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Q5TAT6

- CODA1_HUMAN

UniProt

Q5TAT6 - CODA1_HUMAN

Protein

Collagen alpha-1(XIII) chain

Gene

COL13A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin.By similarity2 Publications

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. cell-matrix adhesion Source: UniProtKB
    3. collagen catabolic process Source: Reactome
    4. endochondral ossification Source: UniProtKB
    5. extracellular matrix disassembly Source: Reactome
    6. extracellular matrix organization Source: Reactome
    7. morphogenesis of a branching structure Source: UniProtKB
    8. single organismal cell-cell adhesion Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cell adhesion, Differentiation, Osteogenesis

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_13552. Integrin cell surface interactions.
    REACT_150401. Collagen degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XIII) chain
    Alternative name(s):
    COLXIIIA1
    Gene namesi
    Name:COL13A1Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:2190. COL13A1.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type II membrane protein By similarity1 Publication

    GO - Cellular componenti

    1. cell-cell junction Source: Ensembl
    2. collagen type XIII trimer Source: UniProtKB
    3. endoplasmic reticulum lumen Source: Reactome
    4. extracellular region Source: Reactome
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26706.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 717717Collagen alpha-1(XIII) chainPRO_0000284679Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ5TAT6.
    PRIDEiQ5TAT6.

    PTM databases

    PhosphoSiteiQ5TAT6.

    Expressioni

    Tissue specificityi

    Widely expressed in both fetal and adult ocular tissues (at protein level). In the eye, expression is accentuated in the ciliary muscle, optic nerve and the neural retina. In early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries and to cells of the cytotrophoblastic columns. Also detected in large decidual cells of the decidual membrane and to stromal cells of the gestational endometrium, but not in the epithelial cells in the endometrial glands.2 Publications

    Gene expression databases

    ArrayExpressiQ5TAT6.
    BgeeiQ5TAT6.
    GenevestigatoriQ5TAT6.

    Organism-specific databases

    HPAiHPA050392.

    Interactioni

    Subunit structurei

    Homotrimer; disulfide-linked. Nucleation of the type XIII collagen triple helix is likely to occur at the N-terminal region with triple helix formation proceeding from the N- to the C-terminus. Interacts with FN1, perlecan/HSPG2 and NID2.2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TAT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini62 – 717656ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6117Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 121121Nonhelical region 1 (NC1)Sequence AnalysisAdd
    BLAST
    Regioni122 – 21695Triple-helical region 1 (COL1)Sequence AnalysisAdd
    BLAST
    Regioni217 – 26953Nonhelical region 2 (NC2)Sequence AnalysisAdd
    BLAST
    Regioni270 – 441172Triple-helical region 2 (COL2)Sequence AnalysisAdd
    BLAST
    Regioni442 – 46322Nonhelical region 3 (NC3)Sequence AnalysisAdd
    BLAST
    Regioni464 – 699236Triple-helical region 3 (COL3)Sequence AnalysisAdd
    BLAST
    Regioni700 – 71718Nonhelical region 4 (NC4)Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Collagen, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG254293.
    HOGENOMiHOG000085653.
    HOVERGENiHBG004933.
    KOiK16617.
    PhylomeDBiQ5TAT6.
    TreeFamiTF338175.

    Family and domain databases

    InterProiIPR008160. Collagen.
    [Graphical view]
    PfamiPF01391. Collagen. 10 hits.
    [Graphical view]

    Sequences (11)i

    Sequence statusi: Complete.

    This entry describes 11 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.Curated

    Isoform 11 Publication (identifier: Q5TAT6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL    50
    ALCSLALSLL AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW 100
    KLHSRRRREA PKTSPGCNCP PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD 150
    AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD GKPGHPGPKG DMGLTGPPGQ 200
    PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKLL PLLNSVRLAP 250
    PPVIKRRTFQ GEQSQASIQG PPGPPGPPGP SGPLGHPGLP GPMGPPGLPG 300
    PPGPKGDPGI QGYHGRKGER GMPGMPGKHG AKGAPGIAVA GMKGEPGIPG 350
    TKGEKGAEGS PGLPGLLGQK GEKGDAGNSI GGGRGEPGPP GLPGPPGPKG 400
    EAGVDGQVGP PGQPGDKGER GAAGEQGPDG PKGSKGEPGK GEMVDYNGNI 450
    NEALQEIRTL ALMGPPGLPG QIGPPGAPGI PGQKGEIGLP GPPGHDGEKG 500
    PRGKPGDMGP PGPQGPPGKD GPPGVKGENG HPGSPGEKGE KGETGQAGSP 550
    GEKGEAGEKG NPGAEVPGLP GPEGPPGPPG LQGVPGPKGE AGLDGAKGEK 600
    GFQGEKGDRG PLGLPGASGL DGRPGPPGTP GPIGVPGPAG PKGERGSKGD 650
    PGMTGPTGAA GLPGLHGPPG DKGNRGERGK KGSRGPKGDK GDQGAPGLDA 700
    PCPLGEDGLP VQGCWNK 717
    Length:717
    Mass (Da):69,950
    Last modified:December 21, 2004 - v1
    Checksum:iFD12CA80CC93540F
    GO
    Isoform 21 Publication (identifier: Q5TAT6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         239-260: Missing.

    Note: Gene prediction based on EST data.Curated

    Show »
    Length:695
    Mass (Da):67,439
    Checksum:i9816F7BCDD8C108B
    GO
    Isoform 31 Publication (identifier: Q5TAT6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         239-260: Missing.
         617-628: Missing.

    Note: Gene prediction based on EST data.Curated

    Show »
    Length:683
    Mass (Da):66,377
    Checksum:i3BB550FD03062C30
    GO
    Isoform 41 Publication (identifier: Q5TAT6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         239-260: Missing.
         551-565: Missing.
         617-628: Missing.

    Show »
    Length:668
    Mass (Da):64,965
    Checksum:iAAC18C9E4B45DA4E
    GO
    Isoform 51 Publication (identifier: Q5TAT6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         551-565: Missing.

    Show »
    Length:702
    Mass (Da):68,538
    Checksum:i66FC08083E0D4A91
    GO
    Isoform 61 Publication (identifier: Q5TAT6-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         566-579: Missing.

    Show »
    Length:703
    Mass (Da):68,700
    Checksum:i62947B1FEEBF6268
    GO
    Isoform 71 Publication (identifier: Q5TAT6-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         566-579: Missing.
         617-628: Missing.

    Show »
    Length:691
    Mass (Da):67,638
    Checksum:iEEC688B6A5364877
    GO
    Isoform 81 Publication (identifier: Q5TAT6-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         220-238: Missing.
         617-628: Missing.

    Show »
    Length:686
    Mass (Da):66,887
    Checksum:i0256074DDF33E752
    GO
    Isoform 91 Publication (identifier: Q5TAT6-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         239-260: Missing.
         551-565: Missing.
         617-628: Missing.
         676-705: Missing.

    Show »
    Length:638
    Mass (Da):62,077
    Checksum:iE172A8ADA30B84DC
    GO
    Isoform 10 (identifier: Q5TAT6-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         122-159: Missing.
         220-238: Missing.
         551-565: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:645
    Mass (Da):63,036
    Checksum:i2BD4AF1794648BDA
    GO
    Isoform 11 (identifier: Q5TAT6-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         135-163: Missing.
         239-260: Missing.
         551-565: Missing.
         617-628: Missing.
         678-706: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:610
    Mass (Da):59,465
    Checksum:iDDDD4D432DD45849
    GO

    Sequence cautioni

    The sequence AAA51685.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti182 – 1821K → F in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti394 – 3941G → A in CAC00688. (PubMed:11013208)Curated
    Sequence conflicti394 – 3941G → A in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti466 – 4661P → L in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti466 – 4661P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti469 – 4691P → L in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti469 – 4691P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti475 – 4751P → L in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti475 – 4751P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti478 – 4781P → L in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti478 – 4781P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti480 – 4812IP → ML in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti480 – 4812IP → ML in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti490 – 4901P → L in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti490 – 4901P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti493 – 4931P → L in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti493 – 4931P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti498 – 4981Missing in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti498 – 4981Missing in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti505 – 5051P → L in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti505 – 5051P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti511 – 5111P → L in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti511 – 5111P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti517 – 5171P → L in AAA51685. (PubMed:1698771)Curated
    Sequence conflicti517 – 5171P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti570 – 5701P → L in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti570 – 5701P → L in AAA51987. (PubMed:2459707)Curated
    Sequence conflicti570 – 5701P → L in AAA51990. (PubMed:2459707)Curated
    Sequence conflicti570 – 5701P → L in AAA51991. (PubMed:2459707)Curated
    Sequence conflicti706 – 7061E → Q in AAA52047. (PubMed:3547403)Curated
    Sequence conflicti706 – 7061E → Q in AAA52048. (PubMed:3547403)Curated
    Sequence conflicti706 – 7061E → Q in AAA51987. (PubMed:2459707)Curated
    Sequence conflicti706 – 7061E → Q in AAA51988. (PubMed:2459707)Curated
    Sequence conflicti706 – 7061E → Q in AAA51989. (PubMed:2459707)Curated
    Sequence conflicti706 – 7061E → Q in AAA51990. (PubMed:2459707)Curated
    Sequence conflicti706 – 7061E → Q in AAA51991. (PubMed:2459707)Curated
    Sequence conflicti709 – 7091L → Y in AAA51987. (PubMed:2459707)Curated
    Sequence conflicti709 – 7091L → Y in AAA51988. (PubMed:2459707)Curated
    Sequence conflicti709 – 7091L → Y in AAA51989. (PubMed:2459707)Curated
    Sequence conflicti709 – 7091L → Y in AAA51990. (PubMed:2459707)Curated
    Sequence conflicti709 – 7091L → Y in AAA51991. (PubMed:2459707)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti531 – 5311H → Q.
    Corresponds to variant rs1061954 [ dbSNP | Ensembl ].
    VAR_055670

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei122 – 15938Missing in isoform 10. 1 PublicationVSP_043361Add
    BLAST
    Alternative sequencei135 – 16329Missing in isoform 11. CuratedVSP_047230Add
    BLAST
    Alternative sequencei220 – 23819Missing in isoform 8 and isoform 10. 2 PublicationsVSP_052382Add
    BLAST
    Alternative sequencei239 – 26022Missing in isoform 2, isoform 3, isoform 4, isoform 9 and isoform 11. 1 PublicationVSP_052383Add
    BLAST
    Alternative sequencei551 – 56515Missing in isoform 4, isoform 5, isoform 9, isoform 10 and isoform 11. 3 PublicationsVSP_052384Add
    BLAST
    Alternative sequencei566 – 57914Missing in isoform 6 and isoform 7. 1 PublicationVSP_052385Add
    BLAST
    Alternative sequencei617 – 62812Missing in isoform 3, isoform 4, isoform 7, isoform 8, isoform 9 and isoform 11. 1 PublicationVSP_052386Add
    BLAST
    Alternative sequencei676 – 70530Missing in isoform 9. 1 PublicationVSP_052387Add
    BLAST
    Alternative sequencei678 – 70629Missing in isoform 11. CuratedVSP_047231Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ293624 mRNA. Translation: CAC00688.1.
    AC024601 Genomic DNA. No translation available.
    AC025426 Genomic DNA. No translation available.
    AL138925 Genomic DNA. No translation available.
    BC136385 mRNA. Translation: AAI36386.1.
    M59217 mRNA. Translation: AAA51685.1. Different initiation.
    M33653 mRNA. Translation: AAA52047.1.
    M15524 mRNA. Translation: AAA52048.1.
    M20803
    , M20795, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804, M20805 Genomic DNA. Translation: AAA51987.1.
    M20803
    , M20795, M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804 Genomic DNA. Translation: AAA51988.1.
    M20803
    , M20795, M20796, M20797, M20798, M20799, M20801, M20802, M20804 Genomic DNA. Translation: AAA51989.1.
    M20803
    , M20796, M20797, M20798, M20799, M20800, M20801, M20802, M20804, M20805 Genomic DNA. Translation: AAA51990.1.
    M20803
    , M20796, M20797, M20798, M20799, M20801, M20802, M20804, M20805 Genomic DNA. Translation: AAA51991.1.
    CCDSiCCDS44419.1. [Q5TAT6-1]
    CCDS44423.2. [Q5TAT6-4]
    CCDS44424.2. [Q5TAT6-2]
    CCDS44425.2. [Q5TAT6-8]
    CCDS44427.2. [Q5TAT6-10]
    CCDS44428.2. [Q5TAT6-11]
    PIRiB40983.
    RefSeqiNP_001123575.1. NM_001130103.1. [Q5TAT6-1]
    NP_542988.3. NM_080798.3. [Q5TAT6-10]
    NP_542990.3. NM_080800.3. [Q5TAT6-8]
    NP_542991.3. NM_080801.3. [Q5TAT6-2]
    NP_542992.3. NM_080802.3. [Q5TAT6-4]
    NP_542995.3. NM_080805.3. [Q5TAT6-11]
    UniGeneiHs.695934.

    Genome annotation databases

    EnsembliENST00000354547; ENSP00000346553; ENSG00000197467. [Q5TAT6-2]
    ENST00000357811; ENSP00000350463; ENSG00000197467. [Q5TAT6-3]
    ENST00000398978; ENSP00000381949; ENSG00000197467. [Q5TAT6-1]
    ENST00000517713; ENSP00000430061; ENSG00000197467. [Q5TAT6-4]
    ENST00000520133; ENSP00000430173; ENSG00000197467. [Q5TAT6-11]
    ENST00000520267; ENSP00000428057; ENSG00000197467. [Q5TAT6-10]
    ENST00000522165; ENSP00000428342; ENSG00000197467. [Q5TAT6-8]
    GeneIDi1305.
    KEGGihsa:1305.
    UCSCiuc001jqk.2. human. [Q5TAT6-2]
    uc001jql.3. human. [Q5TAT6-1]
    uc010qjf.2. human. [Q5TAT6-10]
    uc021prz.1. human. [Q5TAT6-4]
    uc021psc.1. human. [Q5TAT6-8]

    Polymorphism databases

    DMDMi74745860.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ293624 mRNA. Translation: CAC00688.1 .
    AC024601 Genomic DNA. No translation available.
    AC025426 Genomic DNA. No translation available.
    AL138925 Genomic DNA. No translation available.
    BC136385 mRNA. Translation: AAI36386.1 .
    M59217 mRNA. Translation: AAA51685.1 . Different initiation.
    M33653 mRNA. Translation: AAA52047.1 .
    M15524 mRNA. Translation: AAA52048.1 .
    M20803
    , M20795 , M20796 , M20797 , M20798 , M20799 , M20800 , M20801 , M20802 , M20804 , M20805 Genomic DNA. Translation: AAA51987.1 .
    M20803
    , M20795 , M20796 , M20797 , M20798 , M20799 , M20800 , M20801 , M20802 , M20804 Genomic DNA. Translation: AAA51988.1 .
    M20803
    , M20795 , M20796 , M20797 , M20798 , M20799 , M20801 , M20802 , M20804 Genomic DNA. Translation: AAA51989.1 .
    M20803
    , M20796 , M20797 , M20798 , M20799 , M20800 , M20801 , M20802 , M20804 , M20805 Genomic DNA. Translation: AAA51990.1 .
    M20803
    , M20796 , M20797 , M20798 , M20799 , M20801 , M20802 , M20804 , M20805 Genomic DNA. Translation: AAA51991.1 .
    CCDSi CCDS44419.1. [Q5TAT6-1 ]
    CCDS44423.2. [Q5TAT6-4 ]
    CCDS44424.2. [Q5TAT6-2 ]
    CCDS44425.2. [Q5TAT6-8 ]
    CCDS44427.2. [Q5TAT6-10 ]
    CCDS44428.2. [Q5TAT6-11 ]
    PIRi B40983.
    RefSeqi NP_001123575.1. NM_001130103.1. [Q5TAT6-1 ]
    NP_542988.3. NM_080798.3. [Q5TAT6-10 ]
    NP_542990.3. NM_080800.3. [Q5TAT6-8 ]
    NP_542991.3. NM_080801.3. [Q5TAT6-2 ]
    NP_542992.3. NM_080802.3. [Q5TAT6-4 ]
    NP_542995.3. NM_080805.3. [Q5TAT6-11 ]
    UniGenei Hs.695934.

    3D structure databases

    ProteinModelPortali Q5TAT6.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    DrugBanki DB01076. Atorvastatin.
    DB00641. Simvastatin.

    PTM databases

    PhosphoSitei Q5TAT6.

    Polymorphism databases

    DMDMi 74745860.

    Proteomic databases

    PaxDbi Q5TAT6.
    PRIDEi Q5TAT6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354547 ; ENSP00000346553 ; ENSG00000197467 . [Q5TAT6-2 ]
    ENST00000357811 ; ENSP00000350463 ; ENSG00000197467 . [Q5TAT6-3 ]
    ENST00000398978 ; ENSP00000381949 ; ENSG00000197467 . [Q5TAT6-1 ]
    ENST00000517713 ; ENSP00000430061 ; ENSG00000197467 . [Q5TAT6-4 ]
    ENST00000520133 ; ENSP00000430173 ; ENSG00000197467 . [Q5TAT6-11 ]
    ENST00000520267 ; ENSP00000428057 ; ENSG00000197467 . [Q5TAT6-10 ]
    ENST00000522165 ; ENSP00000428342 ; ENSG00000197467 . [Q5TAT6-8 ]
    GeneIDi 1305.
    KEGGi hsa:1305.
    UCSCi uc001jqk.2. human. [Q5TAT6-2 ]
    uc001jql.3. human. [Q5TAT6-1 ]
    uc010qjf.2. human. [Q5TAT6-10 ]
    uc021prz.1. human. [Q5TAT6-4 ]
    uc021psc.1. human. [Q5TAT6-8 ]

    Organism-specific databases

    CTDi 1305.
    GeneCardsi GC10P071561.
    H-InvDB HIX0025928.
    HGNCi HGNC:2190. COL13A1.
    HPAi HPA050392.
    MIMi 120350. gene.
    neXtProti NX_Q5TAT6.
    PharmGKBi PA26706.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254293.
    HOGENOMi HOG000085653.
    HOVERGENi HBG004933.
    KOi K16617.
    PhylomeDBi Q5TAT6.
    TreeFami TF338175.

    Enzyme and pathway databases

    Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
    REACT_13552. Integrin cell surface interactions.
    REACT_150401. Collagen degradation.

    Miscellaneous databases

    GeneWikii Collagen,_type_XIII,_alpha_1.
    GenomeRNAii 1305.
    NextBioi 5305.
    PROi Q5TAT6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5TAT6.
    Bgeei Q5TAT6.
    Genevestigatori Q5TAT6.

    Family and domain databases

    InterProi IPR008160. Collagen.
    [Graphical view ]
    Pfami PF01391. Collagen. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A short sequence in the N-terminal region is required for the trimerization of type XIII collagen and is conserved in other collagenous transmembrane proteins."
      Snellman A., Tu H., Vaisanen T., Kvist A.-P., Huhtala P., Pihlajaniemi T.
      EMBO J. 19:5051-5059(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT, SUBCELLULAR LOCATION.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10).
      Tissue: Testis.
    4. "The alpha 1 chain of type XIII collagen consists of three collagenous and four noncollagenous domains, and its primary transcript undergoes complex alternative splicing."
      Pihlajaniemi T., Tamminen M.
      J. Biol. Chem. 265:16922-16928(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-717 (ISOFORM 4), NUCLEOTIDE SEQUENCE [MRNA] OF 84-717 (ISOFORMS 8 AND 9).
      Tissue: Endothelial cellImported.
    5. "Partial characterization of a low molecular weight human collagen that undergoes alternative splicing."
      Pihlajaniemi T., Myllyla R., Seyer J., Kurkinen M., Prockop D.J.
      Proc. Natl. Acad. Sci. U.S.A. 84:940-944(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 457-717 (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF 573-717 (ISOFORMS 3/4/7/8).
      Tissue: FibrosarcomaImported.
    6. "Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon."
      Tikka L., Pihlajaniemi T., Henttu P., Prockop D.J., Tryggvason K.
      Proc. Natl. Acad. Sci. U.S.A. 85:7491-7495(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 551-717 (ISOFORMS 6 AND 7), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 551-717 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 566-771 (ISOFORMS 3/4/8).
    7. "Characterization of the spectrum of alternative splicing of alpha 1 (XIII) collagen transcripts in HT-1080 cells and calvarial tissue resulted in identification of two previously unidentified alternatively spliced sequences, one previously unidentified exon, and nine new mRNA variants."
      Juvonen M., Pihlajaniemi T.
      J. Biol. Chem. 267:24693-24699(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    8. "Patterns of expression of the six alternatively spliced exons affecting the structures of the COL1 and NC2 domains of the alpha 1(XIII) collagen chain in human tissues and cell lines."
      Juvonen M., Sandberg M., Pihlajaniemi T.
      J. Biol. Chem. 267:24700-24707(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    9. "Location and alternative splicing of type XIII collagen RNA in the early human placenta."
      Juvonen M., Pihlajaniemi T., Autio-Harmainen H.
      Lab. Invest. 69:541-551(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    10. "Type XIII collagen is widely expressed in the adult and developing human eye and accentuated in the ciliary muscle, the optic nerve and the neural retina."
      Sandberg-Lall M., Hagg P.O., Wahlstrom I., Pihlajaniemi T.
      Exp. Eye Res. 70:401-410(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    11. "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin."
      Tu H., Sasaki T., Snellman A., Gohring W., Pirila P., Timpl R., Pihlajaniemi T.
      J. Biol. Chem. 277:23092-23099(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FN1; HSPG2 AND NID2, HEPARIN-BINDING.

    Entry informationi

    Entry nameiCODA1_HUMAN
    AccessioniPrimary (citable) accession number: Q5TAT6
    Secondary accession number(s): A6NFR5
    , B9EGD2, E7EWL8, Q13992, Q13993, Q13994, Q13995, Q13996, Q5TAT4, Q5TAT5, Q7KZ33, Q7KZ49, Q99228, Q9NQ52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3