ID   Q5TDE7_HUMAN            Unreviewed;       259 AA.
AC   Q5TDE7;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   SubName: Full=Ring finger protein 220 {ECO:0000313|Ensembl:ENSP00000388533.2};
DE   Flags: Fragment;
GN   Name=RNF220 {ECO:0000313|Ensembl:ENSP00000388533.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000388533.2, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000388533.2, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA   Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA   Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA   Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA   Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA   Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA   Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA   Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA   Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA   Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA   Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA   Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA   Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA   Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA   Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA   Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA   Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0007829|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000388533.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL122004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL359373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL596225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5TDE7; -.
DR   MassIVE; Q5TDE7; -.
DR   MaxQB; Q5TDE7; -.
DR   PeptideAtlas; Q5TDE7; -.
DR   ProteomicsDB; 65018; -.
DR   Antibodypedia; 32475; 68 antibodies from 15 providers.
DR   Ensembl; ENST00000440132.2; ENSP00000388533.2; ENSG00000187147.19.
DR   UCSC; uc057fui.1; human.
DR   HGNC; HGNC:25552; RNF220.
DR   VEuPathDB; HostDB:ENSG00000187147; -.
DR   GeneTree; ENSGT00390000016573; -.
DR   HOGENOM; CLU_053399_0_0_1; -.
DR   ChiTaRS; RNF220; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000187147; Expressed in C1 segment of cervical spinal cord and 206 other cell types or tissues.
DR   ExpressionAtlas; Q5TDE7; baseline and differential.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031824; RNF220_mid.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13459:SF3; E3 UBIQUITIN-PROTEIN LIGASE RNF220; 1.
DR   PANTHER; PTHR13459; UNCHARACTERIZED; 1.
DR   Pfam; PF15926; RNF220; 1.
DR   Pfam; PF13923; zf-C3HC4_2; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:Q5TDE7,
KW   ECO:0007829|MaxQB:Q5TDE7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          54..159
FT                   /note="E3 ubiquitin-protein ligase RNF220 middle"
FT                   /evidence="ECO:0000259|Pfam:PF15926"
FT   NON_TER         259
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000388533.2"
SQ   SEQUENCE   259 AA;  29305 MW;  A0F41E7A203B68F7 CRC64;
     MPRARSGRRS RGAGGREETF LRVRANRQTR LNARIGKMKR RKQDEGQREG SCMAEDDAVD
     IEHENNNRFE EYEWCGQKRI RATTLLEGGF RGSGFIMCSG KENPDSDADL DVDGDDTLEY
     GKPQYTEADV IPCTGEEPGE AKEREALRGA VLNGGPPSTR ITPEFSKWAS DEMPSTSNGE
     SSKQEAMQKT CKNSDIEKIT EDSAVTTFEA LKARVRELER QLSRGDRYKC LICMDSYSMP
     LTSIQCWHVH CEECWLRTL
//