Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5TCX8

- M3KL4_HUMAN

UniProt

Q5TCX8 - M3KL4_HUMAN

Protein

Mitogen-activated protein kinase kinase kinase MLK4

Gene

MLK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.Curated

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei151 – 1511ATPBy similarityPROSITE-ProRule annotation
    Active sitei263 – 2631Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi130 – 1389ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase kinase activity Source: UniProtKB-EC
    3. protein homodimerization activity Source: UniProtKB
    4. protein tyrosine kinase activity Source: InterPro

    GO - Biological processi

    1. activation of JUN kinase activity Source: UniProtKB
    2. protein autophosphorylation Source: UniProtKB
    3. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase kinase kinase MLK4 (EC:2.7.11.25)
    Alternative name(s):
    Mixed lineage kinase 4
    Gene namesi
    Name:MLK41 Publication
    Synonyms:KIAA1804Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10361036Mitogen-activated protein kinase kinase kinase MLK4PRO_0000086268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei299 – 2991Phosphothreonine; by autocatalysisBy similarity
    Modified residuei303 – 3031Phosphoserine; by autocatalysis and MAP4K1By similarity
    Modified residuei528 – 5281Phosphoserine3 Publications
    Modified residuei592 – 5921Phosphothreonine1 Publication
    Modified residuei614 – 6141Phosphoserine2 Publications

    Post-translational modificationi

    Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5TCX8.
    PaxDbiQ5TCX8.
    PRIDEiQ5TCX8.

    PTM databases

    PhosphoSiteiQ5TCX8.

    Expressioni

    Gene expression databases

    BgeeiQ5TCX8.
    GenevestigatoriQ5TCX8.

    Organism-specific databases

    HPAiHPA007636.

    Interactioni

    Subunit structurei

    Homodimer By similarity. Interacts with TLR4.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi124089. 2 interactions.
    IntActiQ5TCX8. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TCX8.
    SMRiQ5TCX8. Positions 42-99, 117-473.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 10265SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini124 – 401278Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni425 – 44622Leucine-zipper 1Add
    BLAST
    Regioni460 – 48122Leucine-zipper 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 3723Ser-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG067662.
    InParanoidiQ5TCX8.
    KOiK17534.
    OMAiCEEPKLS.
    PhylomeDBiQ5TCX8.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR016231. MAPKKK9/10/11.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR001452. SH3_domain.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000556. MAPKKK9_11. 1 hit.
    PRINTSiPR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q5TCX8-1) [UniParc]FASTAAdd to Basket

    Also known as: MLK4beta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALRGAAGAT DTPVSSAGGA PGGSASSSST SSGGSASAGA GLWAALYDYE     50
    ARGEDELSLR RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC 100
    RPAASPAPPP SRPSSPVHVA FERLELKELI GAGGFGQVYR ATWQGQEVAV 150
    KAARQDPEQD AAAAAESVRR EARLFAMLRH PNIIELRGVC LQQPHLCLVL 200
    EFARGGALNR ALAAANAAPD PRAPGPRRAR RIPPHVLVNW AVQIARGMLY 250
    LHEEAFVPIL HRDLKSSNIL LLEKIEHDDI CNKTLKITDF GLAREWHRTT 300
    KMSTAGTYAW MAPEVIKSSL FSKGSDIWSY GVLLWELLTG EVPYRGIDGL 350
    AVAYGVAVNK LTLPIPSTCP EPFAKLMKEC WQQDPHIRPS FALILEQLTA 400
    IEGAVMTEMP QESFHSMQDD WKLEIQQMFD ELRTKEKELR SREEELTRAA 450
    LQQKSQEELL KRREQQLAER EIDVLERELN ILIFQLNQEK PKVKKRKGKF 500
    KRSRLKLKDG HRISLPSDFQ HKITVQASPN LDKRRSLNSS SSSPPSSPTM 550
    MPRLRAIQLT SDESNKTWGR NTVFRQEEFE DVKRNFKKKG CTWGPNSIQM 600
    KDRTDCKERI RPLSDGNSPW STILIKNQKT MPLASLFVDQ PGSCEEPKLS 650
    PDGLEHRKPK QIKLPSQAYI DLPLGKDAQR ENPAEAESWE EAASANAATV 700
    SIEMTPTNSL SRSPQRKKTE SALYGCTVLL ASVALGLDLR ELHKAQAAEE 750
    PLPKEEKKKR EGIFQRASKS RRSASPPTSL PSTCGEASSP PSLPLSSALG 800
    ILSTPSFSTK CLLQMDSEDP LVDSAPVTCD SEMLTPDFCP TAPGSGREPA 850
    LMPRLDTDCS VSRNLPSSFL QQTCGNVPYC ASSKHRPSHH RRTMSDGNPT 900
    PTGATIISAT GASALPLCPS PAPHSHLPRE VSPKKHSTVH IVPQRRPASL 950
    RSRSDLPQAY PQTAVSQLAQ TACVVGRPGP HPTQFLAAKE RTKSHVPSLL 1000
    DADVEGQSRD YTVPLCRMRS KTSRPSIYEL EKEFLS 1036
    Length:1,036
    Mass (Da):113,957
    Last modified:December 21, 2004 - v1
    Checksum:i2520984802143069
    GO
    Isoform 21 Publication (identifier: Q5TCX8-2) [UniParc]FASTAAdd to Basket

    Also known as: MLK4alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         559-570: LTSDESNKTWGR → CELSALPRGLLC
         571-1036: Missing.

    Show »
    Length:570
    Mass (Da):63,040
    Checksum:i7D8A39D60DBA84F9
    GO
    Isoform 3 (identifier: Q5TCX8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-554: Missing.
         555-559: RAIQL → MFFLVT

    Note: No experimental confirmation available.Curated

    Show »
    Length:483
    Mass (Da):52,817
    Checksum:iB38F2AB9CBA7A614
    GO

    Sequence cautioni

    The sequence BAB47433.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti274 – 2741K → E in CAC84639. 1 PublicationCurated
    Sequence conflicti274 – 2741K → E in CAC84640. 1 PublicationCurated
    Sequence conflicti330 – 3301Y → C in CAC84639. 1 PublicationCurated
    Sequence conflicti330 – 3301Y → C in CAC84640. 1 PublicationCurated
    Sequence conflicti687 – 6871E → G in CAC84640. 1 PublicationCurated
    Sequence conflicti701 – 7011S → T in CAC84640. 1 PublicationCurated
    Sequence conflicti705 – 7051T → A in CAC84640. 1 PublicationCurated
    Sequence conflicti781 – 7811P → S in CAC84640. 1 PublicationCurated
    Sequence conflicti872 – 8721Q → R in CAC84640. 1 PublicationCurated
    Sequence conflicti1002 – 10021A → V in CAC84640. 1 PublicationCurated
    Sequence conflicti1016 – 10161C → G in CAC84640. 1 PublicationCurated
    Isoform 21 Publication (identifier: Q5TCX8-2)
    Sequence conflicti566 – 5661R → P in CAC84639. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti420 – 4201D → N.1 Publication
    Corresponds to variant rs35465006 [ dbSNP | Ensembl ].
    VAR_040729
    Natural varianti563 – 5631E → D.1 Publication
    Corresponds to variant rs35758282 [ dbSNP | Ensembl ].
    VAR_040730
    Natural varianti597 – 5971S → F.1 Publication
    Corresponds to variant rs34984140 [ dbSNP | Ensembl ].
    VAR_040731
    Natural varianti728 – 7281V → I.1 Publication
    Corresponds to variant rs3795375 [ dbSNP | Ensembl ].
    VAR_040732
    Natural varianti741 – 7411E → D.1 Publication
    Corresponds to variant rs3795374 [ dbSNP | Ensembl ].
    VAR_040733
    Natural varianti784 – 7841C → G.1 Publication
    Corresponds to variant rs963981 [ dbSNP | Ensembl ].
    VAR_040734
    Natural varianti892 – 8921R → W.1 Publication
    Corresponds to variant rs55681416 [ dbSNP | Ensembl ].
    VAR_040735
    Natural varianti900 – 9001T → I.1 Publication
    Corresponds to variant rs34499091 [ dbSNP | Ensembl ].
    VAR_040736
    Natural varianti977 – 9771R → C.1 Publication
    Corresponds to variant rs56065162 [ dbSNP | Ensembl ].
    VAR_040737
    Natural varianti982 – 9821P → L.1 Publication
    Corresponds to variant rs34794284 [ dbSNP | Ensembl ].
    VAR_040738

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 554554Missing in isoform 3. 1 PublicationVSP_051731Add
    BLAST
    Alternative sequencei555 – 5595RAIQL → MFFLVT in isoform 3. 1 PublicationVSP_051732
    Alternative sequencei559 – 57012LTSDE…KTWGR → CELSALPRGLLC in isoform 2. 1 PublicationVSP_051733Add
    BLAST
    Alternative sequencei571 – 1036466Missing in isoform 2. 1 PublicationVSP_051734Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311797 mRNA. Translation: CAC84639.1.
    AJ311798 mRNA. Translation: CAC84640.1.
    AB058707 mRNA. Translation: BAB47433.1. Different initiation.
    AL133380 Genomic DNA. Translation: CAI23045.1.
    AL133380 Genomic DNA. Translation: CAI23046.1.
    AL133380 Genomic DNA. Translation: CAI23047.1.
    CH471098 Genomic DNA. Translation: EAW69988.1.
    BC136648 mRNA. Translation: AAI36649.1.
    BC136649 mRNA. Translation: AAI36650.1.
    CCDSiCCDS1598.1. [Q5TCX8-1]
    RefSeqiNP_115811.2. NM_032435.2. [Q5TCX8-1]
    UniGeneiHs.547779.

    Genome annotation databases

    GeneIDi84451.
    KEGGihsa:84451.
    UCSCiuc001hvs.1. human. [Q5TCX8-2]
    uc001hvt.4. human. [Q5TCX8-1]
    uc001hvu.4. human. [Q5TCX8-3]

    Polymorphism databases

    DMDMi71153820.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311797 mRNA. Translation: CAC84639.1 .
    AJ311798 mRNA. Translation: CAC84640.1 .
    AB058707 mRNA. Translation: BAB47433.1 . Different initiation.
    AL133380 Genomic DNA. Translation: CAI23045.1 .
    AL133380 Genomic DNA. Translation: CAI23046.1 .
    AL133380 Genomic DNA. Translation: CAI23047.1 .
    CH471098 Genomic DNA. Translation: EAW69988.1 .
    BC136648 mRNA. Translation: AAI36649.1 .
    BC136649 mRNA. Translation: AAI36650.1 .
    CCDSi CCDS1598.1. [Q5TCX8-1 ]
    RefSeqi NP_115811.2. NM_032435.2. [Q5TCX8-1 ]
    UniGenei Hs.547779.

    3D structure databases

    ProteinModelPortali Q5TCX8.
    SMRi Q5TCX8. Positions 42-99, 117-473.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124089. 2 interactions.
    IntActi Q5TCX8. 2 interactions.

    PTM databases

    PhosphoSitei Q5TCX8.

    Polymorphism databases

    DMDMi 71153820.

    Proteomic databases

    MaxQBi Q5TCX8.
    PaxDbi Q5TCX8.
    PRIDEi Q5TCX8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 84451.
    KEGGi hsa:84451.
    UCSCi uc001hvs.1. human. [Q5TCX8-2 ]
    uc001hvt.4. human. [Q5TCX8-1 ]
    uc001hvu.4. human. [Q5TCX8-3 ]

    Organism-specific databases

    CTDi 84451.
    GeneCardsi GC01P233463.
    H-InvDB HIX0001705.
    HPAi HPA007636.
    MIMi 614793. gene.
    neXtProti NX_Q5TCX8.
    HUGEi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG067662.
    InParanoidi Q5TCX8.
    KOi K17534.
    OMAi CEEPKLS.
    PhylomeDBi Q5TCX8.

    Miscellaneous databases

    GenomeRNAii 84451.
    NextBioi 74235.
    PROi Q5TCX8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5TCX8.
    Genevestigatori Q5TCX8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR016231. MAPKKK9/10/11.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR001452. SH3_domain.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000556. MAPKKK9_11. 1 hit.
    PRINTSi PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MLK4, a new member of mixed lineage kinases."
      Kvasha S., Protopopov A., Rynditch A., Zabarovsky E., Kashuba V.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: HeartImported.
    2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: BrainImported.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-528, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-528; THR-592 AND SER-614, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-528, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "MLK4 has negative effect on TLR4 signaling."
      Seit-Nebi A., Cheng W., Xu H., Han J.
      Cell. Mol. Immunol. 9:27-33(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TLR4.
    12. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-420; ASP-563; PHE-597; ILE-728; ASP-741; GLY-784; TRP-892; ILE-900; CYS-977 AND LEU-982.

    Entry informationi

    Entry nameiM3KL4_HUMAN
    AccessioniPrimary (citable) accession number: Q5TCX8
    Secondary accession number(s): B2RN34
    , Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3