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Protein

Integrator complex subunit 11

Gene

CPSF3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage.1 Publication

GO - Molecular functioni

GO - Biological processi

  • snRNA processing Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 11 (EC:3.1.27.-)
Short name:
Int11
Alternative name(s):
Cleavage and polyadenylation-specific factor 3-like protein
Short name:
CPSF3-like protein
Protein related to CPSF subunits of 68 kDa
Short name:
RC-68
Gene namesi
Name:CPSF3L
Synonyms:INTS11, RC68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26052. CPSF3L.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
  • integrator complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi203 – 2031E → Q: Abolishes the ability of the Integrator complex to process U1 and U2 snRNA genes. 1 Publication

Organism-specific databases

PharmGKBiPA142672080.

Polymorphism and mutation databases

BioMutaiCPSF3L.
DMDMi118572557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Integrator complex subunit 11PRO_0000259563Add
BLAST

Proteomic databases

MaxQBiQ5TA45.
PaxDbiQ5TA45.
PRIDEiQ5TA45.

PTM databases

PhosphoSiteiQ5TA45.

Expressioni

Gene expression databases

BgeeiQ5TA45.
ExpressionAtlasiQ5TA45. baseline and differential.
GenevisibleiQ5TA45. HS.

Organism-specific databases

HPAiHPA028379.
HPA029025.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.1 Publication

Protein-protein interaction databases

BioGridi120310. 18 interactions.
IntActiQ5TA45. 8 interactions.
MINTiMINT-1482228.
STRINGi9606.ENSP00000413493.

Structurei

3D structure databases

ProteinModelPortaliQ5TA45.
SMRiQ5TA45. Positions 3-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi68 – 736HXHXDH motif

Domaini

The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1236.
GeneTreeiENSGT00780000121968.
HOGENOMiHOG000231294.
HOVERGENiHBG080215.
InParanoidiQ5TA45.
KOiK13148.
OMAiKMEFLKG.
OrthoDBiEOG741Z1M.
PhylomeDBiQ5TA45.
TreeFamiTF105878.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR022712. Beta_Casp.
IPR011108. RMMBL.
[Graphical view]
PfamiPF10996. Beta-Casp. 1 hit.
PF00753. Lactamase_B. 1 hit.
PF07521. RMMBL. 1 hit.
[Graphical view]
SMARTiSM01027. Beta-Casp. 1 hit.
SM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5TA45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY
60 70 80 90 100
ITQNGRLTDF LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC
110 120 130 140 150
PILLEDYRKI AVDKKGEANF FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI
160 170 180 190 200
KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN MTPDRHLGAA WIDKCRPNLL
210 220 230 240 250
ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF ALGRAQELCI
260 270 280 290 300
LLETFWERMN LKVPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF
310 320 330 340 350
EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM
360 370 380 390 400
PGYCVQGTVG HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ
410 420 430 440 450
LVGQAEPESV LLVHGEAKKM EFLKQKIEQE LRVNCYMPAN GETVTLPTSP
460 470 480 490 500
SIPVGISLGL LKREMAQGLL PEAKKPRLLH GTLIMKDSNF RLVSSEQALK
510 520 530 540 550
ELGLAEHQLR FTCRVHLHDT RKEQETALRV YSHLKSVLKD HCVQHLPDGS
560 570 580 590 600
VTVESVLLQA AAPSEDPGTK VLLVSWTYQD EELGSFLTSL LKKGLPQAPS
Length:600
Mass (Da):67,663
Last modified:October 31, 2006 - v2
Checksum:i47C4E2E16202B130
GO
Isoform 2 (identifier: Q5TA45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-143: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):56,013
Checksum:i91F01E586DDC4FD1
GO
Isoform 3 (identifier: Q5TA45-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-164: Missing.

Note: No experimental confirmation available.
Show »
Length:578
Mass (Da):65,240
Checksum:iAD63044D90F3D6A2
GO
Isoform 4 (identifier: Q5TA45-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:571
Mass (Da):64,699
Checksum:i4F3056C3490955F1
GO
Isoform 5 (identifier: Q5TA45-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MPEIRVTPL → MCGAGFGHFEWLAGG

Show »
Length:606
Mass (Da):68,147
Checksum:iE943195A6FBB41C5
GO

Sequence cautioni

The sequence BAA91246.1 differs from that shown. Reason: Frameshift at position 587. Curated
The sequence BAB14541.1 differs from that shown. Reason: Frameshift at position 248. Curated
The sequence CAI23174.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI23176.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI23177.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI23179.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI23180.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI23181.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951P → S in CAB66747 (PubMed:11230166).Curated
Sequence conflicti95 – 951P → S in CAG38588 (Ref. 3) Curated
Sequence conflicti253 – 2531E → K in BAB13943 (PubMed:14702039).Curated
Sequence conflicti434 – 4341N → D in BAF84076 (PubMed:14702039).Curated
Sequence conflicti439 – 4391A → V in BAG51775 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform 4. 1 PublicationVSP_045428Add
BLAST
Alternative sequencei1 – 99MPEIRVTPL → MCGAGFGHFEWLAGG in isoform 5. 1 PublicationVSP_046643
Alternative sequencei43 – 143101Missing in isoform 2. 1 PublicationVSP_021472Add
BLAST
Alternative sequencei143 – 16422Missing in isoform 3. 1 PublicationVSP_021473Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136813 mRNA. Translation: CAB66747.1.
AK000549 mRNA. Translation: BAA91246.1. Sequence problems.
AK021939 mRNA. Translation: BAB13943.1.
AK023356 mRNA. Translation: BAB14541.1. Frameshift.
AK056652 mRNA. Translation: BAG51775.1.
AK291387 mRNA. Translation: BAF84076.1.
AK297350 mRNA. Translation: BAG59799.1.
CR533557 mRNA. Translation: CAG38588.1.
AL139287 Genomic DNA. Translation: CAI23174.1. Different initiation.
AL139287 Genomic DNA. Translation: CAI23176.1. Different initiation.
AL139287 Genomic DNA. Translation: CAI23177.1. Different initiation.
AL139287 Genomic DNA. Translation: CAI23179.1. Sequence problems.
AL139287 Genomic DNA. Translation: CAI23180.1. Sequence problems.
AL139287 Genomic DNA. Translation: CAI23181.1. Sequence problems.
CH471183 Genomic DNA. Translation: EAW56238.1.
BC000675 mRNA. Translation: AAH00675.2.
BC007978 mRNA. Translation: AAH07978.1.
BC013904 mRNA. Translation: AAH13904.2.
BK005728 mRNA. Translation: DAA05728.1.
BK005673 mRNA. Translation: DAA05669.1.
CCDSiCCDS21.1. [Q5TA45-1]
CCDS57959.1. [Q5TA45-4]
CCDS57960.1. [Q5TA45-5]
CCDS57961.1. [Q5TA45-2]
RefSeqiNP_001243385.1. NM_001256456.1. [Q5TA45-5]
NP_001243389.1. NM_001256460.1. [Q5TA45-4]
NP_001243391.1. NM_001256462.1.
NP_001243392.1. NM_001256463.1. [Q5TA45-2]
NP_060341.2. NM_017871.5. [Q5TA45-1]
UniGeneiHs.6449.

Genome annotation databases

EnsembliENST00000435064; ENSP00000413493; ENSG00000127054.
ENST00000450926; ENSP00000392848; ENSG00000127054. [Q5TA45-3]
ENST00000540437; ENSP00000445001; ENSG00000127054. [Q5TA45-5]
ENST00000545578; ENSP00000444672; ENSG00000127054. [Q5TA45-4]
GeneIDi54973.
KEGGihsa:54973.
UCSCiuc001aee.2. human. [Q5TA45-1]
uc001aef.2. human.
uc001aeh.2. human. [Q5TA45-2]
uc009vjz.2. human. [Q5TA45-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136813 mRNA. Translation: CAB66747.1.
AK000549 mRNA. Translation: BAA91246.1. Sequence problems.
AK021939 mRNA. Translation: BAB13943.1.
AK023356 mRNA. Translation: BAB14541.1. Frameshift.
AK056652 mRNA. Translation: BAG51775.1.
AK291387 mRNA. Translation: BAF84076.1.
AK297350 mRNA. Translation: BAG59799.1.
CR533557 mRNA. Translation: CAG38588.1.
AL139287 Genomic DNA. Translation: CAI23174.1. Different initiation.
AL139287 Genomic DNA. Translation: CAI23176.1. Different initiation.
AL139287 Genomic DNA. Translation: CAI23177.1. Different initiation.
AL139287 Genomic DNA. Translation: CAI23179.1. Sequence problems.
AL139287 Genomic DNA. Translation: CAI23180.1. Sequence problems.
AL139287 Genomic DNA. Translation: CAI23181.1. Sequence problems.
CH471183 Genomic DNA. Translation: EAW56238.1.
BC000675 mRNA. Translation: AAH00675.2.
BC007978 mRNA. Translation: AAH07978.1.
BC013904 mRNA. Translation: AAH13904.2.
BK005728 mRNA. Translation: DAA05728.1.
BK005673 mRNA. Translation: DAA05669.1.
CCDSiCCDS21.1. [Q5TA45-1]
CCDS57959.1. [Q5TA45-4]
CCDS57960.1. [Q5TA45-5]
CCDS57961.1. [Q5TA45-2]
RefSeqiNP_001243385.1. NM_001256456.1. [Q5TA45-5]
NP_001243389.1. NM_001256460.1. [Q5TA45-4]
NP_001243391.1. NM_001256462.1.
NP_001243392.1. NM_001256463.1. [Q5TA45-2]
NP_060341.2. NM_017871.5. [Q5TA45-1]
UniGeneiHs.6449.

3D structure databases

ProteinModelPortaliQ5TA45.
SMRiQ5TA45. Positions 3-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120310. 18 interactions.
IntActiQ5TA45. 8 interactions.
MINTiMINT-1482228.
STRINGi9606.ENSP00000413493.

PTM databases

PhosphoSiteiQ5TA45.

Polymorphism and mutation databases

BioMutaiCPSF3L.
DMDMi118572557.

Proteomic databases

MaxQBiQ5TA45.
PaxDbiQ5TA45.
PRIDEiQ5TA45.

Protocols and materials databases

DNASUi54973.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435064; ENSP00000413493; ENSG00000127054.
ENST00000450926; ENSP00000392848; ENSG00000127054. [Q5TA45-3]
ENST00000540437; ENSP00000445001; ENSG00000127054. [Q5TA45-5]
ENST00000545578; ENSP00000444672; ENSG00000127054. [Q5TA45-4]
GeneIDi54973.
KEGGihsa:54973.
UCSCiuc001aee.2. human. [Q5TA45-1]
uc001aef.2. human.
uc001aeh.2. human. [Q5TA45-2]
uc009vjz.2. human. [Q5TA45-3]

Organism-specific databases

CTDi54973.
GeneCardsiGC01M001249.
HGNCiHGNC:26052. CPSF3L.
HPAiHPA028379.
HPA029025.
MIMi611354. gene.
neXtProtiNX_Q5TA45.
PharmGKBiPA142672080.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1236.
GeneTreeiENSGT00780000121968.
HOGENOMiHOG000231294.
HOVERGENiHBG080215.
InParanoidiQ5TA45.
KOiK13148.
OMAiKMEFLKG.
OrthoDBiEOG741Z1M.
PhylomeDBiQ5TA45.
TreeFamiTF105878.

Miscellaneous databases

ChiTaRSiCPSF3L. human.
GeneWikiiCPSF3L.
GenomeRNAii54973.
NextBioi58222.
PROiQ5TA45.
SOURCEiSearch...

Gene expression databases

BgeeiQ5TA45.
ExpressionAtlasiQ5TA45. baseline and differential.
GenevisibleiQ5TA45. HS.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR022712. Beta_Casp.
IPR011108. RMMBL.
[Graphical view]
PfamiPF10996. Beta-Casp. 1 hit.
PF00753. Lactamase_B. 1 hit.
PF07521. RMMBL. 1 hit.
[Graphical view]
SMARTiSM01027. Beta-Casp. 1 hit.
SM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5).
    Tissue: Brain and Embryo.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon, Lymph and Ovary.
  7. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
    Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
    Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX, FUNCTION, MUTAGENESIS OF GLU-203.
  8. "A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100."
    Dominski Z., Yang X.-C., Purdy M., Wagner E.J., Marzluff W.F.
    Mol. Cell. Biol. 25:1489-1500(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, INTERACTION WITH INTS9.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiINT11_HUMAN
AccessioniPrimary (citable) accession number: Q5TA45
Secondary accession number(s): A8K5S2
, B3KPR3, B4DM87, G3V1S5, Q5TA46, Q5TA48, Q5TA52, Q5TA53, Q5TA54, Q7L3D7, Q96HY1, Q9BW36, Q9H0F9, Q9H8R5, Q9HAA6, Q9NWX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: July 22, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.