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Protein

Uncharacterized protein C20orf194

Gene

C20orf194

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as an effector for ARL3.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C20orf194
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:17721. C20orf194.

Pathology & Biotechi

Organism-specific databases

DisGeNETi25943.
OpenTargetsiENSG00000088854.
PharmGKBiPA134905007.

Polymorphism and mutation databases

BioMutaiC20orf194.
DMDMi74746271.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002360421 – 1177Uncharacterized protein C20orf194Add BLAST1177

Proteomic databases

EPDiQ5TEA3.
MaxQBiQ5TEA3.
PaxDbiQ5TEA3.
PeptideAtlasiQ5TEA3.
PRIDEiQ5TEA3.

PTM databases

iPTMnetiQ5TEA3.
PhosphoSitePlusiQ5TEA3.

Expressioni

Gene expression databases

BgeeiENSG00000088854.
CleanExiHS_C20orf194.
GenevisibleiQ5TEA3. HS.

Organism-specific databases

HPAiHPA052103.
HPA067418.

Interactioni

Subunit structurei

Interacts with ARL3.1 Publication

Protein-protein interaction databases

BioGridi117440. 2 interactors.
DIPiDIP-61818N.
IntActiQ5TEA3. 1 interactor.
STRINGi9606.ENSP00000252032.

Structurei

3D structure databases

ProteinModelPortaliQ5TEA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFVP. Eukaryota.
ENOG410XS7X. LUCA.
GeneTreeiENSGT00390000003692.
HOGENOMiHOG000231572.
HOVERGENiHBG080333.
InParanoidiQ5TEA3.
OMAiHRFLFPK.
OrthoDBiEOG091G00SF.
PhylomeDBiQ5TEA3.
TreeFamiTF329802.

Sequencei

Sequence statusi: Complete.

Q5TEA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVYPPRRQG LPRARSPGGS SRGSPSVSCS RLRQVQSILT QSSKSRPDGI
60 70 80 90 100
LCILGIDSRY NEGCRELANY LLFGLYNQNT SDFEKTGFSE EVLDDVIILI
110 120 130 140 150
KSDSVHLYCN PVNFRYLLPY VAHWRNLHFH CMTENEYEDE EAAEEFKITS
160 170 180 190 200
FVDMVRDCSR IGIPYSSQGH LQIFDMFVVE KWPIVQAFAL EGIGGDGFFT
210 220 230 240 250
MKYELQDVSL NLWNVYSKMD PMSLESLLSD DLVAFEHQWT SFFANFDTEI
260 270 280 290 300
PFLLELSESQ AGEPFRSYFS HGMISSHITE NSPNRQPFVL FGNHSTRENL
310 320 330 340 350
NAGNFNFPSE GHLVRSTGPG GSFAKHMVAQ CVSPKGPLAC SRTYFFGATH
360 370 380 390 400
VPYLGGDSKL PKKTEQIRLL SQIYAAVIEA VLAGIACYAK TSSLTKAKEV
410 420 430 440 450
AEQTLGSGLD SFELIPFKAA LRSKMTFHIH AVNNQGRIVP LDSEDSLSFV
460 470 480 490 500
KTACMAVYDI PDLLGGNGCL GSVVFSESFL TSQILVKEKD GTVTTETSSV
510 520 530 540 550
VLTAAVPRFC SWLVEDNEVK LSEKTQQAVR GDESFLGTYL TGGEGAYLYS
560 570 580 590 600
SNLQSWPEEG NVHFFSSGLL FSHCRHRSII ISKDHMNSIS FYDGDSTSTV
610 620 630 640 650
AALLIDFKSS LLPHLPVHFH GSSNFLMIAL FPKSKIYQAF YSEVFSLWKQ
660 670 680 690 700
QDNSGISLKV IQEDGLSVEQ KRLHSSAQKL FSALSQPAGE KRSSLKLLSA
710 720 730 740 750
KLPELDWFLQ HFAISSISQE PVMRTHLPVL LQQAEINTTH RIESDKVIIS
760 770 780 790 800
IVTGLPGCHA SELCAFLVTL HKECGRWMVY RQIMDSSECF HAAHFQRYLS
810 820 830 840 850
SALEAQQNRS ARQSAYIRKK TRLLVVLQGY TDVIDVVQAL QTHPDSNVKA
860 870 880 890 900
SFTIGAITAC VEPMSCYMEH RFLFPKCLDQ CSQGLVSNVV FTSHTTEQRH
910 920 930 940 950
PLLVQLQSLI RAANPAAAFI LAENGIVTRN EDIELILSEN SFSSPEMLRS
960 970 980 990 1000
RYLMYPGWYE GKLNAGSVYP LMVQICVWFG RPLEKTRFVA KCKAIQSSIK
1010 1020 1030 1040 1050
PSPFSGNIYH ILGKVKFSDS ERTMEVCYNT LANSLSIMPV LEGPTPPPDS
1060 1070 1080 1090 1100
KSVSQDSSGQ QECYLVFIGC SLKEDSIKDW LRQSAKQKPQ RKALKTRGML
1110 1120 1130 1140 1150
TQQEIRSIHV KRHLEPLPAG YFYNGTQFVN FFGDKTDFHP LMDQFMNDYV
1160 1170
EEANREIEKY NQELEQQEYH DLFELKP
Length:1,177
Mass (Da):132,287
Last modified:December 21, 2004 - v1
Checksum:i9CDC79CC97B6DB1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345F → L in CAB53697 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05963786T → M.Corresponds to variant rs8124486dbSNPEnsembl.1
Natural variantiVAR_065913265F → L.1 PublicationCorresponds to variant rs149767043dbSNPEnsembl.1
Natural variantiVAR_050923481T → P.Corresponds to variant rs16988463dbSNPEnsembl.1
Natural variantiVAR_050924577R → G.1 PublicationCorresponds to variant rs2422864dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117334, AL109976 Genomic DNA. Translation: CAI22431.1.
AL109976, AL117334 Genomic DNA. Translation: CAI22834.1.
AL110249 mRNA. Translation: CAB53697.1.
BC064352 mRNA. Translation: AAH64352.1.
BC080528 mRNA. Translation: AAH80528.1.
CCDSiCCDS42851.1.
PIRiT14777.
RefSeqiNP_001009984.1. NM_001009984.2.
UniGeneiHs.516853.

Genome annotation databases

EnsembliENST00000252032; ENSP00000252032; ENSG00000088854.
GeneIDi25943.
KEGGihsa:25943.
UCSCiuc002wii.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117334, AL109976 Genomic DNA. Translation: CAI22431.1.
AL109976, AL117334 Genomic DNA. Translation: CAI22834.1.
AL110249 mRNA. Translation: CAB53697.1.
BC064352 mRNA. Translation: AAH64352.1.
BC080528 mRNA. Translation: AAH80528.1.
CCDSiCCDS42851.1.
PIRiT14777.
RefSeqiNP_001009984.1. NM_001009984.2.
UniGeneiHs.516853.

3D structure databases

ProteinModelPortaliQ5TEA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117440. 2 interactors.
DIPiDIP-61818N.
IntActiQ5TEA3. 1 interactor.
STRINGi9606.ENSP00000252032.

PTM databases

iPTMnetiQ5TEA3.
PhosphoSitePlusiQ5TEA3.

Polymorphism and mutation databases

BioMutaiC20orf194.
DMDMi74746271.

Proteomic databases

EPDiQ5TEA3.
MaxQBiQ5TEA3.
PaxDbiQ5TEA3.
PeptideAtlasiQ5TEA3.
PRIDEiQ5TEA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252032; ENSP00000252032; ENSG00000088854.
GeneIDi25943.
KEGGihsa:25943.
UCSCiuc002wii.4. human.

Organism-specific databases

CTDi25943.
DisGeNETi25943.
GeneCardsiC20orf194.
H-InvDBHIX0015595.
HGNCiHGNC:17721. C20orf194.
HPAiHPA052103.
HPA067418.
MIMi614146. gene.
neXtProtiNX_Q5TEA3.
OpenTargetsiENSG00000088854.
PharmGKBiPA134905007.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFVP. Eukaryota.
ENOG410XS7X. LUCA.
GeneTreeiENSGT00390000003692.
HOGENOMiHOG000231572.
HOVERGENiHBG080333.
InParanoidiQ5TEA3.
OMAiHRFLFPK.
OrthoDBiEOG091G00SF.
PhylomeDBiQ5TEA3.
TreeFamiTF329802.

Miscellaneous databases

ChiTaRSiC20orf194. human.
GenomeRNAii25943.
PROiQ5TEA3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088854.
CleanExiHS_C20orf194.
GenevisibleiQ5TEA3. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCT194_HUMAN
AccessioniPrimary (citable) accession number: Q5TEA3
Secondary accession number(s): Q66K86, Q6P2R9, Q9UFX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.