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Protein

Growth hormone-regulated TBC protein 1

Gene

GRTP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone-regulated TBC protein 1
Alternative name(s):
TBC1 domain family member 6
Gene namesi
Name:GRTP1
Synonyms:TBC1D6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20310. GRTP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134908043.

Polymorphism and mutation databases

DMDMi206729933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Growth hormone-regulated TBC protein 1PRO_0000288708Add
BLAST

Proteomic databases

MaxQBiQ5TC63.
PaxDbiQ5TC63.
PRIDEiQ5TC63.
TopDownProteomicsiQ5TC63-2. [Q5TC63-2]

PTM databases

iPTMnetiQ5TC63.
PhosphoSiteiQ5TC63.

Expressioni

Gene expression databases

BgeeiQ5TC63.
CleanExiHS_GRTP1.
ExpressionAtlasiQ5TC63. baseline and differential.
GenevisibleiQ5TC63. HS.

Organism-specific databases

HPAiHPA046201.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122876. 6 interactions.
IntActiQ5TC63. 1 interaction.
STRINGi9606.ENSP00000364580.

Structurei

3D structure databases

ProteinModelPortaliQ5TC63.
SMRiQ5TC63. Positions 13-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 258191Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119202.
HOVERGENiHBG107100.
InParanoidiQ5TC63.
KOiK19953.
OMAiLAMFVTH.
OrthoDBiEOG7ZSHTC.
PhylomeDBiQ5TC63.
TreeFamiTF105771.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TC63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPAERSRVP RIDPYGFERP EDFDDAAYEK FFSSYLVTLT RRAIKWSRLL
60 70 80 90 100
QGGGVPRSRT VKRYVRKGVP LEHRARVWMV LSGAQAQMDQ NPGYYHQLLQ
110 120 130 140 150
GERNPRLEDA IRTDLNRTFP DNVKFRKTTD PCLQRTLYNV LLAYGHHNQG
160 170 180 190 200
VGYCQGMNFI AGYLILITNN EEESFWLLDA LVGRILPDYY SPAMLGLKTD
210 220 230 240 250
QEVLGELVRA KLPAVGALME RLGVLWTLLV SRWFICLFVD ILPVETVLRI
260 270 280 290 300
WDCLFNEGSK IIFRVALTLI KQHQELILEA TSVPDICDKF KQITKGSFVM
310 320 330
ECHTFMQKIF SEPGSLSMAT VAKLRESCRA RLLAQG
Length:336
Mass (Da):38,554
Last modified:September 23, 2008 - v4
Checksum:i91CE9EAF71BB131C
GO
Isoform 2 (identifier: Q5TC63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
     308-336: KIFSEPGSLSMATVAKLRESCRARLLAQG → VCGAARGSVPSQGAPPHLQPGGCSDHPEGAQDGHQWA

Show »
Length:266
Mass (Da):29,860
Checksum:iFC31B8B1B30B4E1F
GO
Isoform 3 (identifier: Q5TC63-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-336: KIFSEPGSLSMATVAKLRESCRARLLAQG → VCGAARGSVPSQGAPPHLQPGGCSDHPEGAQDGHQWA

Show »
Length:344
Mass (Da):39,096
Checksum:iA2C6BA52E7E93111
GO

Sequence cautioni

The sequence AAH80640.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI12124.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI12126.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti282 – 2821S → T in AAH33071 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7878Missing in isoform 2. 2 PublicationsVSP_025754Add
BLAST
Alternative sequencei308 – 33629KIFSE…LLAQG → VCGAARGSVPSQGAPPHLQP GGCSDHPEGAQDGHQWA in isoform 2 and isoform 3. 3 PublicationsVSP_025755Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449887 mRNA. Translation: BAH16630.1.
AL136221 Genomic DNA. Translation: CAI13799.2.
AL136221 Genomic DNA. Translation: CAI13800.2.
CH471085 Genomic DNA. Translation: EAX09205.1.
BC033071 mRNA. Translation: AAH33071.2.
BC062461 mRNA. Translation: AAH62461.1.
BC080640 mRNA. Translation: AAH80640.1. Different initiation.
BC112123 mRNA. Translation: AAI12124.1. Different initiation.
BC112125 mRNA. Translation: AAI12126.1. Different initiation.
AK026127 mRNA. Translation: BAB15368.1.
CCDSiCCDS66591.1. [Q5TC63-3]
CCDS9534.2. [Q5TC63-1]
RefSeqiNP_001273661.1. NM_001286732.1. [Q5TC63-3]
NP_001273662.1. NM_001286733.1.
NP_078995.2. NM_024719.3. [Q5TC63-1]
UniGeneiHs.745043.

