Q5TCS8 (AKD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase domain-containing protein 1

Alternative name(s):
Adenylate kinase domain-containing protein 2

Gene names

Name:	AKD1
Synonyms:	AKD2, C6orf199, C6orf224

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1911 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Post-translational modification	Isoform 1 is phosphorylated on Ser-724. Ref.5
Sequence similarities	Belongs to the adenylate kinase family.
Sequence caution	The sequence AAI01715.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI11949.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC05368.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleobase-containing compound metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro nucleobase-containing compound kinase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 4 (identifier: Q5TCS8-4)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q5TCS8-1)

The sequence of this isoform differs from the canonical sequence as follows:
     703-751: EARKATEEEL...EIEGDELEVH → KSHRRGIETR...CYCKQLQYFK
     752-1911: Missing.

Note: No experimental confirmation available. Phosphorylated on Ser-724.

Isoform 2 (identifier: Q5TCS8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     420-421: VD → TN
     422-1911: Missing.

Isoform 3 (identifier: Q5TCS8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     989-1014: APPLRICLVGPQGSGKTMCGRQLAEK → VRQYSYLNDCSHRIFLGLITNHHQFT
     1015-1911: Missing.

Isoform 5 (identifier: Q5TCS8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-921: Missing.
     1212-1257: NVVRDDEEIS...SGEEDEEQET → VSSFVFFFKT...GSSHLSLSKC
     1258-1911: Missing.

Isoform 6 (identifier: Q5TCS8-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1212-1283: NVVRDDEEIS...DTHNLQIIQD → PNKEKRKRGI...LSKQNIHNQK
     1284-1911: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1911	1911	Adenylate kinase domain-containing protein 1		PRO_0000304138
Regions
	Coiled coil	443 – 485	43	Potential
	Coiled coil	676 – 711	36	Potential
	Compositional bias	198 – 275	78	Glu-rich
Natural variations
	Alternative sequence	1 – 921	921	Missing in isoform 5.		VSP_039638
	Alternative sequence	420 – 421	2	VD → TN in isoform 2.		VSP_028008
	Alternative sequence	422 – 1911	1490	Missing in isoform 2.		VSP_028009
	Alternative sequence	703 – 751	49	EARKA…ELEVH → KSHRRGIETRRRKSKATGTY ESEGKRQAQIAMTDDVSWYC YCKQLQYFK in isoform 1.		VSP_039639
	Alternative sequence	752 – 1911	1160	Missing in isoform 1.		VSP_039640
	Alternative sequence	989 – 1014	26	APPLR…QLAEK → VRQYSYLNDCSHRIFLGLIT NHHQFT in isoform 3.		VSP_028010
	Alternative sequence	1015 – 1911	897	Missing in isoform 3.		VSP_028011
	Alternative sequence	1212 – 1283	72	NVVRD…QIIQD → PNKEKRKRGISENTTCYKCN HMSPWCEYAGLPYRGLLILY SATATATAGTKHCRSGAKVI VALSKQNIHNQK in isoform 6.		VSP_039641
	Alternative sequence	1212 – 1257	46	NVVRD…EEQET → VSSFVFFFKTGSHSVAQGRV QWHNHSSLQPRTPGLKGSSH LSLSKC in isoform 5.		VSP_039642
	Alternative sequence	1258 – 1911	654	Missing in isoform 5.		VSP_039643
	Alternative sequence	1284 – 1911	628	Missing in isoform 6.		VSP_039644
Experimental info
	Sequence conflict	222	1	I → T in BAB70945. Ref.1
	Sequence conflict	1716	1	K → R in BAC05368. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 [UniParc]. Last modified August 10, 2010. Version 2. Checksum: 16A1888E727C51A4	FASTA	1,911	221,413
	10 20 30 40 50 60 MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI TQAWKCIRVE 70 80 90 100 110 120 ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE KLNSPEVCHF GYIITEIPSL 130 140 150 160 170 180 SQDAMTTLQQ IELIKNLNLK PDVIINIKCP DYDLCQRISG QRQHNNTGYI YSRDQWDPEV 190 200 210 220 230 240 IENHRKKKKE AQKDGKGEEE EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI 250 260 270 280 290 300 VKLYKETILQ TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG 310 320 330 340 350 360 AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS GLPDYSVSFL 370 380 390 400 410 420 GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ YSGKTTLCNM LAENYKGKVV 430 440 450 460 470 480 DYAQLVQPRF DKARETLVEN TIAEATAAAI KVVKEKLLRE LQARKQAETA LREFQRQYEK 490 500 510 520 530 540 MEFGVFPMEA THSSIDEEGY IQGSQRDRGS SLVDTEEAKT KSENVLHDQA AKVDKDDGKE 550 560 570 580 590 600 TGETFTFKRH SQDASQDVKL YSDTAPTEDL IEEVTADHPE VVTMIEETIK MSQDINFEQP 610 620 630 640 650 660 YEKHAEILQE VLGEVMEENK DRFPGAPKYG GWIVDNCPIV KELWMALIKK GIIPDLVIYL 670 680 690 700 710 720 SDTENNGKCL FNRIYLQKKS EIDSKILERL LEELQKKKKE EEEARKATEE ELRLEEENRR 730 740 750 760 770 780 LLELMKVKAK EAEETDNEDE EEIEGDELEV HEEPEASHDT RGSWLPEEFE ASEVPETEPE 790 800 810 820 830 840 AVSEPIEETT VETEIPKGSK EGLEIEKLSE TVVLPEFPED SYPDVPEMEP FKEKIGSFII 850 860 870 880 890 900 LWKQLEATIS EAYIKILNLE IADRTPQELL QKVVETMEKP FQYTAWELTG EDYEEETEDY 910 920 930 940 950 960 QTEAEVDEEL EEEEEEEGED KMKERKRHLG DTKHFCPVVL KENFILQPGN TEEAAKYREK 970 980 990 1000 1010 1020 IYYFSSAEAK EKFLEHPEDY VAHEEPLKAP PLRICLVGPQ GSGKTMCGRQ LAEKLNIFHI 1030 1040 1050 1060 1070 1080 QFEEVLQEKL LLKTEKKVGP EFEEDSENEQ AAKQELEELA IQANVKVEEE NTKKQLPEVQ 1090 1100 1110 1120 1130 1140 LTEEEEVIKS SLMENEPLPP EILEVILSEW WLKEPIRSTG FILDGFPRYP EEAQFLGDRG 1150 1160 1170 1180 1190 1200 FFPDAAVFIQ VDDQDIFDRL LPAQIEKWKL KQKKKLERKK LIKDMKAKIR VDTIAKRRAE 1210 1220 1230 1240 1250 1260 LILERDKKRR ENVVRDDEEI SEEELEEDND DIENILEDEF PKDEEEMSGE EDEEQETDAI 1270 1280 1290 1300 1310 1320 ERLRGELGEK FEADTHNLQI IQDELERYLI PIISINGARR NHIVQYTLNM KLKPLVENRA 1330 1340 1350 1360 1370 1380 SIFEKCHPIP APLAQKMLTF TYKYISSFGY WDPVKLSEGE TIKPVENAEN PIYPVIHRQY 1390 1400 1410 1420 1430 1440 IYFLSSKETK EKFMKNPIKY IRQPKPKPTV PIRIIIVGPP KSGKTTVAKK ITSEYGLKHL 1450 1460 1470 1480 1490 1500 SIGGALRYVL NNHPETELAL MLNWHLHKGM TAPDELAIQA LELSLMESVC NTAGVVIDGY 1510 1520 1530 1540 1550 1560 PVTKHQMNLL EARSIIPMVI FELSVPSKEI FKRLLLEKEN EQRLPYPLHN SAQIVAVNNV 1570 1580 1590 1600 1610 1620 KYRKNIGEIR QYYQEQHQNW YVIDGFHSKW WVWNEVIKNV QMVNKYMQTY LERIKAGKAA 1630 1640 1650 1660 1670 1680 CIDKLCITPQ ELLSRLGEFE QFCPVSLAES QELFDCSATD SLEFAAEFRG HYYKMSSQEK 1690 1700 1710 1720 1730 1740 LNKFLENPEL YVPPLAPHPL PSADMIPKRL TLSELKSRFP KCAELQGYCP VTYKDGNQRY 1750 1760 1770 1780 1790 1800 EALVPGSINY ALEYHNRIYI CENKEKLQKF LRSPLKYWEQ KLPHKLPPLR EPILLTSLPL 1810 1820 1830 1840 1850 1860 PGYLEQGIAT SLIKAMNAAG CLKPKFPFLS IRRSALLYIA LHLKAFNPKG SEYTRKKYKK 1870 1880 1890 1900 1910 KMEQFMESCE LITYLGAKMT RKYKEPQFRA IDFDHKLKTF LSLRNIDPIN G
	Isoform 1 [UniParc]. Checksum: 5154893EA585590F	FASTA	751	86,644
	10 20 30 40 50 60 MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI TQAWKCIRVE 70 80 90 100 110 120 ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE KLNSPEVCHF GYIITEIPSL 130 140 150 160 170 180 SQDAMTTLQQ IELIKNLNLK PDVIINIKCP DYDLCQRISG QRQHNNTGYI YSRDQWDPEV 190 200 210 220 230 240 IENHRKKKKE AQKDGKGEEE EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI 250 260 270 280 290 300 VKLYKETILQ TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG 310 320 330 340 350 360 AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS GLPDYSVSFL 370 380 390 400 410 420 GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ YSGKTTLCNM LAENYKGKVV 430 440 450 460 470 480 DYAQLVQPRF DKARETLVEN TIAEATAAAI KVVKEKLLRE LQARKQAETA LREFQRQYEK 490 500 510 520 530 540 MEFGVFPMEA THSSIDEEGY IQGSQRDRGS SLVDTEEAKT KSENVLHDQA AKVDKDDGKE 550 560 570 580 590 600 TGETFTFKRH SQDASQDVKL YSDTAPTEDL IEEVTADHPE VVTMIEETIK MSQDINFEQP 610 620 630 640 650 660 YEKHAEILQE VLGEVMEENK DRFPGAPKYG GWIVDNCPIV KELWMALIKK GIIPDLVIYL 670 680 690 700 710 720 SDTENNGKCL FNRIYLQKKS EIDSKILERL LEELQKKKKE EEKSHRRGIE TRRRKSKATG 730 740 750 TYESEGKRQA QIAMTDDVSW YCYCKQLQYF K
	Isoform 2 [UniParc]. Checksum: 18B996C20324D892	FASTA	421	48,501
	10 20 30 40 50 60 MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI TQAWKCIRVE 70 80 90 100 110 120 ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE KLNSPEVCHF GYIITEIPSL 130 140 150 160 170 180 SQDAMTTLQQ IELIKNLNLK PDVIINIKCP DYDLCQRISG QRQHNNTGYI YSRDQWDPEV 190 200 210 220 230 240 IENHRKKKKE AQKDGKGEEE EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI 250 260 270 280 290 300 VKLYKETILQ TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG 310 320 330 340 350 360 AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS GLPDYSVSFL 370 380 390 400 410 420 GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ YSGKTTLCNM LAENYKGKVT N
	Isoform 3 [UniParc]. Checksum: A8A3319DC3635FA1	FASTA	1,014	117,361
