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Protein

Four and a half LIM domains protein 5

Gene

FHL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ5TD97.

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 5
Short name:
FHL-5
Alternative name(s):
Activator of cAMP-responsive element modulator in testis
Short name:
Activator of CREM in testis
Gene namesi
Name:FHL5
Synonyms:ACT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17371. FHL5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9457.
MalaCardsiFHL5.
OpenTargetsiENSG00000112214.
PharmGKBiPA134971720.

Polymorphism and mutation databases

BioMutaiFHL5.
DMDMi68565455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757421 – 284Four and a half LIM domains protein 5Add BLAST284

Proteomic databases

PaxDbiQ5TD97.
PeptideAtlasiQ5TD97.
PRIDEiQ5TD97.

PTM databases

PhosphoSitePlusiQ5TD97.

Expressioni

Tissue specificityi

Testis-specific (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000112214.
CleanExiHS_FHL5.
ExpressionAtlasiQ5TD97. baseline and differential.
GenevisibleiQ5TD97. HS.

Organism-specific databases

HPAiHPA045151.

Interactioni

Subunit structurei

Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAL4O960154EBI-750641,EBI-742362
Hoxa1P090223EBI-750641,EBI-3957603From a different organism.

Protein-protein interaction databases

BioGridi114846. 19 interactors.
IntActiQ5TD97. 21 interactors.
MINTiMINT-2812584.
STRINGi9606.ENSP00000326022.

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni223 – 225Combined sources3
Turni231 – 234Combined sources4
Beta strandi237 – 240Combined sources4
Beta strandi243 – 246Combined sources4
Helixi247 – 249Combined sources3
Turni253 – 255Combined sources3
Beta strandi260 – 262Combined sources3
Beta strandi264 – 267Combined sources4
Beta strandi270 – 273Combined sources4
Turni274 – 277Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X68NMR-A222-284[»]
ProteinModelPortaliQ5TD97.
SMRiQ5TD97.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5TD97.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 100LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini101 – 160LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini161 – 220LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini223 – 283LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 4 LIM zinc-binding domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ5TD97.
OMAiYCVSCYD.
OrthoDBiEOG091G07C5.
PhylomeDBiQ5TD97.
TreeFamiTF314113.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TD97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAHFYCQY CTASLLGKKY VLKDDSPYCV TCYDRVFSNY CEECKKPIES
60 70 80 90 100
DSKDLCYKDR HWHEGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS
110 120 130 140 150
KCFHCKRTIM PGSRKMEFKG NYWHETCFVC ENCRQPIGTK PLISKESGNY
160 170 180 190 200
CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ LWHKECFLCS GCRKDLCEEQ
210 220 230 240 250
FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF QDSQWHSECF
260 270 280
NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DTDI
Length:284
Mass (Da):32,720
Last modified:December 21, 2004 - v1
Checksum:i82C03B1EAA147C11
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55L → F in AAF85978 (PubMed:11327716).Curated1
Sequence conflicti191G → D in AAH21723 (PubMed:15489334).Curated1
Sequence conflicti191G → D in AAH29490 (PubMed:15489334).Curated1
Sequence conflicti254K → R in AAF85978 (PubMed:11327716).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05616035R → H.Corresponds to variant rs35157931dbSNPEnsembl.1
Natural variantiVAR_056161204R → G.Corresponds to variant rs2273621dbSNPEnsembl.1
Natural variantiVAR_022824211V → M.3 PublicationsCorresponds to variant rs2252816dbSNPEnsembl.1
Natural variantiVAR_056162243S → R.Corresponds to variant rs9373985dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF278541 mRNA. Translation: AAF85978.1.
AK057611 mRNA. Translation: BAG51940.1.
AK223539 mRNA. Translation: BAD97259.1.
AK314608 mRNA. Translation: BAG37178.1.
AL132776 Genomic DNA. Translation: CAB86657.1.
AL132776 Genomic DNA. Translation: CAI20400.1.
CH471051 Genomic DNA. Translation: EAW48503.1.
CH471051 Genomic DNA. Translation: EAW48504.1.
CH471051 Genomic DNA. Translation: EAW48505.1.
BC021723 mRNA. Translation: AAH21723.1.
BC029490 mRNA. Translation: AAH29490.1.
CCDSiCCDS5035.1.
PIRiJC7686.
RefSeqiNP_001164278.1. NM_001170807.2.
NP_001309395.1. NM_001322466.1.
NP_001309396.1. NM_001322467.1.
NP_065228.4. NM_020482.5.
UniGeneiHs.632608.

