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Protein

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Gene

MAGI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi121 – 128ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • guanylate kinase activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • regulation of JNK cascade Source: InterPro
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ5TCQ9.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Alternative name(s):
Membrane-associated guanylate kinase inverted 3
Short name:
MAGI-3
Gene namesi
Name:MAGI3
Synonyms:KIAA1634
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29647. MAGI3.

Subcellular locationi

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi260425.
OpenTargetsiENSG00000081026.
PharmGKBiPA142671485.

Chemistry databases

ChEMBLiCHEMBL5212.

Polymorphism and mutation databases

BioMutaiMAGI3.
DMDMi190359882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003414071 – 1506Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3Add BLAST1506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234PhosphoserineBy similarity1
Modified residuei620PhosphoserineCombined sources1
Modified residuei724PhosphoserineBy similarity1
Modified residuei857PhosphoserineCombined sources1
Modified residuei940PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5TCQ9.
MaxQBiQ5TCQ9.
PaxDbiQ5TCQ9.
PeptideAtlasiQ5TCQ9.
PRIDEiQ5TCQ9.

PTM databases

iPTMnetiQ5TCQ9.
PhosphoSitePlusiQ5TCQ9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000081026.
CleanExiHS_MAGI3.
ExpressionAtlasiQ5TCQ9. baseline and differential.
GenevisibleiQ5TCQ9. HS.

Organism-specific databases

HPAiHPA007923.

Interactioni

Subunit structurei

Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified tyrosine phosphorylated proteins (By similarity). Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. In case of infection, interacts with HPV type 16 and HPV type 18 E6 protein. Interacts with DLL1 (By similarity).By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ADRB1P085885EBI-310506,EBI-991009
ADRB2P075509EBI-310506,EBI-491169
MED28Q9H2042EBI-310506,EBI-514199

Protein-protein interaction databases

BioGridi129277. 20 interactors.
IntActiQ5TCQ9. 9 interactors.
MINTiMINT-6800638.
STRINGi9606.ENSP00000304604.

Chemistry databases

BindingDBiQ5TCQ9.

Structurei

Secondary structure

11506
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi601 – 607Combined sources7
Beta strandi612 – 620Combined sources9
Beta strandi623 – 630Combined sources8
Helixi632 – 634Combined sources3
Beta strandi643 – 647Combined sources5
Helixi657 – 666Combined sources10
Beta strandi672 – 681Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SOEX-ray1.60A601-691[»]
ProteinModelPortaliQ5TCQ9.
SMRiQ5TCQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 106PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini114 – 288Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST175
Domaini293 – 326WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini339 – 372WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini435 – 517PDZ 2PROSITE-ProRule annotationAdd BLAST83
Domaini603 – 679PDZ 3PROSITE-ProRule annotationAdd BLAST77
Domaini751 – 833PDZ 4PROSITE-ProRule annotationAdd BLAST83
Domaini876 – 963PDZ 5PROSITE-ProRule annotationAdd BLAST88
Domaini1046 – 1128PDZ 6PROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 106Interaction with ADRB1 and TGFABy similarityAdd BLAST89
Regioni435 – 517Interaction with PTEN1 PublicationAdd BLAST83
Regioni751 – 833Interaction with BAI11 PublicationAdd BLAST83
Regioni876 – 963Interaction with LPAR2 and GRIN2B2 PublicationsAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 9Poly-Lys4
Compositional biasi238 – 243Poly-Glu6
Compositional biasi378 – 381Poly-Pro4

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 6 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0707. Eukaryota.
KOG3209. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00650000092997.
HOVERGENiHBG007091.
InParanoidiQ5TCQ9.
KOiK06112.
OMAiDHGDWDI.
OrthoDBiEOG091G0NSY.
PhylomeDBiQ5TCQ9.
TreeFamiTF316816.

Family and domain databases

Gene3Di2.30.42.10. 6 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR030035. MAGI3.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
[Graphical view]
PANTHERiPTHR10316:SF10. PTHR10316:SF10. 2 hits.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 4 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TCQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKTLKKKKH WLSKVQECAV SWAGPPGDFG AEIRGGAERG EFPYLGRLRE
60 70 80 90 100
EPGGGTCCVV SGKAPSPGDV LLEVNGTPVS GLTNRDTLAV IRHFREPIRL
110 120 130 140 150
KTVKPGKVIN KDLRHYLSLQ FQKGSIDHKL QQVIRDNLYL RTIPCTTRAP
160 170 180 190 200
RDGEVPGVDY NFISVEQFKA LEESGALLES GTYDGNFYGT PKPPAEPSPF
210 220 230 240 250
QPDPVDQVLF DNEFDAESQR KRTTSVSKME RMDSSLPEEE EDEDKEAING
260 270 280 290 300
SGNAENRERH SESSDWMKTV PSYNQTNSSM DFRNYMMRDE TLEPLPKNWE
310 320 330 340 350
MAYTDTGMIY FIDHNTKTTT WLDPRLCKKA KAPEDCEDGE LPYGWEKIED
360 370 380 390 400
PQYGTYYVDF TLVAQAGVQW HDLGSLQPPP PGFNHLNQKT QFENPVEEAK
410 420 430 440 450
RKKQLGQVEI GSSKPDMEKS HFTRDPSQLK GVLVRASLKK STMGFGFTII
460 470 480 490 500
GGDRPDEFLQ VKNVLKDGPA AQDGKIAPGD VIVDINGNCV LGHTHADVVQ
510 520 530 540 550
MFQLVPVNQY VNLTLCRGYP LPDDSEDPVV DIVAATPVIN GQSLTKGETC
560 570 580 590 600
MNPQDFKPGA MVLEQNGKSG HTLTGDGLNG PSDASEQRVS MASSGSSQPE
610 620 630 640 650
LVTIPLIKGP KGFGFAIADS PTGQKVKMIL DSQWCQGLQK GDIIKEIYHQ
660 670 680 690 700
NVQNLTHLQV VEVLKQFPVG ADVPLLILRG GPPSPTKTAK MKTDKKENAG
710 720 730 740 750
SLEAINEPIP QPMPFPPSII RSGSPKLDPS EVYLKSKTLY EDKPPNTKDL
760 770 780 790 800
DVFLRKQESG FGFRVLGGDG PDQSIYIGAI IPLGAAEKDG RLRAADELMC
810 820 830 840 850
IDGIPVKGKS HKQVLDLMTT AARNGHVLLT VRRKIFYGEK QPEDDSSQAF
860 870 880 890 900
ISTQNGSPRL NRAEVPARPA PQEPYDVVLQ RKENEGFGFV ILTSKNKPPP
910 920 930 940 950
GVIPHKIGRV IEGSPADRCG KLKVGDHISA VNGQSIVELS HDNIVQLIKD
960 970 980 990 1000
AGVTVTLTVI AEEEHHGPPS GTNSARQSPA LQHRPMGQSQ ANHIPGDRSA
1010 1020 1030 1040 1050
LEGEIGKDVS TSYRHSWSDH KHLAQPDTAV ISVVGSRHNQ NLGCYPVELE
1060 1070 1080 1090 1100
RGPRGFGFSL RGGKEYNMGL FILRLAEDGP AIKDGRIHVG DQIVEINGEP
1110 1120 1130 1140 1150
TQGITHTRAI ELIQAGGNKV LLLLRPGTGL IPDHGDWDIN NPSSSNVIYD
1160 1170 1180 1190 1200
EQSPLPPSSH FASIFEESHV PVIEESLRVQ ICEKAEELKD IVPEKKSTLN
1210 1220 1230 1240 1250
ENQPEIKHQS LLQKNVSKRD PPSSHGHSNK KNLLKVENGV TRRGRSVSPK
1260 1270 1280 1290 1300
KPASQHSEEH LDKIPSPLKN NPKRRPRDQS LSPSKGENKS CQVSTRAGSG
1310 1320 1330 1340 1350
QDQCRKSRGR SASPKKQQKI EGSKAPSNAE AKLLEGKSRR IAGYTGSNAE
1360 1370 1380 1390 1400
QIPDGKEKSD VIRKDAKQNQ LEKSRTRSPE KKIKRMVEKS LPSKMTNKTT
1410 1420 1430 1440 1450
SKEVSENEKG KKVTTGETSS SNDKIGENVQ LSEKRLKQEP EEKVVSNKTE
1460 1470 1480 1490 1500
DHKGKELEAA DKNKETGRFK PESSSPVKKT LITPGPWKVP SGNKVTGTIG

MAEKRQ
Length:1,506
Mass (Da):165,608
Last modified:June 10, 2008 - v2
Checksum:i0EA98F09F9AB109F
GO
Isoform 2 (identifier: Q5TCQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1136-1150: DWDINNPSSSNVIYD → LAPSGLCSYVKPEQH
     1151-1506: Missing.

Show »
Length:1,150
Mass (Da):125,998
Checksum:i14DED25795278E3C
GO
Isoform 3 (identifier: Q5TCQ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-384: Missing.
     1136-1150: DWDINNPSSSNVIYD → LAPSGLCSYVKPEQH
     1151-1506: Missing.

