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Q5TAP6

- UT14C_HUMAN

UniProt

Q5TAP6 - UT14C_HUMAN

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Protein
U3 small nucleolar RNA-associated protein 14 homolog C
Gene
UTP14C, KIAA0266
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis By similarity.1 Publication

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. meiotic nuclear division Source: UniProtKB-KW
  3. multicellular organismal development Source: UniProtKB-KW
  4. rRNA processing Source: InterPro
  5. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Meiosis, Ribosome biogenesis, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 14 homolog C
Gene namesi
Name:UTP14C
Synonyms:KIAA0266
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:20321. UTP14C.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
  2. small-subunit processome Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 766766U3 small nucleolar RNA-associated protein 14 homolog C
PRO_0000065736Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei28 – 281Phosphoserine By similarity
Modified residuei51 – 511Phosphoserine By similarity
Modified residuei76 – 761Phosphoserine By similarity
Modified residuei204 – 2041Phosphothreonine By similarity
Modified residuei403 – 4031Phosphoserine By similarity
Modified residuei405 – 4051Phosphoserine By similarity
Modified residuei443 – 4431Phosphoserine By similarity
Modified residuei451 – 4511Phosphoserine By similarity
Modified residuei567 – 5671Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5TAP6.

PTM databases

PhosphoSiteiQ5TAP6.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiQ5TAP6.
GenevestigatoriQ5TAP6.

Organism-specific databases

HPAiHPA047217.
HPA054023.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367361.

Structurei

3D structure databases

ProteinModelPortaliQ5TAP6.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili216 – 24530 Reviewed prediction
Add
BLAST
Coiled coili316 – 34631 Reviewed prediction
Add
BLAST
Coiled coili452 – 47019 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the UTP14 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000231396.
HOVERGENiHBG056550.
InParanoidiQ5TAP6.
KOiK14567.
OMAiKANDAMV.
OrthoDBiEOG7DZ8K1.
PhylomeDBiQ5TAP6.
TreeFamiTF314531.

Family and domain databases

InterProiIPR006709. SSU_processome_Utp14.
[Graphical view]
PANTHERiPTHR14150. PTHR14150. 1 hit.
PfamiPF04615. Utp14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TAP6-1 [UniParc]FASTAAdd to Basket

« Hide

MNVNQVAENL ALSHQEELVD LPKNYPLSEN EDEGDSDGER KHQKLLEAII    50
SLDGKNRRKL AERSEASLKV SEFSVSSEGS GEKLGLADLL EPVKTSSSLA 100
TVKKQLNRVK SKKVVELPLN KEKIEQIHRE VAFSKTSQVL SKWDPIILKN 150
QQAEQLVFPL GKEQPAIAPI EHALSGWKAR TPLEQEIFNL LHKNKQPVTD 200
PLLTPMEKAS LQAMSLEEAK MHRAELQRAR ALQSYYEAKA RKEKKIKSKK 250
YHKVVKKGKA KKALKEFEQL QKVNPTVALE EMEKIENARM MERMSLKHQN 300
SGKWAKSKAI MAKYDLEARQ AMQEQLAKNK ELTQKLQVAS ESEEEEGGTE 350
VEELLVPHVA NEVQMNVDGP NPWMFRSCTS DTKEAATQED PEQVPELAAH 400
EVSASEAEER PVAEEEILLR EFEERQSLRK RSELNQDAEP ASSQETKDSS 450
SQEVLSELRA LSQKLKEKHQ SRKQKASSEG TVPQVQREEP APEEAEPLLL 500
QRSERVQTLE ELEELGKEDC FQNKELPRPV LEGQQSERTP NNRPDAPKEK 550
KEKEQLINLQ NFLTTQSPSV RSLAVPTIIE ELEDEEERDQ RQMIKEAFAG 600
DDVIRDFLKE KREAVEASKP KDVDLTLPGW GEWGGVGLKP SAKKRRQFLI 650
KAPEGPPRKD KNLPNVIISE KRNIHAAAHQ VQVLPYPFTH HRQFERTIQT 700
PIGSTWNTQR AFQKLTTPKV VTKPGHIIKP IKAEDVGYQS SSRSDLPVIQ 750
RNPKRITTRH NKEEKL 766
Length:766
Mass (Da):87,188
Last modified:December 21, 2004 - v1
Checksum:i4C90F0754A042986
GO

Sequence cautioni

The sequence BAA13396.2 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851G → V.1 Publication
Corresponds to variant rs3742289 [ dbSNP | Ensembl ].
VAR_022812
Natural varianti101 – 1011T → A.
Corresponds to variant rs3742290 [ dbSNP | Ensembl ].
VAR_022813
Natural varianti319 – 3191R → H.
Corresponds to variant rs17402034 [ dbSNP | Ensembl ].
VAR_051482

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87455 mRNA. Translation: BAA13396.2. Different initiation.
AL139082 Genomic DNA. Translation: CAI12891.1.
BC089407 mRNA. Translation: AAH89407.1.
CCDSiCCDS31978.1.
RefSeqiNP_067677.4. NM_021645.5.
UniGeneiHs.512963.

Genome annotation databases

EnsembliENST00000521776; ENSP00000428619; ENSG00000253797.
GeneIDi9724.
KEGGihsa:9724.
UCSCiuc001vgb.3. human.

Polymorphism databases

DMDMi68566167.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87455 mRNA. Translation: BAA13396.2 . Different initiation.
AL139082 Genomic DNA. Translation: CAI12891.1 .
BC089407 mRNA. Translation: AAH89407.1 .
CCDSi CCDS31978.1.
RefSeqi NP_067677.4. NM_021645.5.
UniGenei Hs.512963.

3D structure databases

ProteinModelPortali Q5TAP6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000367361.

PTM databases

PhosphoSitei Q5TAP6.

Polymorphism databases

DMDMi 68566167.

Proteomic databases

PRIDEi Q5TAP6.

Protocols and materials databases

DNASUi 9724.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000521776 ; ENSP00000428619 ; ENSG00000253797 .
GeneIDi 9724.
KEGGi hsa:9724.
UCSCi uc001vgb.3. human.

Organism-specific databases

CTDi 9724.
GeneCardsi GC13P052599.
HGNCi HGNC:20321. UTP14C.
HPAi HPA047217.
HPA054023.
MIMi 608969. gene.
neXtProti NX_Q5TAP6.
PharmGKBi PA134944828.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000231396.
HOVERGENi HBG056550.
InParanoidi Q5TAP6.
KOi K14567.
OMAi KANDAMV.
OrthoDBi EOG7DZ8K1.
PhylomeDBi Q5TAP6.
TreeFami TF314531.

Miscellaneous databases

GenomeRNAii 9724.
NextBioi 36581.
PROi Q5TAP6.
SOURCEi Search...

Gene expression databases

Bgeei Q5TAP6.
Genevestigatori Q5TAP6.

Family and domain databases

InterProi IPR006709. SSU_processome_Utp14.
[Graphical view ]
PANTHERi PTHR14150. PTHR14150. 1 hit.
Pfami PF04615. Utp14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-85.
    Tissue: Lymph.
  4. "The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b."
    Rohozinski J., Bishop C.E.
    Proc. Natl. Acad. Sci. U.S.A. 101:11695-11700(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUT14C_HUMAN
AccessioniPrimary (citable) accession number: Q5TAP6
Secondary accession number(s): Q5FWG3, Q92555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by an autosomal retrotransposed copy of the X-linked gene UTP14A. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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