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Q5TCY1

- TTBK1_HUMAN

UniProt

Q5TCY1 - TTBK1_HUMAN

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Protein
Tau-tubulin kinase 1
Gene
TTBK1, BDTK, KIAA1855
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Divalent cations. Magnesium or, to a lesser extent, manganese, but not calcium or zinc.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631ATP By similarity
Active sitei154 – 1541Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 489ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. substantia nigra development Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ5TCY1.

Names & Taxonomyi

Protein namesi
Recommended name:
Tau-tubulin kinase 1 (EC:2.7.11.1)
Alternative name(s):
Brain-derived tau kinase
Gene namesi
Name:TTBK1
Synonyms:BDTK, KIAA1855
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:19140. TTBK1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866142.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13211321Tau-tubulin kinase 1
PRO_0000234341Add
BLAST

Proteomic databases

PaxDbiQ5TCY1.
PRIDEiQ5TCY1.

PTM databases

PhosphoSiteiQ5TCY1.

Expressioni

Tissue specificityi

Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.1 Publication

Gene expression databases

BgeeiQ5TCY1.
CleanExiHS_TTBK1.
GenevestigatoriQ5TCY1.

Organism-specific databases

HPAiHPA031736.

Interactioni

Protein-protein interaction databases

BioGridi124159. 4 interactions.
STRINGi9606.ENSP00000259750.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni31 – 333
Beta strandi34 – 429
Beta strandi43 – 453
Beta strandi47 – 537
Turni54 – 563
Beta strandi58 – 669
Helixi74 – 8310
Turni84 – 863
Beta strandi93 – 986
Beta strandi100 – 1089
Helixi114 – 1196
Helixi128 – 14720
Helixi157 – 1593
Beta strandi160 – 1623
Turni166 – 1705
Beta strandi172 – 1743
Beta strandi188 – 1903
Helixi203 – 2053
Helixi208 – 2114
Helixi218 – 23417
Turni238 – 2414
Helixi245 – 25410
Helixi257 – 2615
Beta strandi262 – 2643
Helixi268 – 27710
Beta strandi280 – 2823
Helixi286 – 29914
Turni309 – 3113

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BTJX-ray2.16A/B1-313[»]
4BTKX-ray2.00A1-313[»]
4BTMX-ray2.54A/B1-313[»]
4NFMX-ray2.12A14-343[»]
4NFNX-ray1.42A14-320[»]
ProteinModelPortaliQ5TCY1.
SMRiQ5TCY1. Positions 22-314.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 297264Protein kinase
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili685 – 78197 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi733 – 77139Glu-rich
Add
BLAST
Compositional biasi772 – 7776Poly-Ala
Compositional biasi1110 – 11145Poly-Ser
Compositional biasi1197 – 128993Pro-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000154701.
HOVERGENiHBG094095.
InParanoidiQ5TCY1.
KOiK08815.
OMAiFEMNGLP.
OrthoDBiEOG7RFTGM.
PhylomeDBiQ5TCY1.
TreeFamiTF351646.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5TCY1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQCLAAALKD ETNMSGGGEQ ADILPANYVV KDRWKVLKKI GGGGFGEIYE     50
AMDLLTRENV ALKVESAQQP KQVLKMEVAV LKKLQGKDHV CRFIGCGRNE 100
KFNYVVMQLQ GRNLADLRRS QPRGTFTLST TLRLGKQILE SIEAIHSVGF 150
LHRDIKPSNF AMGRLPSTYR KCYMLDFGLA RQYTNTTGDV RPPRNVAGFR 200
GTVRYASVNA HKNREMGRHD DLWSLFYMLV EFAVGQLPWR KIKDKEQVGM 250
IKEKYEHRML LKHMPSEFHL FLDHIASLDY FTKPDYQLIM SVFENSMKER 300
GIAENEAFDW EKAGTDALLS TSTSTPPQQN TRQTAAMFGV VNVTPVPGDL 350
LRENTEDVLQ GEHLSDQENA PPILPGRPSE GLGPSPHLVP HPGGPEAEVW 400
EETDVNRNKL RINIGKSPCV EEEQSRGMGV PSSPVRAPPD SPTTPVRSLR 450
YRRVNSPESE RLSTADGRVE LPERRSRMDL PGSPSRQACS SQPAQMLSVD 500
TGHADRQASG RMDVSASVEQ EALSNAFRSV PLAEEEDFDS KEWVIIDKET 550
ELKDFPPGAE PSTSGTTDEE PEELRPLPEE GEERRRLGAE PTVRPRGRSM 600
QALAEEDLQH LPPQPLPPQL SQGDGRSETS QPPTPGSPSH SPLHSGPRPR 650
RRESDPTGPQ RQVFSVAPPF EVNGLPRAVP LSLPYQDFKR DLSDYRERAR 700
LLNRVRRVGF SHMLLTTPQV PLAPVQPQAN GKEEEEEEEE DEEEEEEDEE 750
EEEEEEEEEE EEEEEEEEEE EAAAAVALGE VLGPRSGSSS EGSERSTDRS 800
QEGAPSTLLA DDQKESRGRA SMADGDLEPE EGSKTLVLVS PGDMKKSPVT 850
AELAPDPDLG TLAALTPQHE RPQPTGSQLD VSEPGTLSSV LKSEPKPPGP 900
GAGLGAGTVT TGVGGVAVTS SPFTKVERTF VHIAEKTHLN VMSSGGQALR 950
SEEFSAGGEL GLELASDGGA VEEGARAPLE NGLALSGLNG AEIEGSALSG 1000
APRETPSEMA TNSLPNGPAL ADGPAPVSPL EPSPEKVATI SPRRHAMPGS 1050
RPRSRIPVLL SEEDTGSEPS GSLSAKERWS KRARPQQDLA RLVMEKRQGR 1100
LLLRLASGAS SSSSEEQRRA SETLSGTGSE EDTPASEPAA ALPRKSGRAA 1150
ATRSRIPRPI GLRMPMPVAA QQPASRSHGA APALDTAITS RLQLQTPPGS 1200
ATAADLRPKQ PPGRGLGPGR AQAGARPPAP RSPRLPASTS AARNASASPR 1250
SQSLSRRESP SPSHQARPGV PPPRGVPPAR AQPDGTPSPG GSKKGPRGKL 1300
QAQRATTKGR AGGAEGRAGA R 1321
Length:1,321
Mass (Da):142,737
Last modified:May 16, 2006 - v2
Checksum:i844FAA1EB7A45DE2
GO
Isoform 2 (identifier: Q5TCY1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     592-672: TVRPRGRSMQ...VFSVAPPFEV → FPLTPALGTP...RFPHSAQPLG
     673-1321: Missing.

Note: No experimental confirmation available.

Show »
Length:621
Mass (Da):69,084
Checksum:i4A99A34F76D7DD59
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti613 – 6131P → L.1 Publication
Corresponds to variant rs34993661 [ dbSNP | Ensembl ].
VAR_041252
Natural varianti623 – 6231G → A.1 Publication
Corresponds to variant rs3800294 [ dbSNP | Ensembl ].
VAR_041253
Natural varianti649 – 6491P → R.1 Publication
Corresponds to variant rs35175743 [ dbSNP | Ensembl ].
VAR_041254
Natural varianti741 – 7411D → E.1 Publication
Corresponds to variant rs56377340 [ dbSNP | Ensembl ].
VAR_041255
Natural varianti744 – 7441E → D.1 Publication
Corresponds to variant rs3800295 [ dbSNP | Ensembl ].
VAR_041256
Natural varianti806 – 8061S → F in a lung large cell carcinoma sample; somatic mutation. 1 Publication
VAR_041257
Natural varianti855 – 8551P → S in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_041258
Natural varianti1145 – 11451K → R.1 Publication
Corresponds to variant rs3800297 [ dbSNP | Ensembl ].
VAR_041259
Natural varianti1184 – 11841L → S.1 Publication
Corresponds to variant rs3800298 [ dbSNP | Ensembl ].
VAR_041260

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5151Missing in isoform 2.
VSP_026497Add
BLAST
Alternative sequencei592 – 67281TVRPR…PPFEV → FPLTPALGTPPSTERVGPHR PTETVGGGQTLGALPPAVQP PATTGVLRVLLLHAGDGALP SPRRRRLLGLLRFPHSAQPL G in isoform 2.
VSP_026498Add
BLAST
Alternative sequencei673 – 1321649Missing in isoform 2.
VSP_026499Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371L → V in BAE78660. 1 Publication
Sequence conflicti402 – 4021E → G in BAD18405. 1 Publication
Sequence conflicti1190 – 11901S → SS in AAH36764. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB218664 mRNA. Translation: BAE78660.1.
AK131217 mRNA. Translation: BAD18405.1.
AL133375 Genomic DNA. Translation: CAI20206.2.
AL133375 Genomic DNA. Translation: CAM28234.1.
AB058758 mRNA. Translation: BAB47484.1.
BC036764 mRNA. Translation: AAH36764.1.
CCDSiCCDS34455.1. [Q5TCY1-1]
RefSeqiNP_115927.1. NM_032538.1. [Q5TCY1-1]
UniGeneiHs.485436.

Genome annotation databases

EnsembliENST00000259750; ENSP00000259750; ENSG00000146216. [Q5TCY1-1]
GeneIDi84630.
KEGGihsa:84630.
UCSCiuc003ouq.1. human. [Q5TCY1-1]

Polymorphism databases

DMDMi97203020.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB218664 mRNA. Translation: BAE78660.1 .
AK131217 mRNA. Translation: BAD18405.1 .
AL133375 Genomic DNA. Translation: CAI20206.2 .
AL133375 Genomic DNA. Translation: CAM28234.1 .
AB058758 mRNA. Translation: BAB47484.1 .
BC036764 mRNA. Translation: AAH36764.1 .
CCDSi CCDS34455.1. [Q5TCY1-1 ]
RefSeqi NP_115927.1. NM_032538.1. [Q5TCY1-1 ]
UniGenei Hs.485436.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BTJ X-ray 2.16 A/B 1-313 [» ]
4BTK X-ray 2.00 A 1-313 [» ]
4BTM X-ray 2.54 A/B 1-313 [» ]
4NFM X-ray 2.12 A 14-343 [» ]
4NFN X-ray 1.42 A 14-320 [» ]
ProteinModelPortali Q5TCY1.
SMRi Q5TCY1. Positions 22-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124159. 4 interactions.
STRINGi 9606.ENSP00000259750.

Chemistry

ChEMBLi CHEMBL1926492.

PTM databases

PhosphoSitei Q5TCY1.

Polymorphism databases

DMDMi 97203020.

Proteomic databases

PaxDbi Q5TCY1.
PRIDEi Q5TCY1.

Protocols and materials databases

DNASUi 84630.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259750 ; ENSP00000259750 ; ENSG00000146216 . [Q5TCY1-1 ]
GeneIDi 84630.
KEGGi hsa:84630.
UCSCi uc003ouq.1. human. [Q5TCY1-1 ]

Organism-specific databases

CTDi 84630.
GeneCardsi GC06P043259.
H-InvDB HIX0005900.
HGNCi HGNC:19140. TTBK1.
HPAi HPA031736.
neXtProti NX_Q5TCY1.
PharmGKBi PA134866142.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000154701.
HOVERGENi HBG094095.
InParanoidi Q5TCY1.
KOi K08815.
OMAi FEMNGLP.
OrthoDBi EOG7RFTGM.
PhylomeDBi Q5TCY1.
TreeFami TF351646.

Enzyme and pathway databases

SignaLinki Q5TCY1.

Miscellaneous databases

GenomeRNAii 84630.
NextBioi 74547.
PROi Q5TCY1.

Gene expression databases

Bgeei Q5TCY1.
CleanExi HS_TTBK1.
Genevestigatori Q5TCY1.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation."
    Sato S., Cerny R.L., Buescher J.L., Ikezu T.
    J. Neurochem. 98:1573-1584(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 52-1321 (ISOFORM 1).
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 979-1321 (ISOFORM 1).
    Tissue: Brain.
  6. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-613; ALA-623; ARG-649; GLU-741; ASP-744; PHE-806; SER-855; ARG-1145 AND SER-1184.

Entry informationi

Entry nameiTTBK1_HUMAN
AccessioniPrimary (citable) accession number: Q5TCY1
Secondary accession number(s): A2A2U5
, Q2L6C6, Q6ZNH0, Q8N444, Q96JH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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