Q5TAT6 (CODA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(XIII) chain

Alternative name(s):
COLXIIIA1

Gene names

Name:

COL13A1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	717 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. Ref.10 Ref.11 UniProtKB Q9R1N9
Subunit structure	Homotrimer; disulfide-linked. Nucleation of the type XIII collagen triple helix is likely to occur at the N-terminal region with triple helix formation proceeding from the N- to the C-terminus. Interacts with FN1, perlecan/HSPG2 and NID2. Ref.1 Ref.10 Ref.11
Subcellular location	Cell membrane; Single-pass type II membrane protein Ref.1 UniProtKB Q9R1N9.
Tissue specificity	Widely expressed in both fetal and adult ocular tissues (at protein level). In the eye, expression is accentuated in the ciliary muscle, optic nerve and the neural retina. In early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries and to cells of the cytotrophoblastic columns. Also detected in large decidual cells of the decidual membrane and to stromal cells of the gestational endometrium, but not in the epithelial cells in the endometrial glands. Ref.9 Ref.10
Sequence caution	The sequence AAA51685.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion Differentiation Osteogenesis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Collagen Signal-anchor Transmembrane Transmembrane helix
Ligand	Heparin-binding
Molecular function	Developmental protein
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW cell-cell adhesion Inferred from expression pattern Ref.10. Source: UniProtKB cell-matrix adhesion Inferred from physical interaction Ref.11. Source: UniProtKB endochondral ossification Inferred from sequence or structural similarity. Source: UniProtKB extracellular matrix organization Traceable author statement. Source: Reactome morphogenesis of a branching structure Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cell-cell junction Inferred from electronic annotation. Source: Compara collagen type XIII Traceable author statement Ref.6. Source: UniProtKB endoplasmic reticulum lumen Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement PubMed 9624150. Source: ProtInc
Molecular_function	extracellular matrix structural constituent Non-traceable author statement. Source: UniProtKB heparin binding Inferred from direct assay Ref.11. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 10 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 Ref.1 (identifier: Q5TAT6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.2 (identifier: Q5TAT6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     239-260: Missing.

Note: Gene prediction based on EST data.

Isoform 3 Ref.2 (identifier: Q5TAT6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     239-260: Missing.
     617-628: Missing.

Note: Gene prediction based on EST data.

Isoform 4 Ref.4 (identifier: Q5TAT6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     239-260: Missing.
     551-565: Missing.
     617-628: Missing.

Isoform 5 Ref.5 (identifier: Q5TAT6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     551-565: Missing.

Isoform 6 Ref.6 (identifier: Q5TAT6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     566-579: Missing.

Isoform 7 Ref.6 (identifier: Q5TAT6-7)

The sequence of this isoform differs from the canonical sequence as follows:
     566-579: Missing.
     617-628: Missing.

Isoform 8 Ref.4 (identifier: Q5TAT6-8)

The sequence of this isoform differs from the canonical sequence as follows:
     220-238: Missing.
     617-628: Missing.

Isoform 9 Ref.4 (identifier: Q5TAT6-9)

The sequence of this isoform differs from the canonical sequence as follows:
     239-260: Missing.
     551-565: Missing.
     617-628: Missing.
     676-705: Missing.

Isoform 10 (identifier: Q5TAT6-10)

The sequence of this isoform differs from the canonical sequence as follows:
     122-159: Missing.
     220-238: Missing.
     551-565: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 717	717	Collagen alpha-1(XIII) chain		PRO_0000284679
Regions
	Topological domain	1 – 44	44	Cytoplasmic Potential
	Transmembrane	45 – 61	17	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	62 – 717	656	Extracellular Potential
	Region	1 – 121	121	Nonhelical region 1 (NC1)
	Region	122 – 216	95	Triple-helical region 1 (COL1)
	Region	217 – 269	53	Nonhelical region 2 (NC2)
	Region	270 – 441	172	Triple-helical region 2 (COL2)
	Region	442 – 463	22	Nonhelical region 3 (NC3)
	Region	464 – 699	236	Triple-helical region 3 (COL3)
	Region	700 – 717	18	Nonhelical region 4 (NC4)
Natural variations
	Alternative sequence	122 – 159	38	Missing in isoform 10.		VSP_043361
	Alternative sequence	220 – 238	19	Missing in isoform 8 and isoform 10. Ref.4		VSP_052382
	Alternative sequence	239 – 260	22	Missing in isoform 2, isoform 3, isoform 4 and isoform 9. Ref.2 Ref.4 Ref.5		VSP_052383
	Alternative sequence	551 – 565	15	Missing in isoform 4, isoform 5, isoform 9 and isoform 10. Ref.4 Ref.5		VSP_052384
	Alternative sequence	566 – 579	14	Missing in isoform 6 and isoform 7. Ref.6		VSP_052385
	Alternative sequence	617 – 628	12	Missing in isoform 3, isoform 4, isoform 7, isoform 8 and isoform 9. Ref.2 Ref.4 Ref.6		VSP_052386
	Alternative sequence	676 – 705	30	Missing in isoform 9. Ref.4		VSP_052387
	Natural variant	531	1	H → Q. Corresponds to variant rs1061954 [ dbSNP | Ensembl ].		VAR_055670
Experimental info
	Sequence conflict	182	1	K → F in AAA51685. Ref.4
	Sequence conflict	394	1	G → A in CAC00688. Ref.1
	Sequence conflict	394	1	G → A in AAA51685. Ref.4
	Sequence conflict	466	1	P → L in AAA51685. Ref.4
	Sequence conflict	466	1	P → L in AAA52047. Ref.5
	Sequence conflict	469	1	P → L in AAA51685. Ref.4
	Sequence conflict	469	1	P → L in AAA52047. Ref.5
	Sequence conflict	475	1	P → L in AAA51685. Ref.4
	Sequence conflict	475	1	P → L in AAA52047. Ref.5
	Sequence conflict	478	1	P → L in AAA51685. Ref.4
	Sequence conflict	478	1	P → L in AAA52047. Ref.5
	Sequence conflict	480 – 481	2	IP → ML in AAA51685. Ref.4
	Sequence conflict	480 – 481	2	IP → ML in AAA52047. Ref.5
	Sequence conflict	490	1	P → L in AAA51685. Ref.4
	Sequence conflict	490	1	P → L in AAA52047. Ref.5
	Sequence conflict	493	1	P → L in AAA51685. Ref.4
	Sequence conflict	493	1	P → L in AAA52047. Ref.5
	Sequence conflict	498	1	Missing in AAA51685. Ref.4
	Sequence conflict	498	1	Missing in AAA52047. Ref.5
	Sequence conflict	505	1	P → L in AAA51685. Ref.4
	Sequence conflict	505	1	P → L in AAA52047. Ref.5
	Sequence conflict	511	1	P → L in AAA51685. Ref.4
	Sequence conflict	511	1	P → L in AAA52047. Ref.5
	Sequence conflict	517	1	P → L in AAA51685. Ref.4
	Sequence conflict	517	1	P → L in AAA52047. Ref.5
	Sequence conflict	570	1	P → L in AAA52047. Ref.5
	Sequence conflict	570	1	P → L in AAA51987. Ref.6
	Sequence conflict	570	1	P → L in AAA51990. Ref.6
	Sequence conflict	570	1	P → L in AAA51991. Ref.6
	Sequence conflict	706	1	E → Q in AAA52047. Ref.5