Genome annotation databases

EnsembliENST00000326039; ENSP00000321850; ENSG00000139835. [Q5TC63-2]
ENST00000375430; ENSP00000364579; ENSG00000139835. [Q5TC63-3]
ENST00000375431; ENSP00000364580; ENSG00000139835. [Q5TC63-1]
GeneIDi79774.
KEGGihsa:79774.
UCSCiuc001vtn.5. human. [Q5TC63-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449887 mRNA. Translation: BAH16630.1.
AL136221 Genomic DNA. Translation: CAI13799.2.
AL136221 Genomic DNA. Translation: CAI13800.2.
CH471085 Genomic DNA. Translation: EAX09205.1.
BC033071 mRNA. Translation: AAH33071.2.
BC062461 mRNA. Translation: AAH62461.1.
BC080640 mRNA. Translation: AAH80640.1. Different initiation.
BC112123 mRNA. Translation: AAI12124.1. Different initiation.
BC112125 mRNA. Translation: AAI12126.1. Different initiation.
AK026127 mRNA. Translation: BAB15368.1.
CCDSiCCDS66591.1. [Q5TC63-3]
CCDS9534.2. [Q5TC63-1]
RefSeqiNP_001273661.1. NM_001286732.1. [Q5TC63-3]
NP_001273662.1. NM_001286733.1.
NP_078995.2. NM_024719.3. [Q5TC63-1]
UniGeneiHs.745043.

3D structure databases

ProteinModelPortaliQ5TC63.
SMRiQ5TC63. Positions 13-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122876. 6 interactions.
IntActiQ5TC63. 1 interaction.
STRINGi9606.ENSP00000364580.

PTM databases

iPTMnetiQ5TC63.
PhosphoSiteiQ5TC63.

Polymorphism and mutation databases

DMDMi206729933.

Proteomic databases

MaxQBiQ5TC63.
PaxDbiQ5TC63.
PRIDEiQ5TC63.
TopDownProteomicsiQ5TC63-2. [Q5TC63-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326039; ENSP00000321850; ENSG00000139835. [Q5TC63-2]
ENST00000375430; ENSP00000364579; ENSG00000139835. [Q5TC63-3]
ENST00000375431; ENSP00000364580; ENSG00000139835. [Q5TC63-1]
GeneIDi79774.
KEGGihsa:79774.
UCSCiuc001vtn.5. human. [Q5TC63-1]

Organism-specific databases

CTDi79774.
GeneCardsiGRTP1.
HGNCiHGNC:20310. GRTP1.
HPAiHPA046201.
neXtProtiNX_Q5TC63.
PharmGKBiPA134908043.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119202.
HOVERGENiHBG107100.
InParanoidiQ5TC63.
KOiK19953.
OMAiLAMFVTH.
OrthoDBiEOG7ZSHTC.
PhylomeDBiQ5TC63.
TreeFamiTF105771.

Miscellaneous databases

ChiTaRSiGRTP1. human.
GenomeRNAii79774.
PROiQ5TC63.

Gene expression databases

BgeeiQ5TC63.
CleanExiHS_GRTP1.
ExpressionAtlasiQ5TC63. baseline and differential.
GenevisibleiQ5TC63. HS.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity."
    Ishibashi K., Kanno E., Itoh T., Fukuda M.
    Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Ovary, Pancreas and Uterus.
  5. Bienvenut W.V., Calvo F., Kolch W.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 49-57 AND 199-209, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-336 (ISOFORM 2).
    Tissue: Kidney epithelium.

Entry informationi

Entry nameiGRTP1_HUMAN
AccessioniPrimary (citable) accession number: Q5TC63
Secondary accession number(s): B9A6K2
, Q2M232, Q5TC64, Q66K26, Q6P659, Q8N528, Q9H695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 92 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.