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Protein

Late cornified envelope protein 2D

Gene

LCE2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 2D
Alternative name(s):
Late envelope protein 12
Small proline-rich-like epidermal differentiation complex protein 1A
Gene namesi
Name:LCE2D
Synonyms:LEP12, SPRL1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16518. LCE2D.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 110110Late cornified envelope protein 2DPRO_0000235332Add
BLAST

Proteomic databases

PaxDbiQ5TA82.
PRIDEiQ5TA82.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Inductioni

By calcium and UVB.1 Publication

Gene expression databases

BgeeiQ5TA82.
CleanExiHS_LCE2D.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-10246750,EBI-10175576
ADAMTSL4Q6UY14-33EBI-10246750,EBI-10173507
EFEMP2O959673EBI-10246750,EBI-743414
GLRX3O760033EBI-10246750,EBI-374781
KRTAP10-5P603703EBI-10246750,EBI-10172150
KRTAP10-8P604103EBI-10246750,EBI-10171774
KRTAP10-9P604113EBI-10246750,EBI-10172052
KRTAP4-12Q9BQ663EBI-10246750,EBI-739863
NOTCH2NLQ7Z3S93EBI-10246750,EBI-945833
OTX1P322423EBI-10246750,EBI-740446
PLSCR1O151623EBI-10246750,EBI-740019
RGS20O760813EBI-10246750,EBI-1052678
SPRY1O436093EBI-10246750,EBI-3866665
SPRY2O435973EBI-10246750,EBI-742487

Protein-protein interaction databases

BioGridi131647. 15 interactions.
IntActiQ5TA82. 14 interactions.
STRINGi9606.ENSP00000357773.

Structurei

3D structure databases

ProteinModelPortaliQ5TA82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 110108Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

eggNOGiENOG410KC5H. Eukaryota.
ENOG41115GY. LUCA.
GeneTreeiENSGT00730000111502.
HOVERGENiHBG079905.
InParanoidiQ5TA82.
OMAiHDCCESE.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TA82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQNQQQC QPPPKCPPKC TPKCPPKCPP KCPPQCPAPC SPAVSSCCGP
60 70 80 90 100
SSGSCCGPSS GGCCSSGGGG CCLSHHRPRL FHRRRHQSPD CCESEPSGAS
110
GCCHSSGGCC
Length:110
Mass (Da):11,180
Last modified:December 21, 2004 - v1
Checksum:i7F21D02F50A63EED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921C → Y.
Corresponds to variant rs11205064 [ dbSNP | Ensembl ].
VAR_053483

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139247 Genomic DNA. Translation: CAI21682.1.
CH471121 Genomic DNA. Translation: EAW53374.1.
BC130603 mRNA. Translation: AAI30604.1.
BC130605 mRNA. Translation: AAI30606.1.
CCDSiCCDS1018.1.
RefSeqiNP_848517.1. NM_178430.3.
UniGeneiHs.490225.

Genome annotation databases

EnsembliENST00000368784; ENSP00000357773; ENSG00000187223.
GeneIDi353141.
KEGGihsa:353141.
UCSCiuc001fag.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139247 Genomic DNA. Translation: CAI21682.1.
CH471121 Genomic DNA. Translation: EAW53374.1.
BC130603 mRNA. Translation: AAI30604.1.
BC130605 mRNA. Translation: AAI30606.1.
CCDSiCCDS1018.1.
RefSeqiNP_848517.1. NM_178430.3.
UniGeneiHs.490225.

3D structure databases

ProteinModelPortaliQ5TA82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131647. 15 interactions.
IntActiQ5TA82. 14 interactions.
STRINGi9606.ENSP00000357773.

Proteomic databases

PaxDbiQ5TA82.
PRIDEiQ5TA82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368784; ENSP00000357773; ENSG00000187223.
GeneIDi353141.
KEGGihsa:353141.
UCSCiuc001fag.5. human.

Organism-specific databases

CTDi353141.
GeneCardsiLCE2D.
HGNCiHGNC:16518. LCE2D.
MIMi612612. gene.
neXtProtiNX_Q5TA82.
PharmGKBiPA38157.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC5H. Eukaryota.
ENOG41115GY. LUCA.
GeneTreeiENSGT00730000111502.
HOVERGENiHBG079905.
InParanoidiQ5TA82.
OMAiHDCCESE.

Miscellaneous databases

GenomeRNAii353141.
PROiQ5TA82.
SOURCEiSearch...

Gene expression databases

BgeeiQ5TA82.
CleanExiHS_LCE2D.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Late cornified envelope family in differentiating epithelia --response to calcium and ultraviolet irradiation."
    Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G., Byrne C.
    J. Invest. Dermatol. 124:1062-1070(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION BY CALCIUM AND UVB.

Entry informationi

Entry nameiLCE2D_HUMAN
AccessioniPrimary (citable) accession number: Q5TA82
Secondary accession number(s): A1L4M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the LCE cluster present on 1q21.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.