072; ENSP00000367312; ENSG00000101251. [Q5TEA6-2]
GeneIDi80343.
KEGGihsa:80343.
UCSCiuc010zrl.4. human. [Q5TEA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117333, AL109657 Genomic DNA. Translation: CAI22078.1. Sequence problems.
AL354683 Genomic DNA. No translation available.
AK302170 mRNA. Translation: BAG63537.1.
AL109657, AL117333 Genomic DNA. Translation: CAI22983.1. Sequence problems.
CCDSiCCDS59443.1. [Q5TEA6-2]
RefSeqiNP_001258468.1. NM_001271539.1. [Q5TEA6-2]
XP_006723710.1. XM_006723647.2. [Q5TEA6-1]
UniGeneiHs.590879.

3D structure databases

ProteinModelPortaliQ5TEA6.
SMRiQ5TEA6. Positions 113-620.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000284951.

PTM databases

iPTMnetiQ5TEA6.
PhosphoSiteiQ5TEA6.

Polymorphism and mutation databases

DMDMi158706355.

Proteomic databases

PaxDbiQ5TEA6.
PRIDEiQ5TEA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284951; ENSP00000284951; ENSG00000101251. [Q5TEA6-1]
ENST00000378072; ENSP00000367312; ENSG00000101251. [Q5TEA6-2]
GeneIDi80343.
KEGGihsa:80343.
UCSCiuc010zrl.4. human. [Q5TEA6-1]

Organism-specific databases

CTDi80343.
GeneCardsiSEL1L2.
H-InvDBHIX0015651.
HGNCiHGNC:15897. SEL1L2.
HPAiHPA059121.
MIMi614289. gene.
neXtProtiNX_Q5TEA6.
PharmGKBiPA162402870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00530000063170.
HOGENOMiHOG000239927.
HOVERGENiHBG057766.
InParanoidiQ5TEA6.
KOiK14026.
OMAiNCEVALS.
OrthoDBiEOG7DRJ2J.
PhylomeDBiQ5TEA6.
TreeFamiTF315257.

Miscellaneous databases

GenomeRNAii80343.
NextBioi35476086.
PROiQ5TEA6.
SOURCEiSearch...

Gene expression databases

BgeeiQ5TEA6.
CleanExiHS_SEL1L2.
ExpressionAtlasiQ5TEA6. baseline and differential.
GenevisibleiQ5TEA6. HS.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 11 hits.
[Graphical view]
SMARTiSM00671. SEL1. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-101.
    Tissue: Mammary cancer.

Entry informationi

Entry nameiSE1L2_HUMAN
AccessioniPrimary (citable) accession number: Q5TEA6
Secondary accession number(s): B4DXX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 16, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.