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Protein

Adenylate kinase 9

Gene

AK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.1 Publication

Catalytic activityi

ATP + nucleoside phosphate = ADP + nucleoside diphosphate.1 Publication
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.1 Publication

Kineticsi

  1. KM=48 µM for AMP (with ATP as phosphate donor)1 Publication
  2. KM=3600 µM for dAMP (with ATP as phosphate donor)1 Publication
  3. KM=940 µM for CMP (with ATP as phosphate donor)1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291AMP 1By similarity
    Binding sitei1447 – 14471AMP 3By similarity
    Binding sitei1506 – 15061AMP 3By similarity
    Binding sitei1543 – 15431AMP 3By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 456ATP 1By similarity
    Nucleotide bindingi87 – 893AMP 1By similarity
    Nucleotide bindingi116 – 1194AMP 1By similarity
    Nucleotide bindingi1001 – 10066ATP 2By similarity
    Nucleotide bindingi1050 – 10523AMP 2By similarity
    Nucleotide bindingi1079 – 10824AMP 2By similarity
    Nucleotide bindingi1421 – 14266ATP 3By similarity
    Nucleotide bindingi1470 – 14723AMP 3By similarity
    Nucleotide bindingi1499 – 15024AMP 3By similarity

    GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • nucleoside diphosphate kinase activity Source: UniProtKB
    • nucleoside phosphate kinase activity Source: UniProtKB

    GO - Biological processi

    • AMP phosphorylation Source: UniProtKB
    • ATP generation from ADP Source: UniProtKB
    • CDP phosphorylation Source: UniProtKB
    • CMP phosphorylation Source: UniProtKB
    • dADP phosphorylation Source: UniProtKB
    • dAMP phosphorylation Source: UniProtKB
    • dCDP phosphorylation Source: UniProtKB
    • dCMP phosphorylation Source: UniProtKB
    • dGDP phosphorylation Source: UniProtKB
    • GDP phosphorylation Source: UniProtKB
    • nucleobase-containing small molecule interconversion Source: Reactome
    • nucleobase-containing small molecule metabolic process Source: Reactome
    • small molecule metabolic process Source: Reactome
    • TDP phosphorylation Source: UniProtKB
    • UDP phosphorylation Source: UniProtKB
    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiR-HSA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate kinase 9 (EC:2.7.4.4, EC:2.7.4.6)
    Short name:
    AK 9
    Alternative name(s):
    Adenylate kinase domain-containing protein 1
    Adenylate kinase domain-containing protein 2
    Gene namesi
    Name:AK9
    Synonyms:AKD1, AKD2, C6orf199, C6orf224
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:33814. AK9.

    Subcellular locationi

    GO - Cellular componenti

    • cytoplasm Source: UniProtKB
    • cytosol Source: Reactome
    • nuclear membrane Source: HPA
    • nucleoplasm Source: HPA
    • nucleus Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162380441.
    PA164715271.

    Polymorphism and mutation databases

    BioMutaiAK9.
    DMDMi302393675.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19111911Adenylate kinase 9PRO_0000304138Add
    BLAST

    Post-translational modificationi

    Isoform 1 is phosphorylated on Ser-724.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    EPDiQ5TCS8.
    PaxDbiQ5TCS8.
    PRIDEiQ5TCS8.

    PTM databases

    PhosphoSiteiQ5TCS8.

    Expressioni

    Gene expression databases

    BgeeiQ5TCS8.
    CleanExiHS_C6orf199.
    ExpressionAtlasiQ5TCS8. baseline and differential.
    GenevisibleiQ5TCS8. HS.

    Organism-specific databases

    HPAiHPA030804.
    HPA030805.
    HPA031779.
    HPA031781.
    HPA036324.
    HPA036711.

