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Protein

Zinc finger and BTB domain-containing protein 37

Gene

ZBTB37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 395C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 452C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 37
Gene namesi
Name:ZBTB37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000185278.14
HGNCiHGNC:28365 ZBTB37
neXtProtiNX_Q5TC79

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185278
PharmGKBiPA134911383

Polymorphism and mutation databases

BioMutaiZBTB37
DMDMi68566168

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477411 – 503Zinc finger and BTB domain-containing protein 37Add BLAST503

Proteomic databases

PaxDbiQ5TC79
PeptideAtlasiQ5TC79
PRIDEiQ5TC79

PTM databases

iPTMnetiQ5TC79
PhosphoSitePlusiQ5TC79

Expressioni

Gene expression databases

BgeeiENSG00000185278
CleanExiHS_ZBTB37
GenevisibleiQ5TC79 HS

Organism-specific databases

HPAiHPA023438

Interactioni

Protein-protein interaction databases

BioGridi124146, 3 interactors
IntActiQ5TC79, 3 interactors
MINTiQ5TC79
STRINGi9606.ENSP00000356674

Structurei

3D structure databases

ProteinModelPortaliQ5TC79
SMRiQ5TC79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 96BTBPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 395C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 452C2H2-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000043096
HOVERGENiHBG055639
InParanoidiQ5TC79
KOiK10509
OMAiKHPERPP
OrthoDBiEOG091G04SQ
PhylomeDBiQ5TC79
TreeFamiTF331184

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TC79-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKGGNIQLE IPDFSNSVLS HLNQLRMQGR LCDIVVNVQG QAFRAHKVVL
60 70 80 90 100
AASSPYFRDH MSLNEMSTVS ISVIKNPTVF EQLLSFCYTG RICLQLADII
110 120 130 140 150
SYLTAASFLQ MQHIIDKCTQ ILEGIHFKIN VAEVEAELSQ TRTKHQERPP
160 170 180 190 200
ESHRVTPNLN RSLSPRHNTP KGNRRGQVSA VLDIRELSPP EESTSPQIIE
210 220 230 240 250
PSSDVESREP ILRINRAGQW YVETGVADRG GRSDDEVRVL GAVHIKTENL
260 270 280 290 300
EEWLGPENQP SGEDGSSAEE VTAMVIDTTG HGSVGQENYT LGSSGAKVAR
310 320 330 340 350
PTSSEVDRFS PSGSVVPLTE RHRARSESPG RMDEPKQPSS QVEESAMMGV
360 370 380 390 400
SGYVEYLREQ EVSERWFRYN PRLTCIYCAK SFNQKGSLDR HMRLHMGITP
410 420 430 440 450
FVCRMCGKKY TRKDQLEYHI RKHTGNKPFH CHVCGKSFPF QAILNQHFRK
460 470 480 490 500
NHPGCIPLEG PHSISPETTV TSRGQAEEES PSQEETVAPG EAVQGSVSTT

GPD
Note: No experimental confirmation available.
Length:503
Mass (Da):56,055
Last modified:December 21, 2004 - v1
Checksum:i169ECA3DBB556A7B
GO
Isoform 2 (identifier: Q5TC79-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     343-361: EESAMMGVSGYVEYLREQE → WSCGFRTALVVGGIATVYE
     362-503: Missing.

Note: No experimental confirmation available.
Show »
Length:361
Mass (Da):39,767
Checksum:i4CAC555491F1AADB
GO
Isoform 3 (identifier: Q5TC79-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-503: Missing.

Note: No experimental confirmation available.
Show »
Length:308
Mass (Da):34,036
Checksum:i2FCC9EF3CBF952E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153H → R in BAB71422 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014440309 – 503Missing in isoform 3. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_014441343 – 361EESAM…LREQE → WSCGFRTALVVGGIATVYE in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_014442362 – 503Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057310 mRNA Translation: BAB71422.1
AL136170 Genomic DNA No translation available.
BC003116 mRNA Translation: AAH03116.1
BC006315 mRNA Translation: AAH06315.1
CCDSiCCDS1312.1 [Q5TC79-2]
CCDS44278.1 [Q5TC79-1]
RefSeqiNP_001116242.1, NM_001122770.2 [Q5TC79-1]
NP_001333044.1, NM_001346115.1 [Q5TC79-3]
NP_115911.1, NM_032522.4 [Q5TC79-2]
XP_006711641.1, XM_006711578.3 [Q5TC79-1]
XP_011508364.1, XM_011510062.2 [Q5TC79-3]
XP_016858045.1, XM_017002556.1 [Q5TC79-1]
XP_016858046.1, XM_017002557.1 [Q5TC79-3]
XP_016858047.1, XM_017002558.1 [Q5TC79-3]
UniGeneiHs.668497

Genome annotation databases

EnsembliENST00000367701; ENSP00000356674; ENSG00000185278 [Q5TC79-1]
ENST00000367702; ENSP00000356675; ENSG00000185278 [Q5TC79-2]
ENST00000367704; ENSP00000356677; ENSG00000185278 [Q5TC79-3]
ENST00000427304; ENSP00000415293; ENSG00000185278 [Q5TC79-1]
GeneIDi84614
KEGGihsa:84614
UCSCiuc001gjp.1 human [Q5TC79-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZBT37_HUMAN
AccessioniPrimary (citable) accession number: Q5TC79
Secondary accession number(s): Q5TC80, Q96M87, Q9BQ88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

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