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Q5TC82

- RC3H1_HUMAN

UniProt

Q5TC82 - RC3H1_HUMAN

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Protein

Roquin-1

Gene

RC3H1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri14 – 5441RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 44129C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. mRNA 3'-UTR binding Source: BHF-UCL
  2. poly(A) RNA binding Source: UniProtKB
  3. ubiquitin-protein transferase activity Source: BHF-UCL
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. B cell homeostasis Source: Ensembl
  2. cytoplasmic mRNA processing body assembly Source: BHF-UCL
  3. lymph node development Source: Ensembl
  4. negative regulation of activated T cell proliferation Source: BHF-UCL
  5. negative regulation of B cell proliferation Source: BHF-UCL
  6. negative regulation of germinal center formation Source: BHF-UCL
  7. negative regulation of T-helper cell differentiation Source: BHF-UCL
  8. nuclear-transcribed mRNA catabolic process Source: BHF-UCL
  9. positive regulation of NIK/NF-kappaB signaling Source: Ensembl
  10. posttranscriptional regulation of gene expression Source: BHF-UCL
  11. protein ubiquitination Source: GOC
  12. regulation of germinal center formation Source: BHF-UCL
  13. regulation of mRNA stability Source: BHF-UCL
  14. regulation of T cell receptor signaling pathway Source: BHF-UCL
  15. spleen development Source: Ensembl
  16. T cell homeostasis Source: Ensembl
  17. T cell proliferation Source: Ensembl
  18. T follicular helper cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Roquin-1
Short name:
Roquin
Alternative name(s):
RING finger and C3H zinc finger protein 1
RING finger and CCCH-type zinc finger domain-containing protein 1
RING finger protein 198
Gene namesi
Name:RC3H1
Synonyms:KIAA2025, RNF198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29434. RC3H1.

Subcellular locationi

CytoplasmP-body By similarity
Note: During stress, such as that induced by arsenite, localizes to cytosolic stress granules.By similarity

GO - Cellular componenti

  1. cytoplasmic mRNA processing body Source: BHF-UCL
  2. cytoplasmic stress granule Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11331133Roquin-1PRO_0000055965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei535 – 5351Phosphoserine1 Publication
Modified residuei1110 – 11101PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5TC82.
PaxDbiQ5TC82.
PRIDEiQ5TC82.

PTM databases

PhosphoSiteiQ5TC82.

Expressioni

Tissue specificityi

Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver.1 Publication

Gene expression databases

BgeeiQ5TC82.
CleanExiHS_RC3H1.
ExpressionAtlasiQ5TC82. baseline and differential.
GenevestigatoriQ5TC82.

Organism-specific databases

HPAiHPA027428.
HPA027434.
HPA027448.

Interactioni

Subunit structurei

Interacts with DDX6 and EDC4. Interacts with CCR4-NOT deadenylase complex.By similarity

Protein-protein interaction databases

BioGridi127186. 7 interactions.
IntActiQ5TC82. 3 interactions.
MINTiMINT-2809509.
STRINGi9606.ENSP00000258349.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4QIKX-ray1.90A/B88-407[»]
4QILX-ray2.90A/B88-407[»]
ProteinModelPortaliQ5TC82.
SMRiQ5TC82. Positions 9-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni181 – 23252ROQAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi533 – 788256Pro-richAdd
BLAST

Domaini

The RING-type zinc finger is required for proper localization to stress granules, but not to P-bodies.By similarity
The ROQ region is required for CDE RNA-binding. It may also be involved in localization to stress granules.By similarity

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri14 – 5441RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri413 – 44129C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG320727.
GeneTreeiENSGT00390000004311.
HOVERGENiHBG080524.
InParanoidiQ5TC82.
KOiK15690.
OMAiICTQTFD.
OrthoDBiEOG7QNVKM.
PhylomeDBiQ5TC82.
TreeFamiTF317698.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5TC82-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVQAPQWTD FLSCPICTQT FDETIRKPIS LGCGHTVCKM CLNKLHRKAC
60 70 80 90 100
PFDQTTINTD IELLPVNSAL LQLVGAQVPE QQPITLCSGV EDTKHYEEAK
110 120 130 140 150
KCVEELALYL KPLSSARGVG LNSTTQSVLS RPMQRKLVTL VHCQLVEEEG
160 170 180 190 200
RIRAMRAARS LGERTVTELI LQHQNPQQLS SNLWAAVRAR GCQFLGPAMQ
210 220 230 240 250
EEALKLVLLA LEDGSALSRK VLVLFVVQRL EPRFPQASKT SIGHVVQLLY
260 270 280 290 300
RASCFKVTKR DEDSSLMQLK EEFRTYEALR REHDSQIVQI AMEAGLRIAP
310 320 330 340 350
DQWSSLLYGD QSHKSHMQSI IDKLQTPASF AQSVQELTIA LQRTGDPANL
360 370 380 390 400
NRLRPHLELL ANIDPSPDAP PPTWEQLENG LVAVRTVVHG LVDYIQNHSK
410 420 430 440 450
KGADQQQPPQ HSKYKTYMCR DMKQRGGCPR GASCTFAHSQ EELEKFRKMN
460 470 480 490 500
KRLVPRRPLS ASLGQLNEVG LPSAAILPDE GAVDLPSRKP PALPNGIVST
510 520 530 540 550
GNTVTQLIPR GTDPSYDSSL KPGKIDHLSS SAPGSPPDLL ESVPKSISAL
560 570 580 590 600
PVNPHSIPPR GPADLPPMPV TKPLQMVPRG SQLYPAQQTD VYYQDPRGAA
610 620 630 640 650
PPFEPAPYQQ GMYYTPPPQC VSRFVRPPPS APEPAPPYLD HYPPYLQERV
660 670 680 690 700
VNSQYGTQPQ QYPPIYPSHY DGRRVYPAPS YTREEIFRES PIPIEIPPAA
710 720 730 740 750
VPSYVPESRE RYQQIESYYP VAPHPTQIRP SYLREPPYSR LPPPPQPHPS
760 770 780 790 800
LDELHRRRKE IMAQLEERKV ISPPPFAPSP TLPPTFHPEE FLDEDLKVAG
810 820 830 840 850
KYKGNDYSQY SPWSCDTIGS YIGTKDAKPK DVVAAGSVEM MNVESKGMRD
860 870 880 890 900
QRLDLQRRAA ETSDDDLIPF GDRPTVSRFG AISRTSKTIY QGAGPMQAMA
910 920 930 940 950
PQGAPTKSIN ISDYSPYGTH GGWGASPYSP HQNIPSQGHF SERERISMSE
960 970 980 990 1000
VASHGKPLPS AEREQLRLEL QQLNHQISQQ TQLRGLEAVS NRLVLQREAN
1010 1020 1030 1040 1050
TLAGQSQPPP PPPPKWPGMI SSEQLSLELH QVEREIGKRT RELSMENQCS
1060 1070 1080 1090 1100
LDMKSKLNTS KQAENGQPEP QNKVPAEDLT LTFSDVPNGS ALTQENISLL
1110 1120 1130
SNKTSSLNLS EDPEGGGDNN DSQRSGVTPS SAP
Length:1,133
Mass (Da):125,736
Last modified:December 21, 2004 - v1
Checksum:iE307838DF80A7099
GO
Isoform 2 (identifier: Q5TC82-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     988-996: Missing.
     1084-1084: S → SS

Note: No experimental confirmation available.

Show »
Length:1,125
Mass (Da):124,842
Checksum:iEFBE5179071DFA94
GO

Sequence cautioni

The sequence BAC04186.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAH70709.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAH70710.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI19417.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI19419.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti986 – 9861L → P in BAC04186. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei988 – 9969Missing in isoform 2. 1 PublicationVSP_015015
Alternative sequencei1084 – 10841S → SS in isoform 2. 1 PublicationVSP_015016

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK093501 mRNA. Translation: BAC04186.1. Different initiation.
AK122948 mRNA. Translation: BAG53813.1.
AL121983, AL136170 Genomic DNA. Translation: CAH70709.1. Different initiation.
AL121983, AL136170 Genomic DNA. Translation: CAH70710.1. Different initiation.
AL136170, AL121983 Genomic DNA. Translation: CAI19417.1. Different initiation.
AL136170, AL121983 Genomic DNA. Translation: CAI19419.1. Different initiation.
AB095945 mRNA. Translation: BAC23121.1.
CCDSiCCDS30940.1. [Q5TC82-1]
CCDS72987.1. [Q5TC82-2]
RefSeqiNP_742068.1. NM_172071.3. [Q5TC82-1]
UniGeneiHs.30258.

Genome annotation databases

EnsembliENST00000258349; ENSP00000258349; ENSG00000135870. [Q5TC82-1]
ENST00000367694; ENSP00000356667; ENSG00000135870. [Q5TC82-2]
ENST00000367696; ENSP00000356669; ENSG00000135870. [Q5TC82-1]
GeneIDi149041.
KEGGihsa:149041.
UCSCiuc001gju.4. human. [Q5TC82-1]
uc001gjv.3. human. [Q5TC82-2]

Polymorphism databases

DMDMi73621450.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK093501 mRNA. Translation: BAC04186.1 . Different initiation.
AK122948 mRNA. Translation: BAG53813.1 .
AL121983 , AL136170 Genomic DNA. Translation: CAH70709.1 . Different initiation.
AL121983 , AL136170 Genomic DNA. Translation: CAH70710.1 . Different initiation.
AL136170 , AL121983 Genomic DNA. Translation: CAI19417.1 . Different initiation.
AL136170 , AL121983 Genomic DNA. Translation: CAI19419.1 . Different initiation.
AB095945 mRNA. Translation: BAC23121.1 .
CCDSi CCDS30940.1. [Q5TC82-1 ]
CCDS72987.1. [Q5TC82-2 ]
RefSeqi NP_742068.1. NM_172071.3. [Q5TC82-1 ]
UniGenei Hs.30258.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4QIK X-ray 1.90 A/B 88-407 [» ]
4QIL X-ray 2.90 A/B 88-407 [» ]
ProteinModelPortali Q5TC82.
SMRi Q5TC82. Positions 9-74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127186. 7 interactions.
IntActi Q5TC82. 3 interactions.
MINTi MINT-2809509.
STRINGi 9606.ENSP00000258349.

PTM databases

PhosphoSitei Q5TC82.

Polymorphism databases

DMDMi 73621450.

Proteomic databases

MaxQBi Q5TC82.
PaxDbi Q5TC82.
PRIDEi Q5TC82.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258349 ; ENSP00000258349 ; ENSG00000135870 . [Q5TC82-1 ]
ENST00000367694 ; ENSP00000356667 ; ENSG00000135870 . [Q5TC82-2 ]
ENST00000367696 ; ENSP00000356669 ; ENSG00000135870 . [Q5TC82-1 ]
GeneIDi 149041.
KEGGi hsa:149041.
UCSCi uc001gju.4. human. [Q5TC82-1 ]
uc001gjv.3. human. [Q5TC82-2 ]

Organism-specific databases

CTDi 149041.
GeneCardsi GC01M173900.
HGNCi HGNC:29434. RC3H1.
HPAi HPA027428.
HPA027434.
HPA027448.
MIMi 609424. gene.
neXtProti NX_Q5TC82.
PharmGKBi PA142671090.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320727.
GeneTreei ENSGT00390000004311.
HOVERGENi HBG080524.
InParanoidi Q5TC82.
KOi K15690.
OMAi ICTQTFD.
OrthoDBi EOG7QNVKM.
PhylomeDBi Q5TC82.
TreeFami TF317698.

Miscellaneous databases

GenomeRNAii 149041.
NextBioi 86056.
PROi Q5TC82.
SOURCEi Search...

Gene expression databases

Bgeei Q5TC82.
CleanExi HS_RC3H1.
ExpressionAtlasi Q5TC82. baseline and differential.
Genevestigatori Q5TC82.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.1000.10. 1 hit.
InterProi IPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00642. zf-CCCH. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS50103. ZF_C3H1. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 589-1133 (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-1133 (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-535, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Molecular control of Tfh-cell differentiation by Roquin family proteins."
    Heissmeyer V., Vogel K.U.
    Immunol. Rev. 253:273-289(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, MISCELLANEOUS.

Entry informationi

Entry nameiRC3H1_HUMAN
AccessioniPrimary (citable) accession number: Q5TC82
Secondary accession number(s): B3KVK1
, Q5W180, Q5W181, Q8IVE6, Q8N9V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The RING finger is highly conserved among the paralogs and among species, suggesting it may possess E3 ubiquitin ligase activity. A C. elegans homolog, rle-1, is involved in daf-16 ubiquitin-dependent degradation. Although such an activity has not be observed in mammalian cells so far, it is conceivable that RC3H1 may utilize E3 ubiquitin ligase activity in the promotion of mRNA decay (PubMed:23550652).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3