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Q5TA89

- HES5_HUMAN

UniProt

Q5TA89 - HES5_HUMAN

Protein

Transcription factor HES-5

Gene

HES5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
    4. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. astrocyte differentiation Source: UniProtKB
    2. auditory receptor cell differentiation Source: UniProtKB
    3. auditory receptor cell fate determination Source: Ensembl
    4. brain development Source: UniProtKB
    5. camera-type eye development Source: UniProtKB
    6. cartilage development Source: UniProtKB
    7. cell adhesion Source: UniProtKB
    8. cell maturation Source: UniProtKB
    9. central nervous system myelination Source: UniProtKB
    10. comma-shaped body morphogenesis Source: Ensembl
    11. forebrain radial glial cell differentiation Source: Ensembl
    12. glial cell fate commitment Source: UniProtKB
    13. metanephric nephron tubule morphogenesis Source: Ensembl
    14. negative regulation of astrocyte differentiation Source: UniProtKB
    15. negative regulation of forebrain neuron differentiation Source: Ensembl
    16. negative regulation of inner ear receptor cell differentiation Source: Ensembl
    17. negative regulation of neuron differentiation Source: UniProtKB
    18. negative regulation of oligodendrocyte differentiation Source: UniProtKB
    19. negative regulation of pro-B cell differentiation Source: UniProtKB
    20. negative regulation of stem cell differentiation Source: UniProtKB
    21. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    22. neural tube development Source: UniProtKB
    23. neuronal stem cell maintenance Source: UniProtKB
    24. Notch signaling pathway Source: UniProtKB
    25. oligodendrocyte development Source: UniProtKB
    26. positive regulation of BMP signaling pathway Source: UniProtKB
    27. positive regulation of cell proliferation Source: UniProtKB
    28. positive regulation of JAK-STAT cascade Source: UniProtKB
    29. positive regulation of Notch signaling pathway Source: Ensembl
    30. positive regulation of smooth muscle cell proliferation Source: UniProtKB
    31. positive regulation of transcription, DNA-templated Source: UniProtKB
    32. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    33. positive regulation of tyrosine phosphorylation of Stat3 protein Source: UniProtKB
    34. protein complex assembly Source: UniProtKB
    35. regulation of cell differentiation Source: UniProtKB
    36. regulation of myelination Source: UniProtKB
    37. regulation of neurogenesis Source: UniProtKB
    38. smoothened signaling pathway Source: UniProtKB
    39. specification of loop of Henle identity Source: Ensembl
    40. S-shaped body morphogenesis Source: Ensembl
    41. telencephalon development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_163910. NOTCH2 intracellular domain regulates transcription.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor HES-5
    Alternative name(s):
    Class B basic helix-loop-helix protein 38
    Short name:
    bHLHb38
    Hairy and enhancer of split 5
    Gene namesi
    Name:HES5
    Synonyms:BHLHB38
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19764. HES5.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134967985.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 166166Transcription factor HES-5PRO_0000269175Add
    BLAST

    Proteomic databases

    PaxDbiQ5TA89.
    PRIDEiQ5TA89.

    PTM databases

    PhosphoSiteiQ5TA89.

    Expressioni

    Tissue specificityi

    Expressed in fetal heart and brain tumors.1 Publication

    Gene expression databases

    BgeeiQ5TA89.
    CleanExiHS_HES5.
    GenevestigatoriQ5TA89.

