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Protein

Opioid growth factor receptor-like protein 1

Gene

OGFRL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid growth factor receptor-like protein 1
Gene namesi
Name:OGFRL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21378. OGFRL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119900.
PharmGKBiPA128394713.

Chemistry databases

ChEMBLiCHEMBL3638334.

Polymorphism and mutation databases

BioMutaiOGFRL1.
DMDMi74746031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141421 – 451Opioid growth factor receptor-like protein 1Add BLAST451

Proteomic databases

EPDiQ5TC84.
MaxQBiQ5TC84.
PaxDbiQ5TC84.
PeptideAtlasiQ5TC84.
PRIDEiQ5TC84.

PTM databases

iPTMnetiQ5TC84.
PhosphoSitePlusiQ5TC84.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000119900.
CleanExiHS_OGFRL1.
GenevisibleiQ5TC84. HS.

Organism-specific databases

HPAiHPA027122.
HPA027149.

Interactioni

Protein-protein interaction databases

BioGridi122757. 1 interactor.
STRINGi9606.ENSP00000359464.

Chemistry databases

BindingDBiQ5TC84.

Structurei

3D structure databases

ProteinModelPortaliQ5TC84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IH5X. Eukaryota.
ENOG4111XCW. LUCA.
GeneTreeiENSGT00390000018730.
HOGENOMiHOG000231272.
HOVERGENiHBG066276.
InParanoidiQ5TC84.
OMAiNSQTSMH.
OrthoDBiEOG091G04CN.
PhylomeDBiQ5TC84.
TreeFamiTF331377.

Family and domain databases

InterProiIPR006757. OGF_rcpt.
[Graphical view]
PfamiPF04664. OGFr_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TC84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNLLGGVSF REPTTVEDCD STWQTDSEPE PEEPGPGGGS EGPGQESEQP
60 70 80 90 100
AQPPEQAGGR PGASPAPDED AEAAGAEQGG DSTEATAKPK RSFYAARDLY
110 120 130 140 150
KYRHQYPNFK DIRYQNDLSN LRFYKNKIPF KPDGVYIEEV LSKWKGDYEK
160 170 180 190 200
LEHNHTYIQW LFPLREQGLN FYAKELTTYE IEEFKKTKEA IRRFLLAYKM
210 220 230 240 250
MLEFFGIKLT DKTGNVARAV NWQERFQHLN ESQHNYLRIT RILKSLGELG
260 270 280 290 300
YESFKSPLVK FILHEALVEN TIPNIKQSAL EYFVYTIRDR RERRKLLRFA
310 320 330 340 350
QKHYTPSENF IWGPPRKEQS EGSKAQKMSS PLASSHNSQT SMHKKAKDSK
360 370 380 390 400
NSSSAVHLNS KTAEDKKVAP KEPVEETDRP SPEPSNEAAK PRNTEKDSNA
410 420 430 440 450
ENMNSQPEKT VTTPTEKKES VSPENNEEGG NDNQDNENPG NTNCHDVVLV

Q
Length:451
Mass (Da):51,252
Last modified:December 21, 2004 - v1
Checksum:iD33D708BEE382696
GO

Sequence cautioni

The sequence AAI11000 differs from that shown. Reason: Frameshift at position 339.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03784247S → P.1 PublicationCorresponds to variant rs112585190dbSNPEnsembl.1
Natural variantiVAR_037843396Missing .1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136164 Genomic DNA. Translation: CAI20223.1.
CH471051 Genomic DNA. Translation: EAW48802.1.
CH471051 Genomic DNA. Translation: EAW48803.1.
BC018688 mRNA. Translation: AAH18688.1.
BC110999 mRNA. Translation: AAI11000.1. Frameshift.
AK024732 mRNA. Translation: BAB14980.1.
CCDSiCCDS34482.1.
RefSeqiNP_001311195.1. NM_001324266.1.
NP_078852.3. NM_024576.4.
XP_011534419.1. XM_011536117.2.
XP_011534420.1. XM_011536118.2.
XP_016866795.1. XM_017011306.1.
UniGeneiHs.648434.
Hs.656091.
Hs.734751.

Genome annotation databases

EnsembliENST00000370435; ENSP00000359464; ENSG00000119900.
GeneIDi79627.
KEGGihsa:79627.
UCSCiuc003pfx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136164 Genomic DNA. Translation: CAI20223.1.
CH471051 Genomic DNA. Translation: EAW48802.1.
CH471051 Genomic DNA. Translation: EAW48803.1.
BC018688 mRNA. Translation: AAH18688.1.
BC110999 mRNA. Translation: AAI11000.1. Frameshift.
AK024732 mRNA. Translation: BAB14980.1.
CCDSiCCDS34482.1.
RefSeqiNP_001311195.1. NM_001324266.1.
NP_078852.3. NM_024576.4.
XP_011534419.1. XM_011536117.2.
XP_011534420.1. XM_011536118.2.
XP_016866795.1. XM_017011306.1.
UniGeneiHs.648434.
Hs.656091.
Hs.734751.

3D structure databases

ProteinModelPortaliQ5TC84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122757. 1 interactor.
STRINGi9606.ENSP00000359464.

Chemistry databases

BindingDBiQ5TC84.
ChEMBLiCHEMBL3638334.

PTM databases

iPTMnetiQ5TC84.
PhosphoSitePlusiQ5TC84.

Polymorphism and mutation databases

BioMutaiOGFRL1.
DMDMi74746031.

Proteomic databases

EPDiQ5TC84.
MaxQBiQ5TC84.
PaxDbiQ5TC84.
PeptideAtlasiQ5TC84.
PRIDEiQ5TC84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370435; ENSP00000359464; ENSG00000119900.
GeneIDi79627.
KEGGihsa:79627.
UCSCiuc003pfx.2. human.

Organism-specific databases

CTDi79627.
GeneCardsiOGFRL1.
H-InvDBHIX0006001.
HGNCiHGNC:21378. OGFRL1.
HPAiHPA027122.
HPA027149.
neXtProtiNX_Q5TC84.
OpenTargetsiENSG00000119900.
PharmGKBiPA128394713.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH5X. Eukaryota.
ENOG4111XCW. LUCA.
GeneTreeiENSGT00390000018730.
HOGENOMiHOG000231272.
HOVERGENiHBG066276.
InParanoidiQ5TC84.
OMAiNSQTSMH.
OrthoDBiEOG091G04CN.
PhylomeDBiQ5TC84.
TreeFamiTF331377.

Miscellaneous databases

GenomeRNAii79627.
PROiQ5TC84.

Gene expression databases

BgeeiENSG00000119900.
CleanExiHS_OGFRL1.
GenevisibleiQ5TC84. HS.

Family and domain databases

InterProiIPR006757. OGF_rcpt.
[Graphical view]
PfamiPF04664. OGFr_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOGRL1_HUMAN
AccessioniPrimary (citable) accession number: Q5TC84
Secondary accession number(s): Q2TAC1, Q8NEQ4, Q9H7B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.