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Protein

Protein DDI1 homolog 2

Gene

DDI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33873-MONOMER.

Protein family/group databases

MEROPSiA28.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DDI1 homolog 2
Gene namesi
Name:DDI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24578. DDI2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi84301.
OpenTargetsiENSG00000197312.
PharmGKBiPA142672004.

Polymorphism and mutation databases

BioMutaiDDI2.
DMDMi74746201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002870901 – 399Protein DDI1 homolog 2Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104PhosphothreonineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei150PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5TDH0.
MaxQBiQ5TDH0.
PaxDbiQ5TDH0.
PeptideAtlasiQ5TDH0.
PRIDEiQ5TDH0.

PTM databases

iPTMnetiQ5TDH0.
PhosphoSitePlusiQ5TDH0.

Expressioni

Gene expression databases

BgeeiENSG00000197312.
CleanExiHS_DDI2.
ExpressionAtlasiQ5TDH0. baseline and differential.
GenevisibleiQ5TDH0. HS.

Organism-specific databases

HPAiHPA043119.
HPA043225.

Interactioni

Protein-protein interaction databases

BioGridi124027. 25 interactors.
STRINGi9606.ENSP00000417748.

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 9Combined sources9
Beta strandi15 – 21Combined sources7
Helixi27 – 38Combined sources12
Helixi42 – 44Combined sources3
Beta strandi46 – 49Combined sources4
Helixi61 – 63Combined sources3
Beta strandi71 – 76Combined sources6
Turni129 – 131Combined sources3
Helixi135 – 144Combined sources10
Helixi146 – 155Combined sources10
Helixi157 – 164Combined sources8
Helixi168 – 190Combined sources23
Beta strandi237 – 242Combined sources6
Beta strandi245 – 252Combined sources8
Beta strandi259 – 261Combined sources3
Helixi262 – 267Combined sources6
Helixi271 – 273Combined sources3
Helixi276 – 278Combined sources3
Beta strandi290 – 301Combined sources12
Beta strandi304 – 314Combined sources11
Beta strandi317 – 323Combined sources7
Helixi324 – 329Combined sources6
Beta strandi333 – 335Combined sources3
Turni336 – 339Combined sources4
Beta strandi340 – 342Combined sources3
Turni344 – 346Combined sources3
Beta strandi349 – 351Combined sources3
Helixi355 – 357Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N7DNMR-A1-76[»]
4RGHX-ray1.90A/B212-360[»]
5K57NMR-A116-212[»]
ProteinModelPortaliQ5TDH0.
SMRiQ5TDH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the DDI1 family.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0012. Eukaryota.
ENOG410XPA0. LUCA.
GeneTreeiENSGT00510000047125.
HOGENOMiHOG000234736.
HOVERGENiHBG058638.
InParanoidiQ5TDH0.
KOiK11885.
OMAiHNIEENM.
OrthoDBiEOG091G0CIP.
PhylomeDBiQ5TDH0.
TreeFamiTF333421.

Family and domain databases

CDDicd01796. DDI1_N. 1 hit.
Gene3Di2.40.70.10. 1 hit.
InterProiIPR033882. DDI1_N.
IPR019103. Peptidase_aspartic_DDI1-type.
IPR021109. Peptidase_aspartic_dom.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF09668. Asp_protease. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TDH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLTVYCVRR DLSEVTFSLQ VDADFELHNF RALCELESGI PAAESQIVYA
60 70 80 90 100
ERPLTDNHRS LASYGLKDGD VVILRQKENA DPRPPVQFPN LPRIDFSSIA
110 120 130 140 150
VPGTSSPRQR QPPGTQQSHS SPGEITSSPQ GLDNPALLRD MLLANPHELS
160 170 180 190 200
LLKERNPPLA EALLSGDLEK FSRVLVEQQQ DRARREQERI RLFSADPFDL
210 220 230 240 250
EAQAKIEEDI RQQNIEENMT IAMEEAPESF GQVVMLYINC KVNGHPVKAF
260 270 280 290 300
VDSGAQMTIM SQACAERCNI MRLVDRRWAG IAKGVGTQKI IGRVHLAQVQ
310 320 330 340 350
IEGDFLPCSF SILEEQPMDM LLGLDMLKRH QCSIDLKKNV LVIGTTGSQT
360 370 380 390
TFLPEGELPE CARLAYGAGR EDVRPEEIAD QELAEALQKS AEDAERQKP
Length:399
Mass (Da):44,523
Last modified:December 21, 2004 - v1
Checksum:iD04FCA9ECECCD1D8
GO
Isoform 2 (identifier: Q5TDH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-399: Missing.

