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Q5TD97

- FHL5_HUMAN

UniProt

Q5TD97 - FHL5_HUMAN

Protein

Four and a half LIM domains protein 5

Gene

FHL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri8 – 3225C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. transcription coactivator activity Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Four and a half LIM domains protein 5
    Short name:
    FHL-5
    Alternative name(s):
    Activator of cAMP-responsive element modulator in testis
    Short name:
    Activator of CREM in testis
    Gene namesi
    Name:FHL5
    Synonyms:ACT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:17371. FHL5.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Nuclei of round and elongated spermatids.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134971720.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Four and a half LIM domains protein 5PRO_0000075742Add
    BLAST

    Proteomic databases

    PaxDbiQ5TD97.
    PRIDEiQ5TD97.

    PTM databases

    PhosphoSiteiQ5TD97.

    Expressioni

    Tissue specificityi

    Testis-specific (at protein level).1 Publication

    Gene expression databases

    BgeeiQ5TD97.
    CleanExiHS_FHL5.
    GenevestigatoriQ5TD97.

    Organism-specific databases

    HPAiHPA045151.

    Interactioni

    Subunit structurei

    Interacts with CREM via the third LIM domain.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Hoxa1P090223EBI-750641,EBI-3957603From a different organism.

    Protein-protein interaction databases

    BioGridi114846. 10 interactions.
    IntActiQ5TD97. 5 interactions.
    MINTiMINT-2812584.
    STRINGi9606.ENSP00000326022.

    Structurei

    Secondary structure

    1
    284
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni223 – 2253
    Turni231 – 2344
    Beta strandi237 – 2404
    Beta strandi243 – 2464
    Helixi247 – 2493
    Turni253 – 2553
    Beta strandi260 – 2623
    Beta strandi264 – 2674
    Beta strandi270 – 2734
    Turni274 – 2774

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X68NMR-A222-284[»]
    ProteinModelPortaliQ5TD97.
    SMRiQ5TD97. Positions 3-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5TD97.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 10062LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini101 – 16060LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini161 – 22060LIM zinc-binding 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini223 – 28361LIM zinc-binding 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 LIM zinc-binding domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri8 – 3225C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    LIM domain, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG314122.
    HOGENOMiHOG000231075.
    HOVERGENiHBG074526.
    InParanoidiQ5TD97.
    OMAiYCVSCYD.
    OrthoDBiEOG7P8P7M.
    PhylomeDBiQ5TD97.
    TreeFamiTF314113.

    Family and domain databases

    Gene3Di2.10.110.10. 5 hits.
    InterProiIPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 4 hits.
    [Graphical view]
    SMARTiSM00132. LIM. 4 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5TD97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTAHFYCQY CTASLLGKKY VLKDDSPYCV TCYDRVFSNY CEECKKPIES    50
    DSKDLCYKDR HWHEGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS 100
    KCFHCKRTIM PGSRKMEFKG NYWHETCFVC ENCRQPIGTK PLISKESGNY 150
    CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ LWHKECFLCS GCRKDLCEEQ 200
    FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF QDSQWHSECF 250
    NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DTDI 284
    Length:284
    Mass (Da):32,720
    Last modified:December 21, 2004 - v1
    Checksum:i82C03B1EAA147C11
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551L → F in AAF85978. (PubMed:11327716)Curated
    Sequence conflicti191 – 1911G → D in AAH21723. (PubMed:15489334)Curated
    Sequence conflicti191 – 1911G → D in AAH29490. (PubMed:15489334)Curated
    Sequence conflicti254 – 2541K → R in AAF85978. (PubMed:11327716)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351R → H.
    Corresponds to variant rs35157931 [ dbSNP | Ensembl ].
    VAR_056160
    Natural varianti204 – 2041R → G.
    Corresponds to variant rs2273621 [ dbSNP | Ensembl ].
    VAR_056161
    Natural varianti211 – 2111V → M.3 Publications
    Corresponds to variant rs2252816 [ dbSNP | Ensembl ].
    VAR_022824
    Natural varianti243 – 2431S → R.
    Corresponds to variant rs9373985 [ dbSNP | Ensembl ].
    VAR_056162

