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Q5TAH2 (SL9C2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/hydrogen exchanger 11
Alternative name(s):
Na(+)/H(+) exchanger 11
Short name=NHE-11
Solute carrier family 9 member 11
Solute carrier family 9 member C2
Gene names
Name:SLC9C2
Synonyms:SLC9A11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1124 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in pH regulation By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels By similarity.

Sequence similarities

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]

Contains 1 cyclic nucleotide-binding domain.

Ontologies

Keywords
   Biological processAntiport
Ion transport
Sodium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsodium ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsolute:hydrogen antiporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11241124Sodium/hydrogen exchanger 11
PRO_0000295706

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane254 – 27421Helical; Potential
Transmembrane305 – 32521Helical; Potential
Transmembrane335 – 35521Helical; Potential
Transmembrane372 – 39221Helical; Potential
Transmembrane405 – 42521Helical; Potential
Transmembrane612 – 63221Helical; Potential
Transmembrane641 – 66121Helical; Potential
Transmembrane674 – 69421Helical; Potential
Transmembrane706 – 72621Helical; Potential
Nucleotide binding867 – 999133cNMP
Region642 – 72382Ion transport-like By similarity

Amino acid modifications

Glycosylation4471N-linked (GlcNAc...) Potential
Glycosylation4731N-linked (GlcNAc...) Potential

Natural variations

Natural variant4811T → M.
Corresponds to variant rs7551131 [ dbSNP | Ensembl ].
VAR_033331
Natural variant5051A → G.
Corresponds to variant rs16846206 [ dbSNP | Ensembl ].
VAR_033332
Natural variant9341R → S. Ref.2
Corresponds to variant rs17854214 [ dbSNP | Ensembl ].
VAR_033333

Sequences

Sequence LengthMass (Da)Tools
Q5TAH2 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 5D1E20BB33AEDD65

FASTA1,124129,053
        10         20         30         40         50         60 
MSSYFWAQNE SNRPDLLCGQ PADYLVEEKH FTTLVCFIVV LGGLLKMCLK NCEVIVLTIL 

        70         80         90        100        110        120 
SLSGFVIGHM AYNSVEVHQI VYPLLRTSSF SLYSYFSPLI IFMVALDVEF YTLKKMFWQV 

       130        140        150        160        170        180 
LLTGLISFST ASIIIGYVVI KFNKDSWDLQ SCLLFSITLG IIDPLRSVNS LKTIGISKIY 

       190        200        210        220        230        240 
IDLIRGESLI ICSIASIFFG NFRGNRIHFS IFRDLHVGIE LSYDILGSII FGYWCAKIIQ 

       250        260        270        280        290        300 
CILADVFSNM LTNIILCFSM VYMTFYIVEF LGMSGTLALA AVGLNLDSLT FKPKIELVIT 

       310        320        330        340        350        360 
KFLRIFSSVY EHLIYAFFGI VIGCGELSHY EFHTIPFIFI LFTTVNLVRL LTILLVSPIL 

       370        380        390        400        410        420 
MHSNYEYNWR WGVVITWSGI KGVFNLLWAP DVYNLAERKV EVPQMFILYV QVISLLTMGI 

       430        440        450        460        470        480 
NSYVMTQSAR KLDLCVLSLP RQMILQNATQ HIQEIVQNTI TLFKTEKILT NVNWTLVEDK 

       490        500        510        520        530        540 
TRIEYIPFSH VSHNDMKTES TTDEALMEEA RLHVAAIQMS SFEKQRNNGI LEIEAARILI 

       550        560        570        580        590        600 
GAAKCYYSIQ GKFMSIYDVS TYMRTRSWLI KFKNVLTFLE YCIEKIHFIP PESNTFLTFI 

       610        620        630        640        650        660 
FHIVFSEEFE YTGQIINLIY IYPMIIHLWP MARGLNVSAL ISINYYFMFL YVLESTLKII 

       670        680        690        700        710        720 
ILKRKYFQQC WNTLEFFILV IGIIDIFCVY FVKLRPDNLA LIQLTVIMGY LRIIRFLPLF 

       730        740        750        760        770        780 
KIIVPILIRI ADVQIKKRLS LMYSITKGYI KSQEDAKLLI KQIAVCESIY QKLCEILETN 

       790        800        810        820        830        840 
KQDAVKELVL MEHEGRDVVI ALKTKQAIRN VIAKALKNLT FLCSRGIIDK HEVIEINKVL 

       850        860        870        880        890        900 
LKKLKALNNF PKAIPPPTPD IYLHNIIWLE GKDVLIDFFK ERAKLACFDS GDTICKGGEM 

       910        920        930        940        950        960 
PQGIYLIISG MAILHSLSPT FGIESNQRCD RGSRDMFTEF CTTGDIIGEL SCLLKREIEY 

       970        980        990       1000       1010       1020 
TVICETSLQA CFISLEDLYE GFDAFWPSLE YKIWLKLALS TAYQYFESSL IDEDLRFQNC 

      1030       1040       1050       1060       1070       1080 
VMFNQAYVET LSSYSDMIID NMTMKFVIIV YGSVIDTKTE EPYFAPCIIP TTCEQVQGTS 

      1090       1100       1110       1120 
DLSKLLIIQA SELTQRNSNT NVMASVNTVF EQPGKNINGR QKMS 

« Hide

References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-934.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL139142 Genomic DNA. Translation: CAI20938.1.
BC042592 mRNA. Translation: AAH42592.1.
RefSeqNP_848622.2. NM_178527.3.
UniGeneHs.494981.

3D structure databases

ProteinModelPortalQ5TAH2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000356687.

Protein family/group databases

TCDB2.A.36.7.4. the monovalent cation:proton antiporter-1 (cpa1) family.

PTM databases

PhosphoSiteQ5TAH2.

Polymorphism databases

DMDM74745831.

Proteomic databases

PaxDbQ5TAH2.
PRIDEQ5TAH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367714; ENSP00000356687; ENSG00000162753.
GeneID284525.
KEGGhsa:284525.
UCSCuc001giz.2. human.

Organism-specific databases

CTD284525.
GeneCardsGC01M173470.
HGNCHGNC:28664. SLC9C2.
HPAHPA059122.
neXtProtNX_Q5TAH2.
PharmGKBPA134865165.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG126655.
HOGENOMHOG000154241.
HOVERGENHBG102046.
InParanoidQ5TAH2.
KOK14726.
OMAWPSLEYK.
OrthoDBEOG7N37BW.
PhylomeDBQ5TAH2.
TreeFamTF328865.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ5TAH2.
CleanExHS_SLC9A11.
GenevestigatorQ5TAH2.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
2.60.120.10. 1 hit.
InterProIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR027359. Channel_four-helix_dom.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PANTHERPTHR10110. PTHR10110. 1 hit.
PfamPF00027. cNMP_binding. 1 hit.
PF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC9A11.
GenomeRNAi284525.
NextBio94941.
PROQ5TAH2.

Entry information

Entry nameSL9C2_HUMAN
AccessionPrimary (citable) accession number: Q5TAH2
Secondary accession number(s): Q86UF3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM