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Q5TAP6

- UT14C_HUMAN

UniProt

Q5TAP6 - UT14C_HUMAN

Protein

U3 small nucleolar RNA-associated protein 14 homolog C

Gene

UTP14C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis By similarity.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. meiotic nuclear division Source: UniProtKB-KW
    3. multicellular organismal development Source: UniProtKB-KW
    4. rRNA processing Source: InterPro
    5. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Meiosis, Ribosome biogenesis, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U3 small nucleolar RNA-associated protein 14 homolog C
    Gene namesi
    Name:UTP14C
    Synonyms:KIAA0266
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:20321. UTP14C.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell
    2. small-subunit processome Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134944828.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 766766U3 small nucleolar RNA-associated protein 14 homolog CPRO_0000065736Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei28 – 281PhosphoserineBy similarity
    Modified residuei51 – 511PhosphoserineBy similarity
    Modified residuei76 – 761PhosphoserineBy similarity
    Modified residuei204 – 2041PhosphothreonineBy similarity
    Modified residuei403 – 4031PhosphoserineBy similarity
    Modified residuei405 – 4051PhosphoserineBy similarity
    Modified residuei443 – 4431PhosphoserineBy similarity
    Modified residuei451 – 4511PhosphoserineBy similarity
    Modified residuei567 – 5671PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ5TAP6.

    PTM databases

    PhosphoSiteiQ5TAP6.

    Expressioni

    Tissue specificityi

    Expressed in testis.1 Publication

    Gene expression databases

    BgeeiQ5TAP6.
    GenevestigatoriQ5TAP6.

    Organism-specific databases

    HPAiHPA047217.
    HPA054023.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000367361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TAP6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili216 – 24530Sequence AnalysisAdd
    BLAST
    Coiled coili316 – 34631Sequence AnalysisAdd
    BLAST
    Coiled coili452 – 47019Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UTP14 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOGENOMiHOG000231396.
    HOVERGENiHBG056550.
    InParanoidiQ5TAP6.
    KOiK14567.
    OMAiKANDAMV.
    OrthoDBiEOG7DZ8K1.
    PhylomeDBiQ5TAP6.
    TreeFamiTF314531.

    Family and domain databases

    InterProiIPR006709. SSU_processome_Utp14.
    [Graphical view]
    PANTHERiPTHR14150. PTHR14150. 1 hit.
    PfamiPF04615. Utp14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5TAP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVNQVAENL ALSHQEELVD LPKNYPLSEN EDEGDSDGER KHQKLLEAII    50
    SLDGKNRRKL AERSEASLKV SEFSVSSEGS GEKLGLADLL EPVKTSSSLA 100
    TVKKQLNRVK SKKVVELPLN KEKIEQIHRE VAFSKTSQVL SKWDPIILKN 150
    QQAEQLVFPL GKEQPAIAPI EHALSGWKAR TPLEQEIFNL LHKNKQPVTD 200
    PLLTPMEKAS LQAMSLEEAK MHRAELQRAR ALQSYYEAKA RKEKKIKSKK 250
    YHKVVKKGKA KKALKEFEQL QKVNPTVALE EMEKIENARM MERMSLKHQN 300
    SGKWAKSKAI MAKYDLEARQ AMQEQLAKNK ELTQKLQVAS ESEEEEGGTE 350
    VEELLVPHVA NEVQMNVDGP NPWMFRSCTS DTKEAATQED PEQVPELAAH 400
    EVSASEAEER PVAEEEILLR EFEERQSLRK RSELNQDAEP ASSQETKDSS 450
    SQEVLSELRA LSQKLKEKHQ SRKQKASSEG TVPQVQREEP APEEAEPLLL 500
    QRSERVQTLE ELEELGKEDC FQNKELPRPV LEGQQSERTP NNRPDAPKEK 550
    KEKEQLINLQ NFLTTQSPSV RSLAVPTIIE ELEDEEERDQ RQMIKEAFAG 600
    DDVIRDFLKE KREAVEASKP KDVDLTLPGW GEWGGVGLKP SAKKRRQFLI 650
    KAPEGPPRKD KNLPNVIISE KRNIHAAAHQ VQVLPYPFTH HRQFERTIQT 700
    PIGSTWNTQR AFQKLTTPKV VTKPGHIIKP IKAEDVGYQS SSRSDLPVIQ 750
    RNPKRITTRH NKEEKL 766
    Length:766
    Mass (Da):87,188
    Last modified:December 21, 2004 - v1
    Checksum:i4C90F0754A042986
    GO