    Interactioni

    Subunit structurei

    Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

    Protein-protein interaction databases

    BioGridi132759. 3 interactions.
    STRINGi9606.ENSP00000367714.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TA89.
    SMRiQ5TA89. Positions 12-71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 7257bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini88 – 11932OrangePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi163 – 1664WRPW motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 3118Arg/Lys-rich (basic)Add
    BLAST
    Compositional biasi122 – 14221Pro-richAdd
    BLAST
    Compositional biasi147 – 1537Poly-Ala

    Domaini

    Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).By similarity
    The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 1 Orange domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG83691.
    HOGENOMiHOG000236346.
    HOVERGENiHBG005960.
    InParanoidiQ5TA89.
    KOiK06055.
    OMAiHSANTDT.
    OrthoDBiEOG7GN2PQ.
    PhylomeDBiQ5TA89.
    TreeFamiTF351373.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR003650. Orange.
    [Graphical view]
    PfamiPF07527. Hairy_orange. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS51054. ORANGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5TA89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPSTVAVEL LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH    50
    QPNSKLEKAD ILEMAVSYLK HSKAFVAAAG PKSLHQDYSE GYSWCLQEAV 100
    QFLTLHAASD TQMKLLYHFQ RPPAAPAAPA KEPKAPGAAP PPALSAKATA 150
    AAAAAHQPAC GLWRPW 166
    Length:166
    Mass (Da):18,226
    Last modified:December 21, 2004 - v1
    Checksum:i6B0ECF2482EBE43B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ272660 mRNA. Translation: ABB83829.1.
    AL139246 Genomic DNA. Translation: CAX30820.1.
    CH471183 Genomic DNA. Translation: EAW56096.1.
    CCDSiCCDS41233.1.
    RefSeqiNP_001010926.1. NM_001010926.3.
    UniGeneiHs.57971.

    Genome annotation databases

    EnsembliENST00000378453; ENSP00000367714; ENSG00000197921.
    GeneIDi388585.
    KEGGihsa:388585.
    UCSCiuc001ajn.3. human.

    Polymorphism databases

    DMDMi74745795.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ272660 mRNA. Translation: ABB83829.1 .
    AL139246 Genomic DNA. Translation: CAX30820.1 .
    CH471183 Genomic DNA. Translation: EAW56096.1 .
    CCDSi CCDS41233.1.
    RefSeqi NP_001010926.1. NM_001010926.3.
    UniGenei Hs.57971.

    3D structure databases

    ProteinModelPortali Q5TA89.
    SMRi Q5TA89. Positions 12-71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132759. 3 interactions.
    STRINGi 9606.ENSP00000367714.

    PTM databases

    PhosphoSitei Q5TA89.

    Polymorphism databases

    DMDMi 74745795.

    Proteomic databases

    PaxDbi Q5TA89.
    PRIDEi Q5TA89.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378453 ; ENSP00000367714 ; ENSG00000197921 .
    GeneIDi 388585.
    KEGGi hsa:388585.
    UCSCi uc001ajn.3. human.

    Organism-specific databases

    CTDi 388585.
    GeneCardsi GC01M002450.
    HGNCi HGNC:19764. HES5.
    MIMi 607348. gene.
    neXtProti NX_Q5TA89.
    PharmGKBi PA134967985.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83691.
    HOGENOMi HOG000236346.
    HOVERGENi HBG005960.
    InParanoidi Q5TA89.
    KOi K06055.
    OMAi HSANTDT.
    OrthoDBi EOG7GN2PQ.
    PhylomeDBi Q5TA89.
    TreeFami TF351373.

    Enzyme and pathway databases

    Reactomei REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_163910. NOTCH2 intracellular domain regulates transcription.

    Miscellaneous databases

    GeneWikii HES5.
    GenomeRNAii 388585.
    NextBioi 102194.
    PROi Q5TA89.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5TA89.
    CleanExi HS_HES5.
    Genevestigatori Q5TA89.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR003650. Orange.
    [Graphical view ]
    Pfami PF07527. Hairy_orange. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS51054. ORANGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Wistow G.
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Identification and characterization of human HES2, HES3, and HES5 genes in silico."
      Katoh M., Katoh M.
      Int. J. Oncol. 25:529-534(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiHES5_HUMAN
    AccessioniPrimary (citable) accession number: Q5TA89
    Secondary accession number(s): B9DI85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3