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Protein
Submitted name:

Lysosomal associated multispanning membrane protein 5, isoform CRA_a

Gene

LAPTM5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Lysosomal associated multispanning membrane protein 5, isoform CRA_aImported
Submitted name:
Lysosomal multispanning membrane protein 5Imported
Submitted name:
cDNA FLJ75768, highly similar to Homo sapiens lysosomal associated multispanning membrane protein 5 (LAPTM5), mRNAImported
Gene namesi
Name:LAPTM5Imported
ORF Names:hCG_15079Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3723HelicalSequence analysisAdd
BLAST
Transmembranei57 – 8529HelicalSequence analysisAdd
BLAST
Transmembranei91 – 11525HelicalSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953439.

PTM / Processingi

Proteomic databases

MaxQBiQ5TBB8.

Expressioni

Gene expression databases

ExpressionAtlasiQ5TBB8. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiQ5TBB8. 1 interaction.
MINTiMINT-8290504.
STRINGi9606.ENSP00000294507.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFZA. Eukaryota.
ENOG410YPPU. LUCA.
GeneTreeiENSGT00390000012862.
HOVERGENiHBG052307.
KOiK12387.
OMAiCVWRCYK.
PhylomeDBiQ5TBB8.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 2 hits.
PTHR12479:SF2. PTHR12479:SF2. 2 hits.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TBB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC
60 70 80 90 100
KLSQMGYLRI ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI
110 120 130 140 150
MDYLLCLLTL LGSYIELPAY LKLASRSRAS SSKFPLMTLQ LLDFCLSILT
160 170 180 190 200
LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP HNQFIKMMII FSIAFITVLI
210 220 230 240 250
FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE EALSLPSKTP
260
EGGPAPPPYS EV
Length:262
Mass (Da):29,937
Last modified:May 10, 2005 - v1
Checksum:i64A9B3F09C14FCE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106897 mRNA. Translation: AAI06898.1.
AK292009 mRNA. Translation: BAF84698.1.
CH471059 Genomic DNA. Translation: EAX07640.1.
CH471059 Genomic DNA. Translation: EAX07641.1.
RefSeqiNP_006753.1. NM_006762.2.
UniGeneiHs.371021.

Genome annotation databases

GeneIDi7805.
KEGGihsa:7805.
UCSCiuc001bsc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106897 mRNA. Translation: AAI06898.1.
AK292009 mRNA. Translation: BAF84698.1.
CH471059 Genomic DNA. Translation: EAX07640.1.
CH471059 Genomic DNA. Translation: EAX07641.1.
RefSeqiNP_006753.1. NM_006762.2.
UniGeneiHs.371021.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5TBB8. 1 interaction.
MINTiMINT-8290504.
STRINGi9606.ENSP00000294507.

Proteomic databases

MaxQBiQ5TBB8.

Protocols and materials databases

DNASUi7805.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7805.
KEGGihsa:7805.
UCSCiuc001bsc.3. human.

Organism-specific databases

CTDi7805.
PharmGKBiPA134953439.

Phylogenomic databases

eggNOGiENOG410IFZA. Eukaryota.
ENOG410YPPU. LUCA.
GeneTreeiENSGT00390000012862.
HOVERGENiHBG052307.
KOiK12387.
OMAiCVWRCYK.
PhylomeDBiQ5TBB8.

Miscellaneous databases

ChiTaRSiLAPTM5. human.
GenomeRNAii7805.
NextBioi30198.

Gene expression databases

ExpressionAtlasiQ5TBB8. baseline and differential.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 2 hits.
PTHR12479:SF2. PTHR12479:SF2. 2 hits.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00799. mtp. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.

Entry informationi

Entry nameiQ5TBB8_HUMAN
AccessioniPrimary (citable) accession number: Q5TBB8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.