Show »
Length:1,125
Mass (Da):123,339
Checksum:iFA2340EA152503E9
GO
Isoform 4 (identifier: Q5TCQ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-384: Missing.

Note: No experimental confirmation available.
Show »
Length:1,481
Mass (Da):162,949
Checksum:i9C2B604D9B1B1B97
GO

Sequence cautioni

The sequence BAB15479 differs from that shown. Reason: Frameshift at position 1373.Curated
The sequence BAB15479 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9K → R in AAG43837 (PubMed:15652357).Curated1
Sequence conflicti59V → I in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti66 – 68SPG → NPS in AAG24545 (PubMed:10748157).Curated3
Sequence conflicti246E → G in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti257R → G in AAG43837 (PubMed:15652357).Curated1
Sequence conflicti491L → F in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti573L → S in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti641G → E in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti685P → T in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti801I → V in AAG43837 (PubMed:15652357).Curated1
Sequence conflicti823R → P in AAG43837 (PubMed:15652357).Curated1
Sequence conflicti942D → A in AAG24545 (PubMed:10748157).Curated1
Sequence conflicti1018S → P in AAG43837 (PubMed:15652357).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034285360 – 384Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0342861136 – 1150DWDIN…NVIYD → LAPSGLCSYVKPEQH in isoform 2 and isoform 3. 4 PublicationsAdd BLAST15
Alternative sequenceiVSP_0342871151 – 1506Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST356

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257238 mRNA. Translation: AAG24545.1.
AF213259 mRNA. Translation: AAG43837.1.
AL365225
, AL133517, AL389921, AL390759 Genomic DNA. Translation: CAH70944.1.
AL365225
, AL133517, AL389921, AL390759 Genomic DNA. Translation: CAH70945.1.
AL365225
, AL133517, AL389921, AL390759 Genomic DNA. Translation: CAH70946.1.
AL389921
, AL133517, AL365225, AL390759 Genomic DNA. Translation: CAH71507.1.
AL389921
, AL133517, AL365225, AL390759 Genomic DNA. Translation: CAH71508.1.
AL389921
, AL133517, AL365225, AL390759 Genomic DNA. Translation: CAH71509.1.
AL390759
, AL133517, AL365225, AL389921 Genomic DNA. Translation: CAH74141.1.
AL390759
, AL133517, AL365225, AL389921 Genomic DNA. Translation: CAH74142.1.
AL390759
, AL133517, AL365225, AL389921 Genomic DNA. Translation: CAH74143.1.
AL133517
, AL365225, AL389921, AL390759 Genomic DNA. Translation: CAI22553.1.
AL133517
, AL365225, AL389921, AL390759 Genomic DNA. Translation: CAI22554.1.
AL133517
, AL365225, AL389921, AL390759 Genomic DNA. Translation: CAI22555.1.
CH471122 Genomic DNA. Translation: EAW56559.1.
CH471122 Genomic DNA. Translation: EAW56560.1.
CH471122 Genomic DNA. Translation: EAW56562.1.
BC130409 mRNA. Translation: AAI30410.1.
AB046854 mRNA. Translation: BAB13460.1.
AK026417 mRNA. Translation: BAB15479.1. Sequence problems.
CCDSiCCDS44196.1. [Q5TCQ9-4]
CCDS860.1. [Q5TCQ9-3]
RefSeqiNP_001136254.1. NM_001142782.1. [Q5TCQ9-4]
NP_690864.2. NM_152900.2. [Q5TCQ9-3]
XP_005270794.1. XM_005270737.3. [Q5TCQ9-3]
UniGeneiHs.486189.

