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Q5TA45

- INT11_HUMAN

UniProt

Q5TA45 - INT11_HUMAN

Protein

Integrator complex subunit 11

Gene

CPSF3L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage.1 Publication

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    GO - Biological processi

    1. snRNA processing Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrator complex subunit 11 (EC:3.1.27.-)
    Short name:
    Int11
    Alternative name(s):
    Cleavage and polyadenylation-specific factor 3-like protein
    Short name:
    CPSF3-like protein
    Protein related to CPSF subunits of 68 kDa
    Short name:
    RC-68
    Gene namesi
    Name:CPSF3L
    Synonyms:INTS11, RC68
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26052. CPSF3L.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. cytoplasm Source: UniProtKB-SubCell
    3. integrator complex Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi203 – 2031E → Q: Abolishes the ability of the Integrator complex to process U1 and U2 snRNA genes. 1 Publication

    Organism-specific databases

    PharmGKBiPA142672080.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Integrator complex subunit 11PRO_0000259563Add
    BLAST

    Proteomic databases

    MaxQBiQ5TA45.
    PaxDbiQ5TA45.
    PRIDEiQ5TA45.

    PTM databases

    PhosphoSiteiQ5TA45.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5TA45.
    BgeeiQ5TA45.
    GenevestigatoriQ5TA45.

    Organism-specific databases

    HPAiHPA028379.
    HPA029025.

    Interactioni

    Subunit structurei

    Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.1 Publication

    Protein-protein interaction databases

    BioGridi120310. 20 interactions.
    IntActiQ5TA45. 8 interactions.
    MINTiMINT-1482228.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5TA45.
    SMRiQ5TA45. Positions 3-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi68 – 736HXHXDH motif

    Domaini

    The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1236.
    HOVERGENiHBG080215.
    InParanoidiQ5TA45.
    KOiK13148.
    OMAiMAVEYMS.
    OrthoDBiEOG741Z1M.
    PhylomeDBiQ5TA45.
    TreeFamiTF105878.

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    InterProiIPR001279. Beta-lactamas-like.
    IPR022712. Beta_Casp.
    IPR011108. RMMBL.
    [Graphical view]
    PfamiPF10996. Beta-Casp. 1 hit.
    PF00753. Lactamase_B. 1 hit.
    PF07521. RMMBL. 1 hit.
    [Graphical view]
    SMARTiSM01027. Beta-Casp. 1 hit.
    SM00849. Lactamase_B. 1 hit.
    [Graphical view]
    SUPFAMiSSF56281. SSF56281. 1 hit.

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5TA45-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY    50
    ITQNGRLTDF LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC 100
    PILLEDYRKI AVDKKGEANF FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI 150
    KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN MTPDRHLGAA WIDKCRPNLL 200
    ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF ALGRAQELCI 250
    LLETFWERMN LKVPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF 300
    EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM 350
    PGYCVQGTVG HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ 400
    LVGQAEPESV LLVHGEAKKM EFLKQKIEQE LRVNCYMPAN GETVTLPTSP 450
    SIPVGISLGL LKREMAQGLL PEAKKPRLLH GTLIMKDSNF RLVSSEQALK 500
    ELGLAEHQLR FTCRVHLHDT RKEQETALRV YSHLKSVLKD HCVQHLPDGS 550
    VTVESVLLQA AAPSEDPGTK VLLVSWTYQD EELGSFLTSL LKKGLPQAPS 600
    Length:600
    Mass (Da):67,663
    Last modified:October 31, 2006 - v2
    Checksum:i47C4E2E16202B130
    GO
    Isoform 2 (identifier: Q5TA45-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         43-143: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:499
    Mass (Da):56,013
    Checksum:i91F01E586DDC4FD1
    GO
    Isoform 3 (identifier: Q5TA45-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         143-164: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:578
    Mass (Da):65,240
    Checksum:iAD63044D90F3D6A2
    GO
    Isoform 4 (identifier: Q5TA45-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: Missing.

    Show »
    Length:571
    Mass (Da):64,699
    Checksum:i4F3056C3490955F1
    GO
    Isoform 5 (identifier: Q5TA45-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MPEIRVTPL → MCGAGFGHFEWLAGG

    Show »
    Length:606
    Mass (Da):68,147
    Checksum:iE943195A6FBB41C5
    GO

    Sequence cautioni

    The sequence BAA91246.1 differs from that shown. Reason: Frameshift at position 587.
    The sequence BAB14541.1 differs from that shown. Reason: Frameshift at position 248.
    The sequence CAI23174.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI23176.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI23177.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI23179.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI23180.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI23181.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951P → S in CAB66747. (PubMed:11230166)Curated
    Sequence conflicti95 – 951P → S in CAG38588. 1 PublicationCurated
    Sequence conflicti253 – 2531E → K in BAB13943. (PubMed:14702039)Curated
    Sequence conflicti434 – 4341N → D in BAF84076. (PubMed:14702039)Curated
    Sequence conflicti439 – 4391A → V in BAG51775. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2929Missing in isoform 4. 1 PublicationVSP_045428Add
    BLAST
    Alternative sequencei1 – 99MPEIRVTPL → MCGAGFGHFEWLAGG in isoform 5. 1 PublicationVSP_046643
    Alternative sequencei43 – 143101Missing in isoform 2. 1 PublicationVSP_021472Add
    BLAST
    Alternative sequencei143 – 16422Missing in isoform 3. 1 PublicationVSP_021473Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136813 mRNA. Translation: CAB66747.1.
    AK000549 mRNA. Translation: BAA91246.1. Sequence problems.
    AK021939 mRNA. Translation: BAB13943.1.
    AK023356 mRNA. Translation: BAB14541.1. Frameshift.
    AK056652 mRNA. Translation: BAG51775.1.
    AK291387 mRNA. Translation: BAF84076.1.
    AK297350 mRNA. Translation: BAG59799.1.
    CR533557 mRNA. Translation: CAG38588.1.
    AL139287 Genomic DNA. Translation: CAI23174.1. Different initiation.
    AL139287 Genomic DNA. Translation: CAI23176.1. Different initiation.
    AL139287 Genomic DNA. Translation: CAI23177.1. Different initiation.
    AL139287 Genomic DNA. Translation: CAI23179.1. Sequence problems.
    AL139287 Genomic DNA. Translation: CAI23180.1. Sequence problems.
    AL139287 Genomic DNA. Translation: CAI23181.1. Sequence problems.
    CH471183 Genomic DNA. Translation: EAW56238.1.
    BC000675 mRNA. Translation: AAH00675.2.
    BC007978 mRNA. Translation: AAH07978.1.
    BC013904 mRNA. Translation: AAH13904.2.
    BK005728 mRNA. Translation: DAA05728.1.
    BK005673 mRNA. Translation: DAA05669.1.
    CCDSiCCDS21.1. [Q5TA45-1]
    CCDS57959.1. [Q5TA45-4]
    CCDS57960.1. [Q5TA45-5]
    CCDS57961.1. [Q5TA45-2]
    RefSeqiNP_001243385.1. NM_001256456.1. [Q5TA45-5]
    NP_001243389.1. NM_001256460.1. [Q5TA45-4]
    NP_001243391.1. NM_001256462.1.
    NP_001243392.1. NM_001256463.1. [Q5TA45-2]
    NP_060341.2. NM_017871.5. [Q5TA45-1]
    UniGeneiHs.6449.

    Genome annotation databases

    EnsembliENST00000419704; ENSP00000404886; ENSG00000127054. [Q5TA45-2]
    ENST00000435064; ENSP00000413493; ENSG00000127054. [Q5TA45-1]
    ENST00000450926; ENSP00000392848; ENSG00000127054. [Q5TA45-3]
    ENST00000540437; ENSP00000445001; ENSG00000127054. [Q5TA45-5]
    ENST00000545578; ENSP00000444672; ENSG00000127054. [Q5TA45-4]
    GeneIDi54973.
    KEGGihsa:54973.
    UCSCiuc001aee.2. human. [Q5TA45-1]
    uc001aef.2. human.
    uc001aeh.2. human. [Q5TA45-2]
    uc009vjz.2. human. [Q5TA45-3]

    Polymorphism databases

    DMDMi118572557.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136813 mRNA. Translation: CAB66747.1 .
    AK000549 mRNA. Translation: BAA91246.1 . Sequence problems.
    AK021939 mRNA. Translation: BAB13943.1 .
    AK023356 mRNA. Translation: BAB14541.1 . Frameshift.
    AK056652 mRNA. Translation: BAG51775.1 .
    AK291387 mRNA. Translation: BAF84076.1 .
    AK297350 mRNA. Translation: BAG59799.1 .
    CR533557 mRNA. Translation: CAG38588.1 .
    AL139287 Genomic DNA. Translation: CAI23174.1 . Different initiation.
    AL139287 Genomic DNA. Translation: CAI23176.1 . Different initiation.
    AL139287 Genomic DNA. Translation: CAI23177.1 . Different initiation.
    AL139287 Genomic DNA. Translation: CAI23179.1 . Sequence problems.
    AL139287 Genomic DNA. Translation: CAI23180.1 . Sequence problems.
    AL139287 Genomic DNA. Translation: CAI23181.1 . Sequence problems.
    CH471183 Genomic DNA. Translation: EAW56238.1 .
    BC000675 mRNA. Translation: AAH00675.2 .
    BC007978 mRNA. Translation: AAH07978.1 .
    BC013904 mRNA. Translation: AAH13904.2 .
    BK005728 mRNA. Translation: DAA05728.1 .
    BK005673 mRNA. Translation: DAA05669.1 .
    CCDSi CCDS21.1. [Q5TA45-1 ]
    CCDS57959.1. [Q5TA45-4 ]
    CCDS57960.1. [Q5TA45-5 ]
    CCDS57961.1. [Q5TA45-2 ]
    RefSeqi NP_001243385.1. NM_001256456.1. [Q5TA45-5 ]
    NP_001243389.1. NM_001256460.1. [Q5TA45-4 ]
    NP_001243391.1. NM_001256462.1.
    NP_001243392.1. NM_001256463.1. [Q5TA45-2 ]
    NP_060341.2. NM_017871.5. [Q5TA45-1 ]
    UniGenei Hs.6449.

    3D structure databases

    ProteinModelPortali Q5TA45.
    SMRi Q5TA45. Positions 3-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120310. 20 interactions.
    IntActi Q5TA45. 8 interactions.
    MINTi MINT-1482228.

    PTM databases

    PhosphoSitei Q5TA45.

    Polymorphism databases

    DMDMi 118572557.

    Proteomic databases

    MaxQBi Q5TA45.
    PaxDbi Q5TA45.
    PRIDEi Q5TA45.

    Protocols and materials databases

    DNASUi 54973.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000419704 ; ENSP00000404886 ; ENSG00000127054 . [Q5TA45-2 ]
    ENST00000435064 ; ENSP00000413493 ; ENSG00000127054 . [Q5TA45-1 ]
    ENST00000450926 ; ENSP00000392848 ; ENSG00000127054 . [Q5TA45-3 ]
    ENST00000540437 ; ENSP00000445001 ; ENSG00000127054 . [Q5TA45-5 ]
    ENST00000545578 ; ENSP00000444672 ; ENSG00000127054 . [Q5TA45-4 ]
    GeneIDi 54973.
    KEGGi hsa:54973.
    UCSCi uc001aee.2. human. [Q5TA45-1 ]
    uc001aef.2. human.
    uc001aeh.2. human. [Q5TA45-2 ]
    uc009vjz.2. human. [Q5TA45-3 ]

    Organism-specific databases

    CTDi 54973.
    GeneCardsi GC01M001236.
    HGNCi HGNC:26052. CPSF3L.
    HPAi HPA028379.
    HPA029025.
    MIMi 611354. gene.
    neXtProti NX_Q5TA45.
    PharmGKBi PA142672080.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1236.
    HOVERGENi HBG080215.
    InParanoidi Q5TA45.
    KOi K13148.
    OMAi MAVEYMS.
    OrthoDBi EOG741Z1M.
    PhylomeDBi Q5TA45.
    TreeFami TF105878.

    Miscellaneous databases

    ChiTaRSi CPSF3L. human.
    GeneWikii CPSF3L.
    GenomeRNAii 54973.
    NextBioi 58222.
    PROi Q5TA45.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5TA45.
    Bgeei Q5TA45.
    Genevestigatori Q5TA45.

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    InterProi IPR001279. Beta-lactamas-like.
    IPR022712. Beta_Casp.
    IPR011108. RMMBL.
    [Graphical view ]
    Pfami PF10996. Beta-Casp. 1 hit.
    PF00753. Lactamase_B. 1 hit.
    PF07521. RMMBL. 1 hit.
    [Graphical view ]
    SMARTi SM01027. Beta-Casp. 1 hit.
    SM00849. Lactamase_B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56281. SSF56281. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5).
      Tissue: Brain and Embryo.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon, Lymph and Ovary.
    7. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
      Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
      Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX, FUNCTION, MUTAGENESIS OF GLU-203.
    8. "A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100."
      Dominski Z., Yang X.-C., Purdy M., Wagner E.J., Marzluff W.F.
      Mol. Cell. Biol. 25:1489-1500(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, INTERACTION WITH INTS9.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiINT11_HUMAN
    AccessioniPrimary (citable) accession number: Q5TA45
    Secondary accession number(s): A8K5S2
    , B3KPR3, B4DM87, G3V1S5, Q5TA46, Q5TA48, Q5TA52, Q5TA53, Q5TA54, Q7L3D7, Q96HY1, Q9BW36, Q9H0F9, Q9H8R5, Q9HAA6, Q9NWX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3