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Protein

Sodium/hydrogen exchanger 11

Gene

SLC9C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in pH regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi867 – 999133cNMPAdd
BLAST

GO - Molecular functioni

  1. solute:proton antiporter activity Source: InterPro

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Protein family/group databases

TCDBi2.A.36.7.4. the monovalent cation:proton antiporter-1 (cpa1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 11
Alternative name(s):
Na(+)/H(+) exchanger 11
Short name:
NHE-11
Solute carrier family 9 member 11
Solute carrier family 9 member C2
Gene namesi
Name:SLC9C2
Synonyms:SLC9A11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28664. SLC9C2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei254 – 27421HelicalSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence AnalysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Transmembranei612 – 63221HelicalSequence AnalysisAdd
BLAST
Transmembranei641 – 66121HelicalSequence AnalysisAdd
BLAST
Transmembranei674 – 69421HelicalSequence AnalysisAdd
BLAST
Transmembranei706 – 72621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134865165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11241124Sodium/hydrogen exchanger 11PRO_0000295706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5TAH2.
PRIDEiQ5TAH2.

PTM databases

PhosphoSiteiQ5TAH2.

Expressioni

Gene expression databases

BgeeiQ5TAH2.
CleanExiHS_SLC9A11.
ExpressionAtlasiQ5TAH2. baseline.
GenevestigatoriQ5TAH2.

Organism-specific databases

HPAiHPA059122.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356687.

Structurei

3D structure databases

ProteinModelPortaliQ5TAH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni642 – 72382Ion transport-likeBy similarityAdd
BLAST

Domaini

Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.By similarity

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG126655.
GeneTreeiENSGT00530000063840.
HOGENOMiHOG000154241.
HOVERGENiHBG102046.
InParanoidiQ5TAH2.
KOiK14726.
OMAiWPSLEYK.
OrthoDBiEOG7N37BW.
PhylomeDBiQ5TAH2.
TreeFamiTF328865.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR027359. Channel_four-helix_dom.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TAH2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYFWAQNE SNRPDLLCGQ PADYLVEEKH FTTLVCFIVV LGGLLKMCLK
60 70 80 90 100
NCEVIVLTIL SLSGFVIGHM AYNSVEVHQI VYPLLRTSSF SLYSYFSPLI
110 120 130 140 150
IFMVALDVEF YTLKKMFWQV LLTGLISFST ASIIIGYVVI KFNKDSWDLQ
160 170 180 190 200
SCLLFSITLG IIDPLRSVNS LKTIGISKIY IDLIRGESLI ICSIASIFFG
210 220 230 240 250
NFRGNRIHFS IFRDLHVGIE LSYDILGSII FGYWCAKIIQ CILADVFSNM
260 270 280 290 300
LTNIILCFSM VYMTFYIVEF LGMSGTLALA AVGLNLDSLT FKPKIELVIT
310 320 330 340 350
KFLRIFSSVY EHLIYAFFGI VIGCGELSHY EFHTIPFIFI LFTTVNLVRL
360 370 380 390 400
LTILLVSPIL MHSNYEYNWR WGVVITWSGI KGVFNLLWAP DVYNLAERKV
410 420 430 440 450
EVPQMFILYV QVISLLTMGI NSYVMTQSAR KLDLCVLSLP RQMILQNATQ
460 470 480 490 500
HIQEIVQNTI TLFKTEKILT NVNWTLVEDK TRIEYIPFSH VSHNDMKTES
510 520 530 540 550
TTDEALMEEA RLHVAAIQMS SFEKQRNNGI LEIEAARILI GAAKCYYSIQ
560 570 580 590 600
GKFMSIYDVS TYMRTRSWLI KFKNVLTFLE YCIEKIHFIP PESNTFLTFI
610 620 630 640 650
FHIVFSEEFE YTGQIINLIY IYPMIIHLWP MARGLNVSAL ISINYYFMFL
660 670 680 690 700
YVLESTLKII ILKRKYFQQC WNTLEFFILV IGIIDIFCVY FVKLRPDNLA
710 720 730 740 750
LIQLTVIMGY LRIIRFLPLF KIIVPILIRI ADVQIKKRLS LMYSITKGYI
760 770 780 790 800
KSQEDAKLLI KQIAVCESIY QKLCEILETN KQDAVKELVL MEHEGRDVVI
810 820 830 840 850
ALKTKQAIRN VIAKALKNLT FLCSRGIIDK HEVIEINKVL LKKLKALNNF
860 870 880 890 900
PKAIPPPTPD IYLHNIIWLE GKDVLIDFFK ERAKLACFDS GDTICKGGEM
910 920 930 940 950
PQGIYLIISG MAILHSLSPT FGIESNQRCD RGSRDMFTEF CTTGDIIGEL
960 970 980 990 1000
SCLLKREIEY TVICETSLQA CFISLEDLYE GFDAFWPSLE YKIWLKLALS
1010 1020 1030 1040 1050
TAYQYFESSL IDEDLRFQNC VMFNQAYVET LSSYSDMIID NMTMKFVIIV
1060 1070 1080 1090 1100
YGSVIDTKTE EPYFAPCIIP TTCEQVQGTS DLSKLLIIQA SELTQRNSNT
1110 1120
NVMASVNTVF EQPGKNINGR QKMS
Length:1,124
Mass (Da):129,053
Last modified:December 21, 2004 - v1
Checksum:i5D1E20BB33AEDD65
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti481 – 4811T → M.
Corresponds to variant rs7551131 [ dbSNP | Ensembl ].
VAR_033331
Natural varianti505 – 5051A → G.
Corresponds to variant rs16846206 [ dbSNP | Ensembl ].
VAR_033332
Natural varianti934 – 9341R → S.1 Publication
Corresponds to variant rs17854214 [ dbSNP | Ensembl ].
VAR_033333

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139142 Genomic DNA. Translation: CAI20938.1.
BC042592 mRNA. Translation: AAH42592.1.
CCDSiCCDS1308.1.
RefSeqiNP_848622.2. NM_178527.3.
UniGeneiHs.494981.

Genome annotation databases

EnsembliENST00000367714; ENSP00000356687; ENSG00000162753.
GeneIDi284525.
KEGGihsa:284525.
UCSCiuc001giz.2. human.

Polymorphism databases

DMDMi74745831.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139142 Genomic DNA. Translation: CAI20938.1.
BC042592 mRNA. Translation: AAH42592.1.
CCDSiCCDS1308.1.
RefSeqiNP_848622.2. NM_178527.3.
UniGeneiHs.494981.

3D structure databases

ProteinModelPortaliQ5TAH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356687.

Protein family/group databases

TCDBi2.A.36.7.4. the monovalent cation:proton antiporter-1 (cpa1) family.

PTM databases

PhosphoSiteiQ5TAH2.

Polymorphism databases

DMDMi74745831.

Proteomic databases

PaxDbiQ5TAH2.
PRIDEiQ5TAH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367714; ENSP00000356687; ENSG00000162753.
GeneIDi284525.
KEGGihsa:284525.
UCSCiuc001giz.2. human.

Organism-specific databases

CTDi284525.
GeneCardsiGC01M173470.
HGNCiHGNC:28664. SLC9C2.
HPAiHPA059122.
neXtProtiNX_Q5TAH2.
PharmGKBiPA134865165.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG126655.
GeneTreeiENSGT00530000063840.
HOGENOMiHOG000154241.
HOVERGENiHBG102046.
InParanoidiQ5TAH2.
KOiK14726.
OMAiWPSLEYK.
OrthoDBiEOG7N37BW.
PhylomeDBiQ5TAH2.
TreeFamiTF328865.

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Miscellaneous databases

GeneWikiiSLC9A11.
GenomeRNAii284525.
NextBioi94941.
PROiQ5TAH2.

Gene expression databases

BgeeiQ5TAH2.
CleanExiHS_SLC9A11.
ExpressionAtlasiQ5TAH2. baseline.
GenevestigatoriQ5TAH2.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR027359. Channel_four-helix_dom.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00027. cNMP_binding. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-934.
    Tissue: Testis.

Entry informationi

Entry nameiSL9C2_HUMAN
AccessioniPrimary (citable) accession number: Q5TAH2
Secondary accession number(s): Q86UF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 21, 2004
Last modified: January 7, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.