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Protein
Submitted name:

Lysosomal associated multispanning membrane protein 5, isoform CRA_a

Gene

LAPTM5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Lysosomal associated multispanning membrane protein 5, isoform CRA_aImported
Submitted name:
Lysosomal multispanning membrane protein 5Imported
Submitted name:
cDNA FLJ75768, highly similar to Homo sapiens lysosomal associated multispanning membrane protein 5 (LAPTM5), mRNAImported
Gene namesi
Name:LAPTM5Imported
ORF Names:hCG_15079Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000162511.7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Transmembranei57 – 85HelicalSequence analysisAdd BLAST29
Transmembranei91 – 115HelicalSequence analysisAdd BLAST25
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei184 – 205HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953439.

PTM / Processingi

Proteomic databases

MaxQBiQ5TBB8.

Expressioni

Gene expression databases

BgeeiENSG00000162511.

Interactioni

Protein-protein interaction databases

IntActiQ5TBB8. 1 interactor.
MINTiMINT-8290504.

Structurei

3D structure databases

SMRiQ5TBB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFZA. Eukaryota.
ENOG410YPPU. LUCA.
HOVERGENiHBG052307.
KOiK12387.
OMAiCVWRCYK.
OrthoDBiEOG091G0JRF.

Family and domain databases

InterProiView protein in InterPro
IPR004687. LAPTM4/5.
IPR018396. LAPTM_4A/5.
IPR018397. Lysosomal-assoc_TM_prot5.
PANTHERiPTHR12479:SF2. PTHR12479:SF2. 3 hits.
PfamiView protein in Pfam
PF03821. Mtp. 1 hit.
TIGRFAMsiTIGR00799. mtp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TBB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC
60 70 80 90 100
KLSQMGYLRI ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI
110 120 130 140 150
MDYLLCLLTL LGSYIELPAY LKLASRSRAS SSKFPLMTLQ LLDFCLSILT
160 170 180 190 200
LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP HNQFIKMMII FSIAFITVLI
210 220 230 240 250
FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE EALSLPSKTP
260
EGGPAPPPYS EV
Length:262
Mass (Da):29,937
Last modified:May 10, 2005 - v1
Checksum:i64A9B3F09C14FCE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC106897 mRNA. Translation: AAI06898.1.
AK292009 mRNA. Translation: BAF84698.1.
CH471059 Genomic DNA. Translation: EAX07640.1.
CH471059 Genomic DNA. Translation: EAX07641.1.
RefSeqiNP_006753.1. NM_006762.2.
UniGeneiHs.371021.

Genome annotation databases

GeneIDi7805.
KEGGihsa:7805.
UCSCiuc001bsc.3. human.

Similar proteinsi

Entry informationi

Entry nameiQ5TBB8_HUMAN
AccessioniPrimary (citable) accession number: Q5TBB8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 22, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.