    Sequence cautioni

    The sequence BAA13396.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851G → V.1 Publication
    Corresponds to variant rs3742289 [ dbSNP | Ensembl ].
    VAR_022812
    Natural varianti101 – 1011T → A.
    Corresponds to variant rs3742290 [ dbSNP | Ensembl ].
    VAR_022813
    Natural varianti319 – 3191R → H.
    Corresponds to variant rs17402034 [ dbSNP | Ensembl ].
    VAR_051482

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87455 mRNA. Translation: BAA13396.2. Different initiation.
    AL139082 Genomic DNA. Translation: CAI12891.1.
    BC089407 mRNA. Translation: AAH89407.1.
    CCDSiCCDS31978.1.
    RefSeqiNP_067677.4. NM_021645.5.
    UniGeneiHs.512963.

    Genome annotation databases

    EnsembliENST00000521776; ENSP00000428619; ENSG00000253797.
    GeneIDi9724.
    KEGGihsa:9724.
    UCSCiuc001vgb.3. human.

    Polymorphism databases

    DMDMi68566167.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87455 mRNA. Translation: BAA13396.2 . Different initiation.
    AL139082 Genomic DNA. Translation: CAI12891.1 .
    BC089407 mRNA. Translation: AAH89407.1 .
    CCDSi CCDS31978.1.
    RefSeqi NP_067677.4. NM_021645.5.
    UniGenei Hs.512963.

    3D structure databases

    ProteinModelPortali Q5TAP6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000367361.

    PTM databases

    PhosphoSitei Q5TAP6.

    Polymorphism databases

    DMDMi 68566167.

    Proteomic databases

    PRIDEi Q5TAP6.

    Protocols and materials databases

    DNASUi 9724.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000521776 ; ENSP00000428619 ; ENSG00000253797 .
    GeneIDi 9724.
    KEGGi hsa:9724.
    UCSCi uc001vgb.3. human.

    Organism-specific databases

    CTDi 9724.
    GeneCardsi GC13P052599.
    HGNCi HGNC:20321. UTP14C.
    HPAi HPA047217.
    HPA054023.
    MIMi 608969. gene.
    neXtProti NX_Q5TAP6.
    PharmGKBi PA134944828.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000231396.
    HOVERGENi HBG056550.
    InParanoidi Q5TAP6.
    KOi K14567.
    OMAi KANDAMV.
    OrthoDBi EOG7DZ8K1.
    PhylomeDBi Q5TAP6.
    TreeFami TF314531.

    Miscellaneous databases

    GenomeRNAii 9724.
    NextBioi 36581.
    PROi Q5TAP6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5TAP6.
    Genevestigatori Q5TAP6.

    Family and domain databases

    InterProi IPR006709. SSU_processome_Utp14.
    [Graphical view ]
    PANTHERi PTHR14150. PTHR14150. 1 hit.
    Pfami PF04615. Utp14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-85.
      Tissue: Lymph.
    4. "The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b."
      Rohozinski J., Bishop C.E.
      Proc. Natl. Acad. Sci. U.S.A. 101:11695-11700(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUT14C_HUMAN
    AccessioniPrimary (citable) accession number: Q5TAP6
    Secondary accession number(s): Q5FWG3, Q92555
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by an autosomal retrotransposed copy of the X-linked gene UTP14A. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3