	10 20 30 40 50 60 MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI TQAWKCIRVE 70 80 90 100 110 120 ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE KLNSPEVCHF GYIITEIPSL 130 140 150 160 170 180 SQDAMTTLQQ IELIKNLNLK PDVIINIKCP DYDLCQRISG QRQHNNTGYI YSRDQWDPEV 190 200 210 220 230 240 IENHRKKKKE AQKDGKGEEE EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI 250 260 270 280 290 300 VKLYKETILQ TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG 310 320 330 340 350 360 AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS GLPDYSVSFL 370 380 390 400 410 420 GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ YSGKTTLCNM LAENYKGKVV 430 440 450 460 470 480 DYAQLVQPRF DKARETLVEN TIAEATAAAI KVVKEKLLRE LQARKQAETA LREFQRQYEK 490 500 510 520 530 540 MEFGVFPMEA THSSIDEEGY IQGSQRDRGS SLVDTEEAKT KSENVLHDQA AKVDKDDGKE 550 560 570 580 590 600 TGETFTFKRH SQDASQDVKL YSDTAPTEDL IEEVTADHPE VVTMIEETIK MSQDINFEQP 610 620 630 640 650 660 YEKHAEILQE VLGEVMEENK DRFPGAPKYG GWIVDNCPIV KELWMALIKK GIIPDLVIYL 670 680 690 700 710 720 SDTENNGKCL FNRIYLQKKS EIDSKILERL LEELQKKKKE EEEARKATEE ELRLEEENRR 730 740 750 760 770 780 LLELMKVKAK EAEETDNEDE EEIEGDELEV HEEPEASHDT RGSWLPEEFE ASEVPETEPE 790 800 810 820 830 840 AVSEPIEETT VETEIPKGSK EGLEIEKLSE TVVLPEFPED SYPDVPEMEP FKEKIGSFII 850 860 870 880 890 900 LWKQLEATIS EAYIKILNLE IADRTPQELL QKVVETMEKP FQYTAWELTG EDYEEETEDY 910 920 930 940 950 960 QTEAEVDEEL EEEEEEEGED KMKERKRHLG DTKHFCPVVL KENFILQPGN TEEAAKYREK 970 980 990 1000 1010 IYYFSSAEAK EKFLEHPEDY VAHEEPLKVR QYSYLNDCSH RIFLGLITNH HQFT
	Isoform 5 [UniParc] [UniParc]. Checksum: 5FB4ED6C265E1CFE	FASTA	336	39,019
	10 20 30 40 50 60 MKERKRHLGD TKHFCPVVLK ENFILQPGNT EEAAKYREKI YYFSSAEAKE KFLEHPEDYV 70 80 90 100 110 120 AHEEPLKAPP LRICLVGPQG SGKTMCGRQL AEKLNIFHIQ FEEVLQEKLL LKTEKKVGPE 130 140 150 160 170 180 FEEDSENEQA AKQELEELAI QANVKVEEEN TKKQLPEVQL TEEEEVIKSS LMENEPLPPE 190 200 210 220 230 240 ILEVILSEWW LKEPIRSTGF ILDGFPRYPE EAQFLGDRGF FPDAAVFIQV DDQDIFDRLL 250 260 270 280 290 300 PAQIEKWKLK QKKKLERKKL IKDMKAKIRV DTIAKRRAEL ILERDKKRRE VSSFVFFFKT 310 320 330 GSHSVAQGRV QWHNHSSLQP RTPGLKGSSH LSLSKC
	Isoform 6 [UniParc]. Checksum: 7A51010EC1323CE3	FASTA	1,283	148,193
	10 20 30 40 50 60 MTSQEKTEEY PFADIFDEDE TERNFLLSKP VCFVVFGKPG VGKTTLARYI TQAWKCIRVE 70 80 90 100 110 120 ALPILEEQIA AETESGVMLQ SMLISGQSIP DELVIKLMLE KLNSPEVCHF GYIITEIPSL 130 140 150 160 170 180 SQDAMTTLQQ IELIKNLNLK PDVIINIKCP DYDLCQRISG QRQHNNTGYI YSRDQWDPEV 190 200 210 220 230 240 IENHRKKKKE AQKDGKGEEE EEEEEQEEEE AFIAEMQMVA EILHHLVQRP EDYLENVENI 250 260 270 280 290 300 VKLYKETILQ TLEEVMAEHN PQYLIELNGN KPAEELFMIV MDRLKYLNLK RAAILTKLQG 310 320 330 340 350 360 AEEEINDTME NDELFRTLAS YKLIAPRYRW QRSKWGRTCP VNLKDGNIYS GLPDYSVSFL 370 380 390 400 410 420 GKIYCLSSEE ALKPFLLNPR PYLLPPMPGP PCKVFILGPQ YSGKTTLCNM LAENYKGKVV 430 440 450 460 470 480 DYAQLVQPRF DKARETLVEN TIAEATAAAI KVVKEKLLRE LQARKQAETA LREFQRQYEK 490 500 510 520 530 540 MEFGVFPMEA THSSIDEEGY IQGSQRDRGS SLVDTEEAKT KSENVLHDQA AKVDKDDGKE 550 560 570 580 590 600 TGETFTFKRH SQDASQDVKL YSDTAPTEDL IEEVTADHPE VVTMIEETIK MSQDINFEQP 610 620 630 640 650 660 YEKHAEILQE VLGEVMEENK DRFPGAPKYG GWIVDNCPIV KELWMALIKK GIIPDLVIYL 670 680 690 700 710 720 SDTENNGKCL FNRIYLQKKS EIDSKILERL LEELQKKKKE EEEARKATEE ELRLEEENRR 730 740 750 760 770 780 LLELMKVKAK EAEETDNEDE EEIEGDELEV HEEPEASHDT RGSWLPEEFE ASEVPETEPE 790 800 810 820 830 840 AVSEPIEETT VETEIPKGSK EGLEIEKLSE TVVLPEFPED SYPDVPEMEP FKEKIGSFII 850 860 870 880 890 900 LWKQLEATIS EAYIKILNLE IADRTPQELL QKVVETMEKP FQYTAWELTG EDYEEETEDY 910 920 930 940 950 960 QTEAEVDEEL EEEEEEEGED KMKERKRHLG DTKHFCPVVL KENFILQPGN TEEAAKYREK 970 980 990 1000 1010 1020 IYYFSSAEAK EKFLEHPEDY VAHEEPLKAP PLRICLVGPQ GSGKTMCGRQ LAEKLNIFHI 1030 1040 1050 1060 1070 1080 QFEEVLQEKL LLKTEKKVGP EFEEDSENEQ AAKQELEELA IQANVKVEEE NTKKQLPEVQ 1090 1100 1110 1120 1130 1140 LTEEEEVIKS SLMENEPLPP EILEVILSEW WLKEPIRSTG FILDGFPRYP EEAQFLGDRG 1150 1160 1170 1180 1190 1200 FFPDAAVFIQ VDDQDIFDRL LPAQIEKWKL KQKKKLERKK LIKDMKAKIR VDTIAKRRAE 1210 1220 1230 1240 1250 1260 LILERDKKRR EPNKEKRKRG ISENTTCYKC NHMSPWCEYA GLPYRGLLIL YSATATATAG 1270 1280 TKHCRSGAKV IVALSKQNIH NQK

