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Protein

Transcription factor HES-5

Gene

HES5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).By similarity

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. double-stranded DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  4. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. astrocyte differentiation Source: UniProtKB
  2. auditory receptor cell differentiation Source: UniProtKB
  3. auditory receptor cell fate determination Source: Ensembl
  4. brain development Source: UniProtKB
  5. camera-type eye development Source: UniProtKB
  6. cartilage development Source: UniProtKB
  7. cell adhesion Source: UniProtKB
  8. cell maturation Source: UniProtKB
  9. central nervous system myelination Source: UniProtKB
  10. comma-shaped body morphogenesis Source: Ensembl
  11. forebrain radial glial cell differentiation Source: Ensembl
  12. glial cell fate commitment Source: UniProtKB
  13. metanephric nephron tubule morphogenesis Source: Ensembl
  14. negative regulation of astrocyte differentiation Source: UniProtKB
  15. negative regulation of forebrain neuron differentiation Source: Ensembl
  16. negative regulation of inner ear receptor cell differentiation Source: Ensembl
  17. negative regulation of neuron differentiation Source: UniProtKB
  18. negative regulation of oligodendrocyte differentiation Source: UniProtKB
  19. negative regulation of pro-B cell differentiation Source: UniProtKB
  20. negative regulation of stem cell differentiation Source: UniProtKB
  21. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  22. neural tube development Source: UniProtKB
  23. neuronal stem cell maintenance Source: UniProtKB
  24. Notch signaling pathway Source: UniProtKB
  25. oligodendrocyte development Source: UniProtKB
  26. positive regulation of BMP signaling pathway Source: UniProtKB
  27. positive regulation of cell proliferation Source: UniProtKB
  28. positive regulation of JAK-STAT cascade Source: UniProtKB
  29. positive regulation of Notch signaling pathway Source: Ensembl
  30. positive regulation of smooth muscle cell proliferation Source: UniProtKB
  31. positive regulation of transcription, DNA-templated Source: UniProtKB
  32. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  33. positive regulation of tyrosine phosphorylation of Stat3 protein Source: UniProtKB
  34. protein complex assembly Source: UniProtKB
  35. regulation of cell differentiation Source: UniProtKB
  36. regulation of myelination Source: UniProtKB
  37. regulation of neurogenesis Source: UniProtKB
  38. smoothened signaling pathway Source: UniProtKB
  39. specification of loop of Henle identity Source: Ensembl
  40. S-shaped body morphogenesis Source: Ensembl
  41. telencephalon development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_163910. NOTCH2 intracellular domain regulates transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-5
Alternative name(s):
Class B basic helix-loop-helix protein 38
Short name:
bHLHb38
Hairy and enhancer of split 5
Gene namesi
Name:HES5
Synonyms:BHLHB38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 1, Unplaced

Organism-specific databases

HGNCiHGNC:19764. HES5.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134967985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Transcription factor HES-5PRO_0000269175Add
BLAST

Proteomic databases

PaxDbiQ5TA89.
PRIDEiQ5TA89.

PTM databases

PhosphoSiteiQ5TA89.

Expressioni

Tissue specificityi

Expressed in fetal heart and brain tumors.1 Publication

Gene expression databases

BgeeiQ5TA89.
CleanExiHS_HES5.
GenevestigatoriQ5TA89.

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

Protein-protein interaction databases

BioGridi132759. 3 interactions.
STRINGi9606.ENSP00000367714.

Structurei

3D structure databases

ProteinModelPortaliQ5TA89.
SMRiQ5TA89. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 7257bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini88 – 11932OrangePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi163 – 1664WRPW motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 3118Arg/Lys-rich (basic)Add
BLAST
Compositional biasi122 – 14221Pro-richAdd
BLAST
Compositional biasi147 – 1537Poly-Ala

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).By similarity
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 Orange domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG83691.
GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiQ5TA89.
KOiK06055.
OMAiFHFLSLH.
OrthoDBiEOG7GN2PQ.
PhylomeDBiQ5TA89.
TreeFamiTF351373.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TA89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSTVAVEL LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH
60 70 80 90 100
QPNSKLEKAD ILEMAVSYLK HSKAFVAAAG PKSLHQDYSE GYSWCLQEAV
110 120 130 140 150
QFLTLHAASD TQMKLLYHFQ RPPAAPAAPA KEPKAPGAAP PPALSAKATA
160
AAAAAHQPAC GLWRPW
Length:166
Mass (Da):18,226
Last modified:December 20, 2004 - v1
Checksum:i6B0ECF2482EBE43B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272660 mRNA. Translation: ABB83829.1.
AL139246 Genomic DNA. Translation: CAX30820.1.
CH471183 Genomic DNA. Translation: EAW56096.1.
CCDSiCCDS41233.1.
RefSeqiNP_001010926.1. NM_001010926.3.
UniGeneiHs.57971.

Genome annotation databases

EnsembliENST00000378453; ENSP00000367714; ENSG00000197921.
ENST00000612705; ENSP00000482150; ENSG00000273529.
GeneIDi388585.
KEGGihsa:388585.
UCSCiuc001ajn.3. human.

Polymorphism databases

DMDMi74745795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ272660 mRNA. Translation: ABB83829.1.
AL139246 Genomic DNA. Translation: CAX30820.1.
CH471183 Genomic DNA. Translation: EAW56096.1.
CCDSiCCDS41233.1.
RefSeqiNP_001010926.1. NM_001010926.3.
UniGeneiHs.57971.

3D structure databases

ProteinModelPortaliQ5TA89.
SMRiQ5TA89. Positions 12-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132759. 3 interactions.
STRINGi9606.ENSP00000367714.

PTM databases

PhosphoSiteiQ5TA89.

Polymorphism databases

DMDMi74745795.

Proteomic databases

PaxDbiQ5TA89.
PRIDEiQ5TA89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378453; ENSP00000367714; ENSG00000197921.
ENST00000612705; ENSP00000482150; ENSG00000273529.
GeneIDi388585.
KEGGihsa:388585.
UCSCiuc001ajn.3. human.

Organism-specific databases

CTDi388585.
GeneCardsiGC01M002460.
HGNCiHGNC:19764. HES5.
MIMi607348. gene.
neXtProtiNX_Q5TA89.
PharmGKBiPA134967985.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG83691.
GeneTreeiENSGT00700000104168.
HOGENOMiHOG000236346.
HOVERGENiHBG005960.
InParanoidiQ5TA89.
KOiK06055.
OMAiFHFLSLH.
OrthoDBiEOG7GN2PQ.
PhylomeDBiQ5TA89.
TreeFamiTF351373.

Enzyme and pathway databases

ReactomeiREACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_163910. NOTCH2 intracellular domain regulates transcription.

Miscellaneous databases

GeneWikiiHES5.
GenomeRNAii388585.
NextBioi102194.
PROiQ5TA89.
SOURCEiSearch...

Gene expression databases

BgeeiQ5TA89.
CleanExiHS_HES5.
GenevestigatoriQ5TA89.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003650. Orange.
[Graphical view]
PfamiPF07527. Hairy_orange. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS51054. ORANGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Wistow G.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification and characterization of human HES2, HES3, and HES5 genes in silico."
    Katoh M., Katoh M.
    Int. J. Oncol. 25:529-534(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHES5_HUMAN
AccessioniPrimary (citable) accession number: Q5TA89
Secondary accession number(s): B9DI85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 11, 2006
Last sequence update: December 20, 2004
Last modified: January 6, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.