Q5TAG4 (NBPFC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuroblastoma breakpoint family member 12

Alternative name(s):
Chromosome 1 amplified sequence 1

Gene names

Name:	NBPF12
Synonyms:	COAS1, KIAA1245

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm Probable.
Tissue specificity	Widely expressed with highest levels in brain, ovary, mammary gland, skin and adipose tissue. Also expressed in testis. Detected in a number of tumors including osteosarcoma, mammary carcinoma and hepatocellular carcinoma. Ref.3 Ref.4
Miscellaneous	Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.
Sequence similarities	Belongs to the NBPF family. Contains 3 NBPF domains.
Sequence caution	The sequence CAI22485.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Neuroblastoma breakpoint family member 12		PRO_0000288047
Regions
	Domain	3 – 77	75	NBPF 1
	Domain	78 – 170	93	NBPF 2
	Domain	171 – 269	99	NBPF 3

Sequences

	Sequence		Length	Mass (Da)
	Q5TAG4 [UniParc]. Last modified May 29, 2007. Version 2. Checksum: D29E595068B199A9	FASTA	269	31,307
	10 20 30 40 50 60 MDEIEKYQEV EEDQDPSCPR LSRELLAEKE PEVLQDSLDR CYSTPSGYLE LPDLGQPYRS 70 80 90 100 110 120 AVYSLEEQYL GLALDVDRIK KDQEEEEDQG PPCPRLSREL LEVVEPEVLQ DSLDRCYSTP 130 140 150 160 170 180 SSCLEQPDSC QPYRSSFYAL EEKHVGFSLD VGEIEKKGKG KKRRGRRSKK KRRRGRKEGE 190 200 210 220 230 240 EDQNPPCPRL NSVLMEVEEP EVLQDSLDRC YSTPSMYFEL PDSFQHYRSV FYSFEEQHIT 250 260 FALDMDNSFF TLTVTSLHLV FQMGVIFPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mei G., Yu W., Gibbs R.A. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 153-269. Tissue: Brain.
[3]	"Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21." Meza-Zepeda L.A., Forus A., Lygren B., Dahlberg A.B., Godager L.H., South A.P., Marenholz I., Lioumi M., Florenes V.A., Maelandsmo G.M., Serra M., Mischke D., Nizetic D., Ragoussis J., Tarkkanen M., Nesland J.M., Knuutila S., Myklebost O. Oncogene 21:2261-2269(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
[4]	"A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution." Vandepoele K., Van Roy N., Staes K., Speleman F., van Roy F. Mol. Biol. Evol. 22:2265-2274(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL139152 Genomic DNA. Translation: CAI22485.1. Different initiation. AF131738 mRNA. Translation: AAD20027.1.
IPI	IPI00942639.
UniGene	Hs.666981. Hs.721588.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000391116.
PTM databases
PhosphoSite	Q5TAG4.
Polymorphism databases
DMDM	152123241.
Proteomic databases
PaxDb	Q5TAG4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000442909; ENSP00000391116; ENSG00000186275.
UCSC	uc001eqg.3. human.
Organism-specific databases
GeneCards	GC01P146376.
HGNC	HGNC:24297. NBPF12.
MIM	608607. gene.
neXtProt	NX_Q5TAG4.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG116165.
HOVERGEN	HBG058300.
OrthoDB	EOG4F4SBH.
Gene expression databases
ArrayExpress	Q5TAG4.
Bgee	Q5TAG4.
CleanEx	HS_NBPF12.
Genevestigator	Q5TAG4.
Family and domain databases
InterPro	IPR010630. NBPF_dom. [Graphical view]
Pfam	PF06758. DUF1220. 3 hits. [Graphical view]
PROSITE	PS51316. NBPF. 3 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

NBPFC_HUMAN

Accession

Primary (citable) accession number: Q5TAG4
Secondary accession number(s): O95877

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.