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Q5TBC7

- B2L15_HUMAN

UniProt

Q5TBC7 - B2L15_HUMAN

Protein

Bcl-2-like protein 15

Gene

BCL2L15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bcl-2-like protein 15
    Short name:
    Bcl2-L-15
    Gene namesi
    Name:BCL2L15
    Synonyms:C1orf178
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:33624. BCL2L15.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. nucleus Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162377411.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Bcl-2-like protein 15PRO_0000283003Add
    BLAST

    Proteomic databases

    PaxDbiQ5TBC7.
    PRIDEiQ5TBC7.

    PTM databases

    PhosphoSiteiQ5TBC7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5TBC7.
    BgeeiQ5TBC7.
    CleanExiHS_BCL2L15.
    GenevestigatoriQ5TBC7.

    Organism-specific databases

    HPAiHPA029732.
    HPA029733.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000376992.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TBC7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG45798.
    HOGENOMiHOG000043119.
    HOVERGENiHBG100769.
    InParanoidiQ5TBC7.
    OMAiRTFEEQT.
    OrthoDBiEOG757D05.
    PhylomeDBiQ5TBC7.
    TreeFamiTF338066.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5TBC7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSSQTFEEQ TECIVNTLLM DFLSPTLQVA SRNLCCVDEV DSGEPCSFDV    50
    AIIAGRLRML GDQFNGELEA SAKNVIAETI KGQTGAILQD TVESLSKTWC 100
    AQDSSLAYER AFLAVSVKLL EYMAHIAPEV VGQVAIPMTG MINGNQAIRE 150
    FIQGQGGWEN LES 163
    Length:163
    Mass (Da):17,725
    Last modified:December 21, 2004 - v1
    Checksum:i97BF05318C796856
    GO
    Isoform 2 (identifier: Q5TBC7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         44-56: EPCSFDVAIIAGR → KSGELKSWSYSRD
         57-163: Missing.

    Note: Pro-apoptotic when overexpressed.

    Show »
    Length:56
    Mass (Da):6,308
    Checksum:i9BB6C5FE1C36196D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901D → N.2 Publications
    Corresponds to variant rs1217381 [ dbSNP | Ensembl ].
    VAR_031475

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei44 – 5613EPCSF…IIAGR → KSGELKSWSYSRD in isoform 2. 1 PublicationVSP_047627Add
    BLAST
    Alternative sequencei57 – 163107Missing in isoform 2. 1 PublicationVSP_047628Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY265864 mRNA. Translation: AAP93858.1.
    AK289439 mRNA. Translation: BAF82128.1.
    AL137856 Genomic DNA. Translation: CAI19070.1.
    BC127719 mRNA. Translation: AAI27720.1.
    BC127720 mRNA. Translation: AAI27721.1.
    CCDSiCCDS30809.1. [Q5TBC7-1]
    RefSeqiNP_001010922.1. NM_001010922.2. [Q5TBC7-1]
    UniGeneiHs.123106.

    Genome annotation databases

    EnsembliENST00000393316; ENSP00000376992; ENSG00000188761. [Q5TBC7-1]
    ENST00000393320; ENSP00000376995; ENSG00000188761. [Q5TBC7-2]
    GeneIDi440603.
    KEGGihsa:440603.
    UCSCiuc001edw.3. human. [Q5TBC7-1]

    Polymorphism databases

    DMDMi74745939.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY265864 mRNA. Translation: AAP93858.1 .
    AK289439 mRNA. Translation: BAF82128.1 .
    AL137856 Genomic DNA. Translation: CAI19070.1 .
    BC127719 mRNA. Translation: AAI27720.1 .
    BC127720 mRNA. Translation: AAI27721.1 .
    CCDSi CCDS30809.1. [Q5TBC7-1 ]
    RefSeqi NP_001010922.1. NM_001010922.2. [Q5TBC7-1 ]
    UniGenei Hs.123106.

    3D structure databases

    ProteinModelPortali Q5TBC7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000376992.

    PTM databases

    PhosphoSitei Q5TBC7.

    Polymorphism databases

    DMDMi 74745939.

    Proteomic databases

    PaxDbi Q5TBC7.
    PRIDEi Q5TBC7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393316 ; ENSP00000376992 ; ENSG00000188761 . [Q5TBC7-1 ]
    ENST00000393320 ; ENSP00000376995 ; ENSG00000188761 . [Q5TBC7-2 ]
    GeneIDi 440603.
    KEGGi hsa:440603.
    UCSCi uc001edw.3. human. [Q5TBC7-1 ]

    Organism-specific databases

    CTDi 440603.
    GeneCardsi GC01M114419.
    HGNCi HGNC:33624. BCL2L15.
    HPAi HPA029732.
    HPA029733.
    neXtProti NX_Q5TBC7.
    PharmGKBi PA162377411.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45798.
    HOGENOMi HOG000043119.
    HOVERGENi HBG100769.
    InParanoidi Q5TBC7.
    OMAi RTFEEQT.
    OrthoDBi EOG757D05.
    PhylomeDBi Q5TBC7.
    TreeFami TF338066.

    Miscellaneous databases

    GenomeRNAii 440603.
    NextBioi 109421.
    PROi Q5TBC7.

    Gene expression databases

    ArrayExpressi Q5TBC7.
    Bgeei Q5TBC7.
    CleanExi HS_BCL2L15.
    Genevestigatori Q5TBC7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract."
      Dempsey C.E., Dive C., Fletcher D.J., Barnes F.A., Lobo A., Bingle C.D., Whyte M.K., Renshaw S.A.
      FEBS Lett. 579:3646-3650(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-90.
      Tissue: Urinary bladder.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-90.

    Entry informationi

    Entry nameiB2L15_HUMAN
    AccessioniPrimary (citable) accession number: Q5TBC7
    Secondary accession number(s): A0PJY6, A8K074, I6LA82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3