    Interactioni

    Protein-protein interaction databases

    BioGridi128702. 10 interactions.
    IntActiQ5TCS8. 2 interactions.
    MINTiMINT-1369939.
    STRINGi9606.ENSP00000410186.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TCS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni31 – 285255Adenylate kinase 1CuratedAdd
    BLAST
    Regioni60 – 8930NMPbind 1By similarityAdd
    BLAST
    Regioni160 – 20546LID 1By similarityAdd
    BLAST
    Regioni992 – 1203212Adenylate kinase 2CuratedAdd
    BLAST
    Regioni1021 – 105232NMPbind 2By similarityAdd
    BLAST
    Regioni1124 – 114421LID 2By similarityAdd
    BLAST
    Regioni1412 – 1601190Adenylate kinase 3CuratedAdd
    BLAST
    Regioni1441 – 147232NMPbind 3By similarityAdd
    BLAST
    Regioni1536 – 155015LID 3By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili443 – 48543Sequence analysisAdd
    BLAST
    Coiled coili676 – 71136Sequence analysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi198 – 27578Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylate kinase family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiKOG3078. Eukaryota.
    KOG3079. Eukaryota.
    COG0563. LUCA.
    GeneTreeiENSGT00740000115564.
    HOVERGENiHBG107661.
    InParanoidiQ5TCS8.
    KOiK18533.
    OMAiYPVIHRQ.
    PhylomeDBiQ5TCS8.
    TreeFamiTF330805.

    Family and domain databases

    Gene3Di3.40.50.300. 8 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR000850. Adenylat/UMP-CMP_kin.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR23359. PTHR23359. 3 hits.
    SMARTiSM00382. AAA. 3 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 11 hits.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 4 (identifier: Q5TCS8-4) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI
    60 70 80 90 100
    TQAWKCIRVE ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE
    110 120 130 140 150
    KLNSPEVCHF GYIITEIPSL SQDAMTTLQQ IELIKNLNLK PDVIINIKCP
    160 170 180 190 200
    DYDLCQRISG QRQHNNTGYI YSRDQWDPEV IENHRKKKKE AQKDGKGEEE
    210 220 230 240 250
    EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI VKLYKETILQ
    260 270 280 290 300
    TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG
    310 320 330 340 350
    AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS
    360 370 380 390 400
    GLPDYSVSFL GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ
    410 420 430 440 450
    YSGKTTLCNM LAENYKGKVV DYAQLVQPRF DKARETLVEN TIAEATAAAI
    460 470 480 490 500
    KVVKEKLLRE LQARKQAETA LREFQRQYEK MEFGVFPMEA THSSIDEEGY
    510 520 530 540 550
    IQGSQRDRGS SLVDTEEAKT KSENVLHDQA AKVDKDDGKE TGETFTFKRH
    560 570 580 590 600
    SQDASQDVKL YSDTAPTEDL IEEVTADHPE VVTMIEETIK MSQDINFEQP
    610 620 630 640 650
    YEKHAEILQE VLGEVMEENK DRFPGAPKYG GWIVDNCPIV KELWMALIKK
    660 670 680 690 700
    GIIPDLVIYL SDTENNGKCL FNRIYLQKKS EIDSKILERL LEELQKKKKE
    710 720 730 740 750
    EEEARKATEE ELRLEEENRR LLELMKVKAK EAEETDNEDE EEIEGDELEV
    760 770 780 790 800
    HEEPEASHDT RGSWLPEEFE ASEVPETEPE AVSEPIEETT VETEIPKGSK
    810 820 830 840 850
    EGLEIEKLSE TVVLPEFPED SYPDVPEMEP FKEKIGSFII LWKQLEATIS
    860 870 880 890 900
    EAYIKILNLE IADRTPQELL QKVVETMEKP FQYTAWELTG EDYEEETEDY
    910 920 930 940 950
    QTEAEVDEEL EEEEEEEGED KMKERKRHLG DTKHFCPVVL KENFILQPGN
    960 970 980 990 1000
    TEEAAKYREK IYYFSSAEAK EKFLEHPEDY VAHEEPLKAP PLRICLVGPQ
    1010 1020 1030 1040 1050
    GSGKTMCGRQ LAEKLNIFHI QFEEVLQEKL LLKTEKKVGP EFEEDSENEQ
    1060 1070 1080 1090 1100
    AAKQELEELA IQANVKVEEE NTKKQLPEVQ LTEEEEVIKS SLMENEPLPP
    1110 1120 1130 1140 1150
    EILEVILSEW WLKEPIRSTG FILDGFPRYP EEAQFLGDRG FFPDAAVFIQ
    1160 1170 1180 1190 1200
    VDDQDIFDRL LPAQIEKWKL KQKKKLERKK LIKDMKAKIR VDTIAKRRAE
    1210 1220 1230 1240 1250
    LILERDKKRR ENVVRDDEEI SEEELEEDND DIENILEDEF PKDEEEMSGE
    1260 1270 1280 1290 1300
    EDEEQETDAI ERLRGELGEK FEADTHNLQI IQDELERYLI PIISINGARR
    1310 1320 1330 1340 1350
    NHIVQYTLNM KLKPLVENRA SIFEKCHPIP APLAQKMLTF TYKYISSFGY
    1360 1370 1380 1390 1400
    WDPVKLSEGE TIKPVENAEN PIYPVIHRQY IYFLSSKETK EKFMKNPIKY
    1410 1420 1430 1440 1450
    IRQPKPKPTV PIRIIIVGPP KSGKTTVAKK ITSEYGLKHL SIGGALRYVL
    1460 1470 1480 1490 1500
    NNHPETELAL MLNWHLHKGM TAPDELAIQA LELSLMESVC NTAGVVIDGY
    1510 1520 1530 1540 1550
    PVTKHQMNLL EARSIIPMVI FELSVPSKEI FKRLLLEKEN EQRLPYPLHN
    1560 1570 1580 1590 1600
    SAQIVAVNNV KYRKNIGEIR QYYQEQHQNW YVIDGFHSKW WVWNEVIKNV
    1610 1620 1630 1640 1650
    QMVNKYMQTY LERIKAGKAA CIDKLCITPQ ELLSRLGEFE QFCPVSLAES
    1660 1670 1680 1690 1700
    QELFDCSATD SLEFAAEFRG HYYKMSSQEK LNKFLENPEL YVPPLAPHPL
    1710 1720 1730 1740 1750
    PSADMIPKRL TLSELKSRFP KCAELQGYCP VTYKDGNQRY EALVPGSINY
    1760 1770 1780 1790 1800
    ALEYHNRIYI CENKEKLQKF LRSPLKYWEQ KLPHKLPPLR EPILLTSLPL
    1810 1820 1830 1840 1850
    PGYLEQGIAT SLIKAMNAAG CLKPKFPFLS IRRSALLYIA LHLKAFNPKG
    1860 1870 1880 1890 1900
    SEYTRKKYKK KMEQFMESCE LITYLGAKMT RKYKEPQFRA IDFDHKLKTF
    1910
    LSLRNIDPIN G
    Length:1,911
    Mass (Da):221,413
    Last modified:August 10, 2010 - v2
    Checksum:i16A1888E727C51A4
    GO
    Isoform 1 (identifier: Q5TCS8-1) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         703-751: EARKATEEEL...EIEGDELEVH → KSHRRGIETR...CYCKQLQYFK
         752-1911: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:751
    Mass (Da):86,644
    Checksum:i5154893EA585590F
    GO
    Isoform 2 (identifier: Q5TCS8-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         420-421: VD → TN
         422-1911: Missing.

    Show »
    Length:421
    Mass (Da):48,501
    Checksum:i18B996C20324D892
    GO
    Isoform 3 (identifier: Q5TCS8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         989-1014: APPLRICLVGPQGSGKTMCGRQLAEK → VRQYSYLNDCSHRIFLGLITNHHQFT
         1015-1911: Missing.

    Show »
    Length:1,014
    Mass (Da):117,361
    Checksum:iA8A3319DC3635FA1
    GO
    Isoform 5 (identifier: Q5TCS8-5) [UniParc] [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-921: Missing.
         1212-1257: NVVRDDEEIS...SGEEDEEQET → VSSFVFFFKT...GSSHLSLSKC
         1258-1911: Missing.

    Show »
    Length:336
    Mass (Da):39,019
    Checksum:i5FB4ED6C265E1CFE
    GO
    Isoform 6 (identifier: Q5TCS8-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1212-1283: NVVRDDEEIS...DTHNLQIIQD → PNKEKRKRGI...LSKQNIHNQK
         1284-1911: Missing.

    Show »
    Length:1,283
    Mass (Da):148,193
    Checksum:i7A51010EC1323CE3
    GO

    Sequence cautioni

    The sequence AAI01715.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence AAI11949.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence BAC05368.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti222 – 2221I → T in BAB70945 (PubMed:14702039).Curated
    Sequence conflicti1716 – 17161K → R in BAC05368 (PubMed:14702039).Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 921921Missing in isoform 5. 1 PublicationVSP_039638Add
    BLAST
    Alternative sequencei420 – 4212VD → TN in isoform 2. 2 PublicationsVSP_028008
    Alternative sequencei422 – 19111490Missing in isoform 2. 2 PublicationsVSP_028009Add
    BLAST
    Alternative sequencei703 – 75149EARKA…ELEVH → KSHRRGIETRRRKSKATGTY ESEGKRQAQIAMTDDVSWYC YCKQLQYFK in isoform 1. CuratedVSP_039639Add
    BLAST
    Alternative sequencei752 – 19111160Missing in isoform 1. CuratedVSP_039640Add
    BLAST
    Alternative sequencei989 – 101426APPLR…QLAEK → VRQYSYLNDCSHRIFLGLIT NHHQFT in isoform 3. 1 PublicationVSP_028010Add
    BLAST
    Alternative sequencei1015 – 1911897Missing in isoform 3. 1 PublicationVSP_028011Add
    BLAST
    Alternative sequencei1212 – 128372NVVRD…QIIQD → PNKEKRKRGISENTTCYKCN HMSPWCEYAGLPYRGLLILY SATATATAGTKHCRSGAKVI VALSKQNIHNQK in isoform 6. 1 PublicationVSP_039641Add
    BLAST
    Alternative sequencei1212 – 125746NVVRD…EEQET → VSSFVFFFKTGSHSVAQGRV QWHNHSSLQPRTPGLKGSSH LSLSKC in isoform 5. 1 PublicationVSP_039642Add
    BLAST
    Alternative sequencei1258 – 1911654Missing in isoform 5. 1 PublicationVSP_039643Add
    BLAST
    Alternative sequencei1284 – 1911628Missing in isoform 6. 1 PublicationVSP_039644Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK055538 mRNA. Translation: BAB70945.1.
    AK098657 mRNA. Translation: BAC05368.1. Different initiation.
    AK124171 mRNA. No translation available.
    AK131244 mRNA. Translation: BAD18424.1.
    AK315561 mRNA. Translation: BAG37937.1.
    AL133472, AL121788 Genomic DNA. Translation: CAI19667.1.
    AL133472, AL121788 Genomic DNA. Translation: CAI19668.1.
    AL121788, AL133472 Genomic DNA. Translation: CAI22498.1.
    AL121788, AL133472 Genomic DNA. Translation: CAI22499.1.
    AL109947 Genomic DNA. No translation available.
    AL139391 Genomic DNA. No translation available.
    CH471051 Genomic DNA. Translation: EAW48333.1.
    BC022031 mRNA. Translation: AAH22031.1.
    BC087860 mRNA. Translation: AAH87860.1.
    BC101714 mRNA. Translation: AAI01715.1. Different initiation.
    BC111948 mRNA. Translation: AAI11949.1. Different initiation.
    CCDSiCCDS5077.1. [Q5TCS8-2]
    CCDS55048.1. [Q5TCS8-4]
    RefSeqiNP_001138600.2. NM_001145128.2. [Q5TCS8-4]
    NP_659462.1. NM_145025.4. [Q5TCS8-2]
    UniGeneiHs.205144.

