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Protein

Bcl-2-like protein 15

Gene

BCL2L15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 15
Short name:
Bcl2-L-15
Gene namesi
Name:BCL2L15
Synonyms:C1orf178
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188761.11
HGNCiHGNC:33624 BCL2L15
neXtProtiNX_Q5TBC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188761
PharmGKBiPA162377411

Polymorphism and mutation databases

BioMutaiBCL2L15
DMDMi74745939

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830031 – 163Bcl-2-like protein 15Add BLAST163

Proteomic databases

PaxDbiQ5TBC7
PeptideAtlasiQ5TBC7
PRIDEiQ5TBC7

PTM databases

iPTMnetiQ5TBC7
PhosphoSitePlusiQ5TBC7

Expressioni

Gene expression databases

BgeeiENSG00000188761
CleanExiHS_BCL2L15
ExpressionAtlasiQ5TBC7 baseline and differential
GenevisibleiQ5TBC7 HS

Organism-specific databases

HPAiHPA029732
HPA029733

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi136727, 5 interactors
IntActiQ5TBC7, 7 interactors
STRINGi9606.ENSP00000376992

Structurei

3D structure databases

ProteinModelPortaliQ5TBC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IX9E Eukaryota
ENOG410ZCJ4 LUCA
GeneTreeiENSGT00390000018096
HOGENOMiHOG000043119
HOVERGENiHBG100769
InParanoidiQ5TBC7
OMAiRMLGDQF
OrthoDBiEOG091G11J1
PhylomeDBiQ5TBC7
TreeFamiTF338066

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR033543 BCL2L15
IPR036834 Blc2-like_sf
PANTHERiPTHR36466 PTHR36466, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TBC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSSQTFEEQ TECIVNTLLM DFLSPTLQVA SRNLCCVDEV DSGEPCSFDV
60 70 80 90 100
AIIAGRLRML GDQFNGELEA SAKNVIAETI KGQTGAILQD TVESLSKTWC
110 120 130 140 150
AQDSSLAYER AFLAVSVKLL EYMAHIAPEV VGQVAIPMTG MINGNQAIRE
160
FIQGQGGWEN LES
Length:163
Mass (Da):17,725
Last modified:December 21, 2004 - v1
Checksum:i97BF05318C796856
GO
Isoform 2 (identifier: Q5TBC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-56: EPCSFDVAIIAGR → KSGELKSWSYSRD
     57-163: Missing.

Note: Pro-apoptotic when overexpressed.
Show »
Length:56
Mass (Da):6,308
Checksum:i9BB6C5FE1C36196D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03147590D → N2 PublicationsCorresponds to variant dbSNP:rs1217381Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04762744 – 56EPCSF…IIAGR → KSGELKSWSYSRD in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_04762857 – 163Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY265864 mRNA Translation: AAP93858.1
AK289439 mRNA Translation: BAF82128.1
AL137856 Genomic DNA No translation available.
BC127719 mRNA Translation: AAI27720.1
BC127720 mRNA Translation: AAI27721.1
CCDSiCCDS30809.1 [Q5TBC7-1]
RefSeqiNP_001010922.1, NM_001010922.2 [Q5TBC7-1]
UniGeneiHs.123106

Genome annotation databases

EnsembliENST00000393316; ENSP00000376992; ENSG00000188761 [Q5TBC7-1]
ENST00000393320; ENSP00000376995; ENSG00000188761 [Q5TBC7-2]
GeneIDi440603
KEGGihsa:440603
UCSCiuc001edw.4 human [Q5TBC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiB2L15_HUMAN
AccessioniPrimary (citable) accession number: Q5TBC7
Secondary accession number(s): A0PJY6, A8K074, I6LA82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health