SEL1L2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein sel-1 homolog 2 Alternative name(s): Suppressor of lin-12-like protein 2 Short name: Sel-1L2
Gene namesⁱ	Name:SEL1L2 Synonyms:C20orf50
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15897. SEL1L2.

HGNCⁱ

HGNC:15897. SEL1L2.

Subcellular locationⁱ

Membrane; Single-pass type I membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 662	ExtracellularSequence analysisAdd BLAST	639
Transmembraneⁱ	663 – 683	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	684 – 688	CytoplasmicSequence analysis	5

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80343.
Open Targets More...OpenTargetsⁱ	ENSG00000101251.
PharmGKBⁱ	PA162402870.

Polymorphism and mutation databases

DMDMⁱ	158706355.

DMDMⁱ

158706355.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000305159	24 – 688	Protein sel-1 homolog 2Add BLAST		665

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	34	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q5TEA6.
PeptideAtlas More...PeptideAtlasⁱ	Q5TEA6.
PRIDEⁱ	Q5TEA6.

PTM databases

iPTMnetⁱ	Q5TEA6.
PhosphoSitePlusⁱ	Q5TEA6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101251.
CleanExⁱ	HS_SEL1L2.
ExpressionAtlasⁱ	Q5TEA6. baseline and differential.
Genevisibleⁱ	Q5TEA6. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059121.

HPAⁱ

HPA059121.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000284951.

STRINGⁱ

9606.ENSP00000284951.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5TEA6.
SMRⁱ	Q5TEA6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	107 – 142	Sel1-like 1Add BLAST	36
Repeatⁱ	143 – 178	Sel1-like 2Add BLAST	36
Repeatⁱ	179 – 214	Sel1-like 3Add BLAST	36
Repeatⁱ	215 – 250	Sel1-like 4Add BLAST	36
Repeatⁱ	297 – 333	Sel1-like 5Add BLAST	37
Repeatⁱ	334 – 370	Sel1-like 6Add BLAST	37
Repeatⁱ	371 – 406	Sel1-like 7Add BLAST	36
Repeatⁱ	407 – 442	Sel1-like 8Add BLAST	36
Repeatⁱ	443 – 478	Sel1-like 9Add BLAST	36
Repeatⁱ	551 – 586	Sel1-like 10Add BLAST	36
Repeatⁱ	588 – 623	Sel1-like 11Add BLAST	36

Sequence similaritiesⁱ

Belongs to the sel-1 family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1550. Eukaryota. COG0790. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063170.
HOGENOMⁱ	HOG000239927.
HOVERGENⁱ	HBG057766.
InParanoidⁱ	Q5TEA6.
KEGG Orthology (KO) More...KOⁱ	K14026.
OMAⁱ	SMMSQMI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0315.
PhylomeDBⁱ	Q5TEA6.
TreeFamⁱ	TF315257.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006597. Sel1-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08238. Sel1. 11 hits.
SMARTⁱ	View protein in SMART SM00671. SEL1. 11 hits.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q5TEA6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MKPLSLLIEI LIILGVTIKT IKAEEHNKRQ KERNVTTQVS VNEIKQYLSH 
        60         70         80         90        100
ILEQRTSSNV INKRENLLEK KKNQRKIRIK GIQNKDILKR NKNHLQKQAE 
       110        120        130        140        150
KNFTDEGDQL FKMGIKVLQQ SKSQKQKEEA YLLFAKAADM GNLKAMEKMA 
       160        170        180        190        200
DALLFGNFGV QNITAAIQLY ESLAKEGSCK AQNALGFLSS YGIGMEYDQA 
       210        220        230        240        250
KALIYYTFGS AGGNMMSQMI LGYRYLSGIN VLQNCEVALS YYKKVADYIA 
       260        270        280        290        300
DTFEKSEGVP VEKVRLTERP ENLSSNSEIL DWDIYQYYKF LAERGDVQIQ 
       310        320        330        340        350
VSLGQLHLIG RKGLDQDYYK ALHYFLKAAK AGSANAMAFI GKMYLEGNAA 
       360        370        380        390        400
VPQNNATAFK YFSMAASKGN AIGLHGLGLL YFHGKGVPLN YAEALKYFQK 
       410        420        430        440        450
AAEKGWPDAQ FQLGFMYYSG SGIWKDYKLA FKYFYLASQS GQPLAIYYLA 
       460        470        480        490        500
KMYATGTGVV RSCRTAVELY KGVCELGHWA EKFLTAYFAY KDGDIDSSLV 
       510        520        530        540        550
QYALLAEMGY EVAQSNSAFI LESKKANILE KEKMYPMALL LWNRAAIQGN 
       560        570        580        590        600
AFARVKIGDY HYYGYGTKKD YQTAATHYSI AANKYHNAQA MFNLAYMYEH 
       610        620        630        640        650
GLGITKDIHL ARRLYDMAAQ TSPDAHIPVL FAVMKLETTH LLRDILFFNF 
       660        670        680 
TTRWNWLKLD NTIGPHWDLF VIGLIVPGLI LLLRNHHG

