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Protein

NEDD4-binding protein 2-like 1

Gene

N4BP2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD4-binding protein 2-like 1
Gene namesi
Name:N4BP2L1
Synonyms:CG081
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:25037. N4BP2L1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396617.

Polymorphism and mutation databases

BioMutaiN4BP2L1.
DMDMi74745960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243NEDD4-binding protein 2-like 1PRO_0000318958Add
BLAST

Proteomic databases

PaxDbiQ5TBK1.
PeptideAtlasiQ5TBK1.
PRIDEiQ5TBK1.

PTM databases

iPTMnetiQ5TBK1.
PhosphoSiteiQ5TBK1.

Expressioni

Gene expression databases

BgeeiQ5TBK1.
CleanExiHS_N4BP2L1.
ExpressionAtlasiQ5TBK1. baseline and differential.
GenevisibleiQ5TBK1. HS.

Organism-specific databases

HPAiHPA038971.

Structurei

3D structure databases

ProteinModelPortaliQ5TBK1.
SMRiQ5TBK1. Positions 43-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2401. Eukaryota.
ENOG41101K4. LUCA.
GeneTreeiENSGT00510000047015.
HOGENOMiHOG000072698.
HOVERGENiHBG095655.
InParanoidiQ5TBK1.
OMAiRMNRSQD.
OrthoDBiEOG773XF6.
PhylomeDBiQ5TBK1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR026567. NEDD4-bind_pro_2-like_1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR13308:SF5. PTHR13308:SF5. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TBK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDSFLQSFG RLSLQPQQQQ QRQRPPRPPP RGTPPRRHSF RKHLYLLRGL
60 70 80 90 100
PGSGKTTLAR QLQHDFPRAL IFSTDDFFFR EDGAYEFNPD FLEEAHEWNQ
110 120 130 140 150
KRARKAMRNG ISPIIIDNTN LHAWEMKPYA VMALENNYEV IFREPDTRWK
160 170 180 190 200
FNVQELARRN IHGVSREKIH RMKERYEHDV TFHSVLHAEK PSRMNRNQDR
210 220 230 240
NNALPSNNAR YWNSYTEFPN RRAHGGFTNE SSYHRRGGCH HGY
Length:243
Mass (Da):28,981
Last modified:December 21, 2004 - v1
Checksum:iC1C662AD6B78275B
GO
Isoform 2 (identifier: Q5TBK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-243: ALENNYEVIF...HRRGGCHHGY → VFQTEQKNLF...RKNPPNERTV

Show »
Length:173
Mass (Da):20,678
Checksum:iE79510AF6736241E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei133 – 243111ALENN…CHHGY → VFQTEQKNLFRLEMDMVVFR PEMKKHSWCLKRKNPPNERT V in isoform 2. CuratedVSP_031319Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137247 Genomic DNA. Translation: CAI13190.1.
AL137247 Genomic DNA. Translation: CAI13191.1.
CH471075 Genomic DNA. Translation: EAX08502.1.
CH471075 Genomic DNA. Translation: EAX08503.1.
BC125050 mRNA. Translation: AAI25051.1.
CCDSiCCDS41877.1. [Q5TBK1-2]
CCDS9345.2. [Q5TBK1-1]
RefSeqiNP_001073159.1. NM_001079691.1. [Q5TBK1-2]
NP_001273388.1. NM_001286459.1. [Q5TBK1-1]
NP_438169.2. NM_052818.2. [Q5TBK1-1]
UniGeneiHs.732118.

Genome annotation databases

EnsembliENST00000380130; ENSP00000369473; ENSG00000139597. [Q5TBK1-1]
ENST00000380133; ENSP00000369476; ENSG00000139597. [Q5TBK1-1]
ENST00000380139; ENSP00000369484; ENSG00000139597. [Q5TBK1-2]
ENST00000613078; ENSP00000483310; ENSG00000139597. [Q5TBK1-2]
GeneIDi90634.
KEGGihsa:90634.
UCSCiuc001uuc.4. human. [Q5TBK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137247 Genomic DNA. Translation: CAI13190.1.
AL137247 Genomic DNA. Translation: CAI13191.1.
CH471075 Genomic DNA. Translation: EAX08502.1.
CH471075 Genomic DNA. Translation: EAX08503.1.
BC125050 mRNA. Translation: AAI25051.1.
CCDSiCCDS41877.1. [Q5TBK1-2]
CCDS9345.2. [Q5TBK1-1]
RefSeqiNP_001073159.1. NM_001079691.1. [Q5TBK1-2]
NP_001273388.1. NM_001286459.1. [Q5TBK1-1]
NP_438169.2. NM_052818.2. [Q5TBK1-1]
UniGeneiHs.732118.

3D structure databases

ProteinModelPortaliQ5TBK1.
SMRiQ5TBK1. Positions 43-68.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5TBK1.
PhosphoSiteiQ5TBK1.

Polymorphism and mutation databases

BioMutaiN4BP2L1.
DMDMi74745960.

Proteomic databases

PaxDbiQ5TBK1.
PeptideAtlasiQ5TBK1.
PRIDEiQ5TBK1.

Protocols and materials databases

DNASUi90634.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380130; ENSP00000369473; ENSG00000139597. [Q5TBK1-1]
ENST00000380133; ENSP00000369476; ENSG00000139597. [Q5TBK1-1]
ENST00000380139; ENSP00000369484; ENSG00000139597. [Q5TBK1-2]
ENST00000613078; ENSP00000483310; ENSG00000139597. [Q5TBK1-2]
GeneIDi90634.
KEGGihsa:90634.
UCSCiuc001uuc.4. human. [Q5TBK1-1]

Organism-specific databases

CTDi90634.
GeneCardsiN4BP2L1.
HGNCiHGNC:25037. N4BP2L1.
HPAiHPA038971.
neXtProtiNX_Q5TBK1.
PharmGKBiPA162396617.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2401. Eukaryota.
ENOG41101K4. LUCA.
GeneTreeiENSGT00510000047015.
HOGENOMiHOG000072698.
HOVERGENiHBG095655.
InParanoidiQ5TBK1.
OMAiRMNRSQD.
OrthoDBiEOG773XF6.
PhylomeDBiQ5TBK1.

Miscellaneous databases

ChiTaRSiN4BP2L1. human.
GenomeRNAii90634.
PROiQ5TBK1.

Gene expression databases

BgeeiQ5TBK1.
CleanExiHS_N4BP2L1.
ExpressionAtlasiQ5TBK1. baseline and differential.
GenevisibleiQ5TBK1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR026567. NEDD4-bind_pro_2-like_1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR13308:SF5. PTHR13308:SF5. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-243 (ISOFORM 1).

Entry informationi

Entry nameiN42L1_HUMAN
AccessioniPrimary (citable) accession number: Q5TBK1
Secondary accession number(s): A4QN21, Q5TBK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.