Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5T9C9

- PI5L1_HUMAN

UniProt

Q5T9C9 - PI5L1_HUMAN

Protein

Phosphatidylinositol 4-phosphate 5-kinase-like protein 1

Gene

PIP5KL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May act as a scaffold to localize and regulate type I PI4P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.By similarity

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (EC:2.7.1.68)
    Short name:
    PI(4)P 5-kinase-like protein 1
    Short name:
    PtdIns(4)P-5-kinase-like protein 1
    Gene namesi
    Name:PIP5KL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:28711. PIP5KL1.

    Subcellular locationi

    Cytoplasm. Membrane
    Note: Localized to large cytoplasmic vesicular structures.By similarity

    GO - Cellular componenti

    1. cell projection Source: Ensembl
    2. cytoplasm Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134926015.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Phosphatidylinositol 4-phosphate 5-kinase-like protein 1PRO_0000285758Add
    BLAST

    Proteomic databases

    PaxDbiQ5T9C9.
    PRIDEiQ5T9C9.

    PTM databases

    PhosphoSiteiQ5T9C9.

    Expressioni

    Gene expression databases

    BgeeiQ5T9C9.
    CleanExiHS_PIP5KL1.
    GenevestigatoriQ5T9C9.

    Organism-specific databases

    HPAiHPA056240.

    Interactioni

    Subunit structurei

    Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase.By similarity

    Protein-protein interaction databases

    BioGridi126513. 3 interactions.
    STRINGi9606.ENSP00000373399.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T9C9.
    SMRiQ5T9C9. Positions 79-389.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 393358PIPKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5253.
    HOGENOMiHOG000115541.
    HOVERGENiHBG097351.
    InParanoidiQ5T9C9.
    KOiK13712.
    OMAiPQRSWFL.
    OrthoDBiEOG77DJ5R.
    PhylomeDBiQ5T9C9.
    TreeFamiTF354315.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 1 hit.
    InterProiIPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF01504. PIP5K. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T9C9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPSPGPRE VLAPSPEAGC RAVTSSRRGL LWRLRDKQSR LGLFEISPGH    50
    ELHGMTCMMQ AGLWAATQVS MDHPPTGPPS RDDFSEVLTQ VHEGFELGTL 100
    AGPAFAWLRR SLGLAEEDYQ AALGPGGPYL QFLSTSKSKA SFFLSHDQRF 150
    FLKTQGRREV QALLAHLPRY VQHLQRHPHS LLARLLGVHS LRVDRGKKTY 200
    FIVMQSVFYP AGRISERYDI KGCEVSRWVD PAPEGSPLVL VLKDLNFQGK 250
    TINLGPQRSW FLRQMELDTT FLRELNVLDY SLLIAFQRLH EDERGPGSSL 300
    IFRTARSVQG AQSPEESRAQ NRRLLPDAPN ALHILDGPEQ RYFLGVVDLA 350
    TVYGLRKRLE HLWKTLRYPG RTFSTVSPAR YARRLCQWVE AHTE 394
    Length:394
    Mass (Da):44,572
    Last modified:February 20, 2007 - v2
    Checksum:i34D41BC034B574FD
    GO
    Isoform 2 (identifier: Q5T9C9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-203: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:191
    Mass (Da):22,029
    Checksum:iFB87326C01AD8EA7
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 203203Missing in isoform 2. 1 PublicationVSP_024904Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157935 Genomic DNA. Translation: CAI12614.2.
    AL157935 Genomic DNA. Translation: CAM14148.1.
    BC042184 mRNA. Translation: AAH42184.1.
    CCDSiCCDS48030.1. [Q5T9C9-1]
    CCDS6885.1. [Q5T9C9-2]
    RefSeqiNP_001128691.1. NM_001135219.1. [Q5T9C9-1]
    NP_775763.1. NM_173492.1. [Q5T9C9-2]
    UniGeneiHs.734928.

    Genome annotation databases

    EnsembliENST00000300432; ENSP00000300432; ENSG00000167103. [Q5T9C9-2]
    ENST00000388747; ENSP00000373399; ENSG00000167103. [Q5T9C9-1]
    GeneIDi138429.
    KEGGihsa:138429.
    UCSCiuc004bsu.3. human. [Q5T9C9-2]
    uc011mao.2. human. [Q5T9C9-1]

    Polymorphism databases

    DMDMi146325056.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL157935 Genomic DNA. Translation: CAI12614.2 .
    AL157935 Genomic DNA. Translation: CAM14148.1 .
    BC042184 mRNA. Translation: AAH42184.1 .
    CCDSi CCDS48030.1. [Q5T9C9-1 ]
    CCDS6885.1. [Q5T9C9-2 ]
    RefSeqi NP_001128691.1. NM_001135219.1. [Q5T9C9-1 ]
    NP_775763.1. NM_173492.1. [Q5T9C9-2 ]
    UniGenei Hs.734928.

    3D structure databases

    ProteinModelPortali Q5T9C9.
    SMRi Q5T9C9. Positions 79-389.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126513. 3 interactions.
    STRINGi 9606.ENSP00000373399.

    PTM databases

    PhosphoSitei Q5T9C9.

    Polymorphism databases

    DMDMi 146325056.

    Proteomic databases

    PaxDbi Q5T9C9.
    PRIDEi Q5T9C9.

    Protocols and materials databases

    DNASUi 138429.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300432 ; ENSP00000300432 ; ENSG00000167103 . [Q5T9C9-2 ]
    ENST00000388747 ; ENSP00000373399 ; ENSG00000167103 . [Q5T9C9-1 ]
    GeneIDi 138429.
    KEGGi hsa:138429.
    UCSCi uc004bsu.3. human. [Q5T9C9-2 ]
    uc011mao.2. human. [Q5T9C9-1 ]

    Organism-specific databases

    CTDi 138429.
    GeneCardsi GC09M130683.
    HGNCi HGNC:28711. PIP5KL1.
    HPAi HPA056240.
    MIMi 612865. gene.
    neXtProti NX_Q5T9C9.
    PharmGKBi PA134926015.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5253.
    HOGENOMi HOG000115541.
    HOVERGENi HBG097351.
    InParanoidi Q5T9C9.
    KOi K13712.
    OMAi PQRSWFL.
    OrthoDBi EOG77DJ5R.
    PhylomeDBi Q5T9C9.
    TreeFami TF354315.

    Miscellaneous databases

    GenomeRNAii 138429.
    NextBioi 83792.
    PROi Q5T9C9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5T9C9.
    CleanExi HS_PIP5KL1.
    Genevestigatori Q5T9C9.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 1 hit.
    InterProi IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF01504. PIP5K. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiPI5L1_HUMAN
    AccessioniPrimary (citable) accession number: Q5T9C9
    Secondary accession number(s): Q8IVS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3