Q5TC79 (ZBT37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 37

Gene names

Name:

ZBTB37

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5TC79-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q5TC79-2)

The sequence of this isoform differs from the canonical sequence as follows:
     343-361: EESAMMGVSGYVEYLREQE → WSCGFRTALVVGGIATVYE
     362-503: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5TC79-3)

The sequence of this isoform differs from the canonical sequence as follows:
     309-503: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Zinc finger and BTB domain-containing protein 37		PRO_0000047741
Regions
	Domain	32 – 96	65	BTB
	Zinc finger	373 – 395	23	C2H2-type 1
	Zinc finger	401 – 423	23	C2H2-type 2
	Zinc finger	429 – 452	24	C2H2-type 3
Natural variations
	Alternative sequence	309 – 503	195	Missing in isoform 3.		VSP_014440
	Alternative sequence	343 – 361	19	EESAM…LREQE → WSCGFRTALVVGGIATVYE in isoform 2.		VSP_014441
	Alternative sequence	362 – 503	142	Missing in isoform 2.		VSP_014442
Experimental info
	Sequence conflict	153	1	H → R in BAB71422. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 169ECA3DBB556A7B	FASTA	503	56,055
	10 20 30 40 50 60 MEKGGNIQLE IPDFSNSVLS HLNQLRMQGR LCDIVVNVQG QAFRAHKVVL AASSPYFRDH 70 80 90 100 110 120 MSLNEMSTVS ISVIKNPTVF EQLLSFCYTG RICLQLADII SYLTAASFLQ MQHIIDKCTQ 130 140 150 160 170 180 ILEGIHFKIN VAEVEAELSQ TRTKHQERPP ESHRVTPNLN RSLSPRHNTP KGNRRGQVSA 190 200 210 220 230 240 VLDIRELSPP EESTSPQIIE PSSDVESREP ILRINRAGQW YVETGVADRG GRSDDEVRVL 250 260 270 280 290 300 GAVHIKTENL EEWLGPENQP SGEDGSSAEE VTAMVIDTTG HGSVGQENYT LGSSGAKVAR 310 320 330 340 350 360 PTSSEVDRFS PSGSVVPLTE RHRARSESPG RMDEPKQPSS QVEESAMMGV SGYVEYLREQ 370 380 390 400 410 420 EVSERWFRYN PRLTCIYCAK SFNQKGSLDR HMRLHMGITP FVCRMCGKKY TRKDQLEYHI 430 440 450 460 470 480 RKHTGNKPFH CHVCGKSFPF QAILNQHFRK NHPGCIPLEG PHSISPETTV TSRGQAEEES 490 500 PSQEETVAPG EAVQGSVSTT GPD
	Isoform 2 [UniParc]. Checksum: 4CAC555491F1AADB	FASTA	361	39,767
	10 20 30 40 50 60 MEKGGNIQLE IPDFSNSVLS HLNQLRMQGR LCDIVVNVQG QAFRAHKVVL AASSPYFRDH 70 80 90 100 110 120 MSLNEMSTVS ISVIKNPTVF EQLLSFCYTG RICLQLADII SYLTAASFLQ MQHIIDKCTQ 130 140 150 160 170 180 ILEGIHFKIN VAEVEAELSQ TRTKHQERPP ESHRVTPNLN RSLSPRHNTP KGNRRGQVSA 190 200 210 220 230 240 VLDIRELSPP EESTSPQIIE PSSDVESREP ILRINRAGQW YVETGVADRG GRSDDEVRVL 250 260 270 280 290 300 GAVHIKTENL EEWLGPENQP SGEDGSSAEE VTAMVIDTTG HGSVGQENYT LGSSGAKVAR 310 320 330 340 350 360 PTSSEVDRFS PSGSVVPLTE RHRARSESPG RMDEPKQPSS QVWSCGFRTA LVVGGIATVY E
	Isoform 3 [UniParc]. Checksum: 2FCC9EF3CBF952E3	FASTA	308	34,036
	10 20 30 40 50 60 MEKGGNIQLE IPDFSNSVLS HLNQLRMQGR LCDIVVNVQG QAFRAHKVVL AASSPYFRDH 70 80 90 100 110 120 MSLNEMSTVS ISVIKNPTVF EQLLSFCYTG RICLQLADII SYLTAASFLQ MQHIIDKCTQ 130 140 150 160 170 180 ILEGIHFKIN VAEVEAELSQ TRTKHQERPP ESHRVTPNLN RSLSPRHNTP KGNRRGQVSA 190 200 210 220 230 240 VLDIRELSPP EESTSPQIIE PSSDVESREP ILRINRAGQW YVETGVADRG GRSDDEVRVL 250 260 270 280 290 300 GAVHIKTENL EEWLGPENQP SGEDGSSAEE VTAMVIDTTG HGSVGQENYT LGSSGAKVAR PTSSEVDR

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057310 mRNA. Translation: BAB71422.1. AL136170 Genomic DNA. Translation: CAI19420.1. AL136170 Genomic DNA. Translation: CAI19421.1. AL136170 Genomic DNA. Translation: CAI19422.1. BC003116 mRNA. Translation: AAH03116.1. BC006315 mRNA. Translation: AAH06315.1.
IPI	IPI00000141. IPI00607667. IPI00607873.
RefSeq	NP_001116242.1. NM_001122770.1. NP_115911.1. NM_032522.3.
UniGene	Hs.668497.
3D structure databases
ProteinModelPortal	Q5TC79.
SMR	Q5TC79. Positions 6-124, 363-479.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5TC79. 1 interaction.
PTM databases
PhosphoSite	Q5TC79.
Polymorphism databases
DMDM	68566168.
Proteomic databases
PRIDE	Q5TC79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367701; ENSP00000356674; ENSG00000185278. ENST00000427304; ENSP00000415293; ENSG00000185278.
GeneID	84614.
KEGG	hsa:84614.
UCSC	uc001gjp.1. human. uc001gjq.2. human. uc001gjr.1. human.
Organism-specific databases
CTD	84614.
GeneCards	GC01P173837.
HGNC	HGNC:28365. ZBTB37.
HPA	HPA023438.
neXtProt	NX_Q5TC79.
PharmGKB	PA134911383.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17409.
GeneTree	ENSGT00580000081322.
HOGENOM	HBG716354.
HOVERGEN	HBG055639.
InParanoid	Q5TC79.
OMA	HPERPPE.
OrthoDB	EOG4894M7.
PhylomeDB	Q5TC79.
Gene expression databases
ArrayExpress	Q5TC79.
Bgee	Q5TC79.
CleanEx	HS_ZBTB37.
Genevestigator	Q5TC79.
GermOnline	ENSG00000185278. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
KO	K10509.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 3 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 3 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	74478.

Entry information

Entry name

ZBT37_HUMAN

Accession

Primary (citable) accession number: Q5TC79
Secondary accession number(s): Q5TC80, Q96M87, Q9BQ88

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.