	Sequence conflict	706	1	E → Q in AAA52048. Ref.5
	Sequence conflict	706	1	E → Q in AAA51987. Ref.6
	Sequence conflict	706	1	E → Q in AAA51988. Ref.6
	Sequence conflict	706	1	E → Q in AAA51989. Ref.6
	Sequence conflict	706	1	E → Q in AAA51990. Ref.6
	Sequence conflict	706	1	E → Q in AAA51991. Ref.6
	Sequence conflict	709	1	L → Y in AAA51987. Ref.6
	Sequence conflict	709	1	L → Y in AAA51988. Ref.6
	Sequence conflict	709	1	L → Y in AAA51989. Ref.6
	Sequence conflict	709	1	L → Y in AAA51990. Ref.6
	Sequence conflict	709	1	L → Y in AAA51991. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: FD12CA80CC93540F	FASTA	717	69,950
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD 190 200 210 220 230 240 GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKLL 250 260 270 280 290 300 PLLNSVRLAP PPVIKRRTFQ GEQSQASIQG PPGPPGPPGP SGPLGHPGLP GPMGPPGLPG 310 320 330 340 350 360 PPGPKGDPGI QGYHGRKGER GMPGMPGKHG AKGAPGIAVA GMKGEPGIPG TKGEKGAEGS 370 380 390 400 410 420 PGLPGLLGQK GEKGDAGNSI GGGRGEPGPP GLPGPPGPKG EAGVDGQVGP PGQPGDKGER 430 440 450 460 470 480 GAAGEQGPDG PKGSKGEPGK GEMVDYNGNI NEALQEIRTL ALMGPPGLPG QIGPPGAPGI 490 500 510 520 530 540 PGQKGEIGLP GPPGHDGEKG PRGKPGDMGP PGPQGPPGKD GPPGVKGENG HPGSPGEKGE 550 560 570 580 590 600 KGETGQAGSP GEKGEAGEKG NPGAEVPGLP GPEGPPGPPG LQGVPGPKGE AGLDGAKGEK 610 620 630 640 650 660 GFQGEKGDRG PLGLPGASGL DGRPGPPGTP GPIGVPGPAG PKGERGSKGD PGMTGPTGAA 670 680 690 700 710 GLPGLHGPPG DKGNRGERGK KGSRGPKGDK GDQGAPGLDA PCPLGEDGLP VQGCWNK
	Isoform 2 [UniParc]. Checksum: 9816F7BCDD8C108B	FASTA	695	67,439
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD 190 200 210 220 230 240 GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKGE 250 260 270 280 290 300 QSQASIQGPP GPPGPPGPSG PLGHPGLPGP MGPPGLPGPP GPKGDPGIQG YHGRKGERGM 310 320 330 340 350 360 PGMPGKHGAK GAPGIAVAGM KGEPGIPGTK GEKGAEGSPG LPGLLGQKGE KGDAGNSIGG 370 380 390 400 410 420 GRGEPGPPGL PGPPGPKGEA GVDGQVGPPG QPGDKGERGA AGEQGPDGPK GSKGEPGKGE 430 440 450 460 470 480 MVDYNGNINE ALQEIRTLAL MGPPGLPGQI GPPGAPGIPG QKGEIGLPGP PGHDGEKGPR 490 500 510 520 530 540 GKPGDMGPPG PQGPPGKDGP PGVKGENGHP GSPGEKGEKG ETGQAGSPGE KGEAGEKGNP 550 560 570 580 590 600 GAEVPGLPGP EGPPGPPGLQ GVPGPKGEAG LDGAKGEKGF QGEKGDRGPL GLPGASGLDG 610 620 630 640 650 660 RPGPPGTPGP IGVPGPAGPK GERGSKGDPG MTGPTGAAGL PGLHGPPGDK GNRGERGKKG 670 680 690 SRGPKGDKGD QGAPGLDAPC PLGEDGLPVQ GCWNK
	Isoform 3 [UniParc]. Checksum: 3BB550FD03062C30	FASTA	683	66,377
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD 190 200 210 220 230 240 GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKGE 250 260 270 280 290 300 QSQASIQGPP GPPGPPGPSG PLGHPGLPGP MGPPGLPGPP GPKGDPGIQG YHGRKGERGM 310 320 330 340 350 360 PGMPGKHGAK GAPGIAVAGM KGEPGIPGTK GEKGAEGSPG LPGLLGQKGE KGDAGNSIGG 370 380 390 400 410 420 GRGEPGPPGL PGPPGPKGEA GVDGQVGPPG QPGDKGERGA AGEQGPDGPK GSKGEPGKGE 430 440 450 460 470 480 MVDYNGNINE ALQEIRTLAL MGPPGLPGQI GPPGAPGIPG QKGEIGLPGP PGHDGEKGPR 490 500 510 520 530 540 GKPGDMGPPG PQGPPGKDGP PGVKGENGHP GSPGEKGEKG ETGQAGSPGE KGEAGEKGNP 550 560 570 580 590 600 GAEVPGLPGP EGPPGPPGLQ GVPGPKGEAG LDGAKGEKGF QGEKGDRGPL GLPGTPGPIG 610 620 630 640 650 660 VPGPAGPKGE RGSKGDPGMT GPTGAAGLPG LHGPPGDKGN RGERGKKGSR GPKGDKGDQG 670 680 APGLDAPCPL GEDGLPVQGC WNK