Genome annotation databases

EnsembliENST00000307546; ENSP00000304604; ENSG00000081026. [Q5TCQ9-4]
ENST00000369611; ENSP00000358624; ENSG00000081026. [Q5TCQ9-3]
ENST00000369615; ENSP00000358628; ENSG00000081026. [Q5TCQ9-3]
ENST00000369617; ENSP00000358630; ENSG00000081026. [Q5TCQ9-2]
GeneIDi260425.
KEGGihsa:260425.
UCSCiuc001edh.4. human. [Q5TCQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257238 mRNA. Translation: AAG24545.1.
AF213259 mRNA. Translation: AAG43837.1.
AL365225
, AL133517, AL389921, AL390759 Genomic DNA. Translation: CAH70944.1.
AL365225
, AL133517, AL389921, AL390759 Genomic DNA. Translation: CAH70945.1.
AL365225
, AL133517, AL389921, AL390759 Genomic DNA. Translation: CAH70946.1.
AL389921
, AL133517, AL365225, AL390759 Genomic DNA. Translation: CAH71507.1.
AL389921
, AL133517, AL365225, AL390759 Genomic DNA. Translation: CAH71508.1.
AL389921
, AL133517, AL365225, AL390759 Genomic DNA. Translation: CAH71509.1.
AL390759
, AL133517, AL365225, AL389921 Genomic DNA. Translation: CAH74141.1.
AL390759
, AL133517, AL365225, AL389921 Genomic DNA. Translation: CAH74142.1.
AL390759
, AL133517, AL365225, AL389921 Genomic DNA. Translation: CAH74143.1.
AL133517
, AL365225, AL389921, AL390759 Genomic DNA. Translation: CAI22553.1.
AL133517
, AL365225, AL389921, AL390759 Genomic DNA. Translation: CAI22554.1.
AL133517
, AL365225, AL389921, AL390759 Genomic DNA. Translation: CAI22555.1.
CH471122 Genomic DNA. Translation: EAW56559.1.
CH471122 Genomic DNA. Translation: EAW56560.1.
CH471122 Genomic DNA. Translation: EAW56562.1.
BC130409 mRNA. Translation: AAI30410.1.
AB046854 mRNA. Translation: BAB13460.1.
AK026417 mRNA. Translation: BAB15479.1. Sequence problems.
CCDSiCCDS44196.1. [Q5TCQ9-4]
CCDS860.1. [Q5TCQ9-3]
RefSeqiNP_001136254.1. NM_001142782.1. [Q5TCQ9-4]
NP_690864.2. NM_152900.2. [Q5TCQ9-3]
XP_005270794.1. XM_005270737.3. [Q5TCQ9-3]
UniGeneiHs.486189.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SOEX-ray1.60A601-691[»]
ProteinModelPortaliQ5TCQ9.
SMRiQ5TCQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129277. 20 interactors.
IntActiQ5TCQ9. 9 interactors.
MINTiMINT-6800638.
STRINGi9606.ENSP00000304604.

Chemistry databases

BindingDBiQ5TCQ9.
ChEMBLiCHEMBL5212.

PTM databases

iPTMnetiQ5TCQ9.
PhosphoSitePlusiQ5TCQ9.

Polymorphism and mutation databases

BioMutaiMAGI3.
DMDMi190359882.

Proteomic databases

EPDiQ5TCQ9.
MaxQBiQ5TCQ9.
PaxDbiQ5TCQ9.
PeptideAtlasiQ5TCQ9.
PRIDEiQ5TCQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307546; ENSP00000304604; ENSG00000081026. [Q5TCQ9-4]
ENST00000369611; ENSP00000358624; ENSG00000081026. [Q5TCQ9-3]
ENST00000369615; ENSP00000358628; ENSG00000081026. [Q5TCQ9-3]
ENST00000369617; ENSP00000358630; ENSG00000081026. [Q5TCQ9-2]
GeneIDi260425.
KEGGihsa:260425.
UCSCiuc001edh.4. human. [Q5TCQ9-1]

Organism-specific databases

CTDi260425.
DisGeNETi260425.
GeneCardsiMAGI3.
H-InvDBHIX0000900.
HGNCiHGNC:29647. MAGI3.
HPAiHPA007923.
MIMi615943. gene.
neXtProtiNX_Q5TCQ9.
OpenTargetsiENSG00000081026.
PharmGKBiPA142671485.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0707. Eukaryota.
KOG3209. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00650000092997.
HOVERGENiHBG007091.
InParanoidiQ5TCQ9.
KOiK06112.
OMAiDHGDWDI.
OrthoDBiEOG091G0NSY.
PhylomeDBiQ5TCQ9.
TreeFamiTF316816.

Enzyme and pathway databases

SignaLinkiQ5TCQ9.

Miscellaneous databases

ChiTaRSiMAGI3. human.
GeneWikiiMAGI3.
GenomeRNAii260425.
PROiQ5TCQ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081026.
CleanExiHS_MAGI3.
ExpressionAtlasiQ5TCQ9. baseline and differential.
GenevisibleiQ5TCQ9. HS.

Family and domain databases

Gene3Di2.30.42.10. 6 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR030035. MAGI3.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
[Graphical view]
PANTHERiPTHR10316:SF10. PTHR10316:SF10. 2 hits.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 4 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGI3_HUMAN
AccessioniPrimary (citable) accession number: Q5TCQ9
Secondary accession number(s): Q5TCQ8
, Q5TCR0, Q9H2V6, Q9H5Y8, Q9HBC4, Q9HCD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.