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Protein
Submitted name:

Isoleucine--tRNA ligase, cytoplasmic

Gene

IARS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Isoleucine--tRNA ligase, cytoplasmicImported
Gene namesi
Name:IARSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000196305.17
HGNCiHGNC:5330 IARS

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196305

PTM / Processingi

Proteomic databases

MaxQBiQ5TCD1
PeptideAtlasiQ5TCD1
PRIDEiQ5TCD1

Expressioni

Gene expression databases

BgeeiENSG00000196305
ExpressionAtlasiQ5TCD1 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ5TCD1, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ5TCD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 329tRNA-synt_1InterPro annotationAdd BLAST313

Phylogenomic databases

eggNOGiKOG0434 Eukaryota
COG0060 LUCA
GeneTreeiENSGT00550000074921
HOGENOMiHOG000246403
HOVERGENiHBG089131

Family and domain databases

Gene3Di3.40.50.620, 1 hit
3.90.740.10, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002301 Ile-tRNA-ligase
IPR014729 Rossmann-like_a/b/a_fold
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PfamiView protein in Pfam
PF00133 tRNA-synt_1, 1 hit
PRINTSiPR00984 TRNASYNTHILE
SUPFAMiSSF50677 SSF50677, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Fragment.

Q5TCD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQQVPENIN FPAEEEKILE FWTEFNCFQE CLKQSKHKPK FTFYDGPPFA
60 70 80 90 100
TGLPHYGHIL AGTIKDIVTR YAHQSGFHVD RRFGWDCHGL PVEYEIDKTL
110 120 130 140 150
GIRGPEDVAK MGITEYNNQC RAIVMRYSAE WKSTVSRLGR WIDFDNDYKT
160 170 180 190 200
LYPQFMESVW WVFKQLYDKG LVYRGVKVMP FSTACNTPLS NFESHQNYKD
210 220 230 240 250
VQDPSVFVTF PLEEDETVSL VAWTTTPWTL PSNLAVCVNP EMQYVKIKDV
260 270 280 290 300
ARGRLLILME ARLSALYKLE SDYEILERFP GAYLKGKKYR PLFDYFLKCK
310 320 330
ENGAFTVLVD NYVKEEEGTG VVHQAPYFGA
Length:330
Mass (Da):38,344
Last modified:December 21, 2004 - v1
Checksum:iD266FD1A1906295C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei330Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136097 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000395554; ENSP00000378922; ENSG00000196305
UCSCiuc064uhg.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5TCD1_HUMAN
AccessioniPrimary (citable) accession number: Q5TCD1
Secondary accession number(s): B5ME20
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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