UniProtKB - Q5TEA6 (SE1L2_HUMAN)
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Protein
Protein sel-1 homolog 2
Gene
SEL1L2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein sel-1 homolog 2Alternative name(s): Suppressor of lin-12-like protein 2 Short name: Sel-1L2 |
Gene namesi | Name:SEL1L2 Synonyms:C20orf50 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101251.11. |
HGNCi | HGNC:15897. SEL1L2. |
MIMi | 614289. gene. |
neXtProti | NX_Q5TEA6. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 662 | ExtracellularSequence analysisAdd BLAST | 639 | |
Transmembranei | 663 – 683 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 684 – 688 | CytoplasmicSequence analysis | 5 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 80343. |
OpenTargetsi | ENSG00000101251. |
PharmGKBi | PA162402870. |
Polymorphism and mutation databases
DMDMi | 158706355. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000305159 | 24 – 688 | Protein sel-1 homolog 2Add BLAST | 665 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 34 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q5TEA6. |
PeptideAtlasi | Q5TEA6. |
PRIDEi | Q5TEA6. |
PTM databases
iPTMneti | Q5TEA6. |
PhosphoSitePlusi | Q5TEA6. |
Expressioni
Gene expression databases
Bgeei | ENSG00000101251. |
CleanExi | HS_SEL1L2. |
ExpressionAtlasi | Q5TEA6. baseline and differential. |
Genevisiblei | Q5TEA6. HS. |
Organism-specific databases
HPAi | HPA059121. |
Structurei
3D structure databases
ProteinModelPortali | Q5TEA6. |
SMRi | Q5TEA6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 107 – 142 | Sel1-like 1Add BLAST | 36 | |
Repeati | 143 – 178 | Sel1-like 2Add BLAST | 36 | |
Repeati | 179 – 214 | Sel1-like 3Add BLAST | 36 | |
Repeati | 215 – 250 | Sel1-like 4Add BLAST | 36 | |
Repeati | 297 – 333 | Sel1-like 5Add BLAST | 37 | |
Repeati | 334 – 370 | Sel1-like 6Add BLAST | 37 | |
Repeati | 371 – 406 | Sel1-like 7Add BLAST | 36 | |
Repeati | 407 – 442 | Sel1-like 8Add BLAST | 36 | |
Repeati | 443 – 478 | Sel1-like 9Add BLAST | 36 | |
Repeati | 551 – 586 | Sel1-like 10Add BLAST | 36 | |
Repeati | 588 – 623 | Sel1-like 11Add BLAST | 36 |
Sequence similaritiesi
Belongs to the sel-1 family.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1550. Eukaryota. COG0790. LUCA. |
GeneTreei | ENSGT00530000063170. |
HOGENOMi | HOG000239927. |
HOVERGENi | HBG057766. |
InParanoidi | Q5TEA6. |
KOi | K14026. |
OMAi | SMMSQMI. |
OrthoDBi | EOG091G0315. |
PhylomeDBi | Q5TEA6. |
TreeFami | TF315257. |
Family and domain databases
Gene3Di | 1.25.40.10. 2 hits. |
InterProi | View protein in InterPro IPR006597. Sel1-like. IPR011990. TPR-like_helical_dom_sf. |
Pfami | View protein in Pfam PF08238. Sel1. 11 hits. |
SMARTi | View protein in SMART SM00671. SEL1. 11 hits. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5TEA6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MKPLSLLIEI LIILGVTIKT IKAEEHNKRQ KERNVTTQVS VNEIKQYLSH
60 70 80 90 100
ILEQRTSSNV INKRENLLEK KKNQRKIRIK GIQNKDILKR NKNHLQKQAE
110 120 130 140 150
KNFTDEGDQL FKMGIKVLQQ SKSQKQKEEA YLLFAKAADM GNLKAMEKMA
160 170 180 190 200
DALLFGNFGV QNITAAIQLY ESLAKEGSCK AQNALGFLSS YGIGMEYDQA
210 220 230 240 250
KALIYYTFGS AGGNMMSQMI LGYRYLSGIN VLQNCEVALS YYKKVADYIA
260 270 280 290 300
DTFEKSEGVP VEKVRLTERP ENLSSNSEIL DWDIYQYYKF LAERGDVQIQ
310 320 330 340 350
VSLGQLHLIG RKGLDQDYYK ALHYFLKAAK AGSANAMAFI GKMYLEGNAA
360 370 380 390 400
VPQNNATAFK YFSMAASKGN AIGLHGLGLL YFHGKGVPLN YAEALKYFQK
410 420 430 440 450
AAEKGWPDAQ FQLGFMYYSG SGIWKDYKLA FKYFYLASQS GQPLAIYYLA
460 470 480 490 500
KMYATGTGVV RSCRTAVELY KGVCELGHWA EKFLTAYFAY KDGDIDSSLV
510 520 530 540 550
QYALLAEMGY EVAQSNSAFI LESKKANILE KEKMYPMALL LWNRAAIQGN
560 570 580 590 600
AFARVKIGDY HYYGYGTKKD YQTAATHYSI AANKYHNAQA MFNLAYMYEH
610 620 630 640 650
GLGITKDIHL ARRLYDMAAQ TSPDAHIPVL FAVMKLETTH LLRDILFFNF
660 670 680
TTRWNWLKLD NTIGPHWDLF VIGLIVPGLI LLLRNHHG
Sequence cautioni
The sequence CAI22078 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI22983 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053964 | 477 | G → S. Corresponds to variant dbSNP:rs11697581Ensembl. | 1 | |
Natural variantiVAR_035172 | 687 | H → Q. Corresponds to variant dbSNP:rs2073290Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046937 | 469 – 605 | LYKGV…GLGIT → KRLTFLKKRRCIQWRFSYGI ELPF in isoform 2. 1 PublicationAdd BLAST | 137 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117333, AL109657 Genomic DNA. Translation: CAI22078.1. Sequence problems. AL354683 Genomic DNA. No translation available. AK302170 mRNA. Translation: BAG63537.1. AL109657, AL117333 Genomic DNA. Translation: CAI22983.1. Sequence problems. |
CCDSi | CCDS59443.1. [Q5TEA6-2] |
RefSeqi | NP_001258468.1. NM_001271539.1. [Q5TEA6-2] XP_006723710.1. XM_006723647.2. [Q5TEA6-1] |
UniGenei | Hs.590879. |
Genome annotation databases
Ensembli | ENST00000284951; ENSP00000284951; ENSG00000101251. [Q5TEA6-1] ENST00000378072; ENSP00000367312; ENSG00000101251. [Q5TEA6-2] |
GeneIDi | 80343. |
KEGGi | hsa:80343. |
UCSCi | uc010zrl.4. human. [Q5TEA6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | SE1L2_HUMAN | |
Accessioni | Q5TEA6Primary (citable) accession number: Q5TEA6 Secondary accession number(s): B4DXX5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | February 28, 2018 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |