Q5TA45 (INT11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Integrator complex subunit 11
Short name=Int11
EC=3.1.27.-

Alternative name(s):
Cleavage and polyadenylation-specific factor 3-like protein
Short name=CPSF3-like protein
Protein related to CPSF subunits of 68 kDa
Short name=RC-68

Gene names

Name:	CPSF3L
Synonyms:	INTS11, RC68

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	600 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Ref.6
Subunit structure	Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Ref.6
Subcellular location	Nucleus. Cytoplasm Ref.7.
Domain	The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex By similarity.
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
Sequence caution	The sequence BAA91246.1 differs from that shown. Reason: Frameshift at position 587. The sequence BAB14541.1 differs from that shown. Reason: Frameshift at position 248. The sequence CAI23174.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI23176.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI23177.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI23179.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI23180.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI23181.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5TA45-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5TA45-2)

The sequence of this isoform differs from the canonical sequence as follows:
     43-143: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5TA45-3)

The sequence of this isoform differs from the canonical sequence as follows:
     143-164: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q5TA45-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 600	600	Integrator complex subunit 11		PRO_0000259563
Regions
	Motif	68 – 73	6	HXHXDH motif
Natural variations
	Alternative sequence	1 – 29	29	Missing in isoform 4.		VSP_045428
	Alternative sequence	43 – 143	101	Missing in isoform 2.		VSP_021472
	Alternative sequence	143 – 164	22	Missing in isoform 3.		VSP_021473
Experimental info
	Mutagenesis	203	1	E → Q: Abolishes the ability of the Integrator complex to process U1 and U2 snRNA genes. Ref.6
	Sequence conflict	95	1	P → S in CAB66747. Ref.1
	Sequence conflict	95	1	P → S in CAG38588. Ref.3
	Sequence conflict	253	1	E → K in BAB13943. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: 47C4E2E16202B130	FASTA	600	67,663
	10 20 30 40 50 60 MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY ITQNGRLTDF 70 80 90 100 110 120 LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC PILLEDYRKI AVDKKGEANF 130 140 150 160 170 180 FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN 190 200 210 220 230 240 MTPDRHLGAA WIDKCRPNLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF 250 260 270 280 290 300 ALGRAQELCI LLETFWERMN LKVPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF 310 320 330 340 350 360 EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG 370 380 390 400 410 420 HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ LVGQAEPESV LLVHGEAKKM 430 440 450 460 470 480 EFLKQKIEQE LRVNCYMPAN GETVTLPTSP SIPVGISLGL LKREMAQGLL PEAKKPRLLH 490 500 510 520 530 540 GTLIMKDSNF RLVSSEQALK ELGLAEHQLR FTCRVHLHDT RKEQETALRV YSHLKSVLKD 550 560 570 580 590 600 HCVQHLPDGS VTVESVLLQA AAPSEDPGTK VLLVSWTYQD EELGSFLTSL LKKGLPQAPS
	Isoform 2 [UniParc]. Checksum: 91F01E586DDC4FD1	FASTA	499	56,013
	10 20 30 40 50 60 MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDVDDELEIK AYYAGHVLGA 70 80 90 100 110 120 AMFQIKVGSE SVVYTGDYNM TPDRHLGAAW IDKCRPNLLI TESTYATTIR DSKRCRERDF 130 140 150 160 170 180 LKKVHETVER GGKVLIPVFA LGRAQELCIL LETFWERMNL KVPIYFSTGL TEKANHYYKL 190 200 210 220 230 240 FIPWTNQKIR KTFVQRNMFE FKHIKAFDRA FADNPGPMVV FATPGMLHAG QSLQIFRKWA 250 260 270 280 290 300 GNEKNMVIMP GYCVQGTVGH KILSGQRKLE MEGRQVLEVK MQVEYMSFSA HADAKGIMQL 310 320 330 340 350 360 VGQAEPESVL LVHGEAKKME FLKQKIEQEL RVNCYMPANG ETVTLPTSPS IPVGISLGLL 370 380 390 400 410 420 KREMAQGLLP EAKKPRLLHG TLIMKDSNFR LVSSEQALKE LGLAEHQLRF TCRVHLHDTR 430 440 450 460 470 480 KEQETALRVY SHLKSVLKDH CVQHLPDGSV TVESVLLQAA APSEDPGTKV LLVSWTYQDE 490 ELGSFLTSLL KKGLPQAPS
	Isoform 3 [UniParc]. Checksum: AD63044D90F3D6A2	FASTA	578	65,240
	10 20 30 40 50 60 MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY ITQNGRLTDF 70 80 90 100 110 120 LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC PILLEDYRKI AVDKKGEANF 130 140 150 160 170 180 FTSQMIKDCM KKVVAVHLHQ TVQIKVGSES VVYTGDYNMT PDRHLGAAWI DKCRPNLLIT 190 200 210 220 230 240 ESTYATTIRD SKRCRERDFL KKVHETVERG GKVLIPVFAL GRAQELCILL ETFWERMNLK 250 260 270 280 290 300 VPIYFSTGLT EKANHYYKLF IPWTNQKIRK TFVQRNMFEF KHIKAFDRAF ADNPGPMVVF 310 320 330 340 350 360 ATPGMLHAGQ SLQIFRKWAG NEKNMVIMPG YCVQGTVGHK ILSGQRKLEM EGRQVLEVKM 370 380 390 400 410 420 QVEYMSFSAH ADAKGIMQLV GQAEPESVLL VHGEAKKMEF LKQKIEQELR VNCYMPANGE 430 440 450 460 470 480 TVTLPTSPSI PVGISLGLLK REMAQGLLPE AKKPRLLHGT LIMKDSNFRL VSSEQALKEL 490 500 510 520 530 540 GLAEHQLRFT CRVHLHDTRK EQETALRVYS HLKSVLKDHC VQHLPDGSVT VESVLLQAAA 550 560 570 PSEDPGTKVL LVSWTYQDEE LGSFLTSLLK KGLPQAPS
	Isoform 4 [UniParc]. Checksum: 4F3056C3490955F1	FASTA	571	64,699
	10 20 30 40 50 60 MLDCGMHMGF NDDRRFPDFS YITQNGRLTD FLDCVIISHF HLDHCGALPY FSEMVGYDGP 70 80 90 100 110 120 IYMTHPTQAI CPILLEDYRK IAVDKKGEAN FFTSQMIKDC MKKVVAVHLH QTVQVDDELE 130 140 150 160 170 180 IKAYYAGHVL GAAMFQIKVG SESVVYTGDY NMTPDRHLGA AWIDKCRPNL LITESTYATT 190 200 210 220 230 240 IRDSKRCRER DFLKKVHETV ERGGKVLIPV FALGRAQELC ILLETFWERM NLKVPIYFST 250 260 270 280 290 300 GLTEKANHYY KLFIPWTNQK IRKTFVQRNM FEFKHIKAFD RAFADNPGPM VVFATPGMLH 310 320 330 340 350 360 AGQSLQIFRK WAGNEKNMVI MPGYCVQGTV GHKILSGQRK LEMEGRQVLE VKMQVEYMSF 370 380 390 400 410 420 SAHADAKGIM QLVGQAEPES VLLVHGEAKK MEFLKQKIEQ ELRVNCYMPA NGETVTLPTS 430 440 450 460 470 480 PSIPVGISLG LLKREMAQGL LPEAKKPRLL HGTLIMKDSN FRLVSSEQAL KELGLAEHQL 490 500 510 520 530 540 RFTCRVHLHD TRKEQETALR VYSHLKSVLK DHCVQHLPDG SVTVESVLLQ AAAPSEDPGT 550 560 570 KVLLVSWTYQ DEELGSFLTS LLKKGLPQAP S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Brain and Embryo.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon, Lymph and Ovary.
[6]	"Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II." Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R. Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX, FUNCTION, MUTAGENESIS OF GLU-203.
[7]	"A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100." Dominski Z., Yang X.-C., Purdy M., Wagner E.J., Marzluff W.F. Mol. Cell. Biol. 25:1489-1500(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, INTERACTION WITH INTS9.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136813 mRNA. Translation: CAB66747.1. AK000549 mRNA. Translation: BAA91246.1. Sequence problems. AK021939 mRNA. Translation: BAB13943.1. AK023356 mRNA. Translation: BAB14541.1. Frameshift. AK297350 mRNA. Translation: BAG59799.1. CR533557 mRNA. Translation: CAG38588.1. AL139287 Genomic DNA. Translation: CAI23174.1. Different initiation. AL139287 Genomic DNA. Translation: CAI23176.1. Different initiation. AL139287 Genomic DNA. Translation: CAI23177.1. Different initiation. AL139287 Genomic DNA. Translation: CAI23179.1. Sequence problems. AL139287 Genomic DNA. Translation: CAI23180.1. Sequence problems. AL139287 Genomic DNA. Translation: CAI23181.1. Sequence problems. BC000675 mRNA. Translation: AAH00675.2. BC007978 mRNA. Translation: AAH07978.1. BC013904 mRNA. Translation: AAH13904.2. BK005728 mRNA. Translation: DAA05728.1. BK005673 mRNA. Translation: DAA05669.1.
IPI	IPI00063404. IPI00306882. IPI00514973.
RefSeq	NP_001243385.1. NM_001256456.1. NP_001243389.1. NM_001256460.1. NP_001243392.1. NM_001256463.1. NP_060341.2. NM_017871.5.
UniGene	Hs.6449.
3D structure databases
ProteinModelPortal	Q5TA45.
SMR	Q5TA45. Positions 3-446.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5TA45. 4 interactions.
MINT	MINT-1482228.
PTM databases
PhosphoSite	Q5TA45.
Polymorphism databases
DMDM	118572557.
Proteomic databases
PaxDb	Q5TA45.
PRIDE	Q5TA45.
Protocols and materials databases
DNASU	54973.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000419704; ENSP00000404886; ENSG00000127054. ENST00000435064; ENSP00000413493; ENSG00000127054. ENST00000450926; ENSP00000392848; ENSG00000127054. ENST00000545578; ENSP00000444672; ENSG00000127054.
GeneID	54973.
KEGG	hsa:54973.
UCSC	uc001aee.1. human. uc001aeh.1. human. uc009vjz.1. human.
Organism-specific databases
CTD	54973.
GeneCards	GC01M001236.
HGNC	HGNC:26052. CPSF3L.
HPA	HPA028379. HPA029025.
MIM	611354. gene.
neXtProt	NX_Q5TA45.
PharmGKB	PA142672080.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1236.
HOVERGEN	HBG080215.
InParanoid	Q5TA45.
KO	K13148.
OrthoDB	EOG4GXFMB.
PhylomeDB	Q5TA45.
Gene expression databases
ArrayExpress	Q5TA45.
Bgee	Q5TA45.
Genevestigator	Q5TA45.
GermOnline	ENSG00000127054. Homo sapiens.
Family and domain databases
InterPro	IPR001279. Beta-lactamas-like. IPR022712. Beta_Casp. IPR011108. RMMBL. [Graphical view]
Pfam	PF10996. Beta-Casp. 1 hit. PF00753. Lactamase_B. 1 hit. PF07521. RMMBL. 1 hit. [Graphical view]
SMART	SM01027. Beta-Casp. 1 hit. SM00849. Lactamase_B. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CPSF3L. human.
GenomeRNAi	54973.
NextBio	58222.
SOURCE	Search...

Entry information

Entry name

INT11_HUMAN

Accession

Primary (citable) accession number: Q5TA45
Secondary accession number(s): B4DM87 , Q5TA46, Q5TA48, Q5TA52, Q5TA53, Q5TA54, Q7L3D7, Q96HY1, Q9BW36, Q9H0F9, Q9H8R5, Q9HAA6, Q9NWX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.