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Protein

Late cornified envelope protein 2D

Gene

LCE2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

Miscellaneous

Belongs to the LCE cluster present on 1q21.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 2D
Alternative name(s):
Late envelope protein 12
Small proline-rich-like epidermal differentiation complex protein 1A
Gene namesi
Name:LCE2D
Synonyms:LEP12, SPRL1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187223.3.
HGNCiHGNC:16518. LCE2D.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187223.
PharmGKBiPA38157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353321 – 110Late cornified envelope protein 2DAdd BLAST110

Proteomic databases

PaxDbiQ5TA82.
PeptideAtlasiQ5TA82.
PRIDEiQ5TA82.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Inductioni

By calcium and UVB.1 Publication

Gene expression databases

BgeeiENSG00000187223.
CleanExiHS_LCE2D.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131647. 15 interactors.
IntActiQ5TA82. 49 interactors.
STRINGi9606.ENSP00000357773.

Structurei

3D structure databases

ProteinModelPortaliQ5TA82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 110Cys-richAdd BLAST108

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

eggNOGiENOG410KC5H. Eukaryota.
ENOG41115GY. LUCA.
GeneTreeiENSGT00730000111502.
HOVERGENiHBG079905.
InParanoidiQ5TA82.
OMAiHDCCESE.

Family and domain databases

InterProiView protein in InterPro
IPR028205. LCE.
IPR026075. SPRR/LCE.
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiView protein in Pfam
PF14672. LCE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQNQQQC QPPPKCPPKC TPKCPPKCPP KCPPQCPAPC SPAVSSCCGP
60 70 80 90 100
SSGSCCGPSS GGCCSSGGGG CCLSHHRPRL FHRRRHQSPD CCESEPSGAS
110
GCCHSSGGCC
Length:110
Mass (Da):11,180
Last modified:December 21, 2004 - v1
Checksum:i7F21D02F50A63EED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05348392C → Y. Corresponds to variant dbSNP:rs11205064Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139247 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53374.1.
BC130603 mRNA. Translation: AAI30604.1.
BC130605 mRNA. Translation: AAI30606.1.
CCDSiCCDS1018.1.
RefSeqiNP_848517.1. NM_178430.3.
UniGeneiHs.490225.

Genome annotation databases

EnsembliENST00000368784; ENSP00000357773; ENSG00000187223.
GeneIDi353141.
KEGGihsa:353141.
UCSCiuc001fag.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLCE2D_HUMAN
AccessioniPrimary (citable) accession number: Q5TA82
Secondary accession number(s): A1L4M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families