Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol 4-phosphate 5-kinase-like protein 1

Gene

PIP5KL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a scaffold to localize and regulate type I PI4P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.By similarity

Caution

It is unsure if the enzyme has intrinsic kinase activity.Curated

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (EC:2.7.1.68)
Short name:
PI(4)P 5-kinase-like protein 1
Short name:
PtdIns(4)P-5-kinase-like protein 1
Gene namesi
Name:PIP5KL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000167103.11
HGNCiHGNC:28711 PIP5KL1
MIMi612865 gene
neXtProtiNX_Q5T9C9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167103
PharmGKBiPA134926015

Polymorphism and mutation databases

BioMutaiPIP5KL1
DMDMi146325056

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002857581 – 394Phosphatidylinositol 4-phosphate 5-kinase-like protein 1Add BLAST394

Proteomic databases

PaxDbiQ5T9C9
PeptideAtlasiQ5T9C9
PRIDEiQ5T9C9

PTM databases

iPTMnetiQ5T9C9
PhosphoSitePlusiQ5T9C9

Expressioni

Gene expression databases

BgeeiENSG00000167103
CleanExiHS_PIP5KL1
GenevisibleiQ5T9C9 HS

Organism-specific databases

HPAiHPA056240

Interactioni

Subunit structurei

Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase.By similarity

Protein-protein interaction databases

BioGridi126513, 3 interactors
STRINGi9606.ENSP00000373399

Structurei

3D structure databases

ProteinModelPortaliQ5T9C9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 393PIPKPROSITE-ProRule annotationAdd BLAST358

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000115541
HOVERGENiHBG097351
InParanoidiQ5T9C9
KOiK13712
OMAiPQRSWFL
OrthoDBiEOG091G07ZA
PhylomeDBiQ5T9C9
TreeFamiTF354315

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 1 hit
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T9C9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPSPGPRE VLAPSPEAGC RAVTSSRRGL LWRLRDKQSR LGLFEISPGH
60 70 80 90 100
ELHGMTCMMQ AGLWAATQVS MDHPPTGPPS RDDFSEVLTQ VHEGFELGTL
110 120 130 140 150
AGPAFAWLRR SLGLAEEDYQ AALGPGGPYL QFLSTSKSKA SFFLSHDQRF
160 170 180 190 200
FLKTQGRREV QALLAHLPRY VQHLQRHPHS LLARLLGVHS LRVDRGKKTY
210 220 230 240 250
FIVMQSVFYP AGRISERYDI KGCEVSRWVD PAPEGSPLVL VLKDLNFQGK
260 270 280 290 300
TINLGPQRSW FLRQMELDTT FLRELNVLDY SLLIAFQRLH EDERGPGSSL
310 320 330 340 350
IFRTARSVQG AQSPEESRAQ NRRLLPDAPN ALHILDGPEQ RYFLGVVDLA
360 370 380 390
TVYGLRKRLE HLWKTLRYPG RTFSTVSPAR YARRLCQWVE AHTE
Length:394
Mass (Da):44,572
Last modified:February 20, 2007 - v2
Checksum:i34D41BC034B574FD
GO
Isoform 2 (identifier: Q5T9C9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):22,029
Checksum:iFB87326C01AD8EA7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0249041 – 203Missing in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157935 Genomic DNA No translation available.
BC042184 mRNA Translation: AAH42184.1
CCDSiCCDS48030.1 [Q5T9C9-1]
CCDS6885.1 [Q5T9C9-2]
RefSeqiNP_001128691.1, NM_001135219.1 [Q5T9C9-1]
NP_775763.1, NM_173492.1 [Q5T9C9-2]
UniGeneiHs.734928

Genome annotation databases

EnsembliENST00000300432; ENSP00000300432; ENSG00000167103 [Q5T9C9-2]
ENST00000388747; ENSP00000373399; ENSG00000167103 [Q5T9C9-1]
GeneIDi138429
KEGGihsa:138429
UCSCiuc004bsu.3 human [Q5T9C9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPI5L1_HUMAN
AccessioniPrimary (citable) accession number: Q5T9C9
Secondary accession number(s): Q8IVS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health