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Protein

Bcl-2-like protein 15

Gene

BCL2L15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 15
Short name:
Bcl2-L-15
Gene namesi
Name:BCL2L15
Synonyms:C1orf178
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:33624. BCL2L15.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377411.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Bcl-2-like protein 15PRO_0000283003Add
BLAST

Proteomic databases

PaxDbiQ5TBC7.
PRIDEiQ5TBC7.

PTM databases

PhosphoSiteiQ5TBC7.

Expressioni

Gene expression databases

BgeeiQ5TBC7.
CleanExiHS_BCL2L15.
ExpressionAtlasiQ5TBC7. baseline and differential.
GenevestigatoriQ5TBC7.

Organism-specific databases

HPAiHPA029732.
HPA029733.

Interactioni

Protein-protein interaction databases

BioGridi136727. 3 interactions.
STRINGi9606.ENSP00000376992.

Structurei

3D structure databases

ProteinModelPortaliQ5TBC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45798.
GeneTreeiENSGT00390000018096.
HOGENOMiHOG000043119.
HOVERGENiHBG100769.
InParanoidiQ5TBC7.
OMAiRTFEEQT.
OrthoDBiEOG757D05.
PhylomeDBiQ5TBC7.
TreeFamiTF338066.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TBC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSSQTFEEQ TECIVNTLLM DFLSPTLQVA SRNLCCVDEV DSGEPCSFDV
60 70 80 90 100
AIIAGRLRML GDQFNGELEA SAKNVIAETI KGQTGAILQD TVESLSKTWC
110 120 130 140 150
AQDSSLAYER AFLAVSVKLL EYMAHIAPEV VGQVAIPMTG MINGNQAIRE
160
FIQGQGGWEN LES
Length:163
Mass (Da):17,725
Last modified:December 20, 2004 - v1
Checksum:i97BF05318C796856
GO
Isoform 2 (identifier: Q5TBC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-56: EPCSFDVAIIAGR → KSGELKSWSYSRD
     57-163: Missing.

Note: Pro-apoptotic when overexpressed.

Show »
Length:56
Mass (Da):6,308
Checksum:i9BB6C5FE1C36196D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901D → N.2 Publications
Corresponds to variant rs1217381 [ dbSNP | Ensembl ].
VAR_031475

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei44 – 5613EPCSF…IIAGR → KSGELKSWSYSRD in isoform 2. 1 PublicationVSP_047627Add
BLAST
Alternative sequencei57 – 163107Missing in isoform 2. 1 PublicationVSP_047628Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY265864 mRNA. Translation: AAP93858.1.
AK289439 mRNA. Translation: BAF82128.1.
AL137856 Genomic DNA. Translation: CAI19070.1.
BC127719 mRNA. Translation: AAI27720.1.
BC127720 mRNA. Translation: AAI27721.1.
CCDSiCCDS30809.1. [Q5TBC7-1]
RefSeqiNP_001010922.1. NM_001010922.2. [Q5TBC7-1]
UniGeneiHs.123106.

Genome annotation databases

EnsembliENST00000393316; ENSP00000376992; ENSG00000188761. [Q5TBC7-1]
ENST00000393320; ENSP00000376995; ENSG00000188761. [Q5TBC7-2]
GeneIDi440603.
KEGGihsa:440603.
UCSCiuc001edw.3. human. [Q5TBC7-1]

Polymorphism databases

DMDMi74745939.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY265864 mRNA. Translation: AAP93858.1.
AK289439 mRNA. Translation: BAF82128.1.
AL137856 Genomic DNA. Translation: CAI19070.1.
BC127719 mRNA. Translation: AAI27720.1.
BC127720 mRNA. Translation: AAI27721.1.
CCDSiCCDS30809.1. [Q5TBC7-1]
RefSeqiNP_001010922.1. NM_001010922.2. [Q5TBC7-1]
UniGeneiHs.123106.

3D structure databases

ProteinModelPortaliQ5TBC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136727. 3 interactions.
STRINGi9606.ENSP00000376992.

PTM databases

PhosphoSiteiQ5TBC7.

Polymorphism databases

DMDMi74745939.

Proteomic databases

PaxDbiQ5TBC7.
PRIDEiQ5TBC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393316; ENSP00000376992; ENSG00000188761. [Q5TBC7-1]
ENST00000393320; ENSP00000376995; ENSG00000188761. [Q5TBC7-2]
GeneIDi440603.
KEGGihsa:440603.
UCSCiuc001edw.3. human. [Q5TBC7-1]

Organism-specific databases

CTDi440603.
GeneCardsiGC01M114419.
HGNCiHGNC:33624. BCL2L15.
HPAiHPA029732.
HPA029733.
neXtProtiNX_Q5TBC7.
PharmGKBiPA162377411.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45798.
GeneTreeiENSGT00390000018096.
HOGENOMiHOG000043119.
HOVERGENiHBG100769.
InParanoidiQ5TBC7.
OMAiRTFEEQT.
OrthoDBiEOG757D05.
PhylomeDBiQ5TBC7.
TreeFamiTF338066.

Miscellaneous databases

GenomeRNAii440603.
NextBioi109421.
PROiQ5TBC7.

Gene expression databases

BgeeiQ5TBC7.
CleanExiHS_BCL2L15.
ExpressionAtlasiQ5TBC7. baseline and differential.
GenevestigatoriQ5TBC7.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract."
    Dempsey C.E., Dive C., Fletcher D.J., Barnes F.A., Lobo A., Bingle C.D., Whyte M.K., Renshaw S.A.
    FEBS Lett. 579:3646-3650(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-90.
    Tissue: Urinary bladder.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-90.

Entry informationi

Entry nameiB2L15_HUMAN
AccessioniPrimary (citable) accession number: Q5TBC7
Secondary accession number(s): A0PJY6, A8K074, I6LA82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 2, 2007
Last sequence update: December 20, 2004
Last modified: February 3, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.