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):23,721
Checksum:i6B1027CC287835C6
GO
Isoform 3 (identifier: Q5TDH0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     395-399: ERQKP → GIWDGQTLQYLLLMGKPGKCGLQKG

Show »
Length:419
Mass (Da):46,571
Checksum:iECD977FFB8DD56C9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025297212 – 399Missing in isoform 2. 1 PublicationAdd BLAST188
Alternative sequenceiVSP_025298395 – 399ERQKP → GIWDGQTLQYLLLMGKPGKC GLQKG in isoform 3. Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293006 mRNA. Translation: BAF85695.1.
AL121992 Genomic DNA. Translation: CAI22369.1.
CH471167 Genomic DNA. Translation: EAW51743.1.
BC006011 mRNA. Translation: AAH06011.1.
BN000122 mRNA. Translation: CAD67552.1.
CCDSiCCDS30607.1. [Q5TDH0-1]
RefSeqiNP_115717.3. NM_032341.4. [Q5TDH0-1]
UniGeneiHs.718857.

Genome annotation databases

EnsembliENST00000480945; ENSP00000417748; ENSG00000197312. [Q5TDH0-1]
GeneIDi84301.
KEGGihsa:84301.
UCSCiuc001awz.4. human. [Q5TDH0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293006 mRNA. Translation: BAF85695.1.
AL121992 Genomic DNA. Translation: CAI22369.1.
CH471167 Genomic DNA. Translation: EAW51743.1.
BC006011 mRNA. Translation: AAH06011.1.
BN000122 mRNA. Translation: CAD67552.1.
CCDSiCCDS30607.1. [Q5TDH0-1]
RefSeqiNP_115717.3. NM_032341.4. [Q5TDH0-1]
UniGeneiHs.718857.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N7DNMR-A1-76[»]
4RGHX-ray1.90A/B212-360[»]
5K57NMR-A116-212[»]
ProteinModelPortaliQ5TDH0.
SMRiQ5TDH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124027. 25 interactors.
STRINGi9606.ENSP00000417748.

Protein family/group databases

MEROPSiA28.003.

PTM databases

iPTMnetiQ5TDH0.
PhosphoSitePlusiQ5TDH0.

Polymorphism and mutation databases

BioMutaiDDI2.
DMDMi74746201.

Proteomic databases

EPDiQ5TDH0.
MaxQBiQ5TDH0.
PaxDbiQ5TDH0.
PeptideAtlasiQ5TDH0.
PRIDEiQ5TDH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000480945; ENSP00000417748; ENSG00000197312. [Q5TDH0-1]
GeneIDi84301.
KEGGihsa:84301.
UCSCiuc001awz.4. human. [Q5TDH0-1]

Organism-specific databases

CTDi84301.
DisGeNETi84301.
GeneCardsiDDI2.
HGNCiHGNC:24578. DDI2.
HPAiHPA043119.
HPA043225.
neXtProtiNX_Q5TDH0.
OpenTargetsiENSG00000197312.
PharmGKBiPA142672004.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0012. Eukaryota.
ENOG410XPA0. LUCA.
GeneTreeiENSGT00510000047125.
HOGENOMiHOG000234736.
HOVERGENiHBG058638.
InParanoidiQ5TDH0.
KOiK11885.
OMAiHNIEENM.
OrthoDBiEOG091G0CIP.
PhylomeDBiQ5TDH0.
TreeFamiTF333421.

Enzyme and pathway databases

BioCyciZFISH:G66-33873-MONOMER.

Miscellaneous databases

ChiTaRSiDDI2. human.
GenomeRNAii84301.
PROiQ5TDH0.

Gene expression databases

BgeeiENSG00000197312.
CleanExiHS_DDI2.
ExpressionAtlasiQ5TDH0. baseline and differential.
GenevisibleiQ5TDH0. HS.

Family and domain databases

CDDicd01796. DDI1_N. 1 hit.
Gene3Di2.40.70.10. 1 hit.
InterProiIPR033882. DDI1_N.
IPR019103. Peptidase_aspartic_DDI1-type.
IPR021109. Peptidase_aspartic_dom.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF09668. Asp_protease. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDI2_HUMAN
AccessioniPrimary (citable) accession number: Q5TDH0
Secondary accession number(s): A8KAE1, Q7RTZ0, Q9BRT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.