    Genome annotation databases

    EnsembliENST00000285397; ENSP00000285397; ENSG00000155085. [Q5TCS8-2]
    ENST00000355283; ENSP00000347431; ENSG00000155085. [Q5TCS8-5]
    ENST00000424296; ENSP00000410186; ENSG00000155085. [Q5TCS8-4]
    GeneIDi221264.
    KEGGihsa:221264.
    UCSCiuc003ptn.2. human. [Q5TCS8-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK055538 mRNA. Translation: BAB70945.1.
    AK098657 mRNA. Translation: BAC05368.1. Different initiation.
    AK124171 mRNA. No translation available.
    AK131244 mRNA. Translation: BAD18424.1.
    AK315561 mRNA. Translation: BAG37937.1.
    AL133472, AL121788 Genomic DNA. Translation: CAI19667.1.
    AL133472, AL121788 Genomic DNA. Translation: CAI19668.1.
    AL121788, AL133472 Genomic DNA. Translation: CAI22498.1.
    AL121788, AL133472 Genomic DNA. Translation: CAI22499.1.
    AL109947 Genomic DNA. No translation available.
    AL139391 Genomic DNA. No translation available.
    CH471051 Genomic DNA. Translation: EAW48333.1.
    BC022031 mRNA. Translation: AAH22031.1.
    BC087860 mRNA. Translation: AAH87860.1.
    BC101714 mRNA. Translation: AAI01715.1. Different initiation.
    BC111948 mRNA. Translation: AAI11949.1. Different initiation.
    CCDSiCCDS5077.1. [Q5TCS8-2]
    CCDS55048.1. [Q5TCS8-4]
    RefSeqiNP_001138600.2. NM_001145128.2. [Q5TCS8-4]
    NP_659462.1. NM_145025.4. [Q5TCS8-2]
    UniGeneiHs.205144.

    3D structure databases

    ProteinModelPortaliQ5TCS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi128702. 10 interactions.
    IntActiQ5TCS8. 2 interactions.
    MINTiMINT-1369939.
    STRINGi9606.ENSP00000410186.

    PTM databases

    PhosphoSiteiQ5TCS8.

    Polymorphism and mutation databases

    BioMutaiAK9.
    DMDMi302393675.

    Proteomic databases

    EPDiQ5TCS8.
    PaxDbiQ5TCS8.
    PRIDEiQ5TCS8.

    Protocols and materials databases

    DNASUi221264.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000285397; ENSP00000285397; ENSG00000155085. [Q5TCS8-2]
    ENST00000355283; ENSP00000347431; ENSG00000155085. [Q5TCS8-5]
    ENST00000424296; ENSP00000410186; ENSG00000155085. [Q5TCS8-4]
    GeneIDi221264.
    KEGGihsa:221264.
    UCSCiuc003ptn.2. human. [Q5TCS8-4]

    Organism-specific databases

    CTDi221264.
    GeneCardsiAK9.
    H-InvDBHIX0025110.
    HIX0207381.
    HGNCiHGNC:33814. AK9.
    HPAiHPA030804.
    HPA030805.
    HPA031779.
    HPA031781.
    HPA036324.
    HPA036711.
    MIMi615358. gene.
    neXtProtiNX_Q5TCS8.
    PharmGKBiPA162380441.
    PA164715271.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG3078. Eukaryota.
    KOG3079. Eukaryota.
    COG0563. LUCA.
    GeneTreeiENSGT00740000115564.
    HOVERGENiHBG107661.
    InParanoidiQ5TCS8.
    KOiK18533.
    OMAiYPVIHRQ.
    PhylomeDBiQ5TCS8.
    TreeFamiTF330805.

    Enzyme and pathway databases

    ReactomeiR-HSA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

    Miscellaneous databases

    GenomeRNAii221264.
    NextBioi91262.
    PROiQ5TCS8.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ5TCS8.
    CleanExiHS_C6orf199.
    ExpressionAtlasiQ5TCS8. baseline and differential.
    GenevisibleiQ5TCS8. HS.

    Family and domain databases

    Gene3Di3.40.50.300. 8 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR000850. Adenylat/UMP-CMP_kin.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR23359. PTHR23359. 3 hits.
    SMARTiSM00382. AAA. 3 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 11 hits.
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 431-1911 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1563-1911 (ISOFORM 4).
      Tissue: Caudate nucleus, Hair follicle dermal papilla, Placenta, Testis and Thymus.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1067-1911 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1587-1911 (ISOFORM 4).
      Tissue: Heart, Lung, Pituitary and Testis.
    5. "The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase."
      Amiri M., Conserva F., Panayiotou C., Karlsson A., Solaroli N.
      Int. J. Biochem. Cell Biol. 45:925-931(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiKAD9_HUMAN
    AccessioniPrimary (citable) accession number: Q5TCS8
    Secondary accession number(s): A6NL75
    , B2RDJ0, B6ZDM7, Q3MIS4, Q5I0W8, Q6ZNF1, Q6ZVR7, Q8N7C6, Q8WW00, Q96NF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: August 10, 2010
    Last modified: May 11, 2016
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.