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Protein
Submitted name:

Prelamin-A/C

Gene

LMNA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Prelamin-A/CImported
Gene namesi
Name:LMNAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000160789.19
HGNCiHGNC:6636 LMNA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filamentUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160789

PTM / Processingi

Proteomic databases

MaxQBiQ5TCI8
PeptideAtlasiQ5TCI8
PRIDEiQ5TCI8

Expressioni

Gene expression databases

BgeeiENSG00000160789
ExpressionAtlasiQ5TCI8 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5TCI8
SMRiQ5TCI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini354 – 459LTDInterPro annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili39 – 140Sequence analysisAdd BLAST102
Coiled coili161 – 188Sequence analysisAdd BLAST28
Coiled coili211 – 288Sequence analysisAdd BLAST78

Sequence similaritiesi

Belongs to the intermediate filament family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0977 Eukaryota
ENOG410Y2H6 LUCA
GeneTreeiENSGT00910000143989
HOGENOMiHOG000007711
HOVERGENiHBG013015

Family and domain databases

Gene3Di2.60.40.12601 hit
InterProiView protein in InterPro
IPR001664 IF
IPR018039 Intermediate_filament_CS
IPR001322 Lamin_tail_dom
IPR036415 Lamin_tail_dom_sf
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF00932 LTD, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
SUPFAMiSSF74853 SSF74853, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF, 1 hit

Sequencei

Sequence statusi: Complete.

Q5TCI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPLLCLGNL EDARERTGTL LAQHPAWGRT RAKPGSPLNT KKEGDLIAAQ
60 70 80 90 100
ARLKDLEALL NSKEAALSTA LSEKRTLEGE LHDLRGQVAK LEAALGEAKK
110 120 130 140 150
QLQDEMLRRV DAENRLQTMK EELDFQKNIY SEELRETKRR HETRLVEIDN
160 170 180 190 200
GKQREFESRL ADALQELRAQ HEDQVEQYKK ELEKTYSAKL DNARQSAERN
210 220 230 240 250
SNLVGAAHEE LQQSRIRIDS LSAQLSQLQK QLAAKEAKLR DLEDSLARER
260 270 280 290 300
DTSRRLLAEK EREMAEMRAR MQQQLDEYQE LLDIKLALDM EIHAYRKLLE
310 320 330 340 350
GEEERLRLSP SPTSQRSRGR ASSHSSQTQG GGSVTKKRKL ESTESRSSFS
360 370 380 390 400
QHARTSGRVA VEEVDEEGKF VRLRNKSNED QSMGNWQIKR QNGDDPLLTY
410 420 430 440 450
RFPPKFTLKA GQVVTIWAAG AGATHSPPTD LVWKAQNTWG CGNSLRTALI
460 470 480 490
NSTGEEVAMR KLVRSVTVVE DDEDEDGDDL LHHHHVSGSR R
Length:491
Mass (Da):55,762
Last modified:December 21, 2004 - v1
Checksum:i620B6533D9D65D70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135927 Genomic DNA No translation available.
AL355388 Genomic DNA No translation available.
AL356734 Genomic DNA No translation available.
RefSeqiNP_001269553.1, NM_001282624.1
UniGeneiHs.594444
Hs.706897
Hs.733671

Genome annotation databases

EnsembliENST00000368297; ENSP00000357280; ENSG00000160789
GeneIDi4000
UCSCiuc001fnj.5 human

Similar proteinsi

Entry informationi

Entry nameiQ5TCI8_HUMAN
AccessioniPrimary (citable) accession number: Q5TCI8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported