Q5T9C9 (PI5L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
Short name=PI(4)P 5-kinase-like protein 1
Short name=PtdIns(4)P-5-kinase-like protein 1
EC=2.7.1.68

Gene names

Name:

PIP5KL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a scaffold to localize and regulate type I PI4P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3 By similarity.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Subunit structure	Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase By similarity.
Subcellular location	Cytoplasm. Membrane. Note: Localized to large cytoplasmic vesicular structures By similarity.
Sequence similarities	Contains 1 PIPK domain.
Caution	It is unsure if the enzyme has intrinsic kinase activity.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylinositol phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cell projection Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-phosphatidylinositol-4-phosphate 5-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T9C9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T9C9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1		PRO_0000285758
Regions
	Domain	36 – 393	358	PIPK
Natural variations
	Alternative sequence	1 – 203	203	Missing in isoform 2.		VSP_024904

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 34D41BC034B574FD	FASTA	394	44,572
	10 20 30 40 50 60 MAAPSPGPRE VLAPSPEAGC RAVTSSRRGL LWRLRDKQSR LGLFEISPGH ELHGMTCMMQ 70 80 90 100 110 120 AGLWAATQVS MDHPPTGPPS RDDFSEVLTQ VHEGFELGTL AGPAFAWLRR SLGLAEEDYQ 130 140 150 160 170 180 AALGPGGPYL QFLSTSKSKA SFFLSHDQRF FLKTQGRREV QALLAHLPRY VQHLQRHPHS 190 200 210 220 230 240 LLARLLGVHS LRVDRGKKTY FIVMQSVFYP AGRISERYDI KGCEVSRWVD PAPEGSPLVL 250 260 270 280 290 300 VLKDLNFQGK TINLGPQRSW FLRQMELDTT FLRELNVLDY SLLIAFQRLH EDERGPGSSL 310 320 330 340 350 360 IFRTARSVQG AQSPEESRAQ NRRLLPDAPN ALHILDGPEQ RYFLGVVDLA TVYGLRKRLE 370 380 390 HLWKTLRYPG RTFSTVSPAR YARRLCQWVE AHTE
	Isoform 2 [UniParc]. Checksum: FB87326C01AD8EA7	FASTA	191	22,029
	10 20 30 40 50 60 MQSVFYPAGR ISERYDIKGC EVSRWVDPAP EGSPLVLVLK DLNFQGKTIN LGPQRSWFLR 70 80 90 100 110 120 QMELDTTFLR ELNVLDYSLL IAFQRLHEDE RGPGSSLIFR TARSVQGAQS PEESRAQNRR 130 140 150 160 170 180 LLPDAPNALH ILDGPEQRYF LGVVDLATVY GLRKRLEHLW KTLRYPGRTF STVSPARYAR 190 RLCQWVEAHT E

References

[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157935 Genomic DNA. Translation: CAI12614.2. AL157935 Genomic DNA. Translation: CAM14148.1. BC042184 mRNA. Translation: AAH42184.1.
IPI	IPI00161706. IPI00783265.
RefSeq	NP_001128691.1. NM_001135219.1. NP_775763.1. NM_173492.1.
UniGene	Hs.734928.
3D structure databases
HSSP	HSSP built from PDB template 1BO1 based on UniProtKB P78356.
ProteinModelPortal	Q5T9C9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000373399.
PTM databases
PhosphoSite	Q5T9C9.
Polymorphism databases
DMDM	146325056.
Proteomic databases
PaxDb	Q5T9C9.
PRIDE	Q5T9C9.
Protocols and materials databases
DNASU	138429.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300432; ENSP00000300432; ENSG00000167103. ENST00000388747; ENSP00000373399; ENSG00000167103.
GeneID	138429.
KEGG	hsa:138429.
UCSC	uc004bsu.3. human. uc011mao.2. human.
Organism-specific databases
CTD	138429.
GeneCards	GC09M130683.
HGNC	HGNC:28711. PIP5KL1.
MIM	612865. gene.
neXtProt	NX_Q5T9C9.
PharmGKB	PA134926015.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5253.
HOGENOM	HOG000115541.
HOVERGEN	HBG097351.
InParanoid	Q5T9C9.
KO	K13712.
OMA	PQRSWFL.
OrthoDB	EOG4TB4BW.
Gene expression databases
Bgee	Q5T9C9.
CleanEx	HS_PIP5KL1.
Genevestigator	Q5T9C9.
Family and domain databases
InterPro	IPR023610. PInositol-4-P-5-kinase. IPR002498. PInositol-4-P-5-kinase_core. [Graphical view]
PANTHER	PTHR23086. PTHR23086. 1 hit.
Pfam	PF01504. PIP5K. 1 hit. [Graphical view]
PROSITE	PS51455. PIPK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	138429.
NextBio	83792.
SOURCE	Search...

Entry information

Entry name

PI5L1_HUMAN

Accession

Primary (citable) accession number: Q5T9C9
Secondary accession number(s): Q8IVS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	February 20, 2007
Last modified:	May 1, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.