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Protein

U3 small nucleolar RNA-associated protein 14 homolog C

Gene

UTP14C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. maturation of SSU-rRNA Source: GO_Central
  3. meiotic cell cycle Source: UniProtKB-KW
  4. multicellular organismal development Source: UniProtKB-KW
  5. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Meiosis, Ribosome biogenesis, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 14 homolog C
Gene namesi
Name:UTP14C
Synonyms:KIAA0266
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:20321. UTP14C.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: GO_Central
  2. small-subunit processome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 766766U3 small nucleolar RNA-associated protein 14 homolog CPRO_0000065736Add
BLAST

Proteomic databases

MaxQBiQ5TAP6.
PRIDEiQ5TAP6.

PTM databases

PhosphoSiteiQ5TAP6.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiQ5TAP6.
ExpressionAtlasiQ5TAP6. baseline and differential.
GenevestigatoriQ5TAP6.

Organism-specific databases

HPAiHPA047217.
HPA054023.

Interactioni

Protein-protein interaction databases

BioGridi115073. 10 interactions.
STRINGi9606.ENSP00000367361.

Structurei

3D structure databases

ProteinModelPortaliQ5TAP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili216 – 24530Sequence AnalysisAdd
BLAST
Coiled coili316 – 34631Sequence AnalysisAdd
BLAST
Coiled coili452 – 47019Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the UTP14 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000008142.
HOGENOMiHOG000231396.
HOVERGENiHBG056550.
InParanoidiQ5TAP6.
KOiK14567.
OMAiASKETYE.
OrthoDBiEOG7DZ8K1.
PhylomeDBiQ5TAP6.
TreeFamiTF314531.

Family and domain databases

InterProiIPR006709. SSU_processome_Utp14.
[Graphical view]
PANTHERiPTHR14150. PTHR14150. 1 hit.
PfamiPF04615. Utp14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TAP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVNQVAENL ALSHQEELVD LPKNYPLSEN EDEGDSDGER KHQKLLEAII
60 70 80 90 100
SLDGKNRRKL AERSEASLKV SEFSVSSEGS GEKLGLADLL EPVKTSSSLA
110 120 130 140 150
TVKKQLNRVK SKKVVELPLN KEKIEQIHRE VAFSKTSQVL SKWDPIILKN
160 170 180 190 200
QQAEQLVFPL GKEQPAIAPI EHALSGWKAR TPLEQEIFNL LHKNKQPVTD
210 220 230 240 250
PLLTPMEKAS LQAMSLEEAK MHRAELQRAR ALQSYYEAKA RKEKKIKSKK
260 270 280 290 300
YHKVVKKGKA KKALKEFEQL QKVNPTVALE EMEKIENARM MERMSLKHQN
310 320 330 340 350
SGKWAKSKAI MAKYDLEARQ AMQEQLAKNK ELTQKLQVAS ESEEEEGGTE
360 370 380 390 400
VEELLVPHVA NEVQMNVDGP NPWMFRSCTS DTKEAATQED PEQVPELAAH
410 420 430 440 450
EVSASEAEER PVAEEEILLR EFEERQSLRK RSELNQDAEP ASSQETKDSS
460 470 480 490 500
SQEVLSELRA LSQKLKEKHQ SRKQKASSEG TVPQVQREEP APEEAEPLLL
510 520 530 540 550
QRSERVQTLE ELEELGKEDC FQNKELPRPV LEGQQSERTP NNRPDAPKEK
560 570 580 590 600
KEKEQLINLQ NFLTTQSPSV RSLAVPTIIE ELEDEEERDQ RQMIKEAFAG
610 620 630 640 650
DDVIRDFLKE KREAVEASKP KDVDLTLPGW GEWGGVGLKP SAKKRRQFLI
660 670 680 690 700
KAPEGPPRKD KNLPNVIISE KRNIHAAAHQ VQVLPYPFTH HRQFERTIQT
710 720 730 740 750
PIGSTWNTQR AFQKLTTPKV VTKPGHIIKP IKAEDVGYQS SSRSDLPVIQ
760
RNPKRITTRH NKEEKL
Length:766
Mass (Da):87,188
Last modified:December 21, 2004 - v1
Checksum:i4C90F0754A042986
GO

Sequence cautioni

The sequence BAA13396.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851G → V.1 Publication
Corresponds to variant rs3742289 [ dbSNP | Ensembl ].
VAR_022812
Natural varianti101 – 1011T → A.
Corresponds to variant rs3742290 [ dbSNP | Ensembl ].
VAR_022813
Natural varianti319 – 3191R → H.
Corresponds to variant rs17402034 [ dbSNP | Ensembl ].
VAR_051482

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87455 mRNA. Translation: BAA13396.2. Different initiation.
AL139082 Genomic DNA. Translation: CAI12891.1.
BC089407 mRNA. Translation: AAH89407.1.
CCDSiCCDS31978.1.
RefSeqiNP_067677.4. NM_021645.5.
UniGeneiHs.512963.

Genome annotation databases

EnsembliENST00000521776; ENSP00000428619; ENSG00000253797.
GeneIDi9724.
KEGGihsa:9724.
UCSCiuc001vgb.3. human.

Polymorphism databases

DMDMi68566167.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87455 mRNA. Translation: BAA13396.2. Different initiation.
AL139082 Genomic DNA. Translation: CAI12891.1.
BC089407 mRNA. Translation: AAH89407.1.
CCDSiCCDS31978.1.
RefSeqiNP_067677.4. NM_021645.5.
UniGeneiHs.512963.

3D structure databases

ProteinModelPortaliQ5TAP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115073. 10 interactions.
STRINGi9606.ENSP00000367361.

PTM databases

PhosphoSiteiQ5TAP6.

Polymorphism databases

DMDMi68566167.

Proteomic databases

MaxQBiQ5TAP6.
PRIDEiQ5TAP6.

Protocols and materials databases

DNASUi9724.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000521776; ENSP00000428619; ENSG00000253797.
GeneIDi9724.
KEGGihsa:9724.
UCSCiuc001vgb.3. human.

Organism-specific databases

CTDi9724.
GeneCardsiGC13P052599.
HGNCiHGNC:20321. UTP14C.
HPAiHPA047217.
HPA054023.
MIMi608969. gene.
neXtProtiNX_Q5TAP6.
PharmGKBiPA134944828.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000008142.
HOGENOMiHOG000231396.
HOVERGENiHBG056550.
InParanoidiQ5TAP6.
KOiK14567.
OMAiASKETYE.
OrthoDBiEOG7DZ8K1.
PhylomeDBiQ5TAP6.
TreeFamiTF314531.

Miscellaneous databases

GenomeRNAii9724.
NextBioi36581.
PROiQ5TAP6.
SOURCEiSearch...

Gene expression databases

BgeeiQ5TAP6.
ExpressionAtlasiQ5TAP6. baseline and differential.
GenevestigatoriQ5TAP6.

Family and domain databases

InterProiIPR006709. SSU_processome_Utp14.
[Graphical view]
PANTHERiPTHR14150. PTHR14150. 1 hit.
PfamiPF04615. Utp14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-85.
    Tissue: Lymph.
  4. "The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b."
    Rohozinski J., Bishop C.E.
    Proc. Natl. Acad. Sci. U.S.A. 101:11695-11700(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUT14C_HUMAN
AccessioniPrimary (citable) accession number: Q5TAP6
Secondary accession number(s): Q5FWG3, Q92555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: March 4, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by an autosomal retrotransposed copy of the X-linked gene UTP14A. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.