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF278541 mRNA. Translation: AAF85978.1.
    AK057611 mRNA. Translation: BAG51940.1.
    AK223539 mRNA. Translation: BAD97259.1.
    AK314608 mRNA. Translation: BAG37178.1.
    AL132776 Genomic DNA. Translation: CAB86657.1.
    AL132776 Genomic DNA. Translation: CAI20400.1.
    CH471051 Genomic DNA. Translation: EAW48503.1.
    CH471051 Genomic DNA. Translation: EAW48504.1.
    CH471051 Genomic DNA. Translation: EAW48505.1.
    BC021723 mRNA. Translation: AAH21723.1.
    BC029490 mRNA. Translation: AAH29490.1.
    CCDSiCCDS5035.1.
    PIRiJC7686.
    RefSeqiNP_001164278.1. NM_001170807.1.
    NP_065228.4. NM_020482.4.
    XP_006715676.1. XM_006715613.1.
    UniGeneiHs.632608.

    Genome annotation databases

    EnsembliENST00000326771; ENSP00000326022; ENSG00000112214.
    ENST00000541107; ENSP00000442357; ENSG00000112214.
    GeneIDi9457.
    KEGGihsa:9457.
    UCSCiuc003pos.2. human.

    Polymorphism databases

    DMDMi68565455.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF278541 mRNA. Translation: AAF85978.1 .
    AK057611 mRNA. Translation: BAG51940.1 .
    AK223539 mRNA. Translation: BAD97259.1 .
    AK314608 mRNA. Translation: BAG37178.1 .
    AL132776 Genomic DNA. Translation: CAB86657.1 .
    AL132776 Genomic DNA. Translation: CAI20400.1 .
    CH471051 Genomic DNA. Translation: EAW48503.1 .
    CH471051 Genomic DNA. Translation: EAW48504.1 .
    CH471051 Genomic DNA. Translation: EAW48505.1 .
    BC021723 mRNA. Translation: AAH21723.1 .
    BC029490 mRNA. Translation: AAH29490.1 .
    CCDSi CCDS5035.1.
    PIRi JC7686.
    RefSeqi NP_001164278.1. NM_001170807.1.
    NP_065228.4. NM_020482.4.
    XP_006715676.1. XM_006715613.1.
    UniGenei Hs.632608.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X68 NMR - A 222-284 [» ]
    ProteinModelPortali Q5TD97.
    SMRi Q5TD97. Positions 3-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114846. 10 interactions.
    IntActi Q5TD97. 5 interactions.
    MINTi MINT-2812584.
    STRINGi 9606.ENSP00000326022.

    PTM databases

    PhosphoSitei Q5TD97.

    Polymorphism databases

    DMDMi 68565455.

    Proteomic databases

    PaxDbi Q5TD97.
    PRIDEi Q5TD97.

    Protocols and materials databases

    DNASUi 9457.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326771 ; ENSP00000326022 ; ENSG00000112214 .
    ENST00000541107 ; ENSP00000442357 ; ENSG00000112214 .
    GeneIDi 9457.
    KEGGi hsa:9457.
    UCSCi uc003pos.2. human.

    Organism-specific databases

    CTDi 9457.
    GeneCardsi GC06P097056.
    H-InvDB HIX0006080.
    HGNCi HGNC:17371. FHL5.
    HPAi HPA045151.
    MIMi 605126. gene.
    neXtProti NX_Q5TD97.
    PharmGKBi PA134971720.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314122.
    HOGENOMi HOG000231075.
    HOVERGENi HBG074526.
    InParanoidi Q5TD97.
    OMAi YCVSCYD.
    OrthoDBi EOG7P8P7M.
    PhylomeDBi Q5TD97.
    TreeFami TF314113.

    Miscellaneous databases

    EvolutionaryTracei Q5TD97.
    GeneWikii FHL5.
    GenomeRNAii 9457.
    NextBioi 35438.
    PROi Q5TD97.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5TD97.
    CleanExi HS_FHL5.
    Genevestigatori Q5TD97.

    Family and domain databases

    Gene3Di 2.10.110.10. 5 hits.
    InterProi IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 4 hits.
    [Graphical view ]
    SMARTi SM00132. LIM. 4 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-211, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-211.
      Tissue: Trachea.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-211.
      Tissue: Testis.
    7. "Solution structures of the C-terminal LIM domain of human FHL5 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 222-284 IN COMPLEX WITH ZINC IONS.

    Entry informationi

    Entry nameiFHL5_HUMAN
    AccessioniPrimary (citable) accession number: Q5TD97
    Secondary accession number(s): B2RBD1
    , E1P526, Q5TD98, Q8WW21, Q9NQU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3