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Protein
Submitted name:

BCL2-like 1 isoform 2

Gene

BCL2L1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processApoptosisPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
BCL2-like 1 isoform 2Imported
Submitted name:
BCL2-like 1, isoform CRA_cImported
Submitted name:
cDNA FLJ77105, highly similar to Homo sapiens BCL2-like 1 (BCL2L1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNAImported
Gene namesi
Name:BCL2L1Imported
ORF Names:hCG_38811Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA76.

PTM / Processingi

Proteomic databases

MaxQBiQ5TE63.

Expressioni

Gene expression databases

BgeeiENSG00000171552.
ExpressionAtlasiQ5TE63. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302564.

Structurei

3D structure databases

SMRiQ5TE63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 24BH4_2InterPro annotationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 24BH4PROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOGENOMiHOG000056452.
HOVERGENiHBG004472.

Family and domain databases

InterProiView protein in InterPro
IPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiView protein in Pfam
PF02180. BH4. 1 hit.
PRINTSiPR01864. APOPREGBCLX.
SMARTiView protein in SMART
SM00265. BH4. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS01259. BH3. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TE63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQDTFVE LYGNNAAAES RKGQERFNRW
160 170
FLTGMTVAGV VLLGSLFSRK
Length:170
Mass (Da):18,894
Last modified:May 10, 2005 - v1
Checksum:i75D1FC01EC06AD47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei170Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU177939 mRNA. Translation: ALQ33397.1.
AK290968 mRNA. Translation: BAF83657.1.
CH471077 Genomic DNA. Translation: EAW76427.1.
CH471077 Genomic DNA. Translation: EAW76428.1.
RefSeqiNP_001182.1. NM_001191.3.
UniGeneiHs.516966.
Hs.732176.

Genome annotation databases

GeneIDi598.
UCSCiuc002wwm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU177939 mRNA. Translation: ALQ33397.1.
AK290968 mRNA. Translation: BAF83657.1.
CH471077 Genomic DNA. Translation: EAW76427.1.
CH471077 Genomic DNA. Translation: EAW76428.1.
RefSeqiNP_001182.1. NM_001191.3.
UniGeneiHs.516966.
Hs.732176.

3D structure databases

SMRiQ5TE63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302564.

Proteomic databases

MaxQBiQ5TE63.

Protocols and materials databases

DNASUi598.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi598.
UCSCiuc002wwm.4. human.

Organism-specific databases

CTDi598.
PharmGKBiPA76.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOGENOMiHOG000056452.
HOVERGENiHBG004472.

Miscellaneous databases

ChiTaRSiBCL2L1. human.
GenomeRNAii598.

Gene expression databases

BgeeiENSG00000171552.
ExpressionAtlasiQ5TE63. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiView protein in Pfam
PF02180. BH4. 1 hit.
PRINTSiPR01864. APOPREGBCLX.
SMARTiView protein in SMART
SM00265. BH4. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS01259. BH3. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TE63_HUMAN
AccessioniPrimary (citable) accession number: Q5TE63
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: February 15, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.