ID Q5TBG4_HUMAN Unreviewed; 194 AA. AC Q5TBG4; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 27-MAR-2024, entry version 104. DE RecName: Full=NEK6-subfamily protein kinase {ECO:0000256|ARBA:ARBA00039067}; DE EC=2.7.11.34 {ECO:0000256|ARBA:ARBA00039067}; DE Flags: Fragment; GN Name=NEK6 {ECO:0000313|Ensembl:ENSP00000399847.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000399847.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000399847.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [2] {ECO:0007829|PubMed:19369195} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19369195; DOI=10.1074/mcp.M800588-MCP200; RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., RA Mann M., Daub H.; RT "Large-scale proteomics analysis of the human kinome."; RL Mol. Cell. Proteomics 8:1751-1764(2009). RN [3] {ECO:0000313|Ensembl:ENSP00000399847.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL137846; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL162724; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; Q5TBG4; -. DR SMR; Q5TBG4; -. DR MassIVE; Q5TBG4; -. DR MaxQB; Q5TBG4; -. DR PeptideAtlas; Q5TBG4; -. DR ProteomicsDB; 64906; -. DR Antibodypedia; 30447; 349 antibodies from 32 providers. DR Ensembl; ENST00000423785.5; ENSP00000399847.1; ENSG00000119408.17. DR UCSC; uc064vpp.1; human. DR HGNC; HGNC:7749; NEK6. DR VEuPathDB; HostDB:ENSG00000119408; -. DR GeneTree; ENSGT00940000159990; -. DR ChiTaRS; NEK6; human. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000119408; Expressed in sural nerve and 155 other cell types or tissues. DR ExpressionAtlas; Q5TBG4; baseline and differential. DR GO; GO:0034451; C:centriolar satellite; IDA:HPA. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1. DR PANTHER; PTHR43289:SF13; SERINE_THREONINE-PROTEIN KINASE NEK6; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Proteomics identification {ECO:0007829|EPD:Q5TBG4, KW ECO:0007829|MaxQB:Q5TBG4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 79..194 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT BINDING 108 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" FT NON_TER 194 FT /evidence="ECO:0000313|Ensembl:ENSP00000399847.1" SQ SEQUENCE 194 AA; 22353 MW; 2D012E4E83296F90 CRC64; MPRREVCWEA AHFRQEEQSL PRPRVRALVR LACRMAGQPG HMPHGGSSNN LCHTLGPVHP PDPQRHPNTL SFRCSLADFQ IEKKIGRGQF SEVYKATCLL DRKTVALKKV QIFEMMDAKA RQDCVKEIGL LKQLNHPNII KYLDSFIEDN ELNIVLELAD AGDLSQMIKY FKKQKRLIPE RTVWKYFVQL CSAV //