SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5T9C9

- PI5L1_HUMAN

UniProt

Q5T9C9 - PI5L1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
Gene
PIP5KL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as a scaffold to localize and regulate type I PI4P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3 By similarity.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (EC:2.7.1.68)
Short name:
PI(4)P 5-kinase-like protein 1
Short name:
PtdIns(4)P-5-kinase-like protein 1
Gene namesi
Name:PIP5KL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:28711. PIP5KL1.

Subcellular locationi

Cytoplasm. Membrane
Note: Localized to large cytoplasmic vesicular structures By similarity.

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. cytoplasm Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134926015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
PRO_0000285758Add
BLAST

Proteomic databases

PaxDbiQ5T9C9.
PRIDEiQ5T9C9.

PTM databases

PhosphoSiteiQ5T9C9.

Expressioni

Gene expression databases

BgeeiQ5T9C9.
CleanExiHS_PIP5KL1.
GenevestigatoriQ5T9C9.

Organism-specific databases

HPAiHPA056240.

Interactioni

Subunit structurei

Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase By similarity.

Protein-protein interaction databases

BioGridi126513. 3 interactions.
STRINGi9606.ENSP00000373399.

Structurei

3D structure databases

ProteinModelPortaliQ5T9C9.
SMRiQ5T9C9. Positions 79-389.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 393358PIPK
Add
BLAST

Sequence similaritiesi

Contains 1 PIPK domain.

Phylogenomic databases

eggNOGiCOG5253.
HOGENOMiHOG000115541.
HOVERGENiHBG097351.
InParanoidiQ5T9C9.
KOiK13712.
OMAiPQRSWFL.
OrthoDBiEOG77DJ5R.
PhylomeDBiQ5T9C9.
TreeFamiTF354315.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T9C9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAPSPGPRE VLAPSPEAGC RAVTSSRRGL LWRLRDKQSR LGLFEISPGH    50
ELHGMTCMMQ AGLWAATQVS MDHPPTGPPS RDDFSEVLTQ VHEGFELGTL 100
AGPAFAWLRR SLGLAEEDYQ AALGPGGPYL QFLSTSKSKA SFFLSHDQRF 150
FLKTQGRREV QALLAHLPRY VQHLQRHPHS LLARLLGVHS LRVDRGKKTY 200
FIVMQSVFYP AGRISERYDI KGCEVSRWVD PAPEGSPLVL VLKDLNFQGK 250
TINLGPQRSW FLRQMELDTT FLRELNVLDY SLLIAFQRLH EDERGPGSSL 300
IFRTARSVQG AQSPEESRAQ NRRLLPDAPN ALHILDGPEQ RYFLGVVDLA 350
TVYGLRKRLE HLWKTLRYPG RTFSTVSPAR YARRLCQWVE AHTE 394
Length:394
Mass (Da):44,572
Last modified:February 20, 2007 - v2
Checksum:i34D41BC034B574FD
GO
Isoform 2 (identifier: Q5T9C9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.

Note: No experimental confirmation available.

Show »
Length:191
Mass (Da):22,029
Checksum:iFB87326C01AD8EA7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 203203Missing in isoform 2.
VSP_024904Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157935 Genomic DNA. Translation: CAI12614.2.
AL157935 Genomic DNA. Translation: CAM14148.1.
BC042184 mRNA. Translation: AAH42184.1.
CCDSiCCDS48030.1. [Q5T9C9-1]
CCDS6885.1. [Q5T9C9-2]
RefSeqiNP_001128691.1. NM_001135219.1. [Q5T9C9-1]
NP_775763.1. NM_173492.1. [Q5T9C9-2]
UniGeneiHs.734928.

Genome annotation databases

EnsembliENST00000300432; ENSP00000300432; ENSG00000167103. [Q5T9C9-2]
ENST00000388747; ENSP00000373399; ENSG00000167103. [Q5T9C9-1]
GeneIDi138429.
KEGGihsa:138429.
UCSCiuc004bsu.3. human. [Q5T9C9-2]
uc011mao.2. human. [Q5T9C9-1]

Polymorphism databases

DMDMi146325056.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL157935 Genomic DNA. Translation: CAI12614.2 .
AL157935 Genomic DNA. Translation: CAM14148.1 .
BC042184 mRNA. Translation: AAH42184.1 .
CCDSi CCDS48030.1. [Q5T9C9-1 ]
CCDS6885.1. [Q5T9C9-2 ]
RefSeqi NP_001128691.1. NM_001135219.1. [Q5T9C9-1 ]
NP_775763.1. NM_173492.1. [Q5T9C9-2 ]
UniGenei Hs.734928.

3D structure databases

ProteinModelPortali Q5T9C9.
SMRi Q5T9C9. Positions 79-389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126513. 3 interactions.
STRINGi 9606.ENSP00000373399.

PTM databases

PhosphoSitei Q5T9C9.

Polymorphism databases

DMDMi 146325056.

Proteomic databases

PaxDbi Q5T9C9.
PRIDEi Q5T9C9.

Protocols and materials databases

DNASUi 138429.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300432 ; ENSP00000300432 ; ENSG00000167103 . [Q5T9C9-2 ]
ENST00000388747 ; ENSP00000373399 ; ENSG00000167103 . [Q5T9C9-1 ]
GeneIDi 138429.
KEGGi hsa:138429.
UCSCi uc004bsu.3. human. [Q5T9C9-2 ]
uc011mao.2. human. [Q5T9C9-1 ]

Organism-specific databases

CTDi 138429.
GeneCardsi GC09M130683.
HGNCi HGNC:28711. PIP5KL1.
HPAi HPA056240.
MIMi 612865. gene.
neXtProti NX_Q5T9C9.
PharmGKBi PA134926015.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5253.
HOGENOMi HOG000115541.
HOVERGENi HBG097351.
InParanoidi Q5T9C9.
KOi K13712.
OMAi PQRSWFL.
OrthoDBi EOG77DJ5R.
PhylomeDBi Q5T9C9.
TreeFami TF354315.

Miscellaneous databases

GenomeRNAii 138429.
NextBioi 83792.
PROi Q5T9C9.
SOURCEi Search...

Gene expression databases

Bgeei Q5T9C9.
CleanExi HS_PIP5KL1.
Genevestigatori Q5T9C9.

Family and domain databases

Gene3Di 3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProi IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view ]
PANTHERi PTHR23086. PTHR23086. 1 hit.
Pfami PF01504. PIP5K. 1 hit.
[Graphical view ]
PROSITEi PS51455. PIPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiPI5L1_HUMAN
AccessioniPrimary (citable) accession number: Q5T9C9
Secondary accession number(s): Q8IVS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi