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Q5TAP6 (UT14C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U3 small nucleolar RNA-associated protein 14 homolog C
Gene names
Name:UTP14C
Synonyms:KIAA0266
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length766 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis By similarity. Ref.4

Subcellular location

Nucleusnucleolus By similarity.

Tissue specificity

Expressed in testis. Ref.4

Miscellaneous

Encoded by an autosomal retrotransposed copy of the X-linked gene UTP14A. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.

Sequence similarities

Belongs to the UTP14 family.

Sequence caution

The sequence BAA13396.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 766766U3 small nucleolar RNA-associated protein 14 homolog C
PRO_0000065736

Regions

Coiled coil216 – 24530 Potential
Coiled coil316 – 34631 Potential
Coiled coil452 – 47019 Potential

Amino acid modifications

Modified residue281Phosphoserine By similarity
Modified residue511Phosphoserine By similarity
Modified residue761Phosphoserine By similarity
Modified residue2041Phosphothreonine By similarity
Modified residue4031Phosphoserine By similarity
Modified residue4051Phosphoserine By similarity
Modified residue4431Phosphoserine By similarity
Modified residue4511Phosphoserine By similarity
Modified residue5671Phosphoserine By similarity

Natural variations

Natural variant851G → V. Ref.3
Corresponds to variant rs3742289 [ dbSNP | Ensembl ].
VAR_022812
Natural variant1011T → A.
Corresponds to variant rs3742290 [ dbSNP | Ensembl ].
VAR_022813
Natural variant3191R → H.
Corresponds to variant rs17402034 [ dbSNP | Ensembl ].
VAR_051482

Sequences

Sequence LengthMass (Da)Tools
Q5TAP6 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 4C90F0754A042986

FASTA76687,188
        10         20         30         40         50         60 
MNVNQVAENL ALSHQEELVD LPKNYPLSEN EDEGDSDGER KHQKLLEAII SLDGKNRRKL 

        70         80         90        100        110        120 
AERSEASLKV SEFSVSSEGS GEKLGLADLL EPVKTSSSLA TVKKQLNRVK SKKVVELPLN 

       130        140        150        160        170        180 
KEKIEQIHRE VAFSKTSQVL SKWDPIILKN QQAEQLVFPL GKEQPAIAPI EHALSGWKAR 

       190        200        210        220        230        240 
TPLEQEIFNL LHKNKQPVTD PLLTPMEKAS LQAMSLEEAK MHRAELQRAR ALQSYYEAKA 

       250        260        270        280        290        300 
RKEKKIKSKK YHKVVKKGKA KKALKEFEQL QKVNPTVALE EMEKIENARM MERMSLKHQN 

       310        320        330        340        350        360 
SGKWAKSKAI MAKYDLEARQ AMQEQLAKNK ELTQKLQVAS ESEEEEGGTE VEELLVPHVA 

       370        380        390        400        410        420 
NEVQMNVDGP NPWMFRSCTS DTKEAATQED PEQVPELAAH EVSASEAEER PVAEEEILLR 

       430        440        450        460        470        480 
EFEERQSLRK RSELNQDAEP ASSQETKDSS SQEVLSELRA LSQKLKEKHQ SRKQKASSEG 

       490        500        510        520        530        540 
TVPQVQREEP APEEAEPLLL QRSERVQTLE ELEELGKEDC FQNKELPRPV LEGQQSERTP 

       550        560        570        580        590        600 
NNRPDAPKEK KEKEQLINLQ NFLTTQSPSV RSLAVPTIIE ELEDEEERDQ RQMIKEAFAG 

       610        620        630        640        650        660 
DDVIRDFLKE KREAVEASKP KDVDLTLPGW GEWGGVGLKP SAKKRRQFLI KAPEGPPRKD 

       670        680        690        700        710        720 
KNLPNVIISE KRNIHAAAHQ VQVLPYPFTH HRQFERTIQT PIGSTWNTQR AFQKLTTPKV 

       730        740        750        760 
VTKPGHIIKP IKAEDVGYQS SSRSDLPVIQ RNPKRITTRH NKEEKL 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-85.
Tissue: Lymph.
[4]"The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b."
Rohozinski J., Bishop C.E.
Proc. Natl. Acad. Sci. U.S.A. 101:11695-11700(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
[5]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87455 mRNA. Translation: BAA13396.2. Different initiation.
AL139082 Genomic DNA. Translation: CAI12891.1.
BC089407 mRNA. Translation: AAH89407.1.
RefSeqNP_067677.4. NM_021645.5.
UniGeneHs.512963.

3D structure databases

ProteinModelPortalQ5TAP6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000367361.

PTM databases

PhosphoSiteQ5TAP6.

Polymorphism databases

DMDM68566167.

Proteomic databases

PRIDEQ5TAP6.

Protocols and materials databases

DNASU9724.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000521776; ENSP00000428619; ENSG00000253797.
GeneID9724.
KEGGhsa:9724.
UCSCuc001vgb.3. human.

Organism-specific databases

CTD9724.
GeneCardsGC13P052599.
HGNCHGNC:20321. UTP14C.
HPAHPA047217.
HPA054023.
MIM608969. gene.
neXtProtNX_Q5TAP6.
PharmGKBPA134944828.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000231396.
HOVERGENHBG056550.
InParanoidQ5TAP6.
KOK14567.
OMAFASGSWK.
OrthoDBEOG7DZ8K1.
PhylomeDBQ5TAP6.
TreeFamTF314531.

Gene expression databases

BgeeQ5TAP6.
GenevestigatorQ5TAP6.

Family and domain databases

InterProIPR006709. SSU_processome_Utp14.
[Graphical view]
PANTHERPTHR14150. PTHR14150. 1 hit.
PfamPF04615. Utp14. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9724.
NextBio36581.
PROQ5TAP6.
SOURCESearch...

Entry information

Entry nameUT14C_HUMAN
AccessionPrimary (citable) accession number: Q5TAP6
Secondary accession number(s): Q5FWG3, Q92555
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM