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Protein

U1 small nuclear ribonucleoprotein C

Gene

SNRPC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.UniRule annotation
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoproteinUniRule annotationSAAS annotationImported, RNA-bindingUniRule annotationSAAS annotation, Viral nucleoproteinImported
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein CUniRule annotation
Short name:
U1 snRNP CUniRule annotation
Short name:
U1-CUniRule annotation
Short name:
U1CUniRule annotation
Gene namesi
Name:SNRPCUniRule annotationImported
ORF Names:hCG_16077Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35998.

PTM / Processingi

Proteomic databases

MaxQBiQ5TAL4.

Expressioni

Gene expression databases

BgeeiENSG00000124562.
ExpressionAtlasiQ5TAL4. baseline and differential.

Interactioni

Subunit structurei

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.UniRule annotation

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ5TAL4. 15 interactors.

Structurei

3D structure databases

SMRiQ5TAL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 36Matrin-typeInterPro annotationAdd BLAST33

Sequence similaritiesi

Belongs to the U1 small nuclear ribonucleoprotein C family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3454. Eukaryota.
COG5136. LUCA.
HOVERGENiHBG017763.
KOiK11095.

Family and domain databases

HAMAPiMF_03153. U1_C. 1 hit.
InterProiView protein in InterPro
IPR000690. Matrin/U1-C_Znf_C2H2.
IPR003604. Matrin/U1-like-C_Znf_C2H2.
IPR013085. U1-CZ_Znf_C2H2.
IPR017340. U1_snRNP-C.
IPR013087. Znf_C2H2_type.
PANTHERiPTHR31148. PTHR31148. 1 hit.
PfamiView protein in Pfam
PF06220. zf-U1. 1 hit.
PIRSFiPIRSF037969. U1_snRNP-C. 1 hit.
SMARTiView protein in SMART
SM00451. ZnF_U1. 1 hit.
SUPFAMiSSF57667. SSF57667. 1 hit.
PROSITEiView protein in PROSITE
PS50171. ZF_MATRIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TAL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI
60 70 80 90 100
DKTTAAFQQG KIPPTPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP
110 120 130 140 150
PMMPMMGPPP PGMMPVGPAP GMRPPMGGHM PMMPGPPMMR PPARPMMVPT

RPGMTRPDR
Length:159
Mass (Da):17,394
Last modified:May 10, 2005 - v1
Checksum:iEC313A57DEC79D95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121082 mRNA. Translation: AAI21083.1.
BC121083 mRNA. Translation: AAI21084.1.
AK311955 mRNA. Translation: BAG34895.1.
CH471081 Genomic DNA. Translation: EAX03797.1.
RefSeqiNP_003084.1. NM_003093.2.
UniGeneiHs.1063.

Genome annotation databases

GeneIDi6631.
KEGGihsa:6631.
UCSCiuc003ojt.3. human.

Similar proteinsi

Entry informationi

Entry nameiQ5TAL4_HUMAN
AccessioniPrimary (citable) accession number: Q5TAL4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: August 30, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.