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Protein

U1 small nuclear ribonucleoprotein C

Gene

SNRPC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.UniRule annotation
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 3633Matrin-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

RibonucleoproteinUniRule annotationSAAS annotationImported

Keywords - Ligandi

Metal-binding, RNA-bindingUniRule annotationSAAS annotation, Viral nucleoproteinImported, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein CUniRule annotation
Short name:
U1 snRNP CUniRule annotation
Short name:
U1-CUniRule annotation
Short name:
U1CUniRule annotation
Gene namesi
Name:SNRPCUniRule annotationImported
ORF Names:hCG_16077Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35998.

PTM / Processingi

Proteomic databases

MaxQBiQ5TAL4.

Expressioni

Gene expression databases

BgeeiENSG00000124562.

Interactioni

Subunit structurei

Component of the U1 snRNP particle, a subcomplex of the spliceosome. U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G common to all spliceosomal snRNPs, and at least 3 particle-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000244520.

Structurei

3D structure databases

SMRiQ5TAL4. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 3633Matrin-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the U1 small nuclear ribonucleoprotein C family.UniRule annotationSAAS annotation
Contains 1 matrin-type zinc finger.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 3633Matrin-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3454. Eukaryota.
COG5136. LUCA.
HOVERGENiHBG017763.
KOiK11095.

Family and domain databases

HAMAPiMF_03153. U1_C. 1 hit.
InterProiIPR017340. U1_snRNP-C.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PANTHERiPTHR31148. PTHR31148. 1 hit.
PfamiPF06220. zf-U1. 1 hit.
[Graphical view]
PIRSFiPIRSF037969. U1_snRNP-C. 1 hit.
SMARTiSM00451. ZnF_U1. 1 hit.
[Graphical view]
PROSITEiPS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TAL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI
60 70 80 90 100
DKTTAAFQQG KIPPTPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP
110 120 130 140 150
PMMPMMGPPP PGMMPVGPAP GMRPPMGGHM PMMPGPPMMR PPARPMMVPT

RPGMTRPDR
Length:159
Mass (Da):17,394
Last modified:May 10, 2005 - v1
Checksum:iEC313A57DEC79D95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121082 mRNA. Translation: AAI21083.1.
BC121083 mRNA. Translation: AAI21084.1.
AK311955 mRNA. Translation: BAG34895.1.
CH471081 Genomic DNA. Translation: EAX03797.1.
RefSeqiNP_003084.1. NM_003093.2.
UniGeneiHs.1063.

Genome annotation databases

GeneIDi6631.
KEGGihsa:6631.
UCSCiuc003ojt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC121082 mRNA. Translation: AAI21083.1.
BC121083 mRNA. Translation: AAI21084.1.
AK311955 mRNA. Translation: BAG34895.1.
CH471081 Genomic DNA. Translation: EAX03797.1.
RefSeqiNP_003084.1. NM_003093.2.
UniGeneiHs.1063.

3D structure databases

SMRiQ5TAL4. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000244520.

Proteomic databases

MaxQBiQ5TAL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6631.
KEGGihsa:6631.
UCSCiuc003ojt.3. human.

Organism-specific databases

CTDi6631.
PharmGKBiPA35998.

Phylogenomic databases

eggNOGiKOG3454. Eukaryota.
COG5136. LUCA.
HOVERGENiHBG017763.
KOiK11095.

Miscellaneous databases

GenomeRNAii6631.

Gene expression databases

BgeeiENSG00000124562.

Family and domain databases

HAMAPiMF_03153. U1_C. 1 hit.
InterProiIPR017340. U1_snRNP-C.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PANTHERiPTHR31148. PTHR31148. 1 hit.
PfamiPF06220. zf-U1. 1 hit.
[Graphical view]
PIRSFiPIRSF037969. U1_snRNP-C. 1 hit.
SMARTiSM00451. ZnF_U1. 1 hit.
[Graphical view]
PROSITEiPS50171. ZF_MATRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5TAL4_HUMAN
AccessioniPrimary (citable) accession number: Q5TAL4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.