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Protein

Late cornified envelope protein 2A

Gene

LCE2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 2A
Alternative name(s):
Late envelope protein 9
Gene namesi
Name:LCE2A
Synonyms:LEP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29469. LCE2A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911274.

Polymorphism and mutation databases

BioMutaiLCE2A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Late cornified envelope protein 2APRO_0000235330Add
BLAST

Proteomic databases

PaxDbiQ5TA79.
PRIDEiQ5TA79.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Inductioni

By calcium and UVB.1 Publication

Gene expression databases

CleanExiHS_LCE2A.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-10246607,EBI-10175576
KRTAP10-5P603703EBI-10246607,EBI-10172150
KRTAP10-7P604093EBI-10246607,EBI-10172290
KRTAP10-8P604103EBI-10246607,EBI-10171774
KRTAP10-9P604113EBI-10246607,EBI-10172052
KRTAP3-2Q9BYR73EBI-10246607,EBI-751260
KRTAP4-2Q9BYR53EBI-10246607,EBI-10172511
KRTAP5-9P263713EBI-10246607,EBI-3958099
KRTAP9-2Q9BYQ43EBI-10246607,EBI-1044640
MEOX2A4D1273EBI-10246607,EBI-10172134
OTX1P322423EBI-10246607,EBI-740446
RGS17Q9UGC63EBI-10246607,EBI-3918154
RGS20O76081-63EBI-10246607,EBI-10178530

Protein-protein interaction databases

BioGridi131645. 14 interactions.
IntActiQ5TA79. 13 interactions.
STRINGi9606.ENSP00000357768.

Structurei

3D structure databases

ProteinModelPortaliQ5TA79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 106104Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000111502.
OMAiPRLFHRH.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TA79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQNQQQC QPPPKCPPKC PPKCPPKCRP QCPAPCPPPV SSCCGPSSGG
60 70 80 90 100
CCGSSSGGCC SSGGGGCCLS HHRPRLFHRH RHQSPDCCEC EPSGGSGCCH

SSGDCC
Length:106
Mass (Da):10,846
Last modified:December 21, 2004 - v1
Checksum:i7F29B511D282B6AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201C → Y.
Corresponds to variant rs58733562 [ dbSNP | Ensembl ].
VAR_062118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139247 Genomic DNA. Translation: CAI21685.1.
CH471121 Genomic DNA. Translation: EAW53371.1.
BC119707 mRNA. Translation: AAI19708.1.
CCDSiCCDS1021.1.
RefSeqiNP_848515.1. NM_178428.3.
UniGeneiHs.334054.

Genome annotation databases

EnsembliENST00000368779; ENSP00000357768; ENSG00000187173.
GeneIDi353139.
KEGGihsa:353139.
UCSCiuc001faj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139247 Genomic DNA. Translation: CAI21685.1.
CH471121 Genomic DNA. Translation: EAW53371.1.
BC119707 mRNA. Translation: AAI19708.1.
CCDSiCCDS1021.1.
RefSeqiNP_848515.1. NM_178428.3.
UniGeneiHs.334054.

3D structure databases

ProteinModelPortaliQ5TA79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131645. 14 interactions.
IntActiQ5TA79. 13 interactions.
STRINGi9606.ENSP00000357768.

Polymorphism and mutation databases

BioMutaiLCE2A.

Proteomic databases

PaxDbiQ5TA79.
PRIDEiQ5TA79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368779; ENSP00000357768; ENSG00000187173.
GeneIDi353139.
KEGGihsa:353139.
UCSCiuc001faj.3. human.

Organism-specific databases

CTDi353139.
GeneCardsiLCE2A.
H-InvDBHIX0200088.
HGNCiHGNC:29469. LCE2A.
MIMi612609. gene.
neXtProtiNX_Q5TA79.
PharmGKBiPA134911274.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111502.
OMAiPRLFHRH.

Miscellaneous databases

GenomeRNAii353139.
NextBioi99692.
PROiQ5TA79.
SOURCEiSearch...

Gene expression databases

CleanExiHS_LCE2A.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Late cornified envelope family in differentiating epithelia --response to calcium and ultraviolet irradiation."
    Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G., Byrne C.
    J. Invest. Dermatol. 124:1062-1070(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION BY CALCIUM AND UVB.

Entry informationi

Entry nameiLCE2A_HUMAN
AccessioniPrimary (citable) accession number: Q5TA79
Secondary accession number(s): A4QMZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the LCE cluster present on 1q21.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.