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Protein

Ceramide-1-phosphate transfer protein

Gene

CPTP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the intracellular transfer of ceramide-1-phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56Phosphoceramide1
Binding sitei60Phosphoceramide1
Binding sitei106Phosphoceramide1
Binding sitei110Phosphoceramide1
Binding sitei150Phosphoceramide1

GO - Molecular functioni

  • ceramide 1-phosphate binding Source: UniProtKB
  • ceramide 1-phosphate transporter activity Source: UniProtKB
  • glycolipid binding Source: InterPro
  • phospholipid binding Source: UniProtKB
  • phospholipid transporter activity Source: UniProtKB

GO - Biological processi

  • ceramide 1-phosphate transport Source: UniProtKB
  • glycosphingolipid metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31672-MONOMER.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.

Chemistry databases

SwissLipidsiSLP:000000406.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide-1-phosphate transfer protein
Short name:
CPTP
Alternative name(s):
Glycolipid transfer protein domain-containing protein 1
Short name:
GLTP domain-containing protein 1
Gene namesi
Name:CPTP
Synonyms:GLTPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28116. CPTP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi42F → A: Increases phosphoceramide transfer. 1 Publication1
Mutagenesisi43L → R: Nearly abolishes phosphoceramide transfer. 1 Publication1
Mutagenesisi50F → R: Slightly reduces phosphoceramide transfer. 1 Publication1
Mutagenesisi53I → N: Slightly decreases phosphoceramide transfer. 1 Publication1
Mutagenesisi56D → V: Slightly decreases phosphoceramide transfer. 1 Publication1
Mutagenesisi60K → A: Nearly abolishes phosphoceramide transfer. 1 Publication1
Mutagenesisi97R → L: No effect. 1 Publication1
Mutagenesisi106R → L: Nearly abolishes phosphoceramide transfer. 1 Publication1
Mutagenesisi110R → L: Reduces phosphoceramide transfer. 1 Publication1
Mutagenesisi113R → E or L: Strongly reduces phosphoceramide transfer. 1 Publication1
Mutagenesisi117W → A: Slightly reduces phosphoceramide transfer. 1 Publication1
Mutagenesisi118L → R: Abolishes phosphoceramide transfer. 1 Publication1
Mutagenesisi149Y → A: Reduces phosphoceramide transfer. 1 Publication1
Mutagenesisi158V → N: Abolishes phosphoceramide transfer. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000224051.
PharmGKBiPA162389853.

Polymorphism and mutation databases

BioMutaiGLTPD1.
DMDMi74745771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003171561 – 214Ceramide-1-phosphate transfer proteinAdd BLAST214

Proteomic databases

EPDiQ5TA50.
PaxDbiQ5TA50.
PeptideAtlasiQ5TA50.
PRIDEiQ5TA50.

PTM databases

iPTMnetiQ5TA50.

Expressioni

Tissue specificityi

Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000224051.
CleanExiHS_GLTPD1.
ExpressionAtlasiQ5TA50. baseline and differential.
GenevisibleiQ5TA50. HS.

Organism-specific databases

HPAiHPA056832.

Interactioni

Protein-protein interaction databases

BioGridi123305. 7 interactors.
IntActiQ5TA50. 8 interactors.
STRINGi9606.ENSP00000343890.

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 15Combined sources6
Helixi16 – 20Combined sources5
Helixi29 – 46Combined sources18
Helixi48 – 50Combined sources3
Helixi51 – 69Combined sources19
Helixi73 – 76Combined sources4
Helixi79 – 88Combined sources10
Beta strandi94 – 96Combined sources3
Helixi104 – 127Combined sources24
Helixi134 – 144Combined sources11
Helixi146 – 149Combined sources4
Helixi152 – 162Combined sources11
Helixi168 – 174Combined sources7
Beta strandi177 – 179Combined sources3
Helixi180 – 207Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K80X-ray2.05A1-214[»]
4K84X-ray1.90A/B1-214[»]
4K85X-ray1.90A/B/C/D1-214[»]
4K8NX-ray3.10A/B/C/D/E/F1-214[»]
4KBSX-ray1.90A/B1-214[»]
4KF6X-ray3.20A/B/C/D/E/F1-214[»]
ProteinModelPortaliQ5TA50.
SMRiQ5TA50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GLTP family.Curated

Phylogenomic databases

eggNOGiKOG4189. Eukaryota.
ENOG4111NKT. LUCA.
GeneTreeiENSGT00530000063818.
HOGENOMiHOG000046738.
HOVERGENiHBG100515.
InParanoidiQ5TA50.
OMAiDSGCRTV.
OrthoDBiEOG091G0LIV.
PhylomeDBiQ5TA50.
TreeFamiTF316097.

Family and domain databases

Gene3Di1.10.3520.10. 1 hit.
InterProiIPR014830. Glycolipid_transfer_prot_dom.
[Graphical view]
PfamiPF08718. GLTP. 1 hit.
[Graphical view]
SUPFAMiSSF110004. SSF110004. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5TA50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDSETGFNL KVVLVSFKQC LDEKEEVLLD PYIASWKGLV RFLNSLGTIF
60 70 80 90 100
SFISKDVVSK LRIMERLRGG PQSEHYRSLQ AMVAHELSNR LVDLERRSHH
110 120 130 140 150
PESGCRTVLR LHRALHWLQL FLEGLRTSPE DARTSALCAD SYNASLAAYH
160 170 180 190 200
PWVVRRAVTV AFCTLPTREV FLEAMNVGPP EQAVQMLGEA LPFIQRVYNV
210
SQKLYAEHSL LDLP
Length:214
Mass (Da):24,365
Last modified:December 21, 2004 - v1
Checksum:iB66F4581FD9C60A0
GO

Sequence cautioni

The sequence EAW56230 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR599582 mRNA. No translation available.
AL139287 Genomic DNA. Translation: CAI23183.1.
CH471183 Genomic DNA. Translation: EAW56230.1. Sequence problems.
BC098429 mRNA. Translation: AAH98429.1.
CCDSiCCDS30555.1.
RefSeqiNP_001025056.1. NM_001029885.1.
XP_005244858.1. XM_005244801.3.
XP_011540502.1. XM_011542200.2.
UniGeneiHs.515689.

Genome annotation databases

EnsembliENST00000343938; ENSP00000343890; ENSG00000224051.
GeneIDi80772.
KEGGihsa:80772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR599582 mRNA. No translation available.
AL139287 Genomic DNA. Translation: CAI23183.1.
CH471183 Genomic DNA. Translation: EAW56230.1. Sequence problems.
BC098429 mRNA. Translation: AAH98429.1.
CCDSiCCDS30555.1.
RefSeqiNP_001025056.1. NM_001029885.1.
XP_005244858.1. XM_005244801.3.
XP_011540502.1. XM_011542200.2.
UniGeneiHs.515689.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K80X-ray2.05A1-214[»]
4K84X-ray1.90A/B1-214[»]
4K85X-ray1.90A/B/C/D1-214[»]
4K8NX-ray3.10A/B/C/D/E/F1-214[»]
4KBSX-ray1.90A/B1-214[»]
4KF6X-ray3.20A/B/C/D/E/F1-214[»]
ProteinModelPortaliQ5TA50.
SMRiQ5TA50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123305. 7 interactors.
IntActiQ5TA50. 8 interactors.
STRINGi9606.ENSP00000343890.

Chemistry databases

SwissLipidsiSLP:000000406.

PTM databases

iPTMnetiQ5TA50.

Polymorphism and mutation databases

BioMutaiGLTPD1.
DMDMi74745771.

Proteomic databases

EPDiQ5TA50.
PaxDbiQ5TA50.
PeptideAtlasiQ5TA50.
PRIDEiQ5TA50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343938; ENSP00000343890; ENSG00000224051.
GeneIDi80772.
KEGGihsa:80772.

Organism-specific databases

CTDi80772.
GeneCardsiCPTP.
HGNCiHGNC:28116. CPTP.
HPAiHPA056832.
MIMi615467. gene.
neXtProtiNX_Q5TA50.
OpenTargetsiENSG00000224051.
PharmGKBiPA162389853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4189. Eukaryota.
ENOG4111NKT. LUCA.
GeneTreeiENSGT00530000063818.
HOGENOMiHOG000046738.
HOVERGENiHBG100515.
InParanoidiQ5TA50.
OMAiDSGCRTV.
OrthoDBiEOG091G0LIV.
PhylomeDBiQ5TA50.
TreeFamiTF316097.

Enzyme and pathway databases

BioCyciZFISH:G66-31672-MONOMER.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.

Miscellaneous databases

GenomeRNAii80772.
PROiQ5TA50.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000224051.
CleanExiHS_GLTPD1.
ExpressionAtlasiQ5TA50. baseline and differential.
GenevisibleiQ5TA50. HS.

Family and domain databases

Gene3Di1.10.3520.10. 1 hit.
InterProiIPR014830. Glycolipid_transfer_prot_dom.
[Graphical view]
PfamiPF08718. GLTP. 1 hit.
[Graphical view]
SUPFAMiSSF110004. SSF110004. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPTP_HUMAN
AccessioniPrimary (citable) accession number: Q5TA50
Secondary accession number(s): Q4G0E6, Q7L5A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.