Length:688

Mass (Da):77,964

Last modified:October 2, 2007 - v2

Checksum:ⁱCC5ADD19835156B8

GO

Isoform 2 (identifier: Q5TEA6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
469-605: LYKGVCELGH...YMYEHGLGIT → KRLTFLKKRRCIQWRFSYGIELPF

« Hide

        10         20         30         40         50
MKPLSLLIEI LIILGVTIKT IKAEEHNKRQ KERNVTTQVS VNEIKQYLSH 
        60         70         80         90        100
ILEQRTSSNV INKRENLLEK KKNQRKIRIK GIQNKDILKR NKNHLQKQAE 
       110        120        130        140        150
KNFTDEGDQL FKMGIKVLQQ SKSQKQKEEA YLLFAKAADM GNLKAMEKMA 
       160        170        180        190        200
DALLFGNFGV QNITAAIQLY ESLAKEGSCK AQNALGFLSS YGIGMEYDQA 
       210        220        230        240        250
KALIYYTFGS AGGNMMSQMI LGYRYLSGIN VLQNCEVALS YYKKVADYIA 
       260        270        280        290        300
DTFEKSEGVP VEKVRLTERP ENLSSNSEIL DWDIYQYYKF LAERGDVQIQ 
       310        320        330        340        350
VSLGQLHLIG RKGLDQDYYK ALHYFLKAAK AGSANAMAFI GKMYLEGNAA 
       360        370        380        390        400
VPQNNATAFK YFSMAASKGN AIGLHGLGLL YFHGKGVPLN YAEALKYFQK 
       410        420        430        440        450
AAEKGWPDAQ FQLGFMYYSG SGIWKDYKLA FKYFYLASQS GQPLAIYYLA 
       460        470        480        490        500
KMYATGTGVV RSCRTAVEKR LTFLKKRRCI QWRFSYGIEL PFKDIHLARR 
       510        520        530        540        550
LYDMAAQTSP DAHIPVLFAV MKLETTHLLR DILFFNFTTR WNWLKLDNTI 
       560        570 
GPHWDLFVIG LIVPGLILLL RNHHG

Show »

Length:575

Mass (Da):65,485

Checksum:ⁱ87552FD0B42F10CC

GO

Sequence cautionⁱ

The sequence CAI22078 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAI22983 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053964	477	G → S. Corresponds to variant dbSNP:rs11697581Ensembl.		1
Natural variantⁱVAR_035172	687	H → Q. Corresponds to variant dbSNP:rs2073290Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046937	469 – 605	LYKGV…GLGIT → KRLTFLKKRRCIQWRFSYGI ELPF in isoform 2. 1 PublicationAdd BLAST		137

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL117333, AL109657 Genomic DNA. Translation: CAI22078.1. Sequence problems. AL354683 Genomic DNA. No translation available. AK302170 mRNA. Translation: BAG63537.1. AL109657, AL117333 Genomic DNA. Translation: CAI22983.1. Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS59443.1. [Q5TEA6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001258468.1. NM_001271539.1. [Q5TEA6-2] XP_006723710.1. XM_006723647.2. [Q5TEA6-1]
UniGeneⁱ	Hs.590879.