Genome annotation databases

EnsembliENST00000326771; ENSP00000326022; ENSG00000112214.
ENST00000541107; ENSP00000442357; ENSG00000112214.
GeneIDi9457.
KEGGihsa:9457.
UCSCiuc003pos.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF278541 mRNA. Translation: AAF85978.1.
AK057611 mRNA. Translation: BAG51940.1.
AK223539 mRNA. Translation: BAD97259.1.
AK314608 mRNA. Translation: BAG37178.1.
AL132776 Genomic DNA. Translation: CAB86657.1.
AL132776 Genomic DNA. Translation: CAI20400.1.
CH471051 Genomic DNA. Translation: EAW48503.1.
CH471051 Genomic DNA. Translation: EAW48504.1.
CH471051 Genomic DNA. Translation: EAW48505.1.
BC021723 mRNA. Translation: AAH21723.1.
BC029490 mRNA. Translation: AAH29490.1.
CCDSiCCDS5035.1.
PIRiJC7686.
RefSeqiNP_001164278.1. NM_001170807.2.
NP_001309395.1. NM_001322466.1.
NP_001309396.1. NM_001322467.1.
NP_065228.4. NM_020482.5.
UniGeneiHs.632608.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X68NMR-A222-284[»]
ProteinModelPortaliQ5TD97.
SMRiQ5TD97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114846. 19 interactors.
IntActiQ5TD97. 21 interactors.
MINTiMINT-2812584.
STRINGi9606.ENSP00000326022.

PTM databases

PhosphoSitePlusiQ5TD97.

Polymorphism and mutation databases

BioMutaiFHL5.
DMDMi68565455.

Proteomic databases

PaxDbiQ5TD97.
PeptideAtlasiQ5TD97.
PRIDEiQ5TD97.

Protocols and materials databases

DNASUi9457.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326771; ENSP00000326022; ENSG00000112214.
ENST00000541107; ENSP00000442357; ENSG00000112214.
GeneIDi9457.
KEGGihsa:9457.
UCSCiuc003pos.3. human.

Organism-specific databases

CTDi9457.
DisGeNETi9457.
GeneCardsiFHL5.
H-InvDBHIX0006080.
HGNCiHGNC:17371. FHL5.
HPAiHPA045151.
MalaCardsiFHL5.
MIMi605126. gene.
neXtProtiNX_Q5TD97.
OpenTargetsiENSG00000112214.
PharmGKBiPA134971720.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00760000118910.
HOGENOMiHOG000231075.
HOVERGENiHBG074526.
InParanoidiQ5TD97.
OMAiYCVSCYD.
OrthoDBiEOG091G07C5.
PhylomeDBiQ5TD97.
TreeFamiTF314113.

Enzyme and pathway databases

SIGNORiQ5TD97.

Miscellaneous databases

EvolutionaryTraceiQ5TD97.
GeneWikiiFHL5.
GenomeRNAii9457.
PROiQ5TD97.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112214.
CleanExiHS_FHL5.
ExpressionAtlasiQ5TD97. baseline and differential.
GenevisibleiQ5TD97. HS.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 4 hits.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFHL5_HUMAN
AccessioniPrimary (citable) accession number: Q5TD97
Secondary accession number(s): B2RBD1
, E1P526, Q5TD98, Q8WW21, Q9NQU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.