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 431-1911 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1563-1911 (ISOFORM 4). Tissue: Caudate nucleus, Hair follicle dermal papilla, Placenta, Testis and Thymus.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1067-1911 (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1587-1911 (ISOFORM 4). Tissue: Heart, Lung, Pituitary and Testis.
[5]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724 (ISOFORM 1), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK055538 mRNA. Translation: BAB70945.1. AK098657 mRNA. Translation: BAC05368.1. Different initiation. AK124171 mRNA. No translation available. AK131244 mRNA. Translation: BAD18424.1. AK315561 mRNA. Translation: BAG37937.1. AL133472, AL121788 Genomic DNA. Translation: CAI19667.1. AL133472, AL121788 Genomic DNA. Translation: CAI19668.1. AL121788, AL133472 Genomic DNA. Translation: CAI22498.1. AL121788, AL133472 Genomic DNA. Translation: CAI22499.1. AL109947 Genomic DNA. No translation available. AL139391 Genomic DNA. No translation available. CH471051 Genomic DNA. Translation: EAW48333.1. BC022031 mRNA. Translation: AAH22031.1. BC087860 mRNA. Translation: AAH87860.1. BC101714 mRNA. Translation: AAI01715.1. Different initiation. BC111948 mRNA. Translation: AAI11949.1. Different initiation.
IPI	IPI00418605. IPI00552962. IPI00556253. IPI00641136. IPI00856053. IPI00930224.
RefSeq	NP_001138600.2. NM_001145128.2. NP_659462.1. NM_145025.4.
UniGene	Hs.205144.
3D structure databases
HSSP	HSSP built from PDB template 1KAG based on UniProtKB P0A6D7.
ProteinModelPortal	Q5TCS8.
SMR	Q5TCS8. Positions 28-291, 393-428, 1414-1602.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5TCS8. 2 interactions.
MINT	MINT-1369939.
PTM databases
PhosphoSite	Q5TCS8.
Polymorphism databases
DMDM	302393675.
Proteomic databases
PRIDE	Q5TCS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368948; ENSP00000357944; ENSG00000155085.
GeneID	221264.
KEGG	hsa:221264.
UCSC	uc003ptr.2. human.
Organism-specific databases
CTD	221264.
GeneCards	GC06M109814.
HGNC	HGNC:33814. AKD1.
HPA	HPA031779.
neXtProt	NX_Q5TCS8.
PharmGKB	PA162380441. PA164715270.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG107661.
OMA	LGIFHIQ.
Gene expression databases
ArrayExpress	Q5TCS8.
Bgee	Q5TCS8.
CleanEx	HS_C6orf199.
Genevestigator	Q5TCS8.
Family and domain databases
InterPro	IPR000850. Adenylate_kin. IPR003593. ATPase_AAA+_core. IPR007029. YHS. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 3 hits. PF04945. YHS. 1 hit. [Graphical view]
SMART	SM00382. AAA. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	91262. 91612.

Entry information

Entry name

AKD1_HUMAN

Accession

Primary (citable) accession number: Q5TCS8
Secondary accession number(s): A6NL75 , B2RDJ0, B6ZDM7, Q3MIS4, Q5I0W8, Q6ZNF1, Q6ZVR7, Q8N7C6, Q8WW00, Q96NF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	August 10, 2010
Last modified:	January 25, 2012
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.