Q5TAA0 (TTC22_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetratricopeptide repeat protein 22
Short name=TPR repeat protein 22

Gene names

Name:

TTC22

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 7 TPR repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat TPR repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5TAA0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5TAA0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     341-372: IHIRAYLHDLKRAKMGLGGMPDRNHLACAKAD → RRGLTMLPRLVSNSWAQAVLPPRPPKVLEFQV
     373-569: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 569	569	Tetratricopeptide repeat protein 22		PRO_0000263098
Regions
	Repeat	66 – 99	34	TPR 1
	Repeat	101 – 133	33	TPR 2
	Repeat	203 – 237	35	TPR 3
	Repeat	260 – 294	35	TPR 4
	Repeat	295 – 328	34	TPR 5
	Repeat	383 – 418	36	TPR 6
	Repeat	432 – 465	34	TPR 7
Natural variations
	Alternative sequence	341 – 372	32	IHIRA…CAKAD → RRGLTMLPRLVSNSWAQAVL PPRPPKVLEFQV in isoform 2.		VSP_021859
	Alternative sequence	373 – 569	197	Missing in isoform 2.		VSP_021860
	Natural variant	14	1	L → V. Corresponds to variant rs671108 [ dbSNP | Ensembl ].		VAR_029585
Experimental info
	Sequence conflict	229	1	R → H in BAA91293. Ref.1
	Sequence conflict	324	1	V → A in BAA91293. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 95AFA00228FF6402	FASTA	569	63,361
	10 20 30 40 50 60 MAELEAVADD LDALIDDLDY LPGHFHLEMQ LNFEPRSPAP QRARDLKLQR EGLRQELQLA 70 80 90 100 110 120 AAPQRPAVRH LLGAFAFYLE ELDEARECFL EVAHEHPGNL NAWANLAHVY GRLGQEEEEE 130 140 150 160 170 180 ACAARLADLM GLAEEPEAAG DPQLRAARCL AEQGYAHGFD VGCASPEERA RGLAAGIALY 190 200 210 220 230 240 DKALGYGQQI PMEEKRGWYF TMATLYIRLD GIFLELGSEE QKRLPAFNRT LALLRQVLKS 250 260 270 280 290 300 EDPRHRALAW CYLGMLLERK DTFSTTPMGV HDCGYSGTDP LDCFGKAIEI AKNQPPILNR 310 320 330 340 350 360 LAKIFYFLGK QDMAIGTCNM ALDVLRDPEL NWQAYCTRAK IHIRAYLHDL KRAKMGLGGM 370 380 390 400 410 420 PDRNHLACAK ADLEEVVRVC PGFKAYLDIG QVYYYMGVDA VQELLAVDEA ALNQALVFLA 430 440 450 460 470 480 KAGESELGAT LPELQLLRGK CLRIKGEDAN AAACFKRAVE LDDAGSSHTD GFGCLLEALL 490 500 510 520 530 540 AQWSQAQLSD GELGREVDAW LRRAQDKYPA ARLRQELQRV WRGHTDEVLG LARALVAQGR 550 560 PALVRLLFET MEREGEGASA PRDRRAVSF
	Isoform 2 [UniParc]. Checksum: 79C116A687D3C5E4	FASTA	372	41,790
	10 20 30 40 50 60 MAELEAVADD LDALIDDLDY LPGHFHLEMQ LNFEPRSPAP QRARDLKLQR EGLRQELQLA 70 80 90 100 110 120 AAPQRPAVRH LLGAFAFYLE ELDEARECFL EVAHEHPGNL NAWANLAHVY GRLGQEEEEE 130 140 150 160 170 180 ACAARLADLM GLAEEPEAAG DPQLRAARCL AEQGYAHGFD VGCASPEERA RGLAAGIALY 190 200 210 220 230 240 DKALGYGQQI PMEEKRGWYF TMATLYIRLD GIFLELGSEE QKRLPAFNRT LALLRQVLKS 250 260 270 280 290 300 EDPRHRALAW CYLGMLLERK DTFSTTPMGV HDCGYSGTDP LDCFGKAIEI AKNQPPILNR 310 320 330 340 350 360 LAKIFYFLGK QDMAIGTCNM ALDVLRDPEL NWQAYCTRAK RRGLTMLPRL VSNSWAQAVL 370 PPRPPKVLEF QV

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Carcinoma.

[2]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000626 mRNA. Translation: BAA91293.1. AL139244, AC096536 Genomic DNA. Translation: CAI18990.1.
IPI	IPI00016663. IPI00514025.
RefSeq	NP_001107580.1. NM_001114108.1. NP_060374.2. NM_017904.3.
UniGene	Hs.16230.
3D structure databases
ProteinModelPortal	Q5TAA0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000360323.
PTM databases
PhosphoSite	Q5TAA0.
Polymorphism databases
DMDM	74745799.
Proteomic databases
PaxDb	Q5TAA0.
PRIDE	Q5TAA0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371274; ENSP00000360321; ENSG00000006555. ENST00000371276; ENSP00000360323; ENSG00000006555.
GeneID	55001.
KEGG	hsa:55001.
UCSC	uc001cxz.4. human. uc009vzt.1. human.
Organism-specific databases
CTD	55001.
GeneCards	GC01M055246.
HGNC	HGNC:26067. TTC22.
HPA	HPA035072.
neXtProt	NX_Q5TAA0.
PharmGKB	PA142670674.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26130.
HOGENOM	HOG000232031.
HOVERGEN	HBG080526.
InParanoid	Q5TAA0.
OMA	REDPGNL.
OrthoDB	EOG4F7NJS.
Gene expression databases
ArrayExpress	Q5TAA0.
Bgee	Q5TAA0.
CleanEx	HS_TTC22.
Genevestigator	Q5TAA0.
GermOnline	ENSG00000006555. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.10. 3 hits.
InterPro	IPR011990. TPR-like_helical. IPR013105. TPR_2. IPR019734. TPR_repeat. [Graphical view]
Pfam	PF07719. TPR_2. 1 hit. [Graphical view]
SMART	SM00028. TPR. 3 hits. [Graphical view]
PROSITE	PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55001.
NextBio	58324.

Entry information

Entry name

TTC22_HUMAN

Accession

Primary (citable) accession number: Q5TAA0
Secondary accession number(s): Q9NWT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.