Q5TC84 (OGRL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Opioid growth factor receptor-like protein 1

Gene names

Name:

OGFRL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Ubiquitous. Ref.5
Sequence similarities	Belongs to the opioid growth factor receptor family.
Sequence caution	The sequence AAI11000.1 differs from that shown. Reason: Frameshift at position 339.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 451	451	Opioid growth factor receptor-like protein 1		PRO_0000314142
Natural variations
	Natural variant	47	1	S → P. Ref.5		VAR_037842
	Natural variant	396	1	Missing.		VAR_037843

Sequences

	Sequence		Length	Mass (Da)
	Q5TC84 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: D33D708BEE382696	FASTA	451	51,252
	10 20 30 40 50 60 MGNLLGGVSF REPTTVEDCD STWQTDSEPE PEEPGPGGGS EGPGQESEQP AQPPEQAGGR 70 80 90 100 110 120 PGASPAPDED AEAAGAEQGG DSTEATAKPK RSFYAARDLY KYRHQYPNFK DIRYQNDLSN 130 140 150 160 170 180 LRFYKNKIPF KPDGVYIEEV LSKWKGDYEK LEHNHTYIQW LFPLREQGLN FYAKELTTYE 190 200 210 220 230 240 IEEFKKTKEA IRRFLLAYKM MLEFFGIKLT DKTGNVARAV NWQERFQHLN ESQHNYLRIT 250 260 270 280 290 300 RILKSLGELG YESFKSPLVK FILHEALVEN TIPNIKQSAL EYFVYTIRDR RERRKLLRFA 310 320 330 340 350 360 QKHYTPSENF IWGPPRKEQS EGSKAQKMSS PLASSHNSQT SMHKKAKDSK NSSSAVHLNS 370 380 390 400 410 420 KTAEDKKVAP KEPVEETDRP SPEPSNEAAK PRNTEKDSNA ENMNSQPEKT VTTPTEKKES 430 440 450 VSPENNEEGG NDNQDNENPG NTNCHDVVLV Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 149-451.
[5]	"Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and OGFRL1, as causative of autosomal recessive retinitis pigmentosa." Abd El-Aziz M.M., Patel R.J., El-Ashry M.F., Barragan I., Marcos I., Borrego S., Antinolo G., Bhattacharya S.S. Ophthalmic Res. 38:19-23(2006) [PubMed: 16192744] [Abstract] Cited for: TISSUE SPECIFICITY, VARIANTS PRO-47 AND LYS-396 DEL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136164 Genomic DNA. Translation: CAI20223.1. CH471051 Genomic DNA. Translation: EAW48802.1. CH471051 Genomic DNA. Translation: EAW48803.1. BC018688 mRNA. Translation: AAH18688.1. BC110999 mRNA. Translation: AAI11000.1. Frameshift. AK024732 mRNA. Translation: BAB14980.1.
IPI	IPI00385437.
RefSeq	NP_078852.3. NM_024576.3.
UniGene	Hs.648434. Hs.656091.
3D structure databases
ProteinModelPortal	Q5TC84.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5TC84.
PTM databases
PhosphoSite	Q5TC84.
Polymorphism databases
DMDM	74746031.
Proteomic databases
PRIDE	Q5TC84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370435; ENSP00000359464; ENSG00000119900.
GeneID	79627.
KEGG	hsa:79627.
UCSC	uc003pfx.1. human.
Organism-specific databases
CTD	79627.
GeneCards	GC06P071998.
H-InvDB	HIX0006001.
HGNC	HGNC:21378. OGFRL1.
HPA	HPA027122. HPA027149.
neXtProt	NX_Q5TC84.
PharmGKB	PA128394713.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19438.
GeneTree	ENSGT00390000018730.
HOGENOM	HBG445490.
HOVERGEN	HBG066276.
InParanoid	Q5TC84.
OMA	VSFREPT.
OrthoDB	EOG4SQWXH.
PhylomeDB	Q5TC84.
Gene expression databases
ArrayExpress	Q5TC84.
Bgee	Q5TC84.
CleanEx	HS_OGFRL1.
Genevestigator	Q5TC84.
Family and domain databases
InterPro	IPR006757. OGF_rcpt. [Graphical view]
Pfam	PF04664. OGFr_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	68713.

Entry information

Entry name

OGRL1_HUMAN

Accession

Primary (citable) accession number: Q5TC84
Secondary accession number(s): Q2TAC1, Q8NEQ4, Q9H7B5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.