	Isoform 4 [UniParc]. Checksum: AAC18C9E4B45DA4E	FASTA	668	64,965
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD 190 200 210 220 230 240 GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKGE 250 260 270 280 290 300 QSQASIQGPP GPPGPPGPSG PLGHPGLPGP MGPPGLPGPP GPKGDPGIQG YHGRKGERGM 310 320 330 340 350 360 PGMPGKHGAK GAPGIAVAGM KGEPGIPGTK GEKGAEGSPG LPGLLGQKGE KGDAGNSIGG 370 380 390 400 410 420 GRGEPGPPGL PGPPGPKGEA GVDGQVGPPG QPGDKGERGA AGEQGPDGPK GSKGEPGKGE 430 440 450 460 470 480 MVDYNGNINE ALQEIRTLAL MGPPGLPGQI GPPGAPGIPG QKGEIGLPGP PGHDGEKGPR 490 500 510 520 530 540 GKPGDMGPPG PQGPPGKDGP PGVKGENGHP GSPGEKGEKG ETGQAGSPVP GLPGPEGPPG 550 560 570 580 590 600 PPGLQGVPGP KGEAGLDGAK GEKGFQGEKG DRGPLGLPGT PGPIGVPGPA GPKGERGSKG 610 620 630 640 650 660 DPGMTGPTGA AGLPGLHGPP GDKGNRGERG KKGSRGPKGD KGDQGAPGLD APCPLGEDGL PVQGCWNK
	Isoform 5 [UniParc]. Checksum: 66FC08083E0D4A91	FASTA	702	68,538
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD 190 200 210 220 230 240 GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKLL 250 260 270 280 290 300 PLLNSVRLAP PPVIKRRTFQ GEQSQASIQG PPGPPGPPGP SGPLGHPGLP GPMGPPGLPG 310 320 330 340 350 360 PPGPKGDPGI QGYHGRKGER GMPGMPGKHG AKGAPGIAVA GMKGEPGIPG TKGEKGAEGS 370 380 390 400 410 420 PGLPGLLGQK GEKGDAGNSI GGGRGEPGPP GLPGPPGPKG EAGVDGQVGP PGQPGDKGER 430 440 450 460 470 480 GAAGEQGPDG PKGSKGEPGK GEMVDYNGNI NEALQEIRTL ALMGPPGLPG QIGPPGAPGI 490 500 510 520 530 540 PGQKGEIGLP GPPGHDGEKG PRGKPGDMGP PGPQGPPGKD GPPGVKGENG HPGSPGEKGE 550 560 570 580 590 600 KGETGQAGSP VPGLPGPEGP PGPPGLQGVP GPKGEAGLDG AKGEKGFQGE KGDRGPLGLP 610 620 630 640 650 660 GASGLDGRPG PPGTPGPIGV PGPAGPKGER GSKGDPGMTG PTGAAGLPGL HGPPGDKGNR 670 680 690 700 GERGKKGSRG PKGDKGDQGA PGLDAPCPLG EDGLPVQGCW NK
	Isoform 6 [UniParc]. Checksum: 62947B1FEEBF6268	FASTA	703	68,700
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD 190 200 210 220 230 240 GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKLL 250 260 270 280 290 300 PLLNSVRLAP PPVIKRRTFQ GEQSQASIQG PPGPPGPPGP SGPLGHPGLP GPMGPPGLPG 310 320 330 340 350 360 PPGPKGDPGI QGYHGRKGER GMPGMPGKHG AKGAPGIAVA GMKGEPGIPG TKGEKGAEGS 370 380 390 400 410 420 PGLPGLLGQK GEKGDAGNSI GGGRGEPGPP GLPGPPGPKG EAGVDGQVGP PGQPGDKGER 430 440 450 460 470 480 GAAGEQGPDG PKGSKGEPGK GEMVDYNGNI NEALQEIRTL ALMGPPGLPG QIGPPGAPGI 490 500 510 520 530 540 PGQKGEIGLP GPPGHDGEKG PRGKPGDMGP PGPQGPPGKD GPPGVKGENG HPGSPGEKGE 550 560 570 580 590 600 KGETGQAGSP GEKGEAGEKG NPGAEGLQGV PGPKGEAGLD GAKGEKGFQG EKGDRGPLGL 610 620 630 640 650 660 PGASGLDGRP GPPGTPGPIG VPGPAGPKGE RGSKGDPGMT GPTGAAGLPG LHGPPGDKGN 670 680 690 700 RGERGKKGSR GPKGDKGDQG APGLDAPCPL GEDGLPVQGC WNK
	Isoform 7 [UniParc]. Checksum: EEC688B6A5364877	FASTA	691	67,638
