Q5TBK1 (N42L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NEDD4-binding protein 2-like 1

Gene names

Name:	N4BP2L1
Synonyms:	CG081

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5TBK1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5TBK1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     133-243: ALENNYEVIF...HRRGGCHHGY → VFQTEQKNLF...RKNPPNERTV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	NEDD4-binding protein 2-like 1		PRO_0000318958
Natural variations
	Alternative sequence	133 – 243	111	ALENN…CHHGY → VFQTEQKNLFRLEMDMVVFR PEMKKHSWCLKRKNPPNERT V in isoform 2.		VSP_031319

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: C1C662AD6B78275B	FASTA	243	28,981
	10 20 30 40 50 60 MEDSFLQSFG RLSLQPQQQQ QRQRPPRPPP RGTPPRRHSF RKHLYLLRGL PGSGKTTLAR 70 80 90 100 110 120 QLQHDFPRAL IFSTDDFFFR EDGAYEFNPD FLEEAHEWNQ KRARKAMRNG ISPIIIDNTN 130 140 150 160 170 180 LHAWEMKPYA VMALENNYEV IFREPDTRWK FNVQELARRN IHGVSREKIH RMKERYEHDV 190 200 210 220 230 240 TFHSVLHAEK PSRMNRNQDR NNALPSNNAR YWNSYTEFPN RRAHGGFTNE SSYHRRGGCH HGY
	Isoform 2 [UniParc]. Checksum: E79510AF6736241E	FASTA	173	20,678
	10 20 30 40 50 60 MEDSFLQSFG RLSLQPQQQQ QRQRPPRPPP RGTPPRRHSF RKHLYLLRGL PGSGKTTLAR 70 80 90 100 110 120 QLQHDFPRAL IFSTDDFFFR EDGAYEFNPD FLEEAHEWNQ KRARKAMRNG ISPIIIDNTN 130 140 150 160 170 LHAWEMKPYA VMVFQTEQKN LFRLEMDMVV FRPEMKKHSW CLKRKNPPNE RTV

References

[1]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-243 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL137247 Genomic DNA. Translation: CAI13190.1. AL137247 Genomic DNA. Translation: CAI13191.1. CH471075 Genomic DNA. Translation: EAX08502.1. CH471075 Genomic DNA. Translation: EAX08503.1. BC125050 mRNA. Translation: AAI25051.1.
IPI	IPI00102831. IPI00163804.
RefSeq	NP_001073159.1. NM_001079691.1. NP_438169.2. NM_052818.2.
UniGene	Hs.161220.
3D structure databases
ProteinModelPortal	Q5TBK1.
SMR	Q5TBK1. Positions 39-159.
ModBase	Search...
Polymorphism databases
DMDM	74745960.
Proteomic databases
PRIDE	Q5TBK1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380130; ENSP00000369473; ENSG00000139597. ENST00000380133; ENSP00000369476; ENSG00000139597.
GeneID	90634.
KEGG	hsa:90634.
UCSC	uc001uuc.1. human. uc001uud.1. human.
Organism-specific databases
CTD	90634.
GeneCards	GC13M032974.
HGNC	HGNC:25037. N4BP2L1.
HPA	HPA038971.
neXtProt	NX_Q5TBK1.
PharmGKB	PA162396617.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG126527.
HOVERGEN	HBG095655.
InParanoid	Q5TBK1.
OMA	RRGGCHH.
Gene expression databases
ArrayExpress	Q5TBK1.
Bgee	Q5TBK1.
CleanEx	HS_N4BP2L1.
Genevestigator	Q5TBK1.
Family and domain databases
InterPro	IPR010488. Zeta_toxin_domain. [Graphical view]
Pfam	PF06414. Zeta_toxin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	76884.

Entry information

Entry name

N42L1_HUMAN

Accession

Primary (citable) accession number: Q5TBK1
Secondary accession number(s): A4QN21, Q5TBK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.