Genome annotation databases

Ensemblⁱ	ENST00000284951; ENSP00000284951; ENSG00000101251. [Q5TEA6-1] ENST00000378072; ENSP00000367312; ENSG00000101251. [Q5TEA6-2]
GeneIDⁱ	80343.
KEGGⁱ	hsa:80343.
UCSC genome browser More...UCSCⁱ	uc010zrl.4. human. [Q5TEA6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL117333, AL109657 Genomic DNA. Translation: CAI22078.1. Sequence problems. AL354683 Genomic DNA. No translation available. AK302170 mRNA. Translation: BAG63537.1. AL109657, AL117333 Genomic DNA. Translation: CAI22983.1. Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS59443.1. [Q5TEA6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001258468.1. NM_001271539.1. [Q5TEA6-2] XP_006723710.1. XM_006723647.2. [Q5TEA6-1]
UniGeneⁱ	Hs.590879.

3D structure databases

ProteinModelPortalⁱ	Q5TEA6.
SMRⁱ	Q5TEA6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000284951.

STRINGⁱ

9606.ENSP00000284951.

PTM databases

iPTMnetⁱ	Q5TEA6.
PhosphoSitePlusⁱ	Q5TEA6.

Polymorphism and mutation databases

DMDMⁱ	158706355.

DMDMⁱ

158706355.

Proteomic databases

PaxDbⁱ	Q5TEA6.
PeptideAtlas More...PeptideAtlasⁱ	Q5TEA6.
PRIDEⁱ	Q5TEA6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000284951; ENSP00000284951; ENSG00000101251. [Q5TEA6-1] ENST00000378072; ENSP00000367312; ENSG00000101251. [Q5TEA6-2]
GeneIDⁱ	80343.
KEGGⁱ	hsa:80343.
UCSC genome browser More...UCSCⁱ	uc010zrl.4. human. [Q5TEA6-1]

Organism-specific databases

CTDⁱ	80343.
DisGeNET More...DisGeNETⁱ	80343.
GeneCardsⁱ	SEL1L2.
H-InvDBⁱ	HIX0015651.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15897. SEL1L2.
Human Protein Atlas More...HPAⁱ	HPA059121.
MIMⁱ	614289. gene.
neXtProtⁱ	NX_Q5TEA6.
Open Targets More...OpenTargetsⁱ	ENSG00000101251.
PharmGKBⁱ	PA162402870.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1550. Eukaryota. COG0790. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063170.
HOGENOMⁱ	HOG000239927.
HOVERGENⁱ	HBG057766.
InParanoidⁱ	Q5TEA6.
KEGG Orthology (KO) More...KOⁱ	K14026.
OMAⁱ	SMMSQMI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0315.
PhylomeDBⁱ	Q5TEA6.
TreeFamⁱ	TF315257.

Miscellaneous databases

GenomeRNAiⁱ	80343.
Protein Ontology More...PROⁱ	PR:Q5TEA6.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101251.
CleanExⁱ	HS_SEL1L2.
ExpressionAtlasⁱ	Q5TEA6. baseline and differential.
Genevisibleⁱ	Q5TEA6. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006597. Sel1-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08238. Sel1. 11 hits.
SMARTⁱ	View protein in SMART SM00671. SEL1. 11 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SE1L2_HUMAN
Accessionⁱ	Q5TEA6Primary (citable) accession number: Q5TEA6 Secondary accession number(s): B4DXX5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	October 2, 2007
	Last modified:	June 7, 2017
	This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5TEA6 (SE1L2_HUMAN)

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Protein sel-1 homolog 2

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