Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Late cornified envelope protein 4A

Gene

LCE4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 4A
Alternative name(s):
Late envelope protein 8
Small proline-rich-like epidermal differentiation complex protein 4A
Gene namesi
Name:LCE4A
Synonyms:LEP8, SPRL4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16613. LCE4A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38172.

Polymorphism and mutation databases

BioMutaiLCE4A.
DMDMi74745785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Late cornified envelope protein 4APRO_0000235338Add
BLAST

Proteomic databases

PaxDbiQ5TA78.
PRIDEiQ5TA78.

PTM databases

iPTMnetiQ5TA78.
PhosphoSiteiQ5TA78.

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Gene expression databases

BgeeiQ5TA78.
CleanExiHS_LCE4A.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-10246358,EBI-10173507
HOXA1P496393EBI-10246358,EBI-740785
KRT31Q153233EBI-10246358,EBI-948001
KRTAP10-5P603703EBI-10246358,EBI-10172150
KRTAP10-7P604093EBI-10246358,EBI-10172290
KRTAP10-8P604103EBI-10246358,EBI-10171774
KRTAP10-9P604113EBI-10246358,EBI-10172052
KRTAP12-2P599913EBI-10246358,EBI-10176379
KRTAP3-2Q9BYR73EBI-10246358,EBI-751260
KRTAP4-12Q9BQ663EBI-10246358,EBI-739863
KRTAP4-2Q9BYR53EBI-10246358,EBI-10172511
KRTAP5-9P263713EBI-10246358,EBI-3958099
KRTAP9-2Q9BYQ43EBI-10246358,EBI-1044640
KRTAP9-4Q9BYQ23EBI-10246358,EBI-10185730
MDFIQ997503EBI-10246358,EBI-724076
MEOX2A4D1273EBI-10246358,EBI-10172134
OTX1P322423EBI-10246358,EBI-740446
PLSCR1O151623EBI-10246358,EBI-740019
RGS17Q9UGC63EBI-10246358,EBI-3918154
RGS20O760813EBI-10246358,EBI-1052678
RGS20O76081-63EBI-10246358,EBI-10178530
RNF111Q6ZNA43EBI-10246358,EBI-2129175
SMCPP499013EBI-10246358,EBI-750494
SPRY2O435973EBI-10246358,EBI-742487

Protein-protein interaction databases

BioGridi128277. 23 interactions.
IntActiQ5TA78. 23 interactions.
STRINGi9606.ENSP00000335223.

Structurei

3D structure databases

ProteinModelPortaliQ5TA78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 9997Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

InParanoidiQ5TA78.
OMAiKCASSCP.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5TA78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQNQQQC QPPPKCPIPK YPPKCPSKCA SSCPPPISSC CGSSSGGCGC
60 70 80 90
CSSEGGGCCL SHHRHHRSHC HRPKSSNCYG SGSGQQSGGS GCCSGGGCC
Length:99
Mass (Da):9,980
Last modified:December 21, 2004 - v1
Checksum:i744CA56F4C488EC6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951G → V.
Corresponds to variant rs10888510 [ dbSNP | Ensembl ].
VAR_053486

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139247 Genomic DNA. Translation: CAI21686.1.
BC113446 mRNA. Translation: AAI13447.1.
BC113448 mRNA. Translation: AAI13449.1.
CCDSiCCDS1022.1.
RefSeqiNP_848133.1. NM_178356.3.
UniGeneiHs.447955.

Genome annotation databases

EnsembliENST00000335535; ENSP00000335223; ENSG00000187170.
ENST00000368777; ENSP00000357766; ENSG00000187170.
GeneIDi199834.
KEGGihsa:199834.
UCSCiuc001fak.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139247 Genomic DNA. Translation: CAI21686.1.
BC113446 mRNA. Translation: AAI13447.1.
BC113448 mRNA. Translation: AAI13449.1.
CCDSiCCDS1022.1.
RefSeqiNP_848133.1. NM_178356.3.
UniGeneiHs.447955.

3D structure databases

ProteinModelPortaliQ5TA78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128277. 23 interactions.
IntActiQ5TA78. 23 interactions.
STRINGi9606.ENSP00000335223.

PTM databases

iPTMnetiQ5TA78.
PhosphoSiteiQ5TA78.

Polymorphism and mutation databases

BioMutaiLCE4A.
DMDMi74745785.

Proteomic databases

PaxDbiQ5TA78.
PRIDEiQ5TA78.

Protocols and materials databases

DNASUi199834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335535; ENSP00000335223; ENSG00000187170.
ENST00000368777; ENSP00000357766; ENSG00000187170.
GeneIDi199834.
KEGGihsa:199834.
UCSCiuc001fak.2. human.

Organism-specific databases

CTDi199834.
GeneCardsiLCE4A.
HGNCiHGNC:16613. LCE4A.
MIMi612618. gene.
neXtProtiNX_Q5TA78.
PharmGKBiPA38172.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiQ5TA78.
OMAiKCASSCP.

Miscellaneous databases

GenomeRNAii199834.
PROiQ5TA78.
SOURCEiSearch...

Gene expression databases

BgeeiQ5TA78.
CleanExiHS_LCE4A.

Family and domain databases

InterProiIPR028205. LCE.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14672. LCE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Late cornified envelope family in differentiating epithelia --response to calcium and ultraviolet irradiation."
    Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M., Ashcroft G., Byrne C.
    J. Invest. Dermatol. 124:1062-1070(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLCE4A_HUMAN
AccessioniPrimary (citable) accession number: Q5TA78
Secondary accession number(s): Q14D97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the LCE cluster present on 1q21.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.