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Q5TAH2

- SL9C2_HUMAN

UniProt

Q5TAH2 - SL9C2_HUMAN

Protein

Sodium/hydrogen exchanger 11

Gene

SLC9C2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Involved in pH regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi867 – 999133cNMPAdd
    BLAST

    GO - Molecular functioni

    1. solute:proton antiporter activity Source: InterPro

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_160189. Stimuli-sensing channels.

    Protein family/group databases

    TCDBi2.A.36.7.4. the monovalent cation:proton antiporter-1 (cpa1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/hydrogen exchanger 11
    Alternative name(s):
    Na(+)/H(+) exchanger 11
    Short name:
    NHE-11
    Solute carrier family 9 member 11
    Solute carrier family 9 member C2
    Gene namesi
    Name:SLC9C2
    Synonyms:SLC9A11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28664. SLC9C2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134865165.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11241124Sodium/hydrogen exchanger 11PRO_0000295706Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5TAH2.
    PRIDEiQ5TAH2.

    PTM databases

    PhosphoSiteiQ5TAH2.

    Expressioni

    Gene expression databases

    BgeeiQ5TAH2.
    CleanExiHS_SLC9A11.
    GenevestigatoriQ5TAH2.

    Organism-specific databases

    HPAiHPA059122.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356687.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TAH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei612 – 63221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei641 – 66121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei674 – 69421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei706 – 72621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni642 – 72382Ion transport-likeBy similarityAdd
    BLAST

    Domaini

    Contains an ion transport-like region is related to the membrane segments of voltage-gated ion channels.By similarity

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG126655.
    HOGENOMiHOG000154241.
    HOVERGENiHBG102046.
    InParanoidiQ5TAH2.
    KOiK14726.
    OMAiWPSLEYK.
    OrthoDBiEOG7N37BW.
    PhylomeDBiQ5TAH2.
    TreeFamiTF328865.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR027359. Channel_four-helix_dom.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PANTHERiPTHR10110. PTHR10110. 1 hit.
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5TAH2-1 [UniParc]FASTAAdd to Basket

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    MSSYFWAQNE SNRPDLLCGQ PADYLVEEKH FTTLVCFIVV LGGLLKMCLK     50
    NCEVIVLTIL SLSGFVIGHM AYNSVEVHQI VYPLLRTSSF SLYSYFSPLI 100
    IFMVALDVEF YTLKKMFWQV LLTGLISFST ASIIIGYVVI KFNKDSWDLQ 150
    SCLLFSITLG IIDPLRSVNS LKTIGISKIY IDLIRGESLI ICSIASIFFG 200
    NFRGNRIHFS IFRDLHVGIE LSYDILGSII FGYWCAKIIQ CILADVFSNM 250
    LTNIILCFSM VYMTFYIVEF LGMSGTLALA AVGLNLDSLT FKPKIELVIT 300
    KFLRIFSSVY EHLIYAFFGI VIGCGELSHY EFHTIPFIFI LFTTVNLVRL 350
    LTILLVSPIL MHSNYEYNWR WGVVITWSGI KGVFNLLWAP DVYNLAERKV 400
    EVPQMFILYV QVISLLTMGI NSYVMTQSAR KLDLCVLSLP RQMILQNATQ 450
    HIQEIVQNTI TLFKTEKILT NVNWTLVEDK TRIEYIPFSH VSHNDMKTES 500
    TTDEALMEEA RLHVAAIQMS SFEKQRNNGI LEIEAARILI GAAKCYYSIQ 550
    GKFMSIYDVS TYMRTRSWLI KFKNVLTFLE YCIEKIHFIP PESNTFLTFI 600
    FHIVFSEEFE YTGQIINLIY IYPMIIHLWP MARGLNVSAL ISINYYFMFL 650
    YVLESTLKII ILKRKYFQQC WNTLEFFILV IGIIDIFCVY FVKLRPDNLA 700
    LIQLTVIMGY LRIIRFLPLF KIIVPILIRI ADVQIKKRLS LMYSITKGYI 750
    KSQEDAKLLI KQIAVCESIY QKLCEILETN KQDAVKELVL MEHEGRDVVI 800
    ALKTKQAIRN VIAKALKNLT FLCSRGIIDK HEVIEINKVL LKKLKALNNF 850
    PKAIPPPTPD IYLHNIIWLE GKDVLIDFFK ERAKLACFDS GDTICKGGEM 900
    PQGIYLIISG MAILHSLSPT FGIESNQRCD RGSRDMFTEF CTTGDIIGEL 950
    SCLLKREIEY TVICETSLQA CFISLEDLYE GFDAFWPSLE YKIWLKLALS 1000
    TAYQYFESSL IDEDLRFQNC VMFNQAYVET LSSYSDMIID NMTMKFVIIV 1050
    YGSVIDTKTE EPYFAPCIIP TTCEQVQGTS DLSKLLIIQA SELTQRNSNT 1100
    NVMASVNTVF EQPGKNINGR QKMS 1124
    Length:1,124
    Mass (Da):129,053
    Last modified:December 21, 2004 - v1
    Checksum:i5D1E20BB33AEDD65
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti481 – 4811T → M.
    Corresponds to variant rs7551131 [ dbSNP | Ensembl ].
    VAR_033331
    Natural varianti505 – 5051A → G.
    Corresponds to variant rs16846206 [ dbSNP | Ensembl ].
    VAR_033332
    Natural varianti934 – 9341R → S.1 Publication
    Corresponds to variant rs17854214 [ dbSNP | Ensembl ].
    VAR_033333

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL139142 Genomic DNA. Translation: CAI20938.1.
    BC042592 mRNA. Translation: AAH42592.1.
    CCDSiCCDS1308.1.
    RefSeqiNP_848622.2. NM_178527.3.
    UniGeneiHs.494981.

    Genome annotation databases

    EnsembliENST00000367714; ENSP00000356687; ENSG00000162753.
    GeneIDi284525.
    KEGGihsa:284525.
    UCSCiuc001giz.2. human.

    Polymorphism databases

    DMDMi74745831.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL139142 Genomic DNA. Translation: CAI20938.1 .
    BC042592 mRNA. Translation: AAH42592.1 .
    CCDSi CCDS1308.1.
    RefSeqi NP_848622.2. NM_178527.3.
    UniGenei Hs.494981.

    3D structure databases

    ProteinModelPortali Q5TAH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000356687.

    Protein family/group databases

    TCDBi 2.A.36.7.4. the monovalent cation:proton antiporter-1 (cpa1) family.

    PTM databases

    PhosphoSitei Q5TAH2.

    Polymorphism databases

    DMDMi 74745831.

    Proteomic databases

    PaxDbi Q5TAH2.
    PRIDEi Q5TAH2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367714 ; ENSP00000356687 ; ENSG00000162753 .
    GeneIDi 284525.
    KEGGi hsa:284525.
    UCSCi uc001giz.2. human.

    Organism-specific databases

    CTDi 284525.
    GeneCardsi GC01M173470.
    HGNCi HGNC:28664. SLC9C2.
    HPAi HPA059122.
    neXtProti NX_Q5TAH2.
    PharmGKBi PA134865165.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG126655.
    HOGENOMi HOG000154241.
    HOVERGENi HBG102046.
    InParanoidi Q5TAH2.
    KOi K14726.
    OMAi WPSLEYK.
    OrthoDBi EOG7N37BW.
    PhylomeDBi Q5TAH2.
    TreeFami TF328865.

    Enzyme and pathway databases

    Reactomei REACT_160189. Stimuli-sensing channels.

    Miscellaneous databases

    GeneWikii SLC9A11.
    GenomeRNAii 284525.
    NextBioi 94941.
    PROi Q5TAH2.

    Gene expression databases

    Bgeei Q5TAH2.
    CleanExi HS_SLC9A11.
    Genevestigatori Q5TAH2.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR027359. Channel_four-helix_dom.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    PANTHERi PTHR10110. PTHR10110. 1 hit.
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-934.
      Tissue: Testis.

    Entry informationi

    Entry nameiSL9C2_HUMAN
    AccessioniPrimary (citable) accession number: Q5TAH2
    Secondary accession number(s): Q86UF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3