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Q5TCY1

- TTBK1_HUMAN

UniProt

Q5TCY1 - TTBK1_HUMAN

Protein

Tau-tubulin kinase 1

Gene

TTBK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (16 May 2006)
      Previous versions | rss
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    Functioni

    Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.1 Publication

    Cofactori

    Divalent cations. Magnesium or, to a lesser extent, manganese, but not calcium or zinc.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631ATPPROSITE-ProRule annotation
    Active sitei154 – 1541Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 489ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. substantia nigra development Source: UniProt

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ5TCY1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tau-tubulin kinase 1 (EC:2.7.11.1)
    Alternative name(s):
    Brain-derived tau kinase
    Gene namesi
    Name:TTBK1
    Synonyms:BDTK, KIAA1855
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:19140. TTBK1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134866142.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13211321Tau-tubulin kinase 1PRO_0000234341Add
    BLAST

    Proteomic databases

    PaxDbiQ5TCY1.
    PRIDEiQ5TCY1.

    PTM databases

    PhosphoSiteiQ5TCY1.

    Expressioni

    Tissue specificityi

    Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.1 Publication

    Gene expression databases

    BgeeiQ5TCY1.
    CleanExiHS_TTBK1.
    GenevestigatoriQ5TCY1.

    Organism-specific databases

    HPAiHPA031736.

    Interactioni

    Protein-protein interaction databases

    BioGridi124159. 4 interactions.
    STRINGi9606.ENSP00000259750.

    Structurei

    Secondary structure

    1
    1321
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni31 – 333
    Beta strandi34 – 429
    Beta strandi43 – 453
    Beta strandi47 – 537
    Turni54 – 563
    Beta strandi58 – 669
    Helixi74 – 8310
    Turni84 – 863
    Beta strandi93 – 986
    Beta strandi100 – 1089
    Helixi114 – 1196
    Helixi128 – 14720
    Helixi157 – 1593
    Beta strandi160 – 1623
    Turni166 – 1705
    Beta strandi172 – 1743
    Beta strandi188 – 1903
    Helixi203 – 2053
    Helixi208 – 2114
    Helixi218 – 23417
    Turni238 – 2414
    Helixi245 – 25410
    Helixi257 – 2615
    Beta strandi262 – 2643
    Helixi268 – 27710
    Beta strandi280 – 2823
    Helixi286 – 29914
    Turni309 – 3113

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BTJX-ray2.16A/B1-313[»]
    4BTKX-ray2.00A1-313[»]
    4BTMX-ray2.54A/B1-313[»]
    4NFMX-ray2.12A14-343[»]
    4NFNX-ray1.42A14-320[»]
    ProteinModelPortaliQ5TCY1.
    SMRiQ5TCY1. Positions 22-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 297264Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili685 – 78197Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi733 – 77139Glu-richAdd
    BLAST
    Compositional biasi772 – 7776Poly-Ala
    Compositional biasi1110 – 11145Poly-Ser
    Compositional biasi1197 – 128993Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000154701.
    HOVERGENiHBG094095.
    InParanoidiQ5TCY1.
    KOiK08815.
    OMAiFEMNGLP.
    OrthoDBiEOG7RFTGM.
    PhylomeDBiQ5TCY1.
    TreeFamiTF351646.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5TCY1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQCLAAALKD ETNMSGGGEQ ADILPANYVV KDRWKVLKKI GGGGFGEIYE     50
    AMDLLTRENV ALKVESAQQP KQVLKMEVAV LKKLQGKDHV CRFIGCGRNE 100
    KFNYVVMQLQ GRNLADLRRS QPRGTFTLST TLRLGKQILE SIEAIHSVGF 150
    LHRDIKPSNF AMGRLPSTYR KCYMLDFGLA RQYTNTTGDV RPPRNVAGFR 200
    GTVRYASVNA HKNREMGRHD DLWSLFYMLV EFAVGQLPWR KIKDKEQVGM 250
    IKEKYEHRML LKHMPSEFHL FLDHIASLDY FTKPDYQLIM SVFENSMKER 300
    GIAENEAFDW EKAGTDALLS TSTSTPPQQN TRQTAAMFGV VNVTPVPGDL 350
    LRENTEDVLQ GEHLSDQENA PPILPGRPSE GLGPSPHLVP HPGGPEAEVW 400
    EETDVNRNKL RINIGKSPCV EEEQSRGMGV PSSPVRAPPD SPTTPVRSLR 450
    YRRVNSPESE RLSTADGRVE LPERRSRMDL PGSPSRQACS SQPAQMLSVD 500
    TGHADRQASG RMDVSASVEQ EALSNAFRSV PLAEEEDFDS KEWVIIDKET 550
    ELKDFPPGAE PSTSGTTDEE PEELRPLPEE GEERRRLGAE PTVRPRGRSM 600
    QALAEEDLQH LPPQPLPPQL SQGDGRSETS QPPTPGSPSH SPLHSGPRPR 650
    RRESDPTGPQ RQVFSVAPPF EVNGLPRAVP LSLPYQDFKR DLSDYRERAR 700
    LLNRVRRVGF SHMLLTTPQV PLAPVQPQAN GKEEEEEEEE DEEEEEEDEE 750
    EEEEEEEEEE EEEEEEEEEE EAAAAVALGE VLGPRSGSSS EGSERSTDRS 800
    QEGAPSTLLA DDQKESRGRA SMADGDLEPE EGSKTLVLVS PGDMKKSPVT 850
    AELAPDPDLG TLAALTPQHE RPQPTGSQLD VSEPGTLSSV LKSEPKPPGP 900
    GAGLGAGTVT TGVGGVAVTS SPFTKVERTF VHIAEKTHLN VMSSGGQALR 950
    SEEFSAGGEL GLELASDGGA VEEGARAPLE NGLALSGLNG AEIEGSALSG 1000
    APRETPSEMA TNSLPNGPAL ADGPAPVSPL EPSPEKVATI SPRRHAMPGS 1050
    RPRSRIPVLL SEEDTGSEPS GSLSAKERWS KRARPQQDLA RLVMEKRQGR 1100
    LLLRLASGAS SSSSEEQRRA SETLSGTGSE EDTPASEPAA ALPRKSGRAA 1150
    ATRSRIPRPI GLRMPMPVAA QQPASRSHGA APALDTAITS RLQLQTPPGS 1200
    ATAADLRPKQ PPGRGLGPGR AQAGARPPAP RSPRLPASTS AARNASASPR 1250
    SQSLSRRESP SPSHQARPGV PPPRGVPPAR AQPDGTPSPG GSKKGPRGKL 1300
    QAQRATTKGR AGGAEGRAGA R 1321
    Length:1,321
    Mass (Da):142,737
    Last modified:May 16, 2006 - v2
    Checksum:i844FAA1EB7A45DE2
    GO
    Isoform 2 (identifier: Q5TCY1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.
         592-672: TVRPRGRSMQ...VFSVAPPFEV → FPLTPALGTP...RFPHSAQPLG
         673-1321: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:621
    Mass (Da):69,084
    Checksum:i4A99A34F76D7DD59
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371L → V in BAE78660. (PubMed:16923168)Curated
    Sequence conflicti402 – 4021E → G in BAD18405. (PubMed:14702039)Curated
    Sequence conflicti1190 – 11901S → SS in AAH36764. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti613 – 6131P → L.1 Publication
    Corresponds to variant rs34993661 [ dbSNP | Ensembl ].
    VAR_041252
    Natural varianti623 – 6231G → A.1 Publication
    Corresponds to variant rs3800294 [ dbSNP | Ensembl ].
    VAR_041253
    Natural varianti649 – 6491P → R.1 Publication
    Corresponds to variant rs35175743 [ dbSNP | Ensembl ].
    VAR_041254
    Natural varianti741 – 7411D → E.1 Publication
    Corresponds to variant rs56377340 [ dbSNP | Ensembl ].
    VAR_041255
    Natural varianti744 – 7441E → D.1 Publication
    Corresponds to variant rs3800295 [ dbSNP | Ensembl ].
    VAR_041256
    Natural varianti806 – 8061S → F in a lung large cell carcinoma sample; somatic mutation. 1 Publication
    VAR_041257
    Natural varianti855 – 8551P → S in a metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_041258
    Natural varianti1145 – 11451K → R.1 Publication
    Corresponds to variant rs3800297 [ dbSNP | Ensembl ].
    VAR_041259
    Natural varianti1184 – 11841L → S.1 Publication
    Corresponds to variant rs3800298 [ dbSNP | Ensembl ].
    VAR_041260

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5151Missing in isoform 2. 1 PublicationVSP_026497Add
    BLAST
    Alternative sequencei592 – 67281TVRPR…PPFEV → FPLTPALGTPPSTERVGPHR PTETVGGGQTLGALPPAVQP PATTGVLRVLLLHAGDGALP SPRRRRLLGLLRFPHSAQPL G in isoform 2. 1 PublicationVSP_026498Add
    BLAST
    Alternative sequencei673 – 1321649Missing in isoform 2. 1 PublicationVSP_026499Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB218664 mRNA. Translation: BAE78660.1.
    AK131217 mRNA. Translation: BAD18405.1.
    AL133375 Genomic DNA. Translation: CAI20206.2.
    AL133375 Genomic DNA. Translation: CAM28234.1.
    AB058758 mRNA. Translation: BAB47484.1.
    BC036764 mRNA. Translation: AAH36764.1.
    CCDSiCCDS34455.1. [Q5TCY1-1]
    RefSeqiNP_115927.1. NM_032538.1. [Q5TCY1-1]
    UniGeneiHs.485436.

    Genome annotation databases

    EnsembliENST00000259750; ENSP00000259750; ENSG00000146216. [Q5TCY1-1]
    GeneIDi84630.
    KEGGihsa:84630.
    UCSCiuc003ouq.1. human. [Q5TCY1-1]

    Polymorphism databases

    DMDMi97203020.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB218664 mRNA. Translation: BAE78660.1 .
    AK131217 mRNA. Translation: BAD18405.1 .
    AL133375 Genomic DNA. Translation: CAI20206.2 .
    AL133375 Genomic DNA. Translation: CAM28234.1 .
    AB058758 mRNA. Translation: BAB47484.1 .
    BC036764 mRNA. Translation: AAH36764.1 .
    CCDSi CCDS34455.1. [Q5TCY1-1 ]
    RefSeqi NP_115927.1. NM_032538.1. [Q5TCY1-1 ]
    UniGenei Hs.485436.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BTJ X-ray 2.16 A/B 1-313 [» ]
    4BTK X-ray 2.00 A 1-313 [» ]
    4BTM X-ray 2.54 A/B 1-313 [» ]
    4NFM X-ray 2.12 A 14-343 [» ]
    4NFN X-ray 1.42 A 14-320 [» ]
    ProteinModelPortali Q5TCY1.
    SMRi Q5TCY1. Positions 22-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124159. 4 interactions.
    STRINGi 9606.ENSP00000259750.

    Chemistry

    ChEMBLi CHEMBL1926492.

    PTM databases

    PhosphoSitei Q5TCY1.

    Polymorphism databases

    DMDMi 97203020.

    Proteomic databases

    PaxDbi Q5TCY1.
    PRIDEi Q5TCY1.

    Protocols and materials databases

    DNASUi 84630.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259750 ; ENSP00000259750 ; ENSG00000146216 . [Q5TCY1-1 ]
    GeneIDi 84630.
    KEGGi hsa:84630.
    UCSCi uc003ouq.1. human. [Q5TCY1-1 ]

    Organism-specific databases

    CTDi 84630.
    GeneCardsi GC06P043259.
    H-InvDB HIX0005900.
    HGNCi HGNC:19140. TTBK1.
    HPAi HPA031736.
    neXtProti NX_Q5TCY1.
    PharmGKBi PA134866142.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000154701.
    HOVERGENi HBG094095.
    InParanoidi Q5TCY1.
    KOi K08815.
    OMAi FEMNGLP.
    OrthoDBi EOG7RFTGM.
    PhylomeDBi Q5TCY1.
    TreeFami TF351646.

    Enzyme and pathway databases

    SignaLinki Q5TCY1.

    Miscellaneous databases

    GenomeRNAii 84630.
    NextBioi 74547.
    PROi Q5TCY1.

    Gene expression databases

    Bgeei Q5TCY1.
    CleanExi HS_TTBK1.
    Genevestigatori Q5TCY1.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation."
      Sato S., Cerny R.L., Buescher J.L., Ikezu T.
      J. Neurochem. 98:1573-1584(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, COFACTOR, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 52-1321 (ISOFORM 1).
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 979-1321 (ISOFORM 1).
      Tissue: Brain.
    6. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-613; ALA-623; ARG-649; GLU-741; ASP-744; PHE-806; SER-855; ARG-1145 AND SER-1184.

    Entry informationi

    Entry nameiTTBK1_HUMAN
    AccessioniPrimary (citable) accession number: Q5TCY1
    Secondary accession number(s): A2A2U5
    , Q2L6C6, Q6ZNH0, Q8N444, Q96JH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3