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD 190 200 210 220 230 240 GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKLL 250 260 270 280 290 300 PLLNSVRLAP PPVIKRRTFQ GEQSQASIQG PPGPPGPPGP SGPLGHPGLP GPMGPPGLPG 310 320 330 340 350 360 PPGPKGDPGI QGYHGRKGER GMPGMPGKHG AKGAPGIAVA GMKGEPGIPG TKGEKGAEGS 370 380 390 400 410 420 PGLPGLLGQK GEKGDAGNSI GGGRGEPGPP GLPGPPGPKG EAGVDGQVGP PGQPGDKGER 430 440 450 460 470 480 GAAGEQGPDG PKGSKGEPGK GEMVDYNGNI NEALQEIRTL ALMGPPGLPG QIGPPGAPGI 490 500 510 520 530 540 PGQKGEIGLP GPPGHDGEKG PRGKPGDMGP PGPQGPPGKD GPPGVKGENG HPGSPGEKGE 550 560 570 580 590 600 KGETGQAGSP GEKGEAGEKG NPGAEGLQGV PGPKGEAGLD GAKGEKGFQG EKGDRGPLGL 610 620 630 640 650 660 PGTPGPIGVP GPAGPKGERG SKGDPGMTGP TGAAGLPGLH GPPGDKGNRG ERGKKGSRGP 670 680 690 KGDKGDQGAP GLDAPCPLGE DGLPVQGCWN K
	Isoform 8 [UniParc]. Checksum: 0256074DDF33E752	FASTA	686	66,887
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD 190 200 210 220 230 240 GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRL LPLLNSVRLA PPPVIKRRTF 250 260 270 280 290 300 QGEQSQASIQ GPPGPPGPPG PSGPLGHPGL PGPMGPPGLP GPPGPKGDPG IQGYHGRKGE 310 320 330 340 350 360 RGMPGMPGKH GAKGAPGIAV AGMKGEPGIP GTKGEKGAEG SPGLPGLLGQ KGEKGDAGNS 370 380 390 400 410 420 IGGGRGEPGP PGLPGPPGPK GEAGVDGQVG PPGQPGDKGE RGAAGEQGPD GPKGSKGEPG 430 440 450 460 470 480 KGEMVDYNGN INEALQEIRT LALMGPPGLP GQIGPPGAPG IPGQKGEIGL PGPPGHDGEK 490 500 510 520 530 540 GPRGKPGDMG PPGPQGPPGK DGPPGVKGEN GHPGSPGEKG EKGETGQAGS PGEKGEAGEK 550 560 570 580 590 600 GNPGAEVPGL PGPEGPPGPP GLQGVPGPKG EAGLDGAKGE KGFQGEKGDR GPLGLPGTPG 610 620 630 640 650 660 PIGVPGPAGP KGERGSKGDP GMTGPTGAAG LPGLHGPPGD KGNRGERGKK GSRGPKGDKG 670 680 DQGAPGLDAP CPLGEDGLPV QGCWNK
	Isoform 9 [UniParc]. Checksum: E172A8ADA30B84DC	FASTA	638	62,077
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD 190 200 210 220 230 240 GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKGE 250 260 270 280 290 300 QSQASIQGPP GPPGPPGPSG PLGHPGLPGP MGPPGLPGPP GPKGDPGIQG YHGRKGERGM 310 320 330 340 350 360 PGMPGKHGAK GAPGIAVAGM KGEPGIPGTK GEKGAEGSPG LPGLLGQKGE KGDAGNSIGG 370 380 390 400 410 420 GRGEPGPPGL PGPPGPKGEA GVDGQVGPPG QPGDKGERGA AGEQGPDGPK GSKGEPGKGE 430 440 450 460 470 480 MVDYNGNINE ALQEIRTLAL MGPPGLPGQI GPPGAPGIPG QKGEIGLPGP PGHDGEKGPR 490 500 510 520 530 540 GKPGDMGPPG PQGPPGKDGP PGVKGENGHP GSPGEKGEKG ETGQAGSPVP GLPGPEGPPG 550 560 570 580 590 600 PPGLQGVPGP KGEAGLDGAK GEKGFQGEKG DRGPLGLPGT PGPIGVPGPA GPKGERGSKG 610 620 630 DPGMTGPTGA AGLPGLHGPP GDKGNREDGL PVQGCWNK
	Isoform 10 [UniParc]. Checksum: 2BD4AF1794648BDA	FASTA	645	63,036
	10 20 30 40 50 60 MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL 70 80 90 100 110 120 AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP 130 140 150 160 170 180 PGPPGQPGTR GFPGFPGPIG LDGKPGHPGP KGDMGLTGPP GQPGPQGQKG EKGQCGEYPH 190 200 210 220 230 240 RLLPLLNSVR LAPPPVIKRR TFQGEQSQAS IQGPPGPPGP PGPSGPLGHP GLPGPMGPPG 250 260 270 280 290 300 LPGPPGPKGD PGIQGYHGRK GERGMPGMPG KHGAKGAPGI AVAGMKGEPG IPGTKGEKGA 310 320 330 340 350 360 EGSPGLPGLL GQKGEKGDAG NSIGGGRGEP GPPGLPGPPG PKGEAGVDGQ VGPPGQPGDK 370 380 390 400 410 420 GERGAAGEQG PDGPKGSKGE PGKGEMVDYN GNINEALQEI RTLALMGPPG LPGQIGPPGA 430 440 450 460 470 480 PGIPGQKGEI GLPGPPGHDG EKGPRGKPGD MGPPGPQGPP GKDGPPGVKG ENGHPGSPGE 490 500 510 520 530 540 KGEKGETGQA GSPVPGLPGP EGPPGPPGLQ GVPGPKGEAG LDGAKGEKGF QGEKGDRGPL 550 560 570 580 590 600 GLPGASGLDG RPGPPGTPGP IGVPGPAGPK GERGSKGDPG MTGPTGAAGL PGLHGPPGDK 610 620 630 640 GNRGERGKKG SRGPKGDKGD QGAPGLDAPC PLGEDGLPVQ GCWNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A short sequence in the N-terminal region is required for the trimerization of type XIII collagen and is conserved in other collagenous transmembrane proteins." Snellman A., Tu H., Vaisanen T., Kvist A.-P., Huhtala P., Pihlajaniemi T. EMBO J. 19:5051-5059(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, SUBCELLULAR LOCATION.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10). Tissue: Testis.
[4]	"The alpha 1 chain of type XIII collagen consists of three collagenous and four noncollagenous domains, and its primary transcript undergoes complex alternative splicing." Pihlajaniemi T., Tamminen M. J. Biol. Chem. 265:16922-16928(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-717 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 84-717 (ISOFORMS 8 AND 9). Tissue: Endothelial cell.
[5]	"Partial characterization of a low molecular weight human collagen that undergoes alternative splicing." Pihlajaniemi T., Myllyla R., Seyer J., Kurkinen M., Prockop D.J. Proc. Natl. Acad. Sci. U.S.A. 84:940-944(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 457-717 (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF 573-717 (ISOFORMS 3/4/7/8). Tissue: Fibrosarcoma.
[6]	"Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon." Tikka L., Pihlajaniemi T., Henttu P., Prockop D.J., Tryggvason K. Proc. Natl. Acad. Sci. U.S.A. 85:7491-7495(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 551-717 (ISOFORMS 6 AND 7), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 551-717 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 566-771 (ISOFORMS 3/4/8).
[7]	"Characterization of the spectrum of alternative splicing of alpha 1 (XIII) collagen transcripts in HT-1080 cells and calvarial tissue resulted in identification of two previously unidentified alternatively spliced sequences, one previously unidentified exon, and nine new mRNA variants." Juvonen M., Pihlajaniemi T. J. Biol. Chem. 267:24693-24699(1992) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
[8]	"Patterns of expression of the six alternatively spliced exons affecting the structures of the COL1 and NC2 domains of the alpha 1(XIII) collagen chain in human tissues and cell lines." Juvonen M., Sandberg M., Pihlajaniemi T. J. Biol. Chem. 267:24700-24707(1992) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
[9]	"Location and alternative splicing of type XIII collagen RNA in the early human placenta." Juvonen M., Pihlajaniemi T., Autio-Harmainen H. Lab. Invest. 69:541-551(1993) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[10]	"Type XIII collagen is widely expressed in the adult and developing human eye and accentuated in the ciliary muscle, the optic nerve and the neural retina." Sandberg-Lall M., Hagg P.O., Wahlstrom I., Pihlajaniemi T. Exp. Eye Res. 70:401-410(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[11]	"The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin." Tu H., Sasaki T., Snellman A., Gohring W., Pirila P., Timpl R., Pihlajaniemi T. J. Biol. Chem. 277:23092-23099(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FN1; HSPG2 AND NID2, HEPARIN-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ293624 mRNA. Translation: CAC00688.1. AL138925, AC024601, AC025426 Genomic DNA. Translation: CAI15450.1. AL138925, AC024601, AC025426 Genomic DNA. Translation: CAI15451.2. AL138925, AC024601, AC025426 Genomic DNA. Translation: CAI15452.1. BC136385 mRNA. Translation: AAI36386.1. M59217 mRNA. Translation: AAA51685.1. Different initiation. M33653 mRNA. Translation: AAA52047.1. M15524 mRNA. Translation: AAA52048.1. M20803 , M20795, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804, M20805 Genomic DNA. Translation: AAA51987.1. M20803 , M20795, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804 Genomic DNA. Translation: AAA51988.1. M20803 , M20795, M20796, M20797, M20798, M20799, M20801, M20802, M20804 Genomic DNA. Translation: AAA51989.1. M20803 , M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804, M20805 Genomic DNA. Translation: AAA51990.1. M20803 , M20796, M20797, M20798, M20799, M20801, M20802, M20804, M20805 Genomic DNA. Translation: AAA51991.1.
IPI	IPI00299472. IPI00375408. IPI00375412. IPI00375413. IPI00375414. IPI00375417. IPI00377036. IPI00383356. IPI00844070. IPI01008962.
PIR	B40983.
RefSeq	NP_001123575.1. NM_001130103.1. NP_542988.3. NM_080798.3. NP_542990.3. NM_080800.3. NP_542991.3. NM_080801.3. NP_542992.3. NM_080802.3.
UniGene	Hs.695934.
3D structure databases
ProteinModelPortal	Q5TAT6.
ModBase	Search...
PTM databases
PhosphoSite	Q5TAT6.
Polymorphism databases
DMDM	74745860.
Proteomic databases
PaxDb	Q5TAT6.
PRIDE	Q5TAT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354547; ENSP00000346553; ENSG00000197467. ENST00000357811; ENSP00000350463; ENSG00000197467. ENST00000398978; ENSP00000381949; ENSG00000197467. ENST00000517713; ENSP00000430061; ENSG00000197467. ENST00000520267; ENSP00000428057; ENSG00000197467. ENST00000522165; ENSP00000428342; ENSG00000197467.
GeneID	1305.
KEGG	hsa:1305.
UCSC	uc001jqk.2. human. uc001jql.3. human. uc021prz.1. human. uc021psc.1. human.
Organism-specific databases
CTD	1305.
GeneCards	GC10P071561.
H-InvDB	HIX0025928.
HGNC	HGNC:2190. COL13A1.
HPA	HPA050392.
MIM	120350. gene.
neXtProt	NX_Q5TAT6.
PharmGKB	PA26706.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254293.
HOGENOM	HOG000085653.
HOVERGEN	HBG004933.
KO	K16617.
OMA	TSPGCHC.
OrthoDB	EOG4894NC.
Enzyme and pathway databases
Reactome	REACT_118779. Extracellular matrix organization.
Gene expression databases
ArrayExpress	Q5TAT6.
Bgee	Q5TAT6.
Genevestigator	Q5TAT6.
Family and domain databases
InterPro	IPR008160. Collagen. [Graphical view]
Pfam	PF01391. Collagen. 10 hits. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB01076. Atorvastatin. DB00641. Simvastatin.
GenomeRNAi	1305.
NextBio	5305.
SOURCE	Search...

Entry information

Entry name

CODA1_HUMAN

Accession

Primary (citable) accession number: Q5TAT6
Secondary accession number(s): A6NFR5 , B9EGD2, Q13992, Q13993, Q13994, Q13995, Q13996, Q5TAT4, Q5TAT5, Q7KZ33, Q7KZ49, Q99